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Probably Science

Author: Andy Wood, Matt Kirshen

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Professional comedians with so-so STEM pedigrees take you through this week in science. Incompetently. Featuring hosts Matt Kirshen, Andy Wood (and sometimes Jesse Case or Brooks Wheelan) along with a rotating cast of special guests from the worlds of comedy and science.
593 Episodes
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Comedian Michelle Murphy (@meeshoffleash) joins Andy, Matt and Jesse to talk about playing tennis for Grinnell, the Enhanced Games, celebrities trying their hands at winter sports, Jesse's accidental mermaid book purchase and the Dr. Seuss book he was aiming for, Burning Man missionaries, LSD to fight anxiety and surprisingly not too uncommon iridescent mammals.
Episode 579 - Ken Reid

Episode 579 - Ken Reid

2025-09-1701:15:54

Comedian Ken Reid (@kennethwreid) joins Jesse, Matt and Andy to talk about growing up a child of television, mud wrestling, Ken's podcast TV Guidance Counselor, an HIV prevention breakthrough, the insanity of Movie 43, the human washing machine no one asked for, blasting plastic waste with a plasma torch, Doja Cat's nod to Max Headroom, Ladies and Gentlemen, The Fabulous Stains, the reason plastic recycling mostly ended, Andy's Oktoberfest shows in Lake Arrowhead and John Williams polka music.
Comedian Ryan O'Flanagan (@ryanoflan) joins Matt, Jesse and Andy to talk about Ryan and Andy's chance encounter in a bar in Leadville, Married With Children tattoos, neanderthals and homo sapiens interbreeding, a novel telescope shape to help search for exoplanets, an insane impression of a neanderthal voice and Ryan's podcast Laser Show.
Episode 577 - Myq Kaplan

Episode 577 - Myq Kaplan

2025-08-2901:11:37

Comedian Myq Kaplan (@myqkaplan) returns to the show to talk to Andy, Jesse and Matt about growing out his eyebrows during the pandemic, babies distinguishing Ps from Bs, linguistics, sign language variations, standups aping Shane Gillis, the Mr. Beast voice, birds' preference for crapping in the air, strong link versus weak link problems, Ryan North, whether you should pay for bad art, what sequels always get wrong and Myq's great Substack.
Comedian and host of the SSRI’M OK podcast Macey Isaacs joins the gang to talk about a meteorite that’s older than our planet! AI and attachment theory! And some more AI nonsense before Andy’s connection quit in a fury! In the Patreon bonus we find out why living near the ocean extends your life. Follow Macey on instagram and check out her podcast, and her Don’t Tell special when it drops! Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here to subscribe in Stitcher
Episode 575 - Matt Parker

Episode 575 - Matt Parker

2025-08-1101:06:05

Comedian/mathematician/YouTuber/author Matt Parker (@standupmaths) joins Jesse, Andy and Matt to talk about his new book Love Triangle: How Trigonometry Shapes the World, his podcast A Problem Squared, his Edinburgh Fringe show Getting Triggy With It, Mathstodon, a hawk that uses traffic patterns to target prey, desire paths, Earth's leaking core, the Gibeon meteor, Matt's comedy tour dates and Andy's Colorado music dates.
Comedian Josh Gondelman (@joshgondelman) joins Andy and Matt to talk about his new special Positive Reinforcement, his newsletter, his wife Maris Kreizman's new book of essays, the geek/nerd/dweeb/dork Venn diagram, Nancy Kerrigan and Chris Farley, a new ass-grass fad among chimps, ass/gas/grass bumper stickers, neanderthals eating maggots and rotten meat, how surprisingly warm Uranus is and Tylenol inducing risky behavior.
Episode 573 - Kai Humphries

Episode 573 - Kai Humphries

2025-07-2501:09:54

Comedian Kai Humphries (@kaihumphries) joins Matt, Andy and Jesse to talk about his new special Gallivanting, the passing of Hulk Hogan, superheating solid gold, the Air Bud cinematic universe and an enormous 80,000-year-old blob in Utah.
Episode 572 - Eric Rocha

Episode 572 - Eric Rocha

2025-07-2201:11:34

Comedian Eric Rocha (@ericrochacomedy) joins Andy, Jesse and Matt to talk about competing namesakes, fezzes, last suppers, Jesse's macronutrient gas, sleep hygiene, comedy on airplanes, what would happen if you threw a paper airplane from the ISS, a neanderthal fat factory, Matt's standup tour and Andy's Colorado ska tour.
Episode 571 - Bryan Cook

Episode 571 - Bryan Cook

2025-07-1201:03:25

Comedian and Jimmy Kimmel Live! writer Bryan Cook (@bryancooking) returns to the show for a technical difficulty-laden episode in which Jesse and Andy talk with Matt while he's on a cruise ship, covering topics including comedy on a boat, candlepin bowling, a new interstellar object, crypto failures, Anthropic's Claude having an identity crisis, the Sean Connery classic Zardoz, an AI band with way too many Spotify plays, Matt's upcoming standup shows and Andy's upcoming Colorado tour with Warsaw Poland Brothers.
The gang's back together again to talk about how your pets alter your immune system, a plan to bomb an island full of invasive mice, why the Pentagon wants you to believe in UFOs and a rare post-orgasm illness that causes days of flu-like symptoms.
Episode 569 - JT Habersaat

Episode 569 - JT Habersaat

2025-06-1101:06:47

Comedian and author of new book Doing Time: Comedians Talk About Standup JT Habersaat (jtcomedy.com) to talk about the other books on Jawbone Press! Making bespoke action figures! Changing your brainwaves to not feel pain! Infrared contact lenses for night vision! Other contact lenses to cheat at poker! How joke magazine x-ray specs “work”! A shapeshifting octopus! And whether the Loch Ness Monster is a whale penis! In the Patreon bonus we hear about a new Chinese space mission and a paragliding mishap. Please go and see Matt Jul 16 in Columbus OH, Jul 31 in Hartford CT, or Oct 12 in Virginia Beach VA.  
Episode 568 - Tom Rhodes

Episode 568 - Tom Rhodes

2025-06-0301:06:53

Globetrotting headliner Tom Rhodes (tomrhodes.net) has a new special, The Ripest Zebras, available on his website. He joins Jesse and Matt to talk about growing up in NASA’s backyard! The chair challenge! Wasps having surprisingly good memories! While herrings might not! Tom’s hummingbird facts! Plus how to drop an egg! And push straws through potatoes! In the Patreon bonus we hear about an update to the classic marshmallow test and Tom’s key to a good relationship. Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here to subscribe in Stitcher
Comedian and filmmaker Ron Placone (@ronplacone) joins Andy, Jesse and Matt to talk about his new movie Left at Wall, the guy who let venomous snakes bite him hundreds of times for science (kind of), a color no one had seen until now, retinitis pigmentosa and turning lead into gold.
Comedian, writer and author of upcoming novel “First Time, Long Time” Amy Silverberg (@amysilverberg) joins the gang to talk about Andy’s Irish landscape spotting! The optimal amount of bra bounce! Andy’s Iberian adventures! Lions biting gladiators! Men fighting gorillas! And which glasses to wear to avoid the fight yourself! In the Patreon bonus we talk about lucid dreaming and a new state of mind. Please go and see Matt Jul 16 in Columbus OH, Jul 31 in Hartford CT, or Oct 12 in Virginia Beach VA. And Andy’s band on May 31 at Coyote Run Studio in Joshua Tree. Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here to subscribe in Stitcher  
Episode 565 - Tony Camin

Episode 565 - Tony Camin

2025-05-0201:23:53

Great stand-up and co-creator of the Marijuana-Logues Tony Camin (@tony.camin) joins Jesse and Matt to talk about crows’ geometry skills! Tony helping one of the fathers of decision analysis! Why seals don’t drown! Unlikely animal friends! And whether your month of conception shapes your body! Tony’s new album, An Ass Pocket of Whimsy will come out on Stand-Up! Records and you can find him at tonycamin.com. Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here to subscribe in Stitcher
Episode 564 - Samantha Hale

Episode 564 - Samantha Hale

2025-04-2601:23:36

Comedian and Horror Nerd Samantha Hale (@thesamanthahale) joins Jesse and Matt to talk about: A layer of life deep below us! The not actually back from extinction dire wolves! The Earth’s mysterious pulsations! and Reagan’s obsession with the Titanic! In the Patreon bonus we talk about bending sounds. Click here to support Probably Science via Patreon Click here to subscribe in Apple Podcasts Click here to subscribe in Stitcher
Friend of the show Wil Anderson (@officialwilanderson) joins Matt live in Perth along with marine biologist-turned-comedian Robyn Perkins (@robynhperkins) to talk all things coral, nudibranchs, poisonous sea creatures and surprising things to do with dry ice and mouths.
Episode 562 - Shawn Carlow

Episode 562 - Shawn Carlow

2025-03-3101:11:48

Writer/comedian Shawn Carlow (@shawncarlow) joins Jesse, Andy and Matt to talk about his new book People of the Titanic: 30 Tales of Extra-Doomed Souls Who Sailed on The Ship of Dreams, mouse-to-mouse resuscitation, what your poop schedule says about your health and physicists creating a supersolid out of light.
Live from Perth, Matt is joined by Ross Noble, Kirsty Webeck and Paul Savage to talk about if you can cook a chicken by throwing ice cubes at it, dolphins communicating with pee streams, dormant volcanoes that aren’t that dormant and astronauts’ eyesight.
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Comments (13)

unhumen 1

hah! i currently have superglue on a cut.

Feb 14th
Reply

Buck Underbrush

"dot dot line line spider crawling up your spine cool breeze tight squeeze now you got the shiveries"

Apr 29th
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Jared Swapp

He asks what she does at her job and she proceeds to rub her ego for 30 minutes straight..

Apr 16th
Reply

Paul Hart

you guys know too much about fucking vegetables

May 5th
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Duke of Bread

episode 353 should be called boomer talk. "I just deal with my OCD people should just deal with their phobias like me" a whole episode of complaining about nothing. Very old white men of you.

Sep 17th
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Duke of Bread

I dont appreciate the propaganda about the situation in Venezuela at the beginning of this episode. I dont think a comedian from a wealthy background that moved to DC when he was 11 is a good resource. If you're going to talk about this and not even mention the US policy decisions, the petrol dollar or anything then you are spreading ignorance. Seriously going to praise Guado? jesus.. His opinions are clearly colored by a wealthy background and completely full of shit.

Jul 29th
Reply (1)

Paul Hart

I just listened to your show and loved it. have done for years. I was disturbed about your comment n sugar gliders. they are an Australian animal and protected under very strict laws. t is illegal to keep one. for some reason they are pets over there and are transported via your mail system

May 20th
Reply

Riikka

This episode is a rollercoaster. Love it!

Sep 27th
Reply

Paul Hart

listening to your discussion on deaf people "hearing" voices , made me wonder how blind people dream

Jun 22nd
Reply

Mac Gealaí

I would love to be the one providing the material for your inquiry into psilocybin. find Mac Gealai on fb and message me if you'd like to test this out with flies or on yourselves!

Mar 8th
Reply

Jake Specht

Great podcast! Still getting caught up, but even the old (possibly out of date) episodes are hilarious.

Feb 28th
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Noah W

I love these guys. Matt/Andy, keep doing your thing!

Jun 27th
Reply