Discover CircRes

This month on Episode 77 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 26th and October 10th issues of Circulation Research. This Episode also features a discussion with Dr Camilla Wenceslau and Dr Laena Pernomian about their study, Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure Via Attenuation of EndMT in Hypertensive Mice. Article highlights: Brito-Estrada, et al. DWORF Gene Therapy Attenuates Heart Failure Yamaguchi, et al. Calcium Oscillation Within Renin Cell Clusters Parthiban, et al. Macrophage CCL24 Promotes Fibrosis Gonzales, et al. Circ-cdr1as in Cardiac Repair

This month on Episode 76 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 29th and September 12th issues of Circulation Research. This Episode also features a discussion with Drs Swapnil Sonkusare and Mani Kuppusamy about their manuscript, Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.   Article highlights: Tombor, et al. Immunomodulatory Endothelial Cells After Heart Attack Du, et al. CAR-Ms Engineered In Vivo for Attenuating MIRI Pauza, et al. MC4R Activates Carotid Body in Hypertension Cai, et al. Lkb1 KO in PVAT Drives Aortic Aneurysm Formation

This month on Episode 75 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 1st and August 15th issues of Circulation Research. This Episode also features a discussion with Abigail Ajanel, Dr Robbie Campbell and Dr Frederik Denorme about their study, Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.   Article highlights: Lan, et al. TRIM16 Exacerbates Vascular Calcification Zhang, et al. HADHA Lactylation in Septic Myocardial Depression Li, et al. AR Links to CVMs Baudel, et al. Vascular Panx1 in Diabetic Hyperglycemia

This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award.   Article highlights: Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms

This month on Episode 73 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research. This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness.   Article highlights: Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium He, et al. NEP in Placental EVs Triggers Hypertension in PE Dennis, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis in Diabetes

This month on Episode 72 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research. This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF     Article highlights: Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart Yang, et al. Srsf3 Limits AS by Lengthening 3′ UTRs of mtARSs Li, et al.  CircCDYL Contributes to Cardiac Hypertrophy Zhakeer, et al. Treg Cells Regulate Pulmonary Venous Remodeling

This month on Episode 71 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research. This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice.   Article highlights: Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart Perelli, et al. TAX1BP3 and Arrhythmogenic Cardiomyopathy Lalaguna, et al. Overexpression of Wild Type TMEM43 Improves ARVC5 Liu, et al. NR4A1 Inhibits Platelet Function

This month on Episode 70 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women.   Article highlights: Huang, et al. Targeting CXCR3 in ICI-Mediated Myocarditis Ju, et al. RIC-Enhanced Efferocytosis on Stroke Recovery Halmos, et al. Cholesterol Efflux Pathways Control SMC Function Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice  

This month on Episode 69 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research. This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology.   Article highlights: Huang, et al. Vps4a Safeguards Plasma Membrane Integrity Liu, et al. PPM1B Deubiquitination Promotes Arterial Stiffness Muralitharan, et al. GPR41/43 and Blood Pressure Park, et al. Ferroptosis and Its Consequences in Preeclampsia

This month on Episode 68 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research. This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy.   Article highlights: Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis Johansen, et al. TCF21 and Cardiac Fibrosis Pabon, et al. Endothelial METAP1 in Preeclampsia Mutchler, et al. ET-3/ETBR, Immune Cells, and Kidney Lymphatics

This month on Episode 67 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research. This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function.   Article highlights: Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension Ma, et al. Kindlin-2 LLPS Controls Vascular Stability Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury

This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.   Article highlights: Lou, et al. Visualizing irAEs in Atherosclerosis Yoshii, et al. Defective Mitophagy Response in HFpEF Heart Zeller, et al. Shear Stress Dissociates C-Reactive Protein Chen, et al. EPHB4-RASA1 Regulation of Lymphatic Valvulogenesis

This month on Episode 65 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research. This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism.   Article highlights: Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy Pirri, et al. EPAS1 Atheroprotection via Fatty Acid Metabolism Saleem, et al. Myeloid CD11c+ Cells and JAK2/STAT3/SMAD3 in SSBP Pietsch, et al. Chronic Activation of Tubulin Tyrosination

This month on Episode 64 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 30th and September 13th issues of Circulation Research. This Episode also includes a discussion with Drs Stephanie Chung, Ahmed Gharib, and Khalid Abd-Elmoniem from NIDDK about their study, Endothelial Dysfunction in Youth-Onset Diabetes Type 2, A Clinical Translational Study. Article highlights: Zhao, et al. AMPK Phosphorylation of β-Arrestin-1 Blocking β-AR Bashore, et al. Monocytes Profiling and Cardiovascular Disease Chu, et al. Oxysterol-GPR183 Axis and Endothelial Senescence Sigle, et al. Targeting Secreted Cyclophilin A in Failing Hearts

This month on Episode 63 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 2nd and August 16th issues of Circulation Research. This Episode also includes a discussion with Drs Chen Gao and Yibin Wang about their study, Glucagon Receptor Antagonist for Heart Failure with Preserved Ejection Fraction Article highlights: Douvdevany, et al. Imaging the Turnover of the Sarcomere Quelquejay, et al. Wnk1 Deletion in Smooth Muscle Cells Induces Aortitis Paulke, et al. The Role of Dysferlin in Cardiac Hypertrophy Morais, et al. Predictors of Outcome in SPAN

This month on Episode 62 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 5th and July 19th issues of Circulation Research. This Episode also includes a discussion with the four finalists for the Basic Cardiovascular Sciences Outstanding Early Career Investigator Award. Article highlights: Mallaredy, et al. Extracellular Vesicle Reduction Prevents Heart Failure Mori, et al. CD163 Macrophages and EndMT in Plaque Progression Wang, et al. Rbx2 Regulates Mitophagy Nakayama, et al. ARRDC4 Limits Cardiac Reserve in Diabetes

This month on Episode 61 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 7th and June 21st issues of Circulation Research. This Episode also includes a discussion with Dr Chris O'Callaghan and Jiahao Jiang from the University of Oxford about their study, A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Article highlights: Compendium on Interface Between Cardioimmunology, Myocardial Health, and Disease Zafeiropoulo, et al. Splenic Ultrasound Improves Pulmonary Hypertension Roman, et al. MICU3 Enhances Mitochondrial Ca2+ Uptake

This month on Episode 60 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the May 10 and May 24th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Astrof and Dr AnnJosette Ramirez from Rutgers University about their study, Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease. Article highlights: Tamiato, et al. Pericyte RGS5 in Cardiac Aging Zifkos, et al. PTP1B and Venous Thromboinflammation Ma, et al. NR4A3 in Vascular Calcification Sultan, et al. VEGF-B Induced Coronary Endothelial Cell Lineage

This month on Episode 59 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the April 12 and April 26th issues of Circulation Research. This Episode also includes a discussion with Dr Craig Morrell and Chen Li from University of Rochester about their study, Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function. Article highlights: Arkelius, et al. LOX-1 and MMP-9 Inhibition Improves Stroke Outcomes Cruz, et al. C122Y Disrupts Kir2.1-PIP2 Interaction in ATS1 Blaustein, et al. Environmental Impacts on Cardiovascular Health and Biology: An Overview

This month on Episode 58 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 1 and March 15th issues of Circulation Research. This Episode also includes a discussion with Drs Frank Faraci, Tami Martino, and Martin Young about their contributions to the Compendium on Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease. Article highlights: Yan, et al. GCN2 in Ponatinib-Induced Cardiotoxicity Wang, et al. Activating v-ATPase Ameliorates Cardiac Cardiomyopathy