DiscoverFinding Genius Podcast
Finding Genius Podcast

Finding Genius Podcast

Author: Richard Jacobs

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Podcast interviews with genius-level (top .1%) practitioners, scientists, researchers, clinicians and professionals in Cancer, 3D Bio Printing, CRISPR-CAS9, Ketogenic Diets, the Microbiome, Extracellular Vesicles, and more.

Subscribe today for the latest medical, health and bioscience insights from geniuses in their field(s).
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Are genetically modified food products the best option you have when shopping for food? Emerging research shows that there may be better choices both for your health and for the environment. Listen up to learn: The origin of GMO foods How glyphosate interacts within the environment How GMO fish impacts the environment Expert in his field, Dr. Bill McGraw, lends his experience with GMO research and its implications on the long-term health of individuals around the world. Originally thought to have no negative repercussions to consumer health, genetically modified products seemed to be the key to many logistic problems plaguing produce manufacturers. However, in the years since their introduction, GMO products have begun to show their true colors. Without proper labeling required in supermarkets, it can be challenging to determine if a product is genetically modified or comes into contact with other GMO products. GMO salmon or salmon fed with GMO ingredients can leave lasting impacts on the environment by spreading plasmids throughout the area. Visit www.newaquatechpanama.com for more information. Episode also available on Apple Podcasts: apple.co/30PvU9C
Is time what clocks measure, or is it the difference between the shape of two triangles? Explore the answer, and discover: Why Barbour believes the universe is changing shape rather than expanding Why it is important to remember that size is relative What kinematic relativity is, and why it is so essential to Barbour’s work   What the theory of black holes requires of the universe Physicist and author of The Discovery of Dynamics and The Janus Point: A New Theory of Time, Julian Barbour, joins the show for an eye-opening and mind-probing deep dive into his ideas of time and space, and how they’ve been shaped by and differ from the ideas of other great thinkers in history, like Isaac Newton, Albert Einstein, and Johannes Kepler. “Science is always tentative, but my feeling is that people have lost some contact with the real foundation of things, of what reality is really like, and so I think it certainly doesn’t harm to go back and see what people like Kepler did,” he adds. Barbour explains the development and details of his books, elaborating on this statement: “You cannot imagine finding your way if there’s nothing by which you can see your way.”  He also shares his most recent ideas with listeners, such as the idea that the complexity of the universe might literally be time itself, and the most important part of energy itself. Interested in learning more? Tune in and be sure to check out Barbour’s most recent book, The Janus Point: A New Theory of Time. Episode also available on Apple Podcasts: apple.co/30PvU9C
“I am not a conspiracy theorist, I am a fact investigator…I want to know facts as soon as I can possibly get them. Is there a way to do that? Yes, there is,” says David Getoff. Tune in to learn how, and discover: How to know who funds the major media networks, and why it matters Which fats are “good” and which are “bad” and why In the midst of so many competing diets, all claiming to be the best, how to determine which ones are truly healthful What the hygiene hypothesis is, and how it might explain why so many people have weak immune systems Getoff is a board-certified clinical nutritionist, traditional naturopath, author of Abundant Health in a Toxic World, and internationally recognized lecturer on a variety of topics surrounding nutrition and health.   “Almost every holistic professional that I’ve ever met has had something go on in their life where mainstream medicine was not able to help them or cure them or get them better…or save their life…but some other holistic professional was,” he says. But unlike these holistic professionals, Getoff didn’t have this experience; he simply started reading books and magazines and newsletters written by holistic health professionals, which led him to dig deeper and discover why so much information that could transform our health and our lives is not easy to find, or altogether censored. He discusses his work with people who come to him with a range of ailments, including heart disease, autoimmune disorders, diabetes, and cancer. Within months of changing their nutritional intake—often against the advice of their current doctor or nutritionist— and eliminating the many toxins we're exposed to in everyday life, most of the people Getoff works with find that they no longer need their prescription medications, and enjoy a revolutionary level of health and wellness.  Getoff explains what is missing from the vegan and vegetarian diets, the value in listening to experts whose perspectives differ from your own, toxic food preservatives and cleaners most of us use on a daily basis, the health impacts of wireless technology, and why there are no longer enough nutrients in our food, why we need more than we used to, and how to get them. Learn more at https://naturopath4you.com/. Episode also available on Apple Podcasts: apple.co/30PvU9C
“Tumors are kind of like deposits, where the body can store up excess amounts of phosphorus,” says Dr. Ronald Brown. In this continuation of the Finding Genius cancer disease series, he discusses his unconventional and exciting theory on what causes tumor cells to proliferate. Listen and learn Why, because phosphate promotes growth, its excess promotes tumorigenesis, much like fertilizer runoff leads to dangerous algal blooms in water, Why this differs from conventional theories about tumorigenesis, and How this translates into techniques for cancer prevention and cancer therapy treatment through methods like low phosphorus, healthy diets. Ronald B. Brown’s PhD in industrial organizational psychology lends him a unique view of cancer research. In particular, he utilized grounded theory to note the significance of phosphate toxicity and cancer spread, and has continued this work with research partner Mohammed Razzaque. He explains that if we get too much phosphate, our kidneys can’t regulate it and it will start accumulating in our body. It’s acidic quality means that accumulation can cause what’s called phosphate toxicity, which in turn can affect every bodily organ. He explains how this phosphate excess causes cancer cells by explaining the solid characteristics of tumor cells. He adds that tumors and phosphate form “a reciprocal relationship. The phosphorus stimulates the growth and the growth helps to sequester the phosphorus and keep it out of the circulation.” In other words, tumors are our bodies’ way of storing too much phosphorus. He ties this to possible cancer prevention and early detection programs that could help patients integrate low phosphorus diets and appropriate lifestyle changes that boost immune cells. Listen in for more about phosphate’s effects on organs, calcium, bone density, and cellular overgrowth. Episode also available on Apple Podcasts: apple.co/30PvU9C
How can early-onset Alzheimer's detection play a part in treatment as the disease progresses. Early detection may hold a key in finding new and more effective treatments for Alzheimer's. Press play to find: How independence can be maintained for as long as possible The future of how Alzheimer's disease  The red flags to watch out for in the onset of dementia Lucas Driskell, an Assistant Professor at Yale School of Medicine, stops by to share their insight into neurodegenerative diseases and rehabilitation psychology. By focusing on treatment or therapeutic techniques for early-onset neurodegenerative diseases, the threshold for detection may lower. By detecting the disease early and using medication from the onset, there is a much higher chance of making Alzheimer's a disease that can be lived with. Many factors can bring on many cognitive difficulties, and there is no "magic bullet" to treat neurodegenerative diseases across the board. However, effective techniques can help stave off onset or help delay the effects of the disease. For more information, visit https://scn40.org Episode also available on Apple Podcasts: apple.co/30PvU9C
There are natural alliances, when certain kinds of tumors end up in obvious places," says Steve Gullans, and because cancer cells know how to unlock entry into different types of cells and tissue, they naturally settle where their tools let them. This is how he answers Richard's question about communication and cancer cells. As coauthor of Richard's new cancer book, he shares years of insights and experience with listeners. Listen and learn How, as part of the team to first sequence a tumor, he describes single-cell sequencing and informatics, Why immune cells like lymphocytes being present in tumors or around tumors makes a difference with effective drugs, How metastases are much harder to treat than primary tumors and what needs to be done to change that, and Why the microenvironment around tumors is an area currently under active investigation and what scientists hope to discover. Steve Gullans has extensive experience in all aspects of the life sciences, from Chief Executive Officer of Gemphire Therapeutics to the co-founder and managing director of a life sciences venture capital firm. He's an academic scientist, speaker, and author and was been involved in cancer research and therapeutics for decades. He gives listeners a cogent take on what we know about tumor sequencing. For example, while a few genes show up repeatedly because they are fundamental to the mutation that is part of a tumor, "a single mutation is generally not sufficient" for a tumor to take hold. The immune system is too powerful. Instead, they have found sub mutations adapting to the environment. Furthermore, it’s the cells will to survive, to adapt to efforts like chemotherapy, which become the driver in cancer's progression. He gets specific about other types of drugs and therapies, addressing attempts to "untangle the web" of drugs being used, but also about the advances in what may be soon on its way. He says that there is a global effort to develop better treatment, and scientists are thinking about "these multiple cocktails of therapeutics and marrying the true diagnostic markers, the diagnostics with different regimens." Listen in for more about this promising research. Episode also available on Apple Podcasts: apple.co/30PvU9C
Over half of New Orleans is below sea level, and it used to be entirely above it. What is happening, how is it impacting the lives of those in Louisiana, and what can be done about it? Tune in for the answers, and learn: Why water levees speed up the rate of organic material decomposition, and why it’s problematic Various ways in which land loss and subsidence occurs How trees offer resistance to storm surges Michael Hopkins is Assistant Director of Pontchartrain Conservancy (PC), a nonprofit organization whose aim is promote environmental sustainability and address serious environmental challenges in the Lake Pontchartrain Basin, a 10,000 square mile watershed in Louisiana. Over the past 100 years, more than 2,000 square miles of coastal Louisiana have disappeared, detrimentally impacting the lives of so many. Hopkins is a geologist whose focus at PC has been on coastal monitoring and restoration. Much of his work centers around subsidence, which is the gradual sinking of land. In this region of Louisiana, subsidence contributes significantly to various environmental issues. And while it is a natural process in a delta, the situation is this area is unique because it has been cut off from the Mississippi River, which means there is no source of new sediment to maintain land elevation.   Hopkins explains the details of his work and the restoration strategy at PC, which involves the science of bringing back ridges, marshes, and swamps, as well as a process called sediment diversion to combat land loss.   Press play for the full conversation and learn more at https://scienceforourcoast.org/. Episode also available on Apple Podcasts: apple.co/30PvU9C
John McDougall Bio: John McDougall, MD is a board-certified internist, author of 13 national best-selling books, the international on-line “McDougall Newsletter,” and co-founder of the 10-day, live-in McDougall Program in Santa Rosa, CA. He is a clinical instructor for 4 schools training young physicians and licensed in 5 states in the US to practice. Other McDougall activities include seminars and health-oriented adventure vacations. Scientific results of the McDougall Program are published in the Nutrition Journal: (http://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-99) and in MS and Related Disorders: http://www.msard-journal.com/article/S2211-0348(16)30100-6/pdf. Website: www.drmcdougall.com E-mail: drmcdougall@drmcdougall.com Phone: (800) 941-7111 Previous National Best Selling McDougall Books: The McDougall Plan McDougall's Medicine: A Challenging Second Opinion The McDougall Health Supporting Cookbook, Volume 1 The McDougall Health Supporting Cookbook, Volume 2 The McDougall Plan: 12 Days to Dynamic Health The McDougall Program for Maximum Weight Loss The New McDougall Cookbook The McDougall Program for Women The McDougall Program for a Healthy Heart The McDougall Quick and Easy Cookbook Dr. McDougall’s Digestive Tune-up The Starch Solution The Healthiest Diet on the Planet How can eating a healthy diet impact your body's ability to fight disease and other ailments? Research shows that eating nutritionally rich food may stave off lasting health implications over time. Listen up to learn: How ketogenic or plant-based diets impact the body How starches became vilified over the years The part sugar plays in your diet John McDougall, the founder, and director of the nationally renowned McDougall Program, discusses his mission to help change the way people struggling with health or weight view a healthy diet. Even though starchy foods have gotten a bad reputation in recent decades, eating a starch-based diet may improve your overall health. Since rich foods have found their way into the popular menu of America, the lack of nutrition and the requirement for additives has become an issue that drives up the average percent of obesity yearly. Using a combination of proven educational techniques and an introduction to new nutritional options, the success rate for making a lasting change in lifestyle remains incredibly high. Starches may be the dietary answer many people struggling with their health are looking for and establishing a high-starch diet can even affect your chances of contracting various cancers. For more information, visit drmcdougall.com. Episode also available on Apple Podcasts: apple.co/30PvU9C
Controlling cancer depends on controlling tissue microenvironments, according to researcher James DeGregori. “There's going to be pressure on cells in the lungs of a smoker to adapt to that new environment,” he explains, “and by adapting to it, it can basically favor new phenotypes that could lead to a malignancy that could lead to the initiation of a cancer.” He and Richard discuss the initiation of cancer and cancer evolution, opening up an exciting path toward prevention. Listen and learn How cancer development stems from our own cells "going rogue" in concert with selective pressures, like carcinogenic conditions, in their tissue environment, Why, therefore, random mutations are important in the initiation of cancer, but not enough to explain its growth, Why effective prevention of cancer lies with controlling tissue microenvironments, and How modulating inflammation affects carcinogenesis pathology and may be key in cancer prevention.  James DeGregori is the Courtenay C. and Lucy Patten Davis Endowed Chair in Lung Cancer Research, which is part of the Department of Biochemistry and Molecular Genetics at the University of Colorado Anschutz Medical Campus. He explains that genetics, biochemistry, and cell biology work together to prepare the ground for cancer growth. While cancer diagnosis and therapeutics often begin further down the line followed by chemotherapy procedures, researchers like DeGregori are trying to reconfigure the conditions that allow its beginnings. He says it’s a matter of cells adapting to fit a changing tissue environment; therefore, staving off that change in environment looks to be essential. That means addressing chronic inflammation, inflammation that might come from smoking and lungs failure and other stressors. But not all inflammation is created equal, and simply preventing it entirely can lead to the inability to fight off infections, for which inflammation is necessary. He adds that "there's two sides to every process, and while too much inflammation is bad, we do need inflammation to fight off infections, to repair our tissues, and other processes."He and colleagues are working on finding that balance as well as identifying which patients could benefit the most. Listen in for more about how researchers are arresting cancer growth through addressing cell stress, cell aging, and inflammation. Episode also available on Apple Podcasts: apple.co/30PvU9C
Are you consuming high amounts of deuterium without even knowing it? Could this predispose you to a higher likelihood of developing cancer? Press play for the answers to these questions, and discover: How mitochondrial dysfunction might explain the development of cancer, and what can be done in light of this How the oxygen we breathe and food we eat combine to contribute to the production of water in our bodies How diet and lifestyle can protect against the development of cancer László G. Boros is a professor of pediatrics at Harbor-UCLA Medical Center and a member of the Clinical and Translational Science Institute at UCLA and The Lundquist Institute for Biomedical Innovation. He takes a metabolic approach to the problem of cancer, focusing on the metabolic pathways of normal versus tumor cells, and trying to develop therapies that specifically target pathways unique to cancer cells. Boros discusses a variety of interesting topics, including the role of mitochondrial breakdown in the cause of cancer, the function of ATP synthase nanomotors (and how they break, and what happens when they do), why it’s important to avoid high-deuterium foods, deuterium depletion therapies, and much more. Check out https://www.laszlogboros.com to learn more. Episode also available on Apple Podcasts: apple.co/30PvU9C
When does cancer in the body reach a threshold at which it becomes an entity, and what causes it? New research shows that cancer may be a latent part of us already and only becomes hazardous after proliferation. Press play to learn: How cell types can help each other grow If chemotherapy promotes genetic mutation The point of origin in a tumor Adrienne Scheck, an Adjunct Professor at Arizona State University, joins the conversation to share her insight into the field of cancer growth. Each type of cell that comprises or benefits the growth of a tumor has differing preferences for its ideal microbiome. Whether they be slow or fast-growing, the different types of cells require different therapeutic techniques, even depending upon the area of the body. The heterogeneity inherent in tumor cells is the culprit for making it so difficult to treat. Due to the fast-growing nature, the level of adaptability and refresh of cells makes an effective treatment hard to pin down. To learn more, search for Adrienne C. Scheck, Ph.D., online or on pubmed.ncbi.nlm.nih.gov. Episode also available on Apple Podcasts: apple.co/30PvU9C
Ninety-eight percent of the human genome is non-coding. The majority of our DNA instructs and regulates the other two percent. Until recently, this ninety-eight percent was considered junk DNA and held a mystery of purpose akin to dark matter.  George Calin opens the mystery for listeners and explains how researching non-coding RNAs will lead to better cancer treatments. Listen and learn How non-coding RNAs stay in the nucleus and other mechanistics, Why early earth was an “RNA world,” and what that indicates about the evolution of life, How non-coding RNAs are considered “double phase” and why that’s significant for therapeutics and mRNA vaccines, and How his research on non-coding RNA biomarkers in body fluids should lead to targeted interventions. George Calin is a principal investigator with the MD Anderson Cancer Center at the University of Texas. He specializes in how non-coding RNAs impact disease and virus mechanisms, specifically the role of microRNAs in human cancers. He also looks at what they can tell us about how bad and aggressive a particular disease will be for a specific individual. He notes that “a specific type of cancer with a specific localization at a specific stage. . . can behave very differently in another patient” with the same profile. “One is surviving, let's say one month, and other is surviving three years,” he adds, and researchers want to know why. He says that mRNAs may have the answers and could point doctors in the direction of how to help both patients. It could lead to more aggressive measures when the biomarkers point toward that necessity, for example. Because cancer is a genetic disease, understanding the complexities of genes and genomics is vital to its treatment. By studying how and why and when abnormalities are expressed and what these non-coding RNAs are instructing, researchers can open up an entirely new way to treat cancers. He says that some of this biomarker identification is already in use for some bladder cancers. Listen in for more on how advancement in studying the smallest parts of us may make the biggest difference. Episode also available on Apple Podcasts: apple.co/30PvU9C
"The wider view of nature is the more powerful one," says Andreas Mershin, a researcher who stays out of bounds. "Nature is not divided by a textbook," he continues, and this foundation sets the tone for his work. He's a physicist who's exploring the innovative discovery of diseases at their earliest stages, from a prostate cancer diagnosis to breast cancer, by harnessing the smelling acuity of dogs. Listen and learn How studies have shown surprising and encouraging results with dog sniffing and cancer identification, What mechanics of smell and scent enable the dogs to detect cancer when it can't be identified by biomarkers, and How scientists are looking at mechanical devices to do the same thing and more, including sensing our emotional states. Andreas Mershin is a research scientist at the MIT Center for Bits and Atoms. While that department may not seem congruous with researching the latest treatment for prostate cancer, he explains that the physical world doesn’t limit itself to department titles, so why should research? That’s why when he stumbled across two seminal papers on dogs’ abilities to find out more than one different cancer diagnosis by scent, he knew he had a subject worth investigating. But it’s not as straight forward as just smelling cancer, he explains. Rather, “think of the molecules of sense that are being produced by your metabolic pathways as being the sand, and cancer signatures like footsteps on the sand.” Further, the dogs are able to generalize to other types of cancer after learning one type. He says that they are sensing cancer imprints over other molecules almost as emotion moves through various molecules. They’re also teaching machines to do this as well, to recognize an “emergent scent character” of different conditions. Because addressing certain cancers early can be a matter of life and death, this research hopes to save lives by identifying someone with, for example, prostate cancer, and initiating prostate cancer treatment in the earliest stages. Listen in for more about this fascinating research. Visit the Links to know more about his Research: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245530 https://www.wired.com/story/quest-to-make-robot-smell-cancer-dog/ https://news.mit.edu/2021/disease-detection-device-dogs-0217 Episode also available on Apple Podcasts: apple.co/30PvU9C
What causes a primary tumor to form in the body? Metastatic dissemination explains how genetic damage in the cell can develop cancer and begin the spread. Press play to learn: The triggers for the spread of cancer cells How a stroma supports the primary tumor If excess mutations can revert tumors to stem cell-like tissue Robert Weinberg, a member of the Whitehead Institute for Biomedical Research and professor of biology at MIT, discusses his research into the formation and spread of cancer. The tissue in tumors resembles very closely the tissue found in wounds. The inflammatory state which assists in healing all wounds may be responsible for the aggression and proliferation of cancer cells and tumor growth. As the tumor grows and continues to mutate, it begins to recruit several different types of cells to assist in growth and survival. Multiple mutations in a tumor may continue to increase the aggression and inflammatory nature of the tumor as it grows. For more information, search for Robert Weinberg's laboratory in association with the Whitehead Institute on your preferred engine. Episode also available on Apple Podcasts: apple.co/30PvU9C
Could better emotional and physical health be as simple as subtle movement? Anna Jacobsen says it is, but the art of her practice is not quite so simple. Tune in to discover: What it means to say that every organ has an energetic quality How emotions like anger and aggression can manifest physically and be “felt” in certain organs Why depression presents special challenges and a greater level of complexity when it comes to healing through Jacobsen’s approach Jacobsen is an alternative practitioner who focuses on helping people reduce stress and fear in their life, improve their cognition and creativity, and foster physical health through movement—specifically by applying a deep understanding of the correlation between body systems and movement. She’s a somatic movement educator and therapist, but her work with clients is really a hybrid of various techniques and approaches, each of which she tailors to the individual.   She dives into the details of her work, both on a personal and professional basis, touching on her experiences with people who have suffered traumas and sought healing through her practice. An understanding of and communication with cellular consciousness, she says, is an area ripe for exploration and potential, and one that she aims to learn more about in order to improve her life and the lives of others. Press play to hear the full conversation, and learn more at https://www.annajacobsen.de/home-3. Episode also available on Apple Podcasts: apple.co/30PvU9C
Could a vaccine for specific forms of cancer be a realistic prospect in the future? Based upon research into rhythms in the body, research shows that it may be a viable possibility. Press play to learn: If the time cancer treatment is administered can make a difference Can the sequence or timing of vaccines cause variation in efficacy? How the body regulates levels of inflammation Brendon Coventry, Associate Professor of Surgery in Adelaide at the University of South Australia, discusses his work with rhythms in the body and how this can affect optimal treatment. By treating patients at abnormal times throughout the day, new treatments may become more or less effective even if inconvenient for practitioners. This will afford researchers a unique perspective when it comes to treating cancer and may even unlock new therapeutic methods and treatments. Cycles that involve CRP in the body can lead to certain forms of cancer, especially colorectal cancer. Based on a seven-day process, many points of data point towards the body's reliance on cycles and how this reliance will interact with vaccines and treatments for cancer. Search for Brendon Coventry on Google Scholar or https://pubmed.ncbi.nlm.nih.gov for more information. Episode also available on Apple Podcasts: apple.co/30PvU9C
“The anthropomorphic language has been frowned upon in biology for a hundred years…and I think it’s because it’s the only way to understand it,” says Perry Marshall. Press play to learn more about his compelling view of cancer and discover: How Perry’s understanding of cancer might explain why stage four cancers are almost always impossible to treat Why the neo-Darwinian view of evolution and the inability to accept the idea of cellular cognition are major roadblocks to finding a cure for cancer What consequences result from the resistance to change in the medical industry While the idea that cancer is a genetic disease resulting from random DNA damage which triggers endless cell proliferation may be true, Perry Marshall doesn’t think it gets to the essence of what cancer really is. According to him, cancer is when the cells of the body lose their identity and begin evolving or speciating out of control. Marshall says that when the simple laws of physics and chemistry are insufficient to explain everything that happens in the biological world, it leaves a giant elephant in the room that no one knows how to deal with. And in part, this could be why so many scientists, researchers, and doctors still fail to consider anything other than a narrow and restricted definition of cancer, cellular life, and evolution. “I think there are a lot of people who just don’t want to understand it, or if it raises questions that blow [their] mind, then [they] just don’t want to think about it,” says Marshall. He discusses James Shapiro’s paper titled, “All Living Cells Are Cognitive”, in which Shapiro argues that, quite literally, ALL cells have cognition; they can also get stressed out, and then they do, they begin manifesting different behaviors until reaching a tipping point when they forget who they are.  And the result? Cancer. “Whether you’re watching football players chase each other around the football field, or your dog chase a rabbit , or a YouTube video of white blood cells chasing germs, it all kind of looks the same…it is the same intentional behavior happening on radically different scales...” he says. Press play for the details of all this and much more. To contribute to the search for a cancer cure, visit https://evo2.org/cancer/, and if you’re interested in earning $10 million, visit https://www.herox.com/evolution2.0. Also, be sure to check out Marshall’s book, Evolution 2.0: Breaking the Deadlock Between Darwin and Design. Episode also available on Apple Podcasts: apple.co/30PvU9C
What happens when a classically trained medical doctor develops chronic fatigue? When Jeanne Drisko struggled with her health, she discovered integrative medicine and nutrition. Now she’s running a clinic at the University of Kansas with Dr. Kay Chin utilizing translational medicine to unlock better care for cancer patients. Listen and learn What’s the difference between the effects of oral and intravenous vitamin C, How intravenous vitamin C works as a treatment of pancreatic cancer and blood cancer among others, Why it also shows promise in studies with the Covid-19 virus, and How intravenous vitamin C has worked in tandem with chemotherapy. Jeanne Drisko is professor emeritus at the University of Kansas Medical Center. She tells her story of discovering intravenous vitamin C therapy to meet her own health struggles. She was impressed by its effect and, after working with internationally-renowned experts in nutritional medicine like Dr. Hugh Riordan, she started her own program in integrative medicine at the university. She knew she wanted intravenous vitamin C to part of that, and she’s spent years researching its effects on fighting viruses and cancers. Unlike oral vitamin C, the intravenous introduction becomes a drug in the vein at very high levels. It'll go from the vein into what scientists call the extracellular space. At this point, she says, it becomes something called a pro-oxidant, or the opposite of an antioxidant, and forms hydrogen peroxide, a “promiscuous molecule.” When it’s in the extracellular space, hydrogen peroxide can kill viruses, bacteria, and other abnormal cells like cancer. She explains how this works alongside other treatments like chemotherapy and chelation therapy, and why it shows such promise. Listen in for more about this exciting research. Episode also available on Apple Podcasts: apple.co/30PvU9C
How do doctors measure your liver function, kidney function, cholesterol levels, and heart disease? They use biomarkers, and David Wishart helps identify biomarkers with analytical chemistry, mass spectrometry, and other bioinformatics tools. He and his colleagues look at blood or urine and other biological fluids to help in the diagnosis and characterization of human diseases. He explains What characterizes a useful and reliable biomarker and how low false positive rates distinguish them, How the receiver operating characteristic (ROC) curve works and where common tests fall in the curve, What’s the history of biomarker testing and how it’s been improved, and How he’s meeting the challenging task of identifying Alzheimer’s biomarkers in his research. David Wishart is a professor in the Departments of Biological Sciences and Computing Science at the University of Alberta. He works with bioinformatics software, nanobiology, and machine learning in healthcare to fine tune the use of biomarkers in diagnostics. He explains that historically, most biomarkers have been proteins. But developments in identifying cancer biomarkers, for example, have focused on metabolomics. “Cancer is very much a metabolic disorder,” he explains, “and some of the very first changes that happen in cancer are fundamental changes in metabolism.” Furthermore, tests can be combined, like a “gene test with a protein test with a chemical test,” and that improves sensitivity and the chances of catching a cancer earlier. Neurodegenerative diseases pose a particular challenge, he explains. An Alzheimer’s biomarker is hard to identify because the consequences of the disease and causes are not always clear. Researchers are even pointing to microbiome connections and brain metabolism. Therefore, it may actually be a gut microbiome test that indicates Alzheimer’s. He adds, “we're finding, for instance, bile acids in the brains of Alzheimer's patients.” He describes what other chemicals they’re finding and how this research might lead to better understandings of its pathogenesis and how earlier testing and prevention might be possible. Episode also available on Apple Podcasts: apple.co/30PvU9C
How should cancer be viewed while in the body. Research shows that it may be classified as a separate entity rather than a component of tissue. Listen in to learn: The percentage of cells that do not metastasize How tumors coerce the surrounding healthy tissue to serve its needs How "clusters of death" interact with populations around the world Christos Chinopoulos, associate professor and project manager of the RPPA facility, joins us to discuss his work with finding metabolic pathways that differ in cancerous tissue when compared to healthy tissue. Depending on the stage of development that cancer has reached, it is motivated by different factors within the body. Since the subject ultimately dies in the end, there must be other contributing factors along the path of growth and spreading. Using promising new technologies like liquid biopsies, there may be a way to detect signs of cancer even earlier. From biomarkers like DNA, RNA, and lipids, early detection of afflicted tissue can be much simpler than previously thought possible. For more information, visit rppa.hu. Episode also available on Apple Podcasts: apple.co/30PvU9C
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Comments (9)

Eva

the sound quality of this episode is horrible

Mar 10th
Reply

Soumen Sengupta

Such an awesome Podcast. Heard it thrice back to back. Great job....Kudos.

Oct 20th
Reply

gg

eh

Aug 31st
Reply

Austin Peek

Insightful episode. Learned a lot, thanks!

Jan 30th
Reply

Richard Jacobs

Thank you for all you do, Dinesh!

Jan 17th
Reply

Chris Hartigan

can you provide a link to the article he mentions in the interview please

Nov 5th
Reply

Jorge Luna

Theme music volume is too high. Host and guest volume too low. Difficult to listen while driving.

Jul 22nd
Reply (1)

Gonzalo Garcia Luna

This is teally interesting

Mar 7th
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