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Finding Genius Podcast

Finding Genius Podcast

Author: Richard Jacobs

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Podcast interviews with genius-level (top .1%) practitioners, scientists, researchers, clinicians and professionals in Cancer, 3D Bio Printing, CRISPR-CAS9, Ketogenic Diets, the Microbiome, Extracellular Vesicles, and more.

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Royal jelly, honey, propolis, pollen…the list of bee products that many of use from day to day is long. But fewer people are aware that there’s something less tangible yet just as healing about bees: their energy. Press play to step into the medicinal world of bees and learn: Why and how one teaspoon of honey per day can prolong your life How bees clean the air inside their hives, and how humans can benefit from this too What studies have shown about the regenerative properties of royal jelly, and how this provides additional evidence of its effectiveness in treating multiple sclerosis (MS) What is known about the composition and properties of different types of propolis around the world Since entering the field of medicine 33 years ago, Cristina Aosan wanted to treat everything—including that which conventional medicine said was untreatable or uncurable. To this end, she began studying various topics on her own, which led her to apitherapy, a branch of medicine that uses honey bee products to treat people. As a physician at Melidava Consulting in Romania, Aosan treats people with nearly every type of ailment you can imagine, including multiple sclerosis, tumors, liver viruses, and obstructive atherosclerosis. She takes an individualized approach with each patient, drawing from an extensive toolbox containing honey, propolis, royal jelly, drone larvae, pollen, and more. In some places, patients can even stay in homes arranged near bee hives to take in the healing and harmonious energy of the bees themselves—a practice that is becoming increasingly well-known. Aosan explains the applications of various bee products, the history of apitherapy and its use by the Egyptians and other ancient civilizations, how bees use propolis as an air-cleaning mechanism, and what she hopes is in store for the future of apitherapy. Tune in for all the details. Available on Apple Podcasts: apple.co/2Os0myK
Timothy Saunders, Associate Professor at the National University of Singapore’s Mechanobiology Institute, shares his insights on the science of morphogenesis developmental biology, the study of tissue formation and organization in plant and animal species. Listen to learn more about: How organs are formed The morphological features of plants versus animals How organs change during pregnancy How vital organs develop, particularly in human embryos, is considered a long standing mystery by much of humanity. How do our cells know how to organize and replicate in order to form correctly structured and functional organs? How do they know when to stop replicating and not to continue growing past the ideal size? Timothy and his team aim to increase the understanding of developmental biology in both the medical community and the general public. Much of the research done in this area has centered around plants and fish, which can repair injury and regrow after amputation. What can be learned from these types of organisms? What can be gained from the study of human tissue generation in utero? Large-scale, high-resolution imaging technology is enabling the study of precisely how tissues interact during organ formation in humans. This in combination with the use of organoids grown from organ tissue and stem cells could break open the case of how to apply morphogenesis embryology to possible heal damaged organs in the future. For more information visit https://www.mbi.nus.edu.sg/timothy-saunders/saunders-lab/ Available on Apple Podcasts: apple.co/2Os0myK
Are customized cancer treatments a real possibility? Benjamin D. Hopkins, Ph.D. is Assistant Professor of Genomics and Genetic Sciences, Oncological Sciences, and the co-leader of the Functional Genomics Pipeline at The Tisch Cancer Institute. His cancer genetics research has developed an automated screening platform that can be used to identify tumor-specific drug sensitivities used for highly specialized cancer treatment. Tune in to learn more about: Cancer genetics and genomes What the ability to identify a drug resistance mechanism means for cancer treatment The importance of the cancer research impact factor when searching for the most accurate information Dr. Hopkins focuses particularly on lung, breast, and pancreatic cancer, which is one of the 20% of cancers with no specific standard treatment plan. The Functional Genomics Pipeline as a whole screens cancer therapies to identify which types of patients with which types of tumors may be able to benefit from those therapies. Using cancer genome sequencing, it has become possible to identify tumor-specific vulnerabilities, which can then be exploited for cancer treatment purposes. This includes using one medication to sensitize tumor cells to another medication, as a way to reduce the collateral damage done to healthy cells during cancer treatment. Knowing exactly which mutational events are driving each specific tumor allows Dr. Hopkins and his team to target the specific mechanisms that tumor relies upon to thrive and multiply. This highly individualized approach in combination with public campaigns such as Breast Cancer Awareness month could lead to a future where cancer is considered a treatable disease across the board. For more information visit https://labs.icahn.mssm.edu/hopkinslab/ Available on Apple Podcasts: apple.co/2Os0myK
What is missing when it comes to Western medicine’s standard approach to treating chronic health problems? Dr. Will Cole, author of Intuitive Fasting: The Flexible Four-Week Intermittent Fasting Plan to Recharge Your Metabolism and Renew Your Health, grew up watching his loved ones battle autoimmune disorders. Now, he is leading a movement to change the way we treat chronic diseases using functional medicine. Tune in to discover: New ways to discover the underlying causes of chronic disease How to get out of fight or flight mode and back into a state of “rest and digest” The role of intuition in intermittent fasting Dr. Cole looks beyond simple numbers and lab results in order to treat the whole patient and not just their current symptoms. His natural and holistic approach often utilizes functional medicine nutrition, intuitive eating intermittent fasting, and a hormonal imbalance diet. Understanding autoimmune thyroid disease, for example, and which foods can prompt the body to produce its own thyroid hormones can avoid unnecessary dependence on medications and highlight the importance of lifestyle in disease treatment. Intuitively intermittent fasting combined with a mostly plant based high fat, moderate protein, low carbohydrate diet has been shown to support the metabolic process and protect against insulin resistance and digestive problems symptoms. Dr. Cole’s four-week plan makes the benefits of fasting and eating a plant based ketogenic diet accessible to beginners who may want to treat specific issues, improve their overall health, or both. Embracing functional medicine education can provide those suffering from chronic illness with a way to take their health and their personal power back into their own hands. To learn more or book a consult visit https://drwillcole.com/ Available on Apple Podcasts: apple.co/2Os0myK
Is hustle and hope really enough to make it big in the modern world of online finance? Jeff Rose, Youtube’s Wealth Hacker and Founder of the finance blog Good Financial Cents shares how he went from cold calling and holding underwhelming local finance planning and analysis seminars to creating one of the most popular financial advice blogs on the internet. Listen to learn more about: Investment strategies Recovering from financial loss and depression The power of mentorship for online entrepreneurs Jeff’s down to earth approach to finance and willingness to use his own mistakes as a teaching tool has made him a crowd favorite on YouTube. Wealth Hacker offers how-to videos on financial topics like how to create passive income streams, how to invest your first $100, and how to turn $500 into $520,367. His blog, Good Financial Cents, has been featured on Fox Business, ABC News, CNN Money, CNBC, and more. Weighing in on the recent GameStop stock market debacle, modern investment management, and life as a financial planner, Jeff gives his honest opinion on what it really takes to get rich in today’s economy. After providing free content for years and finally taking part in an exclusive coaching program for entrepreneurs, Jeff has launched Good Financial Cent’s latest online finance course. This course is all about how to set (and actually reach) accelerated financial goals. For more information or to sign up for Jeff’s new online course visit https://www.goodfinancialcents.com/ Available on Apple Podcasts: apple.co/2Os0myK
Dr. Eric Zielinski, author of the national bestseller, The Healing Power of Essential Oils, is back on the podcast with a new book available for preorder called The Essential Oils Apothecary. He shares his professional views on and personal experiences with essential oils as a key part of a healthy lifestyle. Tune in to discover: The power of natural remedies and natural healing products General healthy living tips Why sitting is now considered more dangerous than smoking Perfume, laundry detergent, scented candles, fabric freshener, hand sanitizer, bleach, new car smell; how many chemicals do you inhale, ingest, or absorb each day? Studies have suggested that wealthy countries that can afford to practice over-sanitization with cleaning chemicals tend have higher rates of Alzheimer’s Disease. Why? A lack of bacteria in the environment creates poorly developed immune systems, which puts brains at higher risk of inflammation. How many other diseases could we be inadvertently inviting into our bodies? What is the difference between the average American and people who live in a “Blue Zone”, or an area with low rates of chronic illness, where it is considered normal to live 100 years or more? How can we use essential oils to change our lives and bring us closer to optimum health? Eric reveals the beneficial properties of common and easy to obtain oils, like cinnamon bark, lime, orange, and grapefruit. Dr. Zielinski’s healthy lifestyle motivation brand offers simple recipes for natural, nonchemical household cleaners, personal hygiene items, and immune boosters. His website is a substantial resource for essential oil news, basic education for beginners, and where to begin with natural remedies in your own home and life. For more information visit https://naturallivingfamily.com/ Available on Apple Podcasts: apple.co/2Os0myK
Scott Young, former Finding Genius guest and author of Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career, shares tips of how to use a more focused mind to live a more productive life. Listen to discover: How to be more productive in life The difference between general focus and focusing in one direction How to stay focused on tasks and goals Technology detoxes, sheer willpower, unyielding impulse control; these traditional approaches to increased productivity simply cannot be relied upon. A new system for focusing is required for the new age. Scott has created a series of courses, including Rapid Learner, Life of Focus, Top Performer, and Make It Happen, that offer people the opportunity to learn how to increase focus using unique concentration exercises. Deep work is the concept of achieving a level of cognitive depth through periods of continuous distraction-free, interruption-free concentration. Scott’s books and courses provide guidance on how to enter the state necessary in order for deep work to occur, troubleshooting for when you get stuck on a task, and how you can track your productivity progress. The effects of guided consistency on your ability to focus can be staggering. Is mental focus like physical exercise? Can the ability to enter a deep work or flow state become a matter of muscle memory for your brain? Is everyone even capable of blocking out environmental distractions? Scott explains the differences in approach to his productivity system that can become necessary based on age, working memory capacity, and other factors, and how it can be adjusted to work for anyone. For more information or to grab a free copy of Scott’s e-book, 7 Must-know Strategies to Learn Anything faster! visit https://www.scotthyoung.com/ Available on Apple Podcasts: apple.co/2Os0myK
What if everything we have been told about breast cancer prevention is wrong? Dr. Susan Wadia-Ells, author of the new book, Busting Breast Cancer: Five Simple Steps to Keep Breast Cancer Out of Your Body, has combined decades of ignored statistical studies with the recently published metabolic theory of cancer,  to help women learn how to block most breast cancer from taking form in their bodies. Tune in to learn more about: Why 75 percent of US women are now overweight or obese, causing the US to have the highest breast cancer rates in the world, no matter one’s age. Why year-round outdoor/indoor tanning and taking 5,000-10,000 IUs of D3 supplements daily, can block most breast cancer from happening. What is causing today’s growing, but still unreported, metastatic breast cancer epidemic that is reaping billions, annually, for the cancer industry After losing three close friends to recurrent metastatic breast cancer, Dr Wadia-Ells decided to try and understand how to best protect herself and other women from developing breast cancer.  In 2013 she discovered the newly published book, Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, by Dr. Thomas N. Seyfried, the eminent Boston College biologist.  Now understanding the exact biological steps that suffocate our cell’s power batteries or mitochondria to create that first cancer cell, as described in Dr Seyfried, textbook, Dr Wadia-Ells was now able to develop  the Five Simple Steps for effective breast cancer prevention. These steps include: losing all excess body fat; raising vitamin D3 blood levels above 60 ng/ml; avoiding all birth control drugs, IUDs and menopausal relief drugs that contain the man-made chemical progestin; keeping one’s body detoxified of hormone-like chemicals found in food, water, air, furniture and personal care products, and having an annual thermogram to monitor any pre-cancerous inflammation in breast tissue. Together, her five simple steps and the metabolic theory of cancer tell us why one woman develops breast cancer, while another woman never will. To support the development of effective non-toxic metabolic protocols to treat early stage and metastatic cancer, Dr. Wadia-Ells has committed 20 percent of her book’s profits to the Foundation for Metabolic Cancer Therapies. For more information visit https://www.bustingbreastcancer.com/ Available on Apple Podcasts: apple.co/2Os0myK
Can mathematics really be applied to brain cancer treatment? Dr. Kristin Swanson, Vasek, and Anna Maria Polak Professor in Cancer Research at Mayo Clinic, goes to work each day to create individualized predictive models using mathematics to more effectively treat patients diagnosed with brain cancer.  Listen to learn more about: The most common symptoms of brain cancer Theories on what causes brain cancer How cancer cells prey on normal brain functions Imagine an exact 3-D replica of your brain that you can hold in your hands. Using mathematical model predictions, it is now possible to print a 3-D MRI of an actual human brain with cancer. This model can predict and show both current and predicted cancer cell density bands, making it possible to choose more efficient cancer treatment methods sooner. Mathematic models and the data they provide have also revealed differences in male versus female brain cancer survivors and their gene signatures, along with other differences in the typical brain cancer story in women compared to in men. After experiencing a personal loss due to cancer, Dr. Swanson set out to use new technology like artificial intelligence, mathematical mapping, and image localized biopsies to diagnose and treat the most aggressive type of brain cancer, Glioblastoma.  Kristin’s research lab is akin to a hurricane center, but instead of predicting storms, its advanced technology forecasts cancerous tumor development. When shared with cancer patients and their physicians, this type of detailed predictive model can offer a sense of education and control over treatment that traditional methods simply cannot offer. For more information visit http://mathematical-oncology.org/ Episode also available on Apple Podcasts: http://apple.co/30PvU9C
How is the rest of the world responding to the Covid-19 pandemic and how is the virus itself changing over time? Jim Bijl, Finding Genius listener and Pulmonary Function Technician in The Netherlands, weighs in on the state of the global Covid-19 pandemic.  Tune in to discover: The typical stages of a Covid-19 infection The effectiveness of mask mandates and other public health interventions  The role of the media and politics in response to the pandemic  As a technician who administers pulmonary function tests and has access to the pulmonary function test results of patients with Covid-19 in comparison to those with other lung diseases, such as cystic fibrosis, SARS, Influenza, pulmonary fibrosis, and MERS, Jim has a unique perspective on the pandemic and the world’s response to its threats in both the short and the long term. If most of the people who suffer severe consequences from Covid-19 have preexisting conditions, such as a cystic fibrosis diagnosis, does this mean that precautions should be relaxed for the rest of the population? If the rate of survival in those who are hospitalized in intensive care units for Covid-19 related complications is increasing, should the status of the pandemic as a whole be re-evaluated?  After working up close and personal with Covid-19 patients, Jim shares his experiences and opinions on the potential for longer term side effects of the virus, including reduced lung capacity, and how long they might last for most patients. From vaccines and masks to politics and the media, Jim offers insights from inside the medical community on how the world may look post Covid-19 pandemic.  To contact Jim directly, send an email to jimbijl@protonmail.com Available on Apple Podcasts: http://apple.co/2Os0myK
How do genes affect your health? Dr. Yael Joffe, Adjunct Professor of nutrigenomics at Rutgers University and Chief Scientific Officer at 3x4 Genetics, has dedicated her career to finding out exactly how much bearing a person’s genetics has on their weight, on their ability to manage it with diet and exercise, and on their heath as a whole. Tune in to discover: What a nutrigenomics diet is and how it can help with weight control How a DNA based diet and fitness regime can activate or deactivate certain genes The connection between DNA based dieting and disease prevention and management Every human being on the planet shares 99.9% of the same DNA. It is the remaining 0.1% that determines the ways in which we are all unique from each other. Yael explains how she has led the way in the emerging field of nutrigenomics and personalized nutrition. The nutrigenetic testing she has developed can be used to analyze a person’s hunger cues, satiety response, fat burning abilities, behavioral responses to food, and more. Genetic variants like the FTO and LEP genes can help to predict whether a particular person will struggle with binge eating, excessive grazing or snacking behaviors, or food addiction, and how much Leptin their body will produce. Leptin plays a major role in energy regulation and hunger signals. Depending on what is revealed by a person’s nutrigenetic testing, he or she may be given specific diet and exercise recommendations or referred to a behavioral therapist. It may turn out that genetics play no real role in some men and women’s difficulty with body weight or weight loss. In some cases, other avenues may still need to be explored. For the time being, Dr. Joffe’s nutrigenetic DNA testing is available to physicians only. If you are interested in being tested, visit https://www.3x4genetics.com/ to find a participating provider in your area. Available on Apple Podcasts: apple.co/2Os0myK
What is Metabolic Syndrome and how is it related to obesity and Type 2 Diabetes? Vivian Tran, Ph.D. candidate in the Vascular Biology and Immunopharmacology group at La Trobe University, shares what her studies on mice have revealed about Metabolic Syndrome, the cardiovascular complications of Diabetes, and the risk factors of obesity. Listen to learn more about: The differences in fat distribution between men and women and the associated obesity risks Whether or not obesity should be considered a Type 2 Diabetes cause The different types of fat cells and which type is more dangerous to your health Metabolic Syndrome is not one disease; it is a group of medical conditions that occur together in the same person. These conditions include high blood pressure, heart disease, stroke, Type 2 Diabetes, obesity, and high cholesterol. Due to rising rates of obesity, it is estimated that nearly one third of the U.S. population suffers from Metabolic Syndrome. Vivian has set out to find the answers to questions including why more men than women die from Metabolic Syndrome related cardiovascular events when more women than men are diagnosed with the disease. Could this be due to the difference in fat distribution and the presence of subcutaneous versus visceral fat cells in men and women? Vivian explains the differences in the health risks associated with belly fat in comparison to fat on other areas of the body and the dangerous of visceral fat, which can attach itself to internal organs. Her research on the role of fat tissue surrounding blood vessels and how it affects vascular function in those with Metabolic Syndrome could lead to major advancements in the prevention of cardiovascular disease in those who suffer from it. For more information follow Vivian on Twitter at https://twitter.com/vivianvtran Available on Apple Podcasts: apple.co/2Os0myK
Could female Kenyan sex workers be the key to preventing HIV spread on a much larger scale? Keith Fowke, Head of the Department of Medical Microbiology and Infectious Diseases Professor at the University of Manitoba, explains the connection between these Kenyan sex workers and HIV resistance, plus what this could mean for the future of HIV prevention as a whole. Tune in to discover: The genetic basis for resistance to HIV transmission in certain ethnic groups Stages of the HIV life cycle HIV and immune system factors that could translate to new disease prevention technology HIV and AIDS have devastated parts of the world over the past five decades. Africa has been particularly affected by the epidemic. Now, specific populations of sex workers in Kenya have shown resistance to the HIV virus, despite repeated exposure for decades, thanks to their quiescent immune systems. What information can be taken from these women and applied to other groups of people across the world to prevent more HIV infections? Keith and Fowke Lab has been studying alternative HIV prevention methods, including low dose aspirin therapy and genital topical antiviral agents, with promising results. If certain genes increase HIV resistance in some people, can other genes contribute to faster and more aggressive disease progression in others? Can the human immune system be further manipulated by medication or other treatments to protect against HIV infection or progression? How important are the genetics of the person being potentially infected versus the genetics of the virus? Professor Fowke shares the answers to these questions and much more. For more information on new methods of HIV treatment and ways to prevent infection visit https://www.fowkelab.com/ Available on Apple Podcasts: apple.co/2Os0myK
Who pays for scientific studies and what types of biases can the matter of this funding create? Professor Sheldon Krimsky, author of Conflicts of Interest In Science: How Corporate-Funded Academic Research Can Threaten Public Health, uses his more than 30 years of studying conflicts of interest in science to weigh in on the issue of corporate influence inside the world of science. Listen to learn more about how corporate funding has impacted scientific research in the areas of: The risks of burning of coal and fossil fuels for energy Side effects of vaccines and other medications Tobacco product safety concerns Sheldon is a Professor of Humanities and Social Sciences at Tufts University and an Adjunct Professor in the Department of Family Medicine and Community Health at Tufts University School of Medicine. In this revealing interview, he shines a bright light upon the matters of ethics vs science, the importance of environmental ethics, and the role of genetics in society today. What type of role should public health and government really play in scientific advancement, research, and truth telling? Where should the line be firmly drawn between ethics and public policy? These are the kinds of important questions Sheldon has set out to answer along with the Hastings Center, an independent bioethics research institution of which he is a fellow. Professor Krimsky discusses the fallout of the Bayh-Dole Act, the highs and lows of the scientific peer review process, the pros and cons of the government funding of scientific research, and the role of National Institute of Allergy and Infectious Diseases Director, Dr. Anthony Fauci, in the United States’ fight against the deadly COVID-19 pandemic. For more information visit https://sites.tufts.edu/sheldonkrimsky/ Available on Apple Podcasts: apple.co/2Os0myK
“There may not be a cure for cancer, but there may be a strategy, a set of principles that can lead to the eradication of cancer,” says Dr. Robert A Gatenby of the Moffitt Cancer Center. He is working on a novel approach to the treatment of metastatic prostate cancer that could one day prove effective for many other types of cancers as well. Press play to discover: What the evolutionary dynamics of Anthropocene extinction can tell us about the potential eradication of cancer How mathematical models can be used to better understand cancer as a complex, nonlinear system, and predict the success of certain therapies How to avoid selecting for chemo-resistant cancer cells with the use of chemotherapy Dr. Gatenby’s background in physics led him to a key insight: cancer is a complex dynamic system with nonlinear interactions, and to understand such systems, mathematical models are necessary. This insight underlies his most recent work, which involves a novel approach to the treatment of metastatic prostate cancer. Unintuitively, this approach requires that chemotherapy be used to knock down the number of cancer cells a bit, but not with the goal of wiping all of them out completely. The tumor is then allowed to grow back within certain biomarker parameters before another cycle of therapy is delivered. This is continued indefinitely, driving the cancer system into a near steady state that is oscillating. In other words, the tumor is still there, but it doesn’t change significantly over the course of months or even years. Why not just try to kill all of the cancer cells using massive doses of chemotherapy? Dr. Gatenby explains that this approach is only recommended when chemotherapy has a high likelihood of being curative, which is rarely the case when it comes to metastatic cancer. When treating metastatic cancer, the “try to kill as many cancer cells as possible” approach only leads to greater toxicity, higher costs, and lower quality of life for the patient. Perhaps even more importantly, this approach actually selects for chemo-resistant cells, allowing them to proliferate rapidly with no constraints, leading to a worsening state of metastasis. Among many compelling topics, Dr. Gatenby explains the use of mathematical models and principles of evolutionary biology in taking this approach to the treatment of metastatic prostate cancer, extinction therapy,  induction therapy for pediatric leukemia, how and when to integrate immunotherapy in the treatment of cancer, and more.   Available on Apple Podcasts: apple.co/2Os0myK
What can wildlife research teach us about the nature of life, death, and disease? Carolyn Hogg, Senior Research Manager for the Australasian Wildlife Genomics Group, explains the importance of wildlife conservation and the preservation of our natural world for future generations. Tune in to discover: The ecological importance of wildlife Why Australia has the fastest extinction rate in the world The secret venomous nature of the Platypus The Australasian Wildlife Genomics Group researches Koala, Tasmanian Devil, and other Australian animal genes to find ways to fight back against the endangerment and extinction of these unique creatures. Due to the effects of climate change, invasive species, human habitat destruction, and disease, the populations of many of Australia’s most loved and well-known wildlife animals are rapidly dwindling. When animal populations shrink down to a certain size, the risk of inbreeding depression becomes a reality and a threat to the species. This lack of genetic diversity results in an increasingly biologically unfit population. Carolyn and the Australasian Wildlife Genomics Group work closely with other conservation groups to move and integrate groups of animals, resulting in an expansion of genetic variants and higher levels of biological fitness. Native Australian animals like the Koala are facing serious issues, including the Koala Retrovirus, an AIDS-like immunodeficiency disorder. Tasmanian Devils are being plagued by a contagious facial cancer. Invasive feral cats kill billions of indigenous animals each and every year. The importance of wildlife research and conservation cannot be overstated at this point in history. These animals need help and Carolyn is committed to saving them. To learn more about the Australasian Wildlife Genomics Group visit https://www.sydney.edu.au/science/our-research/research-areas/life-and-environmental-sciences/wildlife-genomics-group.html For more information on the Threatened Species Initiative, visit https://threatenedspeciesinitiative.com/ Available on Apple Podcasts: apple.co/2Os0myK
Can recurring skin infections in dogs be effectively treated without the use of antibiotics? Stephanie Lynch, Ph.D. Researcher at La Trobe University in Melbourne, is working on a potentially groundbreaking treatment for canine pyoderma known as bacteriophage therapy. Listen to learn more about: The most common skin infections types seen in dogs by veterinarians The types of skin infections that can potentially be treated with bacteriophage therapy How this emerging skin infections treatment could change the veterinary landscape  Canine pyoderma is one of the most common skin diseases in dogs. Unfortunately, it can also be one of the most persistent. The standard treatment for pyoderma is a month-long course of systematic antibiotics, with or without the addition of routine bathing with a medicated shampoo. Unfortunately, some strains of the bacteria that cause pyoderma have become antibiotic resistant over the years, creating a big, red, itchy problem for some unlucky dogs and their owners. Bacteriophages are viruses that can infect bacteria cells. Once they have infected their bacterial host, they take over those cells and prompt the bacteria to begin to produce viral components rather than bacterial components. The bacteriophages are then capable of forcing their way out of the bacterium, in a process known as lysis, through which they may retain some of the host’s DNA information.  Stephanie hopes to find an answer to the difficult question of how to treat dogs with antibiotic resistant skin infections somewhere in the bacteriophages life cycle. Her research on isolating bacteriophages could pave the way to treating more uncommon bacterial skin infections in dogs, other animals, and even humans without relying upon antibiotics. For more information follow Stephanie on Twitter at https://twitter.com/stephh_lynch 
The link between a keto diet and weight loss is very well known, but can this approach to nutrition really be used to heal chronic disease? Dr. David Jockers believes it can. David is functional nutrition counselor, popular guest on The Dr. Oz Show, and the author of Keto Metabolic Breakthrough and The Fasting Transformation. His natural health website receives over a million views per month from people curious about keto and natural health. Tune in to discover: How David used a keto diet plan and intermittent fasting to reverse his own cancer The importance of herbal medicine and other natural health tips How women can use functional nutrition training to work with their natural hormone cycles After suffering from severe irritable bowel syndrome to the point of becoming quite underweight for his height, David began to experiment with adhering to a ketogenic diet. After receiving a skin cancer diagnosis, he got even more serious about tackling the issue of nutrition. The results of these personal experiments not only changed his life; they continue to change the lives of the people he educates every day. What do inexpensive cooking oils, pesticides, and factory farmed meat have in common? They all cause inflammation and inflammation causes chronic diseases, like cancer. According to Dr. Jockers, cancer cells thrive when they are feeding on glucose. When we eat carbohydrates, those carbs are converted into glucose, which feeds cancer cells. Removing carbohydrates and feeding our healthy cells with ketones means starvation for cancer. Cancer is not the only ailment that may need to look out for the keto approach to nutrition. Stress is at an all-time high throughout the world today and it can take a major toll on a person’s digestive health. A ketogenic diet in combination with a healthy exercise routine and natural herbal supplementation can promote bile flow and a healthy environment within the stomach, without using commonly prescribed acid bocking medications.   For more information visit https://drjockers.com/ 
Why is there anything but cancer? If we are nothing but a collection of individual cells, and if individual cells are perfectly competent at fulfilling their own morphological, behavioral, and physiological needs, then how is it that multicellular organisms—and healthy, functioning ones at that—even exist? Michael Levin explores these questions and more, including: Is cancer a form of swarm intelligence, or the breakdown of it? Are cancer cells particularly “selfish,” as many scientists believe, or are they just as selfish as any other biological system? How does the regeneration of amphibian legs stop at just the right point, and what does this tell us about collective cell decision-making? In the absence of broken hardware (e.g. mutated proteins), how and why does cancer begin? Is there a common language amongst many different cell types in the body? Michael Levin is a Distinguished Professor, Principal Investigator of the Levin Lab, and Director of the Allen Discovery Center at Tufts University, where he investigates how biological and non-biological systems underlie decision-making processes. How does memory storage, decision-making capabilities, and coherent, system-level behaviors emerge from biological and artificial artifacts? According to Michael Levin, the answer lies in the cooperative behavior of individual cells—a type of swarm intelligence. Just like the individual ants in an ant colony behave collectively to reach a larger goal, so too do individual cells in the “colony” of an organism, like a human being. In order to repair and build a human body, individual cells must be connected to and behave in accordance with the collective, rather than operate at the individual level.  But it goes so much deeper than that. Consider, for instance, the regeneration of a salamander limb. Following amputation, a normal limb indistinguishable from the original is developed over the course of a few weeks. How does this regeneration stop precisely where it should? Why doesn’t the salamander end up with a limb that never stops getting longer? Levin says that the stopping point of regeneration requires that the cellular collective compare the current anatomy of the organism to the layout of a correct salamander forelimb, and stop when the error rate is zero (or close to). In other words, the cellular collective can ascertain whether and when the anatomy is correct, and cease growth when appropriate.  Mechanisms of cellular communication are many, and it is this communication—this connectedness between individual cells—that allows for a cellular collective to have goal-directedness, which in turn, leads to salamanders with perfectly regenerated limbs (as just one of many examples). Levin and his group are investigating what happens when an individual cell is unable to perceive the communication signals that normally keep it tightly harnessed to the greater system, like an entire human body. The ‘self’ of the cell shrinks from the level of an organ or organism to the level of a single cell, deaf to the sounds of its neighbors. In this place, the isolated cell does what it knows: proliferates as much as it can and exploits the resources as much as possible. …And what do you get? Metastatic cancer. Levin believes that when a cell loses its ability to communicate electrically with its neighbors, it converts to this state where its behavior leads to metastatic cancer. This is supported by the fact that when ion channel drugs are used to temporarily block cells from proper electrical connection to their neighbors, they convert to metastatic melanoma, even in the absence of mutation and carcinogens. This understanding could one day lead to a commercial application that serves as an effective anti-cancer therapy. Levin discusses the details of all this and so much more. It’s not one to miss—tune in now, and visit https://ase.tufts.edu/biology/labs/levin/ to learn more. Available on Apple Podcasts: apple.co/2Os0myK
Is it possible to synchronize the biological clocks of immune cells and tumor cells to bypass cancer’s ability to avoid the human body’s defense system? Maria Casanova Acebes, Postdoctoral fellow at Mount Sinai Icahn School of Medicine, believes that it absolutely is. Tune in to discover: Differences between the innate and adaptive immune systems The connection between circadian rhythms, macrophages, and cancer cells A new immunotherapy approach for treating lung carcinoma and other common cancers A circadian rhythm is an internal process that triggers behavioral changes in relation to light and dark cycles on a 24-hour schedule. Every living being, whether nocturnal or diurnal, is affected by these changes. Maria’s research group, the Cancer Immunity Group, studies the connection between circadian rhythms, the immune system, and the development of cancer cells and tumors. So far, studies have shown that animals whose circadian rhythms are disrupted become more susceptible to diseases, including viruses and cancers. The innate immune system, which is the immune system humans are born with, features signaling cells known as neutrophils, monocytes, and macrophages. These cells are heavily influenced by circadian rhythms. Maria hypothesizes that cancer cells have their own internal clocks that are able to tune into and mimic the circadian rhythms of the tissues they infect. Is this how they evade the human immune system? By synchronizing the internal clocks of both cancer cells and immune system cells, can we teach our immune systems to eliminate cancer? The Cancer Immunity Group’s approach to immunotherapy could lead to major breakthroughs in a number of the most common areas of cancer treatment and diagnosis, including lung adenocarcinoma pathology and lung adenocarcinoma staging, and management of more treatment resistant cancers such as esophagus cancer. For more information visit https://www.cnio.es/en/ Available on Apple Podcasts: apple.co/2Os0myK
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Comments (8)

Soumen Sengupta

Such an awesome Podcast. Heard it thrice back to back. Great job....Kudos.

Oct 20th
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gg

eh

Aug 31st
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Austin Peek

Insightful episode. Learned a lot, thanks!

Jan 30th
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Richard Jacobs

Thank you for all you do, Dinesh!

Jan 17th
Reply

Chris Hartigan

can you provide a link to the article he mentions in the interview please

Nov 5th
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Jorge Luna

Theme music volume is too high. Host and guest volume too low. Difficult to listen while driving.

Jul 22nd
Reply (1)

Gonzalo Garcia Luna

This is teally interesting

Mar 7th
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