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Finding Genius Podcast

Finding Genius Podcast

Author: Richard Jacobs

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Podcast interviews with genius-level (top .1%) practitioners, scientists, researchers, clinicians and professionals in Cancer, 3D Bio Printing, CRISPR-CAS9, Ketogenic Diets, the Microbiome, Extracellular Vesicles, and more.

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When it comes to radiation therapy for cancer, cellular resistance to it can be a death sentence. What is the genetic basis for this resistance in humans? And what on earth do zebrafish have to do with it? Well…a lot.  Tune in to learn: Why it’s nearly impossible to conduct unbiased research on mice and other mammals How zebrafish are helping researchers overcome a major obstacle to cancer drug discovery   Why it may be more beneficial to focus on eliminating radiation resistance than on targeted therapeutics in cancer When Samuel Sidi attended a French geneticist’s lecture in the early 90s, he had no idea the impact it would have on him and his career trajectory. The lecture was on a new zebrafish model, which would allow for the first time ever, unbiased forward genetic screening on a vertebrate. Since vertebrates are more genetically and pathophysiologically similar to humans than the invertebrates commonly used for this research approach (e.g. Drosophila, worms, yeast), the zebrafish model opened the door to unprecedented and exciting opportunities in research—research that’s no longer limited by cost, time, and spatial constraints that previously existed for this approach in vertebrates.   The zebrafish model also addresses a concern of Sidi’s and other researchers: invertebrates lack many pathways and mechanisms that are deregulated in disease, which means they are lacking as a research model for human disease. Sidi is currently an associate professor at Icahn School of Medicine at Mount Sinai, where he's directing research in the Sidi Lab. Unique among other researchers in the zebrafish model world, he is applying the unbiased approach to cancer drug discovery research. During his post-doc, Sidi developed a zebrafish model that models the problem of resistance to radiation therapy in human cancer. And recently, his MD/PhD student used this model to run an unbiased drug screen, which led to the identification of a compound that can restore radiation sensitivity in mutant zebrafish. The result? “Totally unexpected,” says Sidi. Tune in for all the details. Learn more at these links:  https://labs.icahn.mssm.edu/sidilab/meet-the-team/  https://youtu.be/LnyxoxvtcPo Episode also available on Apple Podcasts: apple.co/30PvU9C
The latest in cancer therapeutics is just around the corner. Press play to learn from a true expert in the field and discover: How immune checkpoint inhibitors work What can be learned from the triangular communication that occurs between a primary tumor, metastatic site, and bone marrow When new and unprecedented therapeutics for cancer may be commercially available Dr. Doru Paul is Associate Professor of Clinical Medicine at Weill Cornell Medical College, a practicing oncologist and hematologist who has treated more than 10,000 patients with various types of cancers over the years, and a clinical and translational researcher who has been involved with over 30 studies in oncology. He also works within the realm of theoretical biology, all with the goal of better understanding cancer and finding more effective, less toxic ways to treat it. Dr. Paul has only been practicing at Cornell for the past three years, but he’s been at the cancer riddle for more than 33 years now. While at Cornell, he has focused on the treatment of head and neck cancers, some of the most common being throat, nasopharynx, and thyroid cancer. In today’s show, he explains the recent success with immunotherapy, both by itself and in combination with chemotherapy, as well as some of the newest medications being used, like monoclonal antibody (MAB) immune checkpoint inhibitors. He discusses the use of FDG-PET (fluorodeoxyglucose-positron emission tomography) to attack cancer vulnerabilities, dispels some of the misconceptions surrounding this approach, and explains why it’s actually effective and free of side effects. He also discusses an idea that he’s been developing over the past six years, which requires zooming out from the microscopic level to the macroscopic level and focusing on the killer of 90 percent of patients: metastasis. Specifically, he talks about the communication that occurs between primary tumors, metastatic sites, and bone marrow, and targeted approaches that function at this level. Tune in for details on these topics and more. Episode also available on Apple Podcasts: apple.co/30PvU9C
Cancer has impacted almost every single person on the planet in one way or another. Maybe you’ve had it yourself, or know someone who has. Despite how long it’s plagued the human species, the opportunities for a deeper understanding of its causes and mechanisms are vast. Tune in to discover: How cells undergo non-genetic heritable changes, and how this might explain the development of cancer Whether it’s actually true that all cancer cells undergo unlimited proliferation What properties make certain tumor types particularly aggressive Gάbor Balάzsi is Henry Laufer Endowed Professor of physical and quantitative biology, and professor of biomedical engineering at Stony Brook University in New York. He joins the show to answer a series of challenging and important questions about cancer. How does cancer first start and why? What abilities do cancer cells have that other cells don’t? And why do certain types of cancers seem to prefer specific sites for metastasis? There are just a few of the compelling questions that Balάzsi offers insight on, diving into the details of tumor heterogeneity, the positive feedback mechanism that can perpetuate cytoplasmic conditions, whether there’s a certain point at which a tumor establishes a sense of ‘self’ versus ‘other’, the impact of cell-to cell signaling disruption, tumor structure, the difference between primary tumors and metastasis, and the latest breakthroughs in cancer treatment. Balάzsi discusses immunotherapy, the drawbacks of targeted drug therapies, gene therapy and RNA or DNA-based vaccines, and more innovative approaches to cancer treatment. Learn more at https://www.stonybrook.edu/commcms/bme/people/g_balazsi.php. Episode also available on Apple Podcasts: apple.co/30PvU9C
Imagine being given two options: lose your license to practice medicine, or keep quiet about a substance that you know has revolutionary therapeutic applications. You might think no doctor would ever find themselves in such a position. Think again.    And press play to learn: How chlorine dioxide is able to kill pathogens, but not biological tissues How chlorine dioxide and its use as a therapy for some illnesses was discovered Why you won’t find the information in this podcast anywhere else, unless you dig really deep Ken McCarthy, a pioneer in the movement to commercialize the internet, a wealth of knowledge on internet advertising and marketing, and former student of neuroscience at Princeton University, presents a compelling argument for the safe and effective use of chlorine dioxide as a therapeutic for a range of illnesses. If he’s right, why don’t you know about it? Or maybe what you do know about it is that it's a dangerous toxin, not to be touched. McCarthy begins with some indisputable facts: 1)      Chlorine dioxide is an FDA-approved Class II food additive 2)      The EPA has approved the use of chlorine dioxide as a water purifier 3)      Chlorine dioxide was used during the 2001 anthrax attacks to clear the Capitol Building of any anthrax remnants 4)      Chlorine dioxide is used as a sterilization substance in the treatment of Ebola 5)      The administration of trace amounts of chlorine dioxide is part of some protocols for the treatment of children with autism 6)      Chlorine dioxide can kill coronaviruses McCarthy also offers an impressive and surprising amount of anecdotal evidence in support of the argument that chlorine dioxide is an effective therapy. He names specific people who have written articles or news stories that contain misinformation or flat-out lies about chlorine dioxide, and explains what motivates the powers that be to conceal the truth from the public.   Could it have something to do with the fact that one therapeutic dose of chlorine dioxide costs less than a penny? And that, given its true potential as a treatment for a range of common ailments, Big Pharma might not like this? McCarthy seems to think so, and by the end of the podcast, you probably will too. Press play to learn more. Episode also available on Apple Podcasts: apple.co/30PvU9C
Does your brain function as a filtering device for your mind? It might sound strange, and you might think there’s no way. But consider that the eyes filter visual input and the ears filter auditory input, leaving us only with the stimuli we need for physical survival.  Couldn’t the brain also act as a filtering device, allowing only those thoughts which enable our survival in one way or another? Press play to explore this idea and discover: What might happen to the mind-brain connection during near-death experiences, and what this says about the function of the brain versus the mind How cultural background influences the way people interpret near-death experiences Whether there’s evidence that non-human animals also have near-death experiences and are similarly impacted by them What terminal lucidity is, and how it might relate to near-death experiences Professor Emeritus of Psychiatry and Neurobehavioral Sciences at the University of Virginia School of Medicine, Dr. Bruce Greyson, was raised in a scientific household void of any focus on things in the nonphysical, spiritual, or religious realm. As such, he journeyed through college and medical school with a materialistic mindset. But it wasn’t long before he began encountering inexplicable stories of people who had come close to death, and recounted "near-death experiences." As a skeptic, Dr. Greyson wanted to test the phenomena with hypotheses that fit into his materialistic understanding of life and death. Could near-death experiences be explained by oxygen deprivation or high levels of CO2? Could it be unusual activity in the brain? Or the drugs that are often administered to people on the verge of death? Could it be chemicals produced by the brain itself? These hypotheses and more have been tested using data gathered over the last 20 to 30 years, and not one of them has held up in near-death situations. “Most people find near-death experiences interesting because of what they may tell us about death and dying and what happens after death, but for me as a psychiatrist, what’s most interesting is what they tell us about life and living,” says Dr. Greyson. He continues this line of thought by sharing with listeners the profound impact that near-death experiences have on the people who experience them. The overarching commonality is this: a near-death experience leaves the person with a new outlook on life and value, and a new desire to help people by living in accordance with the Golden Rule. Dr. Greyson has heard countless stories of people who worked in violent or competitive business professions, and following a near-death experience, could not possibly continue the same lifestyle. Instead, they entered a helping profession. In essence, the things these people had known their entire lives become foreign and nearly inconceivable to them. Dr. Greyson has recently written a book on the topic called After: A Doctor Explores What Near-Death Experiences Reveal about Life and Beyond, which is slated for release on March 2, 2021. Tune in to explore this other-worldly topic in more depth, and keep an eye out for Dr. Greyson’s book. Episode also available on Apple Podcasts: apple.co/30PvU9C
You could very well have cancer cells circulating in your body at this very moment. But don’t worry, because if you do, you’ll probably never know it. And you can thank your immune system for that. So how does cancer develop at all? Why and when does the immune system fail to protect us from cancer? And how can this knowledge lead to an effective treatment? Tune in for the answers to these questions and more, including: Why patchy losses of skin color in people who have melanoma is a good sign that the immune system is doing its job How the body can develop a memory of tumors, equipping it to promptly attack cancer cells that show up months, years, or even decades after the initial tumor About how many immunosuppressive mechanisms exist, and how they work At Dartmouth College, Steven Fiering is a professor of microbiology, immunology, and genetics, with a primary focus on immunotherapy for cancer. While there are good treatments for cancers that have not metastasized, like surgery and radiation, outcomes for metastatic solid tumors are almost universally poor. According to Fiering and many others, immunotherapy might be the solution. The bulk of Fiering’s work boils down to a rather simple understanding of the immune system: it is a constant balance between suppressive and stimulatory signals from other cells in the body. When it receives a certain level of stimulatory signals, the immune response kicks into gear; when it receives a certain level of suppressive signals, its function is reduced. We also know that there are immunosuppressant characteristics of cancer that the immune system can’t destroy. “Any immunotherapy that works has to overcome the immunosuppression that’s manifested by the tumor,” explains Fiering. In light of this understanding, Fiering is focused on using known immunostimulatory reagents to directly change the environment within a tumor, from immunosuppressive to immunostimulatory. He is researching how to optimize the use of these reagents for the best immune response against tumors that are directly treated by them, as well as the best systemic response against metastatic disease. In short, immunotherapy might hold the key to effective treatment of metastatic cancers without the detrimental side effects of chemotherapy. This would be an absolute breakthrough in the world of cancer. Press play for an in-depth conversation about this work and so much more. Learn more at https://geiselmed.dartmouth.edu/faculty/facultydb/view.php/?uid=126. Check out https://www.mosaicie.com/ to learn about a new startup that Fiering is involved in. Episode also available on Apple Podcasts: apple.co/30PvU9C
The US Federal Government continues to hide clear evidence resulting from a 10-year, $30 million study funded by the FDA: radiation from wireless technology causes cancer and breaks DNA. In fact, the government not only has this knowledge, but uses it as a weapon. Thousands of studies over past decades show clear evidence of biological harm caused by wireless technology radiation, yet most of us don’t think twice about our exposure to it. Listeners will learn: How the frequencies in wireless technology can be weaponized    The true reason 5G is being rolled out, and it’s not to improve the speed of your internet The difference between ionizing and non-ionizing radiation, and how both cause the same level of biological damage What legal recourse is being taken against the FCC for having ignored over 11,000 pages of evidence submitted to Docket No. 13-84 Why and how adverse health effects are less about radiation levels, and more about the pulsation and modulation of carrier waves, which are what make wireless transmission of information possible “We are electric beings, and this is electricity, millions and trillions of times higher than what our bodies can tolerate. There are clearly going to be effects, even if we want to believe otherwise,” says Dafna Tachover. Tachover worked with and developed a passion for wireless technology for many years…until it made her so sick that she had to stop. This compelled her to find out why and how this technology has the ability to cause her and others so much sickness. She has since become Director of the Stop 5G & Wireless Harms Project for Children’s Health Defense and Founder of We Are The Evidence, an advocacy organization which helps protect the rights of those who have been injured by wireless technology radiation. And as an attorney, Tachover is tackling the issue from a legal perspective. She explains the details of her intensive and unprecedented case against the FCC. She also explains the science behind the impacts of wireless technology radiation on our health, which often begin with tingling in the hands or fingers and can lead to severe headaches, ringing in the ears, heart palpitations, nose bleeds, noise sensitivities, visual impairments, cognitive and memory problems, and symptoms characteristic of ADHD. It’s estimated that at least 10 percent of people already have symptoms of radiation sickness without knowing it, and the true percentage is probably much higher. So, what can you do? Tachover lists practical, simple steps that you can take to protect yourself and those you love. This isn’t one to miss. Press play and check out these resources to learn more: https://childrenshealthdefense.org/ https://www.americansforresponsibletech.org/ https://mdsafetech.org/ Episode also available on Apple Podcasts: apple.co/30PvU9C
Royal jelly, honey, propolis, pollen…the list of bee products that many of use from day to day is long. But fewer people are aware that there’s something less tangible yet just as healing about bees: their energy. Press play to step into the medicinal world of bees and learn: Why and how one teaspoon of honey per day can prolong your life How bees clean the air inside their hives, and how humans can benefit from this too What studies have shown about the regenerative properties of royal jelly, and how this provides additional evidence of its effectiveness in treating multiple sclerosis (MS) What is known about the composition and properties of different types of propolis around the world Since entering the field of medicine 33 years ago, Cristina Aosan wanted to treat everything—including that which conventional medicine said was untreatable or uncurable. To this end, she began studying various topics on her own, which led her to apitherapy, a branch of medicine that uses honey bee products to treat people. As a physician at Melidava Consulting in Romania, Aosan treats people with nearly every type of ailment you can imagine, including multiple sclerosis, tumors, liver viruses, and obstructive atherosclerosis. She takes an individualized approach with each patient, drawing from an extensive toolbox containing honey, propolis, royal jelly, drone larvae, pollen, and more. In some places, patients can even stay in homes arranged near bee hives to take in the healing and harmonious energy of the bees themselves—a practice that is becoming increasingly well-known. Aosan explains the applications of various bee products, the history of apitherapy and its use by the Egyptians and other ancient civilizations, how bees use propolis as an air-cleaning mechanism, and what she hopes is in store for the future of apitherapy. Tune in for all the details. Available on Apple Podcasts: apple.co/2Os0myK
Timothy Saunders, Associate Professor at the National University of Singapore’s Mechanobiology Institute, shares his insights on the science of morphogenesis developmental biology, the study of tissue formation and organization in plant and animal species. Listen to learn more about: How organs are formed The morphological features of plants versus animals How organs change during pregnancy How vital organs develop, particularly in human embryos, is considered a long standing mystery by much of humanity. How do our cells know how to organize and replicate in order to form correctly structured and functional organs? How do they know when to stop replicating and not to continue growing past the ideal size? Timothy and his team aim to increase the understanding of developmental biology in both the medical community and the general public. Much of the research done in this area has centered around plants and fish, which can repair injury and regrow after amputation. What can be learned from these types of organisms? What can be gained from the study of human tissue generation in utero? Large-scale, high-resolution imaging technology is enabling the study of precisely how tissues interact during organ formation in humans. This in combination with the use of organoids grown from organ tissue and stem cells could break open the case of how to apply morphogenesis embryology to possible heal damaged organs in the future. For more information visit https://www.mbi.nus.edu.sg/timothy-saunders/saunders-lab/ Available on Apple Podcasts: apple.co/2Os0myK
Are customized cancer treatments a real possibility? Benjamin D. Hopkins, Ph.D. is Assistant Professor of Genomics and Genetic Sciences, Oncological Sciences, and the co-leader of the Functional Genomics Pipeline at The Tisch Cancer Institute. His cancer genetics research has developed an automated screening platform that can be used to identify tumor-specific drug sensitivities used for highly specialized cancer treatment. Tune in to learn more about: Cancer genetics and genomes What the ability to identify a drug resistance mechanism means for cancer treatment The importance of the cancer research impact factor when searching for the most accurate information Dr. Hopkins focuses particularly on lung, breast, and pancreatic cancer, which is one of the 20% of cancers with no specific standard treatment plan. The Functional Genomics Pipeline as a whole screens cancer therapies to identify which types of patients with which types of tumors may be able to benefit from those therapies. Using cancer genome sequencing, it has become possible to identify tumor-specific vulnerabilities, which can then be exploited for cancer treatment purposes. This includes using one medication to sensitize tumor cells to another medication, as a way to reduce the collateral damage done to healthy cells during cancer treatment. Knowing exactly which mutational events are driving each specific tumor allows Dr. Hopkins and his team to target the specific mechanisms that tumor relies upon to thrive and multiply. This highly individualized approach in combination with public campaigns such as Breast Cancer Awareness month could lead to a future where cancer is considered a treatable disease across the board. For more information visit https://labs.icahn.mssm.edu/hopkinslab/ Available on Apple Podcasts: apple.co/2Os0myK
What is missing when it comes to Western medicine’s standard approach to treating chronic health problems? Dr. Will Cole, author of Intuitive Fasting: The Flexible Four-Week Intermittent Fasting Plan to Recharge Your Metabolism and Renew Your Health, grew up watching his loved ones battle autoimmune disorders. Now, he is leading a movement to change the way we treat chronic diseases using functional medicine. Tune in to discover: New ways to discover the underlying causes of chronic disease How to get out of fight or flight mode and back into a state of “rest and digest” The role of intuition in intermittent fasting Dr. Cole looks beyond simple numbers and lab results in order to treat the whole patient and not just their current symptoms. His natural and holistic approach often utilizes functional medicine nutrition, intuitive eating intermittent fasting, and a hormonal imbalance diet. Understanding autoimmune thyroid disease, for example, and which foods can prompt the body to produce its own thyroid hormones can avoid unnecessary dependence on medications and highlight the importance of lifestyle in disease treatment. Intuitively intermittent fasting combined with a mostly plant based high fat, moderate protein, low carbohydrate diet has been shown to support the metabolic process and protect against insulin resistance and digestive problems symptoms. Dr. Cole’s four-week plan makes the benefits of fasting and eating a plant based ketogenic diet accessible to beginners who may want to treat specific issues, improve their overall health, or both. Embracing functional medicine education can provide those suffering from chronic illness with a way to take their health and their personal power back into their own hands. To learn more or book a consult visit https://drwillcole.com/ Available on Apple Podcasts: apple.co/2Os0myK
Is hustle and hope really enough to make it big in the modern world of online finance? Jeff Rose, Youtube’s Wealth Hacker and Founder of the finance blog Good Financial Cents shares how he went from cold calling and holding underwhelming local finance planning and analysis seminars to creating one of the most popular financial advice blogs on the internet. Listen to learn more about: Investment strategies Recovering from financial loss and depression The power of mentorship for online entrepreneurs Jeff’s down to earth approach to finance and willingness to use his own mistakes as a teaching tool has made him a crowd favorite on YouTube. Wealth Hacker offers how-to videos on financial topics like how to create passive income streams, how to invest your first $100, and how to turn $500 into $520,367. His blog, Good Financial Cents, has been featured on Fox Business, ABC News, CNN Money, CNBC, and more. Weighing in on the recent GameStop stock market debacle, modern investment management, and life as a financial planner, Jeff gives his honest opinion on what it really takes to get rich in today’s economy. After providing free content for years and finally taking part in an exclusive coaching program for entrepreneurs, Jeff has launched Good Financial Cent’s latest online finance course. This course is all about how to set (and actually reach) accelerated financial goals. For more information or to sign up for Jeff’s new online course visit https://www.goodfinancialcents.com/ Available on Apple Podcasts: apple.co/2Os0myK
Dr. Eric Zielinski, author of the national bestseller, The Healing Power of Essential Oils, is back on the podcast with a new book available for preorder called The Essential Oils Apothecary. He shares his professional views on and personal experiences with essential oils as a key part of a healthy lifestyle. Tune in to discover: The power of natural remedies and natural healing products General healthy living tips Why sitting is now considered more dangerous than smoking Perfume, laundry detergent, scented candles, fabric freshener, hand sanitizer, bleach, new car smell; how many chemicals do you inhale, ingest, or absorb each day? Studies have suggested that wealthy countries that can afford to practice over-sanitization with cleaning chemicals tend have higher rates of Alzheimer’s Disease. Why? A lack of bacteria in the environment creates poorly developed immune systems, which puts brains at higher risk of inflammation. How many other diseases could we be inadvertently inviting into our bodies? What is the difference between the average American and people who live in a “Blue Zone”, or an area with low rates of chronic illness, where it is considered normal to live 100 years or more? How can we use essential oils to change our lives and bring us closer to optimum health? Eric reveals the beneficial properties of common and easy to obtain oils, like cinnamon bark, lime, orange, and grapefruit. Dr. Zielinski’s healthy lifestyle motivation brand offers simple recipes for natural, nonchemical household cleaners, personal hygiene items, and immune boosters. His website is a substantial resource for essential oil news, basic education for beginners, and where to begin with natural remedies in your own home and life. For more information visit https://naturallivingfamily.com/ Available on Apple Podcasts: apple.co/2Os0myK
Scott Young, former Finding Genius guest and author of Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career, shares tips of how to use a more focused mind to live a more productive life. Listen to discover: How to be more productive in life The difference between general focus and focusing in one direction How to stay focused on tasks and goals Technology detoxes, sheer willpower, unyielding impulse control; these traditional approaches to increased productivity simply cannot be relied upon. A new system for focusing is required for the new age. Scott has created a series of courses, including Rapid Learner, Life of Focus, Top Performer, and Make It Happen, that offer people the opportunity to learn how to increase focus using unique concentration exercises. Deep work is the concept of achieving a level of cognitive depth through periods of continuous distraction-free, interruption-free concentration. Scott’s books and courses provide guidance on how to enter the state necessary in order for deep work to occur, troubleshooting for when you get stuck on a task, and how you can track your productivity progress. The effects of guided consistency on your ability to focus can be staggering. Is mental focus like physical exercise? Can the ability to enter a deep work or flow state become a matter of muscle memory for your brain? Is everyone even capable of blocking out environmental distractions? Scott explains the differences in approach to his productivity system that can become necessary based on age, working memory capacity, and other factors, and how it can be adjusted to work for anyone. For more information or to grab a free copy of Scott’s e-book, 7 Must-know Strategies to Learn Anything faster! visit https://www.scotthyoung.com/ Available on Apple Podcasts: apple.co/2Os0myK
What if everything we have been told about breast cancer prevention is wrong? Dr. Susan Wadia-Ells, author of the new book, Busting Breast Cancer: Five Simple Steps to Keep Breast Cancer Out of Your Body, has combined decades of ignored statistical studies with the recently published metabolic theory of cancer,  to help women learn how to block most breast cancer from taking form in their bodies. Tune in to learn more about: Why 75 percent of US women are now overweight or obese, causing the US to have the highest breast cancer rates in the world, no matter one’s age. Why year-round outdoor/indoor tanning and taking 5,000-10,000 IUs of D3 supplements daily, can block most breast cancer from happening. What is causing today’s growing, but still unreported, metastatic breast cancer epidemic that is reaping billions, annually, for the cancer industry After losing three close friends to recurrent metastatic breast cancer, Dr Wadia-Ells decided to try and understand how to best protect herself and other women from developing breast cancer.  In 2013 she discovered the newly published book, Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, by Dr. Thomas N. Seyfried, the eminent Boston College biologist.  Now understanding the exact biological steps that suffocate our cell’s power batteries or mitochondria to create that first cancer cell, as described in Dr Seyfried, textbook, Dr Wadia-Ells was now able to develop  the Five Simple Steps for effective breast cancer prevention. These steps include: losing all excess body fat; raising vitamin D3 blood levels above 60 ng/ml; avoiding all birth control drugs, IUDs and menopausal relief drugs that contain the man-made chemical progestin; keeping one’s body detoxified of hormone-like chemicals found in food, water, air, furniture and personal care products, and having an annual thermogram to monitor any pre-cancerous inflammation in breast tissue. Together, her five simple steps and the metabolic theory of cancer tell us why one woman develops breast cancer, while another woman never will. To support the development of effective non-toxic metabolic protocols to treat early stage and metastatic cancer, Dr. Wadia-Ells has committed 20 percent of her book’s profits to the Foundation for Metabolic Cancer Therapies. For more information visit https://www.bustingbreastcancer.com/ Available on Apple Podcasts: apple.co/2Os0myK
Can mathematics really be applied to brain cancer treatment? Dr. Kristin Swanson, Vasek, and Anna Maria Polak Professor in Cancer Research at Mayo Clinic, goes to work each day to create individualized predictive models using mathematics to more effectively treat patients diagnosed with brain cancer.  Listen to learn more about: The most common symptoms of brain cancer Theories on what causes brain cancer How cancer cells prey on normal brain functions Imagine an exact 3-D replica of your brain that you can hold in your hands. Using mathematical model predictions, it is now possible to print a 3-D MRI of an actual human brain with cancer. This model can predict and show both current and predicted cancer cell density bands, making it possible to choose more efficient cancer treatment methods sooner. Mathematic models and the data they provide have also revealed differences in male versus female brain cancer survivors and their gene signatures, along with other differences in the typical brain cancer story in women compared to in men. After experiencing a personal loss due to cancer, Dr. Swanson set out to use new technology like artificial intelligence, mathematical mapping, and image localized biopsies to diagnose and treat the most aggressive type of brain cancer, Glioblastoma.  Kristin’s research lab is akin to a hurricane center, but instead of predicting storms, its advanced technology forecasts cancerous tumor development. When shared with cancer patients and their physicians, this type of detailed predictive model can offer a sense of education and control over treatment that traditional methods simply cannot offer. For more information visit http://mathematical-oncology.org/ Episode also available on Apple Podcasts: http://apple.co/30PvU9C
How is the rest of the world responding to the Covid-19 pandemic and how is the virus itself changing over time? Jim Bijl, Finding Genius listener and Pulmonary Function Technician in The Netherlands, weighs in on the state of the global Covid-19 pandemic.  Tune in to discover: The typical stages of a Covid-19 infection The effectiveness of mask mandates and other public health interventions  The role of the media and politics in response to the pandemic  As a technician who administers pulmonary function tests and has access to the pulmonary function test results of patients with Covid-19 in comparison to those with other lung diseases, such as cystic fibrosis, SARS, Influenza, pulmonary fibrosis, and MERS, Jim has a unique perspective on the pandemic and the world’s response to its threats in both the short and the long term. If most of the people who suffer severe consequences from Covid-19 have preexisting conditions, such as a cystic fibrosis diagnosis, does this mean that precautions should be relaxed for the rest of the population? If the rate of survival in those who are hospitalized in intensive care units for Covid-19 related complications is increasing, should the status of the pandemic as a whole be re-evaluated?  After working up close and personal with Covid-19 patients, Jim shares his experiences and opinions on the potential for longer term side effects of the virus, including reduced lung capacity, and how long they might last for most patients. From vaccines and masks to politics and the media, Jim offers insights from inside the medical community on how the world may look post Covid-19 pandemic.  To contact Jim directly, send an email to jimbijl@protonmail.com Available on Apple Podcasts: http://apple.co/2Os0myK
How do genes affect your health? Dr. Yael Joffe, Adjunct Professor of nutrigenomics at Rutgers University and Chief Scientific Officer at 3x4 Genetics, has dedicated her career to finding out exactly how much bearing a person’s genetics has on their weight, on their ability to manage it with diet and exercise, and on their heath as a whole. Tune in to discover: What a nutrigenomics diet is and how it can help with weight control How a DNA based diet and fitness regime can activate or deactivate certain genes The connection between DNA based dieting and disease prevention and management Every human being on the planet shares 99.9% of the same DNA. It is the remaining 0.1% that determines the ways in which we are all unique from each other. Yael explains how she has led the way in the emerging field of nutrigenomics and personalized nutrition. The nutrigenetic testing she has developed can be used to analyze a person’s hunger cues, satiety response, fat burning abilities, behavioral responses to food, and more. Genetic variants like the FTO and LEP genes can help to predict whether a particular person will struggle with binge eating, excessive grazing or snacking behaviors, or food addiction, and how much Leptin their body will produce. Leptin plays a major role in energy regulation and hunger signals. Depending on what is revealed by a person’s nutrigenetic testing, he or she may be given specific diet and exercise recommendations or referred to a behavioral therapist. It may turn out that genetics play no real role in some men and women’s difficulty with body weight or weight loss. In some cases, other avenues may still need to be explored. For the time being, Dr. Joffe’s nutrigenetic DNA testing is available to physicians only. If you are interested in being tested, visit https://www.3x4genetics.com/ to find a participating provider in your area. Available on Apple Podcasts: apple.co/2Os0myK
What is Metabolic Syndrome and how is it related to obesity and Type 2 Diabetes? Vivian Tran, Ph.D. candidate in the Vascular Biology and Immunopharmacology group at La Trobe University, shares what her studies on mice have revealed about Metabolic Syndrome, the cardiovascular complications of Diabetes, and the risk factors of obesity. Listen to learn more about: The differences in fat distribution between men and women and the associated obesity risks Whether or not obesity should be considered a Type 2 Diabetes cause The different types of fat cells and which type is more dangerous to your health Metabolic Syndrome is not one disease; it is a group of medical conditions that occur together in the same person. These conditions include high blood pressure, heart disease, stroke, Type 2 Diabetes, obesity, and high cholesterol. Due to rising rates of obesity, it is estimated that nearly one third of the U.S. population suffers from Metabolic Syndrome. Vivian has set out to find the answers to questions including why more men than women die from Metabolic Syndrome related cardiovascular events when more women than men are diagnosed with the disease. Could this be due to the difference in fat distribution and the presence of subcutaneous versus visceral fat cells in men and women? Vivian explains the differences in the health risks associated with belly fat in comparison to fat on other areas of the body and the dangerous of visceral fat, which can attach itself to internal organs. Her research on the role of fat tissue surrounding blood vessels and how it affects vascular function in those with Metabolic Syndrome could lead to major advancements in the prevention of cardiovascular disease in those who suffer from it. For more information follow Vivian on Twitter at https://twitter.com/vivianvtran Available on Apple Podcasts: apple.co/2Os0myK
Could female Kenyan sex workers be the key to preventing HIV spread on a much larger scale? Keith Fowke, Head of the Department of Medical Microbiology and Infectious Diseases Professor at the University of Manitoba, explains the connection between these Kenyan sex workers and HIV resistance, plus what this could mean for the future of HIV prevention as a whole. Tune in to discover: The genetic basis for resistance to HIV transmission in certain ethnic groups Stages of the HIV life cycle HIV and immune system factors that could translate to new disease prevention technology HIV and AIDS have devastated parts of the world over the past five decades. Africa has been particularly affected by the epidemic. Now, specific populations of sex workers in Kenya have shown resistance to the HIV virus, despite repeated exposure for decades, thanks to their quiescent immune systems. What information can be taken from these women and applied to other groups of people across the world to prevent more HIV infections? Keith and Fowke Lab has been studying alternative HIV prevention methods, including low dose aspirin therapy and genital topical antiviral agents, with promising results. If certain genes increase HIV resistance in some people, can other genes contribute to faster and more aggressive disease progression in others? Can the human immune system be further manipulated by medication or other treatments to protect against HIV infection or progression? How important are the genetics of the person being potentially infected versus the genetics of the virus? Professor Fowke shares the answers to these questions and much more. For more information on new methods of HIV treatment and ways to prevent infection visit https://www.fowkelab.com/ Available on Apple Podcasts: apple.co/2Os0myK
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Comments (8)

Soumen Sengupta

Such an awesome Podcast. Heard it thrice back to back. Great job....Kudos.

Oct 20th
Reply

gg

eh

Aug 31st
Reply

Austin Peek

Insightful episode. Learned a lot, thanks!

Jan 30th
Reply

Richard Jacobs

Thank you for all you do, Dinesh!

Jan 17th
Reply

Chris Hartigan

can you provide a link to the article he mentions in the interview please

Nov 5th
Reply

Jorge Luna

Theme music volume is too high. Host and guest volume too low. Difficult to listen while driving.

Jul 22nd
Reply (1)

Gonzalo Garcia Luna

This is teally interesting

Mar 7th
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