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The Energy Balance Podcast

Author: Jay Feldman Wellness

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Discover how you can live without constant hunger and fatigue, brain fog, poor sleep, and other low-energy symptoms. The Energy Balance Podcast will teach you how to maximize your cellular energy so you can take back your health and finally experience clear-headed focus, restful sleep, and all-day energy you didn’t think was possible.
112 Episodes
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In this episode we discuss: How spore-based probiotics differ from typical probiotics and whether we should be using either of them to improve our gut health  Whether low-carb or ketogenic diets are an ideal solution for epilepsy  The role of gut health and metabolism in epileptic seizures Concerns with using low- or no-calorie sweeteners Whether stevia is actually any better than artificial sweeteners   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-111-stevia-vs-sugar-ketogenic-diets-for-epilepsy-and-spore-based-vs-standard-probiotics-qa   Timestamps: 0:00 – intro 1:17 – whether spore-based probiotics can cause bacterial overgrowths like SIBO 4:53 – the drawbacks of standard probiotic use and the limitations of stool testing 9:55 – how spore-based probiotics protect against pathogenic bacteria and endotoxin and which spore-based product Jay recommends 15:39 – long-term benefits of spore-based probiotics and how long you need to use them for these benefits 21:05 – whether low-carb or ketogenic diets are necessary to improve epilepsy  29:25 – using ketones for fuel and why the production of ketones isn't the problem on a ketogenic diet  30:48 – the main drivers of epileptic seizures and how ketones help to prevent or reverse them  34:17 – the role of the gut microbiome in brain health and epilepsy 42:18 – concerns with low- or no-calorie sweeteners like stevia 48:03 – whether we should be concerned about the lack of nutrients in table sugar, honey, and maple syrup  54:55 – stevia as a potential endocrine disruptor that may have negative effects on the thyroid, liver, and kidneys 
In this episode we discuss: Why insulin resistance and diabetes are not caused by excess carbohydrate consumption and are not actually an insulin signaling problem  The problems with the idea of metabolic flexibility, earning your carbs, and the carb-insulin model of obesity  Why carbs are beneficial even for people who have insulin resistance or diabetes  The role of fat burning and stress in driving insulin resistance  Specific diet, movement, and supplement recommendations to reverse insulin resistance and diabetes    Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-110-the-true-cause-of-insulin-resistance-and-diabetes-from-the-bioenergetic-view/   Timestamps: 0:00 – intro 1:14 – metabolic flexibility, earning your carbs, the carb-insulin model of obesity, and dispelling other common insulin resistance myths 7:48 – low-carb, keto, and carnivore diets may improve symptoms but are not the solution for insulin resistance 13:13 – what the mainstream views of insulin resistance gets wrong when it comes to what causes insulin resistance 15:50 – why you might not want to use a continuous glucose monitor and the unnecessary fear of blood glucose spikes 17:48 – whether insulin is harmful and whether we want to keep insulin levels as low as possible 22:15 – whether we can restore optimal insulin sensitivity without low-carb diets  25:16 –the bioenergetic view of insulin resistance  27:12 – insulin resistance as an adaptive evolutionary process that is crucial for survival 31:22 – the difference between physiological and pathological insulin resistance 34:40 – how inhibited glucose oxidation causes insulin resistance 40:46 – how fatty acid oxidation causes increased production of ROS, slows cellular respiration, and blocks glucose oxidation (The Randle Cycle) 51:06 – the harms of ROS production from fatty acid oxidation and other forms of stress 53:04 – insulin resistance as an energy deficient state 54:19 – insulin resistance is not an insulin signaling problem, it’s an energy production problem  58:30 – the role of stress hormones (like cortisol) in insulin resistance  1:02:09 – how insulin and carbohydrates decrease stress  1:05:59 – how to fix insulin resistance and restore insulin sensitivity by fixing our capacity to produce energy   1:10:38 – specific diet, movement, and supplementation recommendations for insulin resistance and diabetes  1:17:55 – why you don’t need to tailor your carb intake to your carb tolerance   
In this episode we discuss: Our thoughts on Chris Palmer’s “Brain Energy” theory of mental health Why low carb diets are not the solution for anxiety and depression and what to do instead What most people miss when it comes to weight loss and why we shouldn’t focus on fat-burning Strategies to optimally manage blood sugar for Type 1 Diabetes Whether we should lower our fat intake to lose weight    Sign up for the Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide    Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-109-chris-palmers-brain-energy-type-1-diabetes-and-low-fat-diets-for-weight-loss-qa   Timestamps: 0:00 – intro 1:19 – our take on Chris Palmer's “Brain Energy” theory of mental health disorders 5:04 – challenging the misconception of a separation between the brain and body 8:03 – why low-carb, ketogenic, and carnivore diets can produce temporary mental health benefits 10:36 – how impaired energy production underlies poor brain health and how to fix it without using low-carb diets 14:05 – how fat burning can temporarily relieve symptoms of poor glucose utilization (with a major cost) 18:29 – why fatty acid oxidation is our default metabolic state under stress and underlies all chronic disease 22:20 – whether ketogenic diets promote metabolic flexibility 24:53 – poor glucose metabolism as a driver of Alzheimer’s disease and other mental health conditions 28:13 – the adaptive benefit of burning fat during stress 31:31 – blood sugar management for Type 1 Diabetes and whether a low-carb diet is optimal 38:13 – whether lowering fat intake is necessary for burning and losing fat 42:09 – whether improving metabolic function alone is enough to reduce stored fat and when a decrease in dietary fat intake may be necessary 47:32 – the difference between subcutaneous fat and visceral fat and their potential implications 50:34 – how to fix our hunger signals to prevent excessive eating 54:33 – weighing the costs of extreme diets and the need for more innovative thinking around health
In this episode we discuss: The unexpected costs of using excess exercise to lose weight  Our thoughts on Herman Pontzer’s book Burn and the Constrained Model of Energy Expenditure  Our thoughts on Ted Naiman’s protein to energy ratio diet (PE Diet)  The cost of eating too much protein and what to do instead  How to increase caloric intake to raise your metabolism and reverse hypothyroidism  The major category of nutrients that’s often missed for optimizing mitochondrial function      Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy     Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-108-herman-pontzers-burn-ted-naimans-pe-diet-and-increasing-calorie-intake-to-raise-metabolism-qa/   Timestamps: 1:25 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits 7:13 – problems with the additive model of energy expenditure and the physiological cost of excess exercise 10:40 – environmental factors that we can change to increase metabolism 16:42 – the unexpected costs of using excessive exercise to lose weight 19:16 – weight gain as an adaptive response to an energy deficit 22:46 – when eating too much can be a problem and how to identify your ideal calorie intake 32:18 – Ted Naiman’s protein to energy ratio diet and optimal protein intake 41:13 – the problems with using protein as an energy source 46:45 – how to increase caloric intake to raise metabolism and reverse hypothyroidism 50:47 – how to track your symptoms and progress to better guide your nutrient goals 56:55 – the best foods for increasing calorie intake and what to do if you have a low appetite 1:00:30 – the essential role of both macro and micronutrient density in promoting mitochondrial health 1:04:00 – why sugar cravings are not the same as sugar addiction 1:06:46 – easy ways to incorporate more macro and micro nutrient dense foods into your diet
In this episode we discuss: Studies showing that omega-3 consumption decreases lifespan and increases disease processes  The potentially harmful effects of omega-3 usage during pregnancy on offspring  The impact of omega-3s on inflammation, endotoxin, and mitochondrial respiration  The data in native cultures showing that omega-3 intake doesn’t improve cardiovascular disease or mortality  Extremely healthy populations that consume high-carb and high-saturated fat diets with almost no omega-3s      Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/     Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-107-omega-3s-decrease-lifespan-and-increase-disease   Timestamps: 0:00 – intro 1:30 – studies showing that omega-3 consumption decreases lifespan and increases disease processes in animals 13:55 – studies on animals showing the harmful effects of omega-3 consumption during pregnancy on offspring 17:37 – studies showing that omega-3 consumption contributes to disease processes, increases inflammation, causes oxidative stress, increases endotoxin, and interferes with mitochondrial respiration 28:19 – whether we should be concerned about saturated fats increasing endotoxin absorption 29:33 – how omega-3 consumption leaves us more susceptible to damage when we’re under stress 32:53 – whether we should be consuming fatty fish 35:01 – the lack of benefit of omega-3 consumption in native populations consuming large amounts of fatty fish and seafood 38:40 – low incidence of cardiovascular disease in native populations consuming very little omega-3s 59:30 – concluding thoughts on whether we should consume omega-3s based on the data on omega-3s in RBCs and phospholipids and mortality
In this episode we discuss: Studies showing that fish oil and cod liver oil supplementation increase oxidative damage in humans, even in the triglyceride form alongside antioxidants  Why omega-3s are harmful in both healthy and unhealthy humans  The harmful metabolic and hormetic effects of omega-3s (and why omega-3s aren’t beneficial due to hormesis)  The research showing that omega-3s do not improve chronic health conditions or mortality in humans      Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy     Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-106-omega-3s-increase-inflammation-and-oxidative-stress/   Timestamps: 0:00 – intro 1:26 – a summary of the harmful effects of omega-3 consumption in humans 9:14 – omega-3 consumption amplifies the damage from stress (including fasting) 17:08 – vitamin E does not protect against lipid peroxidation from fish oil consumption 20:06 – studies showing that increased omega-3 consumption (including fish oil and cod liver oil) in humans and other animals increases lipid peroxidation, even in triglyceride form 31:45 - how omega-3s triggers hormesis, and why this doesn’t make omega-3s beneficial 39:50 – the context of the omega-3 research and its application 42:57 – studies showing that omega-3 supplementation doesn’t improve chronic health conditions or reduce mortality in humans
In this episode we discuss: Whether the research suggesting that omega-3s decrease mortality is valid Omega-6 intake as a major confounding variable when looking at omega-3 research The dramatic lifespan-lowering effect of omega-3s and total PUFA across all species How omega-3s increase susceptibility to oxidative stress and damage Looking at the Masai diet as an example of a low-omega-3 diet with high omega-3s in the red blood cells     Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/     Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/     Click here to check out the show notes:  https://jayfeldmanwellness.com/ep-105-challenging-the-idea-that-increased-omega-3-consumption-lowers-mortality/   Timestamps: 0:00 – intro 1:35 – why we’re discussing omega-3s and lifespan 8:10 – the studies showing an association between omega-3 content in phospholipid and reduced mortality 16:48 – conflict of interest as a confounding variable in these studies 18:12 – healthy user bias as a confounding variable in these studies 20:46 – omega-6 consumption as a confounding variable in these studies 29:04 – problems with using RBC phospholipids and serum fatty acids as markers of fatty acid composition of the diet 30:35 – a low omega-6 diet will increase omega-3 content in the RBC phospholipids and serum fatty acids 36:35 – the effect of heritability on RBC phospholipid and serum fatty acid composition 43:58 – the effect of oxidative stress on RBC phospholipid and serum fatty acid composition 52:57 – why it’s important to consider interventional studies and other research to determine whether we should increase omega-3 consumption to reduce mortality 55:30 – research looking at the relationship between composition of phospholipids and lifespan across species 1:07:33 – research looking at the relationship between composition of phospholipids and lifespan within species 1:23:30 – increased consumption of omega-3s increases omega-3 content in phospholipids and therefore the peroxidizability index 1:28:53 – looking at the Masai diet: low omega-6 intake increases omega-3 content in RBC fatty acids
In this episode we discuss: Individualism and competition vs. collaboration and communitarianism Whether humans are inherently selfish and destructive  The cost of social media and other forms of distraction How drugs and alcohol can function as numbing agents  Why many causes that appear worthy turn out to be distractions from the real problems   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/   Click here to check out the show notes:  https://jayfeldmanwellness.com/ep-104-how-western-culture-keeps-us-distracted-and-fighting-amongst-ourselves/   Timestamps: 1:14 – individualism and competition vs. collaboration and communitarianism 25:45 – randomness, subjectivism, moral relativism, and the resulting nihilism 31:20 – the consequences of the idea that humans are selfish, destructive, and useless other than what we can produce 41:39 – how potentially beneficial advancements become co-opted to maintain the current power structure 48:04 – how western culture degrades esteem and prevents self-actualization 49:43 – the many aspects of modern technology and entertainment that distract us from what’s important 55:26 – how drugs and alcohol can also function as numbing agents 1:03:42 – how worthy causes become co-opted to prevent legitimate progress 1:13:18 – contrasting with cultures that are family-oriented and less distracted by technology 1:16:10 – the effects of culture in science, health, and everyday life   
In this episode we discuss: How lower wages and higher costs have dramatically reduced our quality of life How we’ve ended up working more and resting less with worse outcomes Whether advancements in technology have improved the quality of life of the average person How marketing and consumerism keep us on the hamster wheel The hidden costs of convenience culture Concerns surrounding the collusion between government and corporations How divide and conquer tactics convince us to blame each other rather than the powers that oppress us   Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes:  https://jayfeldmanwellness.com/ep-103-how-western-culture-keeps-us-poor-and-destroys-our-family-community-and-relationships/   Timestamps: 1:34 – how western culture degrades safety and security through financial means 7:33 – how lower wages with higher costs reduces safety and forces people to prioritize work over quality of life 15:14 – we currently work more with less leisure time than ever before, with worse outcomes 20:24 – the cost of consumer culture and marketing as an engine that drives consumerism 30:53 – the cost of convenience culture: freedom, privacy, morals, ethics, and health 36:14 – the problems with profit-driven motives and the collusion between government and corporations 45:36 – how western society has become fragile and unstable 51:13 – how western culture degrades relationships and feelings of love and belonging 52:41 – continued how western culture degrades relationships and feelings of love and belonging 53:27 – divide and conquer tactics within western culture and encouraging the “us vs. them” mentality   
In this episode we discuss: Why culture matters and how we can effectively navigate it The impact of the diet culture and the “eat less exercise more” paradigm How Western culture blames the individual for their poor health and the toll that this takes  The problems with excess work, time indoors, and sedentarism How the modern medical system takes away your capacity to improve your health Why the alternative health sphere can be just as problematic as mainstream medicine    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-102-how-western-culture-mainstream-medicine-keep-us-sick/   Timestamps: 0:00 – why we’re discussing culture and our concerns with the culture in the US and the relationship between culture and health   6:05 – frames through which we can view culture and the importance of Maslow’s hierarchy of needs 13:00 – how western culture degrades health: diet culture and the food industry 27:43 – how western culture degrades health: excess work, time indoors, and sedentarism  34:30 – how easily we can become numb to the effects of our culture or environment  38:07 – the broken modern medical system and the problems with the allopathic, symptom management model  48:21 – problems with the alternative health sphere  
In this episode we discuss: Why you want to avoid vegetarian-fed chicken and acorn-fed pork  The best bioenergetic fat, protein, and carb sources  Why it’s best to avoid salmon and bluefin tuna, and what fish and seafood to have instead  Whether we should be including vegetables and fiber in our diet  How to avoid vegetable oils and what fats to use instead  When it makes sense to include high-FODMAP foods    Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-101-building-a-bioenergetic-diet-optimal-carb-fat-and-protein-sources/   Timestamps: 0:00 – intro  1:34 - bioenergetic food guide  2:59 - bioenergetic fat sources  6:20 - bioenergetic protein sources  15:01 - the importance of collagen/gelatin  18:51 - bioenergetic carbohydrate sources  31:25 – foods and additives to avoid  34:15 – experimentation and context as primary components of the bioenergetic view   
In this episode we discuss: Optimal macronutrient breakdowns for meals and snacks How to calculate your protein, carbohydrate, and fat needs How to use taste, cravings, hunger, and experimentation to guide your macro intake How to find your starting calorie intake The optimal number of meals and snacks to have in a day   Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-100-building-a-bioenergetic-diet-macros-calories-and-meal-timing/   Timestamps: 0:00 – intro  1:21 – context for these dietary guidelines and the importance of the “why”  7:58 – guidelines for optimal protein intake from the bioenergetic view  14:46 – guidelines for optimal fat intake from the bioenergetic view  29:27 – guidelines for optimal carb intake from the bioenergetic view   31:32 – how to find your starting calorie intake  35:29 – guidelines for optimal carb intake from the bioenergetic view (continued)  42:00 – using taste, cravings, hunger, and experimentation to adjust these guidelines  45:35 – guidelines for optimal meal and snack timing and composition from the bioenergetic view   
In this episode we discuss: The problems with using T4-only medications like Synthroid and levothyroxine for hypothyroidism   When it makes sense to use thyroid hormone supplements  How to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism   Whether thyroid hormones should be taken away from food due to absorption concerns   Whether we should be concerned about thyroid hormone supplementation suppressing our own thyroid hormone production    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-99-medications-supplements-for-hypothyroidism-and-the-problems-with-t4-medications-hypothyroidism-part-5/   Timestamps: 0:00 – intro  1:24 – vitamin and mineral supplementation for thyroid function  5:22 – the context for using thyroid hormone supplementation  7:16 – the problems with using T4-only medications (like Synthroid and levothyroxine) for hypothyroidism  13:58 – evidence that T4 monotherapy is less effective than T3/T4 combination therapy  21:48 – how to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism  37:15 – whether thyroid hormones should be taken away from food due to absorption concerns  41:49 – how much is 1 grain of desiccated thyroid?  42:29 – whether thyroid hormone supplements are pharmaceuticals, food, or something in between  44:30 – whether we should be concerned about thyroid hormone supplementation suppressing endogenous thyroid hormone production  46:50 – thyroid hormone supplements in context 
In this episode we discuss: How fasting decreases thyroid function   Why carbs are essential for thyroid function  Specific anti-thyroid foods to avoid   Why interventions like cold thermogenesis, caloric restriction, and fasting are not the answer for hypothyroidism  The impact of sleep on our thyroid health    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-98-how-to-optimize-your-diet-lifestyle-for-hypothyroidism-hypothyroidism-part-4   Timestamps: 0:00 – intro  1:06 – how to address and reverse hypothyroidism 2:36 – the importance of carbs, calories, and fat for improving thyroid function 16:24 – the importance of eating consistently (and not fasting) for thyroid function 18:00 – saturated fats vs. PUFA and micronutrients for thyroid function 19:45 – basic bioenergetic diet recommendations for hypothyroidism 22:14 – anti-thyroid foods (goitrogens) to avoid 23:08 – other diet considerations when transitioning to a bioenergetic approach 25:56 – low iron in women and excess iron from carnivore or keto diets 27:47 – cruciferous vegetables and thyroid health 28:43 – how to properly address nutrient deficiencies for thyroid health 35:06 – whether stressors like exercise, cold thermogenesis, caloric restriction, and fasting are supportive of thyroid health 47:54 – optimizing sleep for thyroid function
In this episode we discuss: What causes Hashimoto’s hypothyroidism  How to properly interpret your thyroid bloodwork (and what your doctor likely doesn’t know about thyroid testing) How your cholesterol values can be used as markers of thyroid status  How symptoms like metabolic rate, body temperature, and pulse rate can be more helpful than blood tests when identifying thyroid status  Ideal blood test values for optimal thyroid function    Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-97-how-to-properly-test-for-thyroid-function-hypothyroidism-part-3   Timestamps: 0:00 – intro  1:17 – what causes Hashimoto’s hypothyroidism and autoimmunity in general 13:30 – how to interpret thyroid blood tests (TSH, T3, T4, rT3)  31:34 – what reverse T3 means on a blood test and how to interpret rT3 values 34:44 – looking at all thyroid markers together to determine thyroid status  37:05 – the anti-thyroid effects of reverse T3 40:38 – cholesterol levels as a marker of thyroid status, and the problems with cholesterol levels that are too high or too low 52:34 – the relationship between cholesterol, heart disease, and thyroid status 56:04 – other blood markers that can be indicative of thyroid status (SHBG, ferritin) 57:02 – how we can use symptoms like metabolic rate, body temperature, and pulse rate to determine thyroid status   1:12:14 – other symptoms that can be used as indicators of thyroid status (low energy, fatigue, low immune function, dry or cracking skin, hair loss brittle nails, slow motility, weight gain, low mood)
In this episode we discuss: The factors that affect thyroid hormone production, conversion, transport, and uptake How high TSH levels cause damage to the thyroid gland High-carb diets vs. low-carb diets for thyroid health Why restricting calories is not the way to go if you’re struggling with hypothyroidism The effects of PUFA and endotoxin on thyroid hormone activity The problems with both deficiencies and excesses of iron, iodine, and vitamin A for thyroid health   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/   Timestamps: 0:00 – intro  1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake 3:45 – the impact of stress on thyroid hormone production and conversion  5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion 16:44 – thyroid hormones increase sensitivity to stress hormones  21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding 23:26 – how a lack of energy prevents the cells from taking up thyroid hormone 30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress 38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health 47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn’t mean you should avoid carbohydrates   51:39 – how caloric restriction affects thyroid status 55:04 – the effects of fasting on thyroid status 56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement 1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity 1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity 1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term 1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity 1:25:20 – the effect of sleep on thyroid hormone production and conversion 
In this episode we discuss: Why hypothyroidism is not the root cause of your issues Why TSH on its own is not a good marker of thyroid status The importance of thyroid hormones for sex hormone production, gut health, and immune function T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-95-hypothyroidism-in-context-thyroid-hormone-basics-hypothyroidism-part-1/    Timestamps: 0:00 – intro  1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism 9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state  12:45 – why hypothyroidism is not the root cause 16:23 – the basics of the different thyroid hormones and their regulation 19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops 24:45 – the basics of thyroid hormone production 29:37 – the basics of thyroid hormone conversion 35:17 – the larger context of thyroid hormone production and conversion 38:58 – the basics of thyroid hormone transport   41:44 – the basics of thyroid hormone uptake 46:23 – the nutrients involved in thyroid hormone production and conversion 50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol) 57:29 – the effects of T3 on gut health, immune function, and aging 1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign 1:08:41 – the relationship between vitamin A and thyroid hormones 
In this episode we discuss: Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response How stress prevents our mitochondria from effectively producing energy How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease How sugar and fat cravings result from stress and why listening to them is beneficial How adaptations to stress get passed on through generations   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/   Timestamps: 0:00 – intro  2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids 6:05 – the short-term effects of catecholamines 8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling 14:40 – the protective effects of uncoupling as a part of the stress response 20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response 37:33 – the effect of acute stress on energy production in mitochondria 45:18– the effect of chronic stress on energy production in mitochondria 48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states 1:05:24 – the relationship between mental health, mood, and metabolic function 1:10:21 – how adaptations to stress get passed on through mitochondrial DNA 1:18:32 – how to best improve mitochondrial function and our health
In this episode we discuss: Why stress is not your friend The effects of cortisol on your mitochondria Hans Selye’s general adaptation syndrome How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism Why acute stress does not lead to improved health via hormesis   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/    Timestamps: 3:00 – an introduction to the paper: mitochondria as key components of the stress response    4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance   23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response  31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts  34:04 – how long-term stress causes degeneration  34:55 – functions of the mitochondria  38:54 – mitochondria upregulate energy production in response to stress  41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol) 44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time 50:30 – how mitochondria respond to excess stress and how this relates to fat gain 59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-92-celebrating-ray-peat/ Ray Peat's Website: http://raypeat.com/ Ray Peat Interviews, Articles, Related Websites, and Other Resources: https://www.selftestable.com/ray-peat-stuff/sites      
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