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Oxford Sparks Big Questions

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'Will my bacon sandwich kill me?', 'Is vaping better than smoking?', 'How do you become an astronaut?' - just some of the Big Questions we ask some of the brightest minds behind Oxford science. Join us in each podcast as we explore a different area of science.
207 Episodes
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Want to make something feel immediately complicated, inaccessible or downright mysterious? Stick the word 'quantum' in front of it. Or, at least, that's how many of us feel. But don't worry! Experimental physicist William Cutler from Oxford's Department of Physics is here to break things down, explaining exactly what a quantum computer is, and sharing the remarkable potential that quantum computing holds for advancing fields ranging from drug-discovery to internet security.
Finding a cure for cancer is unarguably one of the biggest medical challenges that we face. But what if we could find a way to prevent cancer before it even starts? In this special extended edition of the Big Questions Podcast, we chat to Professor Sarah Blagden, an experimental oncologist at the University of Oxford, and Anna Fry, who has the cancer predisposing condition Lynch Syndrome - putting her at increased risk of developing colorectal and other cancers. Sarah explains how clinical trials of vaccines targeting 'pre-cancer' could revolutionise the fight against cancer, beginning with those at greatest risk.
Many of us will be familiar with Body-Focused Repetitive Behaviours (BFRBs), perhaps without even realising it. Such behaviours - which include hair-pulling, nail biting and skin picking - can not only cause physical harm, but also often bring feelings of shame. Because of this, open discussion around BFRBs has been limited. In this episode of The Big Questions Podcast, we chat to Prof Clare Mackay from Oxford's Department of Psychiatry, who both studies and lives with BFRBs. 
How do you detect a particle that emits no light - in other words, something invisible? This is the intriguing challenge faced by scientists hunting for 'dark matter'. In our series finale, we talk to Elizabeth Bloomfield from Oxford's Department of Physics about dark matter, how we know it exists, and why her research is taking her deep beneath a mountain in Italy in the quest to find it.
What's the best gift you can give? To the millions of people whose lives have been saved by complete strangers, the answer would be simple: blood. But what exactly happens when blood has been donated, and how do we know it is safe? We chat to Dr Richard Mayne from Oxford's Experimental Medicine Division about genomics, Next-Generation Sequencing, blood screening (...and Star Trek).  Could you be a blood-donating hero? Blood stocks are currently critically low, with the NHS Blood and Transplant (NHSBT) group in urgent need of new donors. Click here, and you'll be on your way to saving lives: https://www.blood.co.uk/news-and-campaigns/campaigns/blood-donor-appeal/
Whether you've been served an advert for it, or just heard about it in the media, it's likely that 'Ozempic' isn't a totally unfamiliar word. Now often associated with weight-loss, Ozempic is actually the brand name for a drug used to treat diabetes. So what exactly is it, how does it work, and is it safe? We chat to diabetes and endocrinology (hormone) expert Dr Annie de Bray to find out.  
We've all been there...you're on the train, maybe tired after a long day, and all you can hear is one side of a fellow passenger's not-too-interesting phone conversation. Or worse, their choice of music, made tinny and monotonous by the awkward angle of their phone speaker. It's irritating, sure, but for some people it goes beyond mild annoyance, into the realms of anger and panic. For these people - who suffer from a condition called 'misophonia' - phone noise, or sounds such as chewing or breathing, are a real problem. We chat to Dr Jane Gregory, a researcher at Oxford's Department of Experimental Psychology who has misophonia, to find out more about this little-known condition.
With more than 70% of its surface covered in water, Earth is rightly known as the "blue planet". But where did this water - so essential to life - originate? While some theories suggest that hydrogen was delivered to Earth from space via asteroids, new research indicates that the building blocks for water may have been present on our planet all along. We chat to Tom Barrett from Oxford's Department of Earth Sciences to find out more.    
What do you do when the subject of your research lies deep beneath the waves? Send down an underwater robot, of course! We chat to volcanologist Sofia Della Sala about her recent fieldwork expedition to Santorini, where she used a Remotely Operated Vehicle, or ROV, to search for hydrothermal vents in the Aegean Sea. These vents - which are like hot springs on the sea floor - could provide vital insight into the volcanic and tectonic activity in the region.
"I still don't believe it happened..." What's it like to face the most famous clock on television? We chat to Oxford mathematician Dr Tom Crawford - best known as the creator of the award-winning 'Tom Rocks Maths' outreach programme - about what it was like to step into Rachel Riley's shoes on Countdown.  What's the best tactic for tackling the numbers round? How did he prepare? Did he really only have 30 seconds to find a solution? Tom gives us a glimpse behind-the-scenes of this British institution. 
One in two people will be affected by dementia in their lifetime - whether that is as a patient, or somebody caring for a loved one. But what happens after a dementia diagnosis? Is there a clear pathway ahead? We chat to Jasmine Blane, a DPhil researcher at the Oxford Brain Health Clinic, about the work she is doing to help support patients in the midst of a dementia diagnosis, and into the future.
In popular culture, Tourette's syndrome is wrongly associated solely with outbursts of swearing in the context of lazy jokes. But in reality, the condition is far more complex than this stereotype suggests. When people without Tourette's jokingly blame their lack of self-control on the condition, it spreads misinformation and invalidates those who actually live with it. Despite this, comedy - when created by those who experience stigma - can sometimes help challenge stereotypes and shift public perceptions. We chat with Dr Melina Malli from the Oxford Institute of Population Ageing to explore whether laughter can really be the best medicine.
If you were hunting for some fossilised dinosaur footprints, where would you go? To a remote part of North or South America, perhaps? A deserted wilderness for sure... But how about Oxfordshire? We chat to Dr Duncan Murdock from the Oxford University Museum of Natural History about an incredible discovery made right on our doorstep. Photo © Dr Emma Nicholls / Oxford University Museum of Natural History
Shh...hedgehog! It always feels like a privilege to catch a glimpse of one, as it snuffles away under the garden fence. And come the spring, our spiny - and usually solitary - little friends will be feeling in the mood for...romance. But what exactly does a female look for in a mate? And how do their intimate encounters even work when things are so very... spiky? Join us for this special Valentine's Day edition of the Big Questions Podcast, as we ask Dr Sophie Lund Rasmussen (aka Dr Hedgehog) "how horny are hedgehogs?"
Electric eels are pretty amazing creatures. Their bodies can release powerful electric charges - in some cases reaching 650 volts! So, what can scientists learn from these animals? Could nature hold the key to advancing our own energy solutions? We chat to Dr Yujia Zhang about how electric eels might inspire the batteries of the future.
Whether it's the bottle of water that you hastily grab at the train station, or your favourite guilty-pleasure fizzy pop, you may have noticed something different about your drinks lately - or at least their containers. Since July 2024, it's been EU law that bottle caps are attached, or 'tethered', on all single-use plastic bottles. But what exactly is the reason for this change? Will it really help to save the planet, or is it just there to annoy us? We chat to Dr Diogo Veríssimo about "nudge", "sludge", and changing human behaviour for a better world.
Even if you'd never previously given much thought to the Northern Lights, chances are they were brought to your attention in 2024, when our social media feeds were set ablaze with beautiful images captured by awe-struck stargazers. Usually restricted to more northerly latitudes, this colourful natural phenomenon could be observed in the UK as far south as Cornwall. But why were we treated to this spectacle, and why now? Dr Carly Howett from the Department of Physics explains why we're seeing the Northern Lights more often this year, and gives hope to those yet to catch a glimpse.  
Why track mistletoe?

Why track mistletoe?

2024-12-1113:40

Mistletoe has long been associated with fertility, and even today, its presence hanging from the ceiling can prompt a few blushes. But, did you know, mistletoe is more than something beneath which to kiss at Christmas? It is actually a parasite, and has some rather peculiar biology behind it. We chat to mistletoe expert Ollie Spacey about what makes it so special, where you can spot it and - importantly - how you can get involved with his research through MistleGO!
Evolutionarily speaking, it makes sense to have a lot of children. At the very least, we might expect a population to replace itself, with each couple having an average of two children. However, this evolutionary logic is not mirrored by current data: birth rates are falling in the UK, with many people choosing to either have one child, or no children at all. We speak to evolutionary anthropologist Dr Paula Sheppard about the drivers, and consequences, of this observed trend.
Chances are, you didn't notice the week-long wind drought that the UK experienced towards the end of 2023. However, this period of low wind speeds, combined with a cold snap, drove up our energy prices - something that may have caught your attention. So, what exactly do we know about wind droughts, and how can we apply this knowledge to plan for the low-carbon energy systems of the future? We chat to Matthew Wright from Oxford's Department of Physics to find out.
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Comments (3)

Milania Greendevald

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Feb 8th
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ForexTraderNYC

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Oct 11th
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Byront III

It's too verbose and there are few scientific parts

Aug 12th
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