Lungcast

Episode Highlights 0:11 Intro 1:05 Introducing Stephanie Lovinsky-Desir, MD, MS 2:09 Understanding asthma endotypes and phenotypes 5:03 The effect of SMART guideline updates 11:50 Are pulmonary & allergy specialists adopting it? 12:46 The value of biologics in asthma care 18:11 Could they interrupt the atopic march? 19:53 COVID-19 risks in asthma 23:24 Environmental and non-viral illness impacts on asthma 26:11 Research into asthma care inequities 31:47 HFA-containing metered dose inhalers 35:37 Outro In honor of World Asthma Day, Dr. Stephanie Lovinsky-Desir of Columbia University Irving Medical Center in New York visits our virtual studio to talk about all things asthma. Dr. Lovinsky-Desir, who has a deep understanding of how environmental factors impact children with asthma, touches upon inequities in asthma care, the role of climate change and COVID-19 lessons learned. She also hones in on whether biologic therapies may help interrupt pathways in the atopic march. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:16 Intro 2:17 What caused the particle pollution spike? 6:28 The health effects of fine particle pollution exposure 10:23 The new EPA particle pollution standard 14:27 Improvements to ozone pollution and the Clean Air Act 18:46 How to advocate for improvement 20:23 Air quality inequity 24:03 Reflecting on 25 years, and looking ahead 25:52 Outro  Dr. John Balmes, a renowned environmental health sciences expert from the University of California, San Francisco, join Lungcast for a deep dive into the American Lung Association’s newly released 2024 “State of the Air” report. Balmes specifically provides context behind several concerning trends, notably a spike in deadly particle pollution—the highest levels in the past 25 years largely due to wildfires.  The eye-opening conversation also impresses upon the importance of clean transportation and power generation to help mitigate population-wide risk.  Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

0:16 Intro 2:28 Recent modifications to the lung allocation score 5:11 Monitoring chronic graft rejection 9:23 The rising use of ex vivo lung perfusion  16:17 The presence of post-COVID patients on the lung transplant waitlist 21:01 Impact of long Covid on transplant rehabilitation 22:51 Double lung transplant in bilateral lung cancer—what’s the future? 26:52 Effect of LAS on lung transplant survival racial disparity 31:05 What lies ahead in the practice of lung transplantation 35:00 Outro Cleveland Clinic’s Maryam Valapour, MD, MPP, rejoins the broadcast, along with her colleague Kenneth McCurry, MD to discuss optimization of the lung allocation system to continue reducing waitlist times and patient mortality.  It includes commentary on how recent changes to scoring protocols are expected to impact ongoing disparities related to race and socioeconomic status. They additionally talk about the role of transplantation in patients who have severely damaged lungs resulting from COVID-19 infection, an update since our April 2021 conversation. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 3:09 Low-dose CT screening uptake in Canada 4:45 Evolution of adjuvant, neoadjuvant therapies 7:10 Reviewing CheckMate 816 10:56 Reviewing KEYNOTE-671 12:58 The impact of neoadjuvants on operability 16:15 Treatment-specific biomarkers for lung cancer 21:13 The short-term future of lung cancer therapy 24:31 Outro Precision medicine–delivering the right drug at the right time to the right patient–is the direction in which lung cancer treatment is heading. In this episode, we talk about an exciting, emerging drug class with one of the most prominent investigators involved with its development, Dr. Jonathan Spicer at McGill University’s Thoracic Oncology Network.  It provides a deep dive into neoadjuvant therapy for patients who have operable lung cancer, offering insight into what is currently known about response and failure rates. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Intro 1:48 Remembering the 1964 Surgeon General Report 3:01 The impact of the report on cardiology 6:47 The strategies and impact of anti-smoking campaigns 10:33 The modern vaping challenge 17:38 Outro In recognition of 60 years since the 1964 Surgeon General Report—a historic contribution to our understanding of the negative health impacts of cigarette smoking—host Albert Rizzo, MD, meets with preventive cardiology expert Viet Le, DMSc, PA-C to reflect on the myriad of cascading effects delivered by this landmark report. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:15 Introducing Sue Padernacht, EDd, PCC 1:16 The definition of burnout 3:53 The history of burnout 7:45 Differences between stress and burnout 14:34 Physical and behavioral signs of burnout 20:55 Steps the health care industry can take against burnout We are beginning 2024 with a matter that extends beyond the confines of pulmonary medicine and really has become something of a crisis in the U.S. healthcare system over the last decades. Organizational psychology expert Dr. Sue Padernacht joins Lungcast to provide an in-depth look into physician burnout—what are its drivers, what factors are exacerbating it, and how the collective medical community can work toward curbing its effect among caregivers. Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Episode Highlights 0:16 Intro 1:44 How to approach stage IV lung cancer, with Dr. David Tom Cooke 4:13 The ALA Lung Health Cohort Research Study, with Dr. Ravi Kalhan 8:42 What is the atopic march, with Dr. Payel Gupta 10:53 Weight loss for asthma care, with Dr. Anne Dixon 15:11 Air Quality Index 101, with Dr. Al Rizzo 18:47 Lung Cancer Age Equity, with Dr. Carolyn Presley 21:45 The emerging treatments for long Covid, with Dr. Julia Moore Vogel 24:28 The future of pulmonary embolism care, with Dr. Parth Rali 28:08 The modern fight against RSV, with Dr. Barbara Taylor 33:26 Detecting unhealthy air exposure, with Dr. Mark Hernandez 36:12 Living while fighting lung cancer, with Christy Fischer 38:51 Outro Though some subjects are clear favorites, it is nearly impossible to select a single answer to the question, “What was the biggest story in pulmonology this year?”  Since the American Lung Association (ALA) and HCPLive launched Lungcast in the summer of 2020, the field of respiratory health has evolved in unprecedented fashion. One doesn’t have to look further than the show’s episode library to appreciate the great shifts in the field—brought on by a global pandemic, numerous public health phenomena, and practice-changing innovations in screening, diagnostics, prevention and therapy. From vaccination to late-stage lung cancer care, the world of respiratory health is irrevocably changed from just a short span of 4 years. To reflect on this year’s spectacular headlines in the field, HCPLive presents the annual recap episode in conjunction with This Year In Medicine, where the Lungcast team reflects on their favorite interview segments of 2023. Subscribe to Lungcast on YouTube: https://www.youtube.com/@Lungcast Want more content? Visit us at https://www.hcplive.com/podcasts/lungcast and https://www.lung.org/professional-education/lungcast.

For this episode fully focused on indoor air pollution, we are joined by Professor Mark Hernandez who serves as director of the Aerobiology and Disinfection Lab at the University of Colorado. Listen in to learn about the harmful impact of pollutants such as mold, toxic chemicals and asbestos on respiratory health, particularly in a school setting. Equally important, what can be done to help alleviate these effects? Episode highlights 0:16 Intro 0:50 Introducing Mark Hernandez, PhD, PE 2:15 The most pressing issues of school air quality 4:12 Advice for school administrators 6:25 The link to pediatric asthma 12:23 Trends in national monitoring 14:16 How COVID-19 changed ventilation priorities 16:29 An equitable, affordable solution 18:34 Signs of unhealthy air exposure 20:53 How clinicians and guardians can get involved 23:47 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Christy Fischer, a miraculous 17-year stage IV lung cancer survivor, connects with us to discuss stress, stigma and significant changes in the treatment landscape. Hear how Christy transformed a daunting diagnosis into hope for others. This educational and inspirational episode touches upon the raw emotions of what it is like to live (and thrive!) with advanced cancer. Episode Highlights 0:17 Intro 1:55 Christy's first diagnosis 3:53 Reacting to Stage IV lung cancer 5:28 Initiating treatment 7:18 The lung cancer stigma 9:51 Finding the right doctor 11:16 How lung cancer care changed over 17 years 14:20 Clinical trial participation 16:51 Becoming an advocate 20:33 Advice for physicians diagnosing lung cancer 22:18 How to keep living after diagnosis Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

With cases of Respiratory Syncytial Virus (RSV) on the rise this fall, Dr. Barbara Taylor, professor of infectious diseases at UT Health San Antonio, joins us for this timely episode all about RSV. Importantly, she covers the unprecedented events of the 2022-2023 season that was marred by a ‘tripledemic’ of respiratory diseases.  How do the lessons learned change the preventive approach to better protect against the deadly infection?   Episode Highlights 0:16 Intro 0:48 The burden of RSV today 2:11 Transmission, presentation and diagnosis of RSV 4:33 Likelihood of an RSV, COVID-19, flu “triple-demic” 7:35 The history of RSV vaccine development 12:09 Risk of RSV mutation and variants 14:19 The new RSV vaccines 20:09 Spacing the RSV vaccine with other seasonal shots 22:14 Age and comorbidities as vaccine criteria 24:30 In vitro immunization 27:39 Nirsevimab and monoclonal antibodies for RSV 29:31 Using the full toolset against RSV 31:50 Yearly COVID-19 vaccine updates? 33:24 A universal flu vaccine? 37:20 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

Pulmonary vascular disease expert Dr. Parth Rali at Temple Lung Center helps break down what is known about massive and submassive pulmonary emboli (PE), namely blood clots. This episode provides a comprehensive overview of PE, from the complications of diagnosis to the evolution of therapeutic modalities. Episode highlights 0:16 Intro 2:34 Defining pulmonary embolism classifications 8:18 The Pulmonary Embolism Severity Index 15:47 The role of D-dimer in diagnosis 17:08 Anticoagulation strategies 22:26 The Pulmonary Embolism Multidisciplinary Response Team 25:38 Long-term outlooks for acute PE 31:38 When to stop anticoagulation 35:27 The future of PE diagnosis and treatment 38:50 Outro Want more Lungcast? Visit us at HCPLive.com/podcasts/lungcast or www.lung.org/professional-education/lungcast

In this must-listen episode, Dr. Julia Moore Vogel at Scripps Research takes center stage to confer the still-emerging and always-evolving space of long COVID. As patient numbers continue to rise at an alarming rate, she makes a strong case about the critical need to better define the disease, mitigate its impact and, ultimately, break the taboo. Episode highlights 0:15 Introduction 1:27 Moore Vogel’s background in Long Covid 4:30 Lacking terminology in Long Covid 6:20 Quantifying Long Covid disease 8:38 The mechanism of action: what we know 10:27 Pediatric Long Covid 16:00 Similarities to post-viral syndromes 16:58 Key diagnostic tools 18:37 The current Long Covid treatment landscape 20:57 Influence of SARS-CoV-2 variants and vaccines 22:02 Considering social determinants of health 23:35 Needs for professional and public education 27:00 Final thoughts 28:28 Outro Want more Lungcast? Visit us at HCPLive.com or Lung.org.

For this episode focusing on the role of medical oncology, we are joined by Dr. Carolyn Presley, thoracic oncologist and associate professor with tenure at Ohio State University. As a geriatric expert, she provides a poignant point-of-view on the need for a multidisciplinary approach to patient care, as well as advances in treatment that include targeted therapies.

Amid mass poor air quality exposure due to ongoing Canadian wildfires, Lungcast host and ALA Chief Medical Officer Albert Rizzo, MD, explains air quality index (AQI), signs and symptoms of acute and long-term poor air exposure, high-risk patient populations, and the concerning future of particle pollution exposure. Want more Lungcast? Visit us at HCPLive.com or Lung.org. Episode Highlights 0:15 Intro 1:23 What is the Air Quality Index? 3:14 Risk factors of poor air quality 4:30 Acute signs and symptoms 6:42 Recommendations for patients with pre-existing conditions 8:09 How long will this last? 10:28 When to resume livelihood 11:12 The long-term impact of air pollution exposure 14:02 Outro

Anne Dixon, MD, Director of Pulmonary and Critical Care Medicine at University of Vermont Medical Center and the first repeat guest in the history of Lungcast, rejoins American Lung Association Chief Medical Officer Albert Rizzo, MD, on the floor at the American Thoracic Society (ATS) 2023 International Conference in Washington, DC, to discuss headline news from the annual meeting and her ongoing work in clinical airway research. Want more Lungcast? Visit us at HCPLive.com or Lung.org. Episode Highlights 0:15 Intro 1:00 Obesity burdens in asthma 3:22 Weight loss intervention data at ATS 2023 4:53 ALA grants program 7:00 Airways Clinical Research Network 10:52 Seeking research collaborators 12:46 Merging clinicians, patients and industry in innovative research 13:54 Outro

Just in time for May’s Asthma and Allergy Awareness Month, allergist and immunologist Dr. Payel Gupta of LifeMD.com headlines a conversation about the clinical presentation of asthma and its role in the atopic march. She also details various phenotypes, endotypes and other molecular mechanisms of asthma that can be applied to help guide disease management and treatment decisions. Episode highlights 0:15 Intro 1:16 Introducing Payel Gupta, MD 2:31 Classifications of asthma 5:35 What is the atopic march? 8:46 The bridge from allergy testing to immunotherapy 12:00 How to initially diagnose asthma 16:02 When to add secondary therapies 18:11 Biologics for uncontrolled asthma 23:20 Real-world use of the SMART therapy guidance 25:40 Assuring asthma treatment adherence 28:35 Addressing asthma care disparities 32:26 The future of asthma research 33:58 Outro Check out other allergy and/or asthma episodes of Lungcast: Poor Indoor Air Quality Exposure and Clinical Risks with Edward Brooks, MD, and Charlene McEvoy, MD How PREPARE Data, SMART Recommendations Alter Modern Asthma Strategy Fighting Disparities in Pediatric Asthma Care with Dr. LeRoy Graham Get More From Lungcast Lungcast on HCPLive: https://www.hcplive.com/podcasts/lungcast Lungcast on American Lung Association: https://www.lung.org/professional-education/lungcast Spotify: https://spoti.fi/3YEDxKw Apple Podcasts: http://bit.ly/3jCVevq YouTube: https://www.youtube.com/@Lungcast/videos

For our 30th episode of Lungcast™, pulmonologist Dr. Ravi Kalhan of Northwestern Medicine joins for a core-level discussion on the modeling of respiratory health and pulmonary mechanisms.  In addition to sharing how a novel machine learning method may one day soon predict lung disease susceptibility, Dr. Kalhan describes the science behind the American Lung Association Lung Health Cohort Research Study.

David Tom Cooke, MD, Founding Chief of the Division of General Thoracic Surgery at UC Davis, joins the first episode of 2023 to discuss his colleague’s specific role in lung cancer screening and intervention, advances to minimally invasive, robotic and bronchoscopic techniques, and evolving strategies in individualized patient care. Episode Highlights 0:14 Intro 1:52 Introducing David T. Cooke, MD 3:23 The role of thoracic surgeons in improving lung cancer screening rates 6:22 Shared decision making in thoracic surgery 8:16 Lobar, wedge resection or segmentectomy? Plus, robotic techniques? 12:22 PET/CT scans in the staging process 13:52 The surgeon approach to stage IV lung cancer 16:02 Patient follow-up—improved mortality and longer life expectancy 18:50 Prioritizing surgery and neoadjuvant therapy regimens 20:48 Thoracic surgeon role in palliative care 22:57 What’s on the horizon in the field: robotic surgery 24:17 Outro Check out other lung cancer episodes of Lungcast: Innovations in Interventional Pulmonology with Dr. Carla Lamb  Lung Cancer Screening: Trials, Tribulations & Triumphs with Dr. James Mulshine Future of Lung Cancer Precision Medicine with Andrea Mazzochi Get More From Lungcast Lungcast on HCPLive: https://www.hcplive.com/podcasts/lungcast Lungcast on American Lung Association: https://www.lung.org/professional-education/lungcast Spotify: https://spoti.fi/3YEDxKw Apple Podcasts: http://bit.ly/3jCVevq YouTube: https://www.youtube.com/@Lungcast/videos

Will your New Year’s resolution kick off the journey to quit smoking? In our final Lungcast™ interview of 2022, Bob Levey, former Washington Post columnist and founder of the Super Stoppers Club, and the Lung Association’s national senior director of tobacco programs, Jennifer Folkenroth, come together to review the intricacies of smoking cessation. The lively and informative discussion outlines the path to a smoke-free life, which is often riddled with hurdles and stressors. 0:16 Ernst Wynder, Evarts Graham and the discovery of smoking - lung cancer risk 1:52 Introducing Jennifer Folkenroth and Bob Levey 4:46 Bob Levey and the Super Stoppers Club 11:25 The clinical effect of group cessation 14:00 Why is it hard to quit smoking? 17:45 The value of cessation support systems and social groups 20:03 Navigating patient concerns around cessation treatments 21:54 Combating stigma and social trends 26:35 Resources for aspiring quitters 31:26 Outro

Among many unintended and unexpected effects of sheltering in place during the COVID-19 pandemic is the substantial increase in exposures to indoor allergens and pollutants. Here, Dr. Edward Brooks at University of Texas at San Antonio and Dr. Charlene McEvoy at University of Minnesota bring a shared expertise on air quality health and research to discuss the resulting health ramifications. It is an enlightening conversation about the patient populations who are most impacted, plus what can be done to help mitigate the consequences. Episode highlights 0:16 The history of indoor air environments 2:50 Introducing Edward G. Brooks, MD, and Charlene McEvoy, MD 4:39 The factors of poor indoor air quality 6:25 Ways to improve indoor air quality 8:59 The underlying pathophysiology of pollutants 13:02 Benzene recalls 14:18 High-risk behaviors and disease risks 17:14 Recommendations for exposed patients 21:02 Radon as a lung cancer risk 22:35 Final thoughts 25:42 Outro For additional news and insights, visit us at HCPLive.com and Lung.org.