pharmaphorum Podcast

At the JP Morgan Healthcare conference this year, a lot of the discourse around AI drug discovery focused on making the leap from purely in silico drug discovery operations to real-world operations that are able to incorporate wet lab data in an iterative way. This is easily said, but to do it requires innovating new processes and infrastructures. On the sidelines of the show, pharmaphorum’s Jonah Comstock caught up with Yann Gaston-Mathe, founder and CEO of Iktos, an AI drug discovery company that just signed a billion euro deal with Servier to put this technology into action. In this quick dispatch from JPM (and we apologise for the shaky audio), Gaston-Mathe describes this shift in AI drug discovery, why it needs to happen, and what it takes, as well as giving some insights on why Servier and Iktos are a good fit as partners. “You need to think about how effective you are in the transition between the in vitro world and the in silico world,” Gaston-Mathe says. “Building on the data which is available is not enough.” You can listen to episode 242 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

The global impact of digital transformation in the last few decades cannot be understated. And now, of course, artificial intelligence (or AI) is making headlines for its potential to transform lives. In a new pharmaphorum podcast, Deep Dive editor Eloise McLennan speaks with Mohit Manrao, SVP, head of US oncology at AstraZeneca, and president of the AstraZeneca Foundation. The conversation explores the application of AI in cancer care, some of the most promising potential applications of AI in the life sciences setting generally, as well as AZ’s multi-year partnership with Pangaea Data, focused on advancing precision healthcare with multimodal AI. Additionally, Manrao discusses how equity gaps in oncology can be minimized, but also the importance of maintaining the human touch when it comes to applying AI in the cancer setting. You can listen to episode 241 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

On-site on the sidelines of JP Morgan Healthcare conference in San Francisco this year, pharmaphorum editor-in-chief Jonah Comstock sat down with Andrew Beck, co-founder and CEO at PathAI. The conversation covers what PathAI has been up to lately in AI within diagnostics in pathology, explores what’s been discussed on the ground at the conference, and also touches upon equality and access to precision diagnostics. Additionally, Beck notes the company’s work in prospective clinical trials in life sciences, as well as co-partnering with pharma. Having seen an over 10 x growth of adoption of their technology in 2025, Beck also discusses advances in the MASH field. Listen to this and other conversations from JPM2026 here. You can listen to episode 240 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

An increasing prevalence of immunodeficiency and autoimmune disorders has led to increasing demand for plasma-derived immunoglobulin therapies and a need for scalable and sustainable treatment solutions. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Jörg Schüttrumpf, MD, PhD, Chief Scientific Innovation Officer of Grifols and Chief Executive Officer at Biotest, a Grifols company. The conversation explores advancing immunoglobulin (or IG) treatment for immune disorders, looking broadly at the field and current innovation that is working towards redefining how these therapies are delivered, accessed, and optimised for a growing and diverse patient population. Dr Schüttrumpf also discusses emerging platforms such as recombinant polyclonal therapeutics, as well as the integration of Real World Evidence (RWE) and artificial intelligence (AI) in shaping the future of immunodeficiency care. You can listen to episode 239 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

A liquid biopsy is a blood test that detects signs of cancerous tumors, including tumour cells and cancer cell DNA. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Andrew Newland, CEO of ANGLE, about why live cell liquid biopsies should become standard in oncology. Newland explains how current US FDA-approved tests can detect some types of advanced cancers, predict prognosis, and help healthcare providers make treatment decisions. And importantly, Newland describes how live cell liquid biopsies are a UK-developed technology that aligns with national efforts to modernise cancer diagnostics, as well as potentially reduce healthcare costs by minimising ineffective treatments. You can listen to episode 238 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

It goes without saying that drug pricing and accessibility in the United States are complex indeed. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Vinay Patel, an innovative pharmacist who's set out to transform the healthcare industry, about these intricacies. Patel discusses some intriguing stories about crafting innovative solutions for employers, revitalising struggling independent pharmacies, and implementing hybrid care models that can make healthcare more attainable for everyone. The conversation touches upon how biosimilars driving pharmaceutical innovation and reducing health costs, the role of telemedicine, also. You can listen to episode 237 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Gefion is Denmark’s first AI supercomputer, named after a goddess in Danish mythology. It is operated by the Danish Centre for AI Innovation (DCAI), a company established with funding from the Novo Nordisk Foundation, the world’s wealthiest charitable foundation, as well as the Export and Investment Fund of Denmark. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Tarek Samad, Lundbeck’s senior vice president and head of research, for a conversation on AI – specifically, Lundbeck’s agreement with the DCAI to run and operate Gefion – and accelerating drug discovery and development within the neurological and psychiatric field. You can listen to episode 236 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Illumina innovative sequencing and array technologies are fuelling groundbreaking advancements in life sciences research, translational and consumer genomics, and molecular diagnostics. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Markus Vossman, Germany general manager at Illumina, about innovative genomic applications and projects in the region. Vossman discusses the genomics landscape, as well as next-generation sequencing (or NGS), and the Model Project, a large-scale national pilot project aiming to evaluate the utility of genomic sequencing for patients with advanced cancer and rare diseases. You can listen to episode 235 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

The FDA recently announced that it will begin offering faster drug reviews to certain medicines, reducing the drug review process from approximately ten months to one or two months. This news follows a series of rapid changes from the FDA since the Trump administration took office. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Amy Bucher, chief behavioural officer at Lirio, a healthcare personalization platform helping insurers, health systems, and pharmacies deliver precision nudges to move patients into action. Bucher discusses the risks of the declining trust in healthcare institutions from a behavioural science perspective, as well as how regulatory changes, such as fast-tracking drug approvals as seen with the FDA lately, can impact patient perception. You can listen to episode 234 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

In a new pharmaphorum podcast, guest Patrick Leung – chief technology officer at Faro Health – discusses how AI can transform clinical trials. The conversation touches upon how large language models (or LLMs) can be gotten into production in regulated spaces – and why generic models won’t cut it in this domain – as well as the role of real-world data in quantifying and reducing patient burden. You can listen to episode 233 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

The Women in AI Healthcare event series - hosted by Real Chemistry in collaboration with Pharma Brands – brings together dynamic female leaders to discuss the transformative role of artificial intelligence in life sciences. It is also a call to action: to ensure women are not only present, but pivotal in shaping the future of AI in healthcare. In a new pharmaphorum podcast focused on the important and timely subject of women in AI, web editor Nicole Raleigh spoke with: Kate Eversole, event director at Pharma Brands; Celine Parmentier, EVP, head of global med comms at Real Chemistry; and Emma Slade, head of applied AI at Tangram Therapeutics. The guests discuss their own work with AI, the risk of training AI models predominantly on male data, and how, within life sciences, women are already shaping, challenging, and advocating for AI. The conversation also touches upon the possible next greatest impacts of AI in the sector, and the need to keep the ‘human in the loop’, as well as the possible negative impacts if AI is relied upon too much. You can listen to episode 232 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.   Resources mentioned within the conversation are as below: Kotek, H., Dockum, R., & Sun, C. (2023). Gender Bias and Stereotypes in Large Language Models. arXiv:2304.02485. UN Women & UNESCO (2020). I'd Blush If I Could: Closing Gender Divides in Digital Skills Through Education. Tatman, R. (2017). Gender and dialect bias in YouTube’s automatic captions. Criado-Perez, C. (2019). Invisible Women: Data Bias in a World Designed for Men. King, M. (2020). The Fix: Overcome the Invisible Barriers That Are Holding Women Back at Work.   You can register to be a part of the women in AI community here: https://www.pharmabrands.ca/womeninai   Information on the survey being run by Dr Michelle Penelope King, on AI and workplace motivation, can be found here: https://lnkd.in/eCg87_7w

AI’s growing influence in pharma is transforming traditional drug discovery timelines. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Alan Roth, CEO of Oxford Drug Design, about the use of AI to accelerate discovery of new treatments for cancer, infectious diseases, and cystic fibrosis. Roth discusses combining deep enzyme biology expertise with GenAI and targeting leucyl-tRNA synthetase. You can listen to episode 231 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

AI and computational small molecule drug discovery approaches are helping to realise the potential of targeted protein degradation (TPD) in molecular glue development. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Benedict Cross, Chief Technology Officer at PhoreMost, a company that’s specialises in next-gen TPD and which is progressing a pipeline of degrader therapeutics within oncology and inflammation. Cross discusses TPD market growth, PhoreMost’s high-throughput GlueSEEKER platform, and the future horizon of TPD, of molecular glues going forward. You can listen to episode 230 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Blood is a rich source for biomarker development, and CTCs are increasingly proving themselves to be valuable in cancer prognosis and treatment prediction. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Craig Eagle, Chief Medical Officer of Guardant Health, a precision medicine company that offers blood tests to inform cancer treatment decisions. Eagle discusses Guardant’s participation in the National Cancer Institute’s Vanguard Study, as well as screening, recurrence monitoring, and therapy selection focused on conquering cancer with data, with examples especially in the colorectal cancer space. You can listen to episode 229 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

There is a world of difference between the NHS from its beginnings in 1948 and the NHS as it is now. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Ruth Chambers OBE, co-director of Raparu Consult CIC and a visiting professor at Staffordshire University, for a conversation on her book, “Our NHS for better or worse?”. Chambers discusses her personal experience as a GP in the NHS, including the discrimination she faced as a woman, and analyses the notion of ‘burden’ in respect of the National Health Service, as well as differences in mental health care now and her proposed ‘Prescription for Change’. You can listen to episode 228 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

CB1 inhibition is an approach that taps into the body’s natural metabolism to burn fat while preserving muscle for more sustainable weight loss. Unlike GLP-1s, which suppress appetite, CB1 inhibition activates fat-burning processes. In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with Punit Dhillon, CEO of Skye Bioscience, for a conversation on CB1 inhibitor antibodies in the obesity space. Dhillon discusses GLP-1 weight-loss drugs like semaglutide having taken the world by storm, despite the concerns over side effects, as well as what CB1s could mean for the obesity and weight-loss field. You can listen to episode 227 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Technology and AI can help healthcare systems tackle the affordability challenge while ensuring patients still benefit from cutting-edge treatments. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Alfred Olivares, global managing partner, healthcare & medtech, at HTEC, in a conversation addressing how innovation can reach patients in a financially sustainable way. Olivares discusses digital transformation that makes care delivery smarter, faster, and more sustainable, as well as how data-driven platforms can support pharma in negotiating outcomes-based agreements with payers like the NHS. You can listen to episode 226 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

There are many efforts at the moment to transform the expensive, labour intensive, and high failure rate processes of drug discovery into automated drug design. And Simon Kohl, founder and CEO of Latent Labs, knows this intimately. In a new episode of the pharmaphorum podcast, Kohl discusses Latent Labs’ emergence from stealth, as well as protein design and drug discovery acceleration in more detail, as well as the importance of democratizing research. You can listen to episode 225 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

A CDMO plays a crucial role in the pharmaceutical and biotechnology industries by providing comprehensive drug development and manufacturing services, enabling companies to efficiently bring new medicines to market. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Sigma Mostafa, CSO at KBI BioPharma, about the role of CDMOs and the important factors companies should consider when selecting one. Mostafa sets out what a CDMO does, how they help to advance medicine into clinical and then commercial trials, and the critical role of partnership in drug development. You can listen to episode 224 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Drug shortages are a critical issue in the US, leaving patients and healthcare providers struggling. Compounding pharmacies, however, can curb drug shortages and help lessen this growing threat to the public's health.  In a  new pharmaphorum podcast, web editor Nicole Raleigh speaks with Shawn Hodges, CEO of Revelation Pharma, a nationwide network of 503A and 503B compounding pharmacies, spanning across various locations. Hodges discusses the true state of drug shortages in the US at the moment, the essential role compounding played during COVID-19, and opportunities for policy reform. You can listen to episode 223 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.