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Checkpoint NOW

Author: Afreen Shariff

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All you need to know about the latest evidence based practice in the diagnosis and management of immune related toxicities from cancer therapies straight from the experts in the field.
32 Episodes
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Join Dr. Afreen Shariff and Dr. Pauline Funchain as they break down Adrenal Insufficiency from cancer treatments in simple terms for patients, caregivers and care teams.
Join host Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Psychologist, Dr. Rebecca Shelby about the emotional impacts like stress, depression, and anxiety associated with side effects from cancer treatments.
Hosts: Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and thyroidologists Dr. Trevor Angell and Dr. Anupam Kotwal as they discuss information regarding thyroid disease in cancer patients for patients and caregivers.
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with Dena Battle from KCCure- an evidence based, patient driven advocacy organization. Dena shares her deep insight on patient, caregiver experiences around toxicity management and how we can learn from each other to improve patient outcomes.
Learn from the experts about the costs associated with irAEs in patients treated for Renal Cell Carcinoma. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologists Dr. Daniel Geynisman and Dr. Bradley McGregor, MD for an informative and high yield discussion regarding real and hidden costs of adverse events and how this impacts patients. 
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts from Dana Farber Cancer Institute, GU Oncologist Dr. Toni Choueiri and Quantitative Geneticist Dr. Sasha Gusev as they discuss Germline variants associated with immune checkpoint blockade and associated irAEs.
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they talk to expert oncologists Dr. Sharon and Dr. Nagash to learn about Immune Checkpoint Inhibitors in special populations. Dr. Sharon is an accomplished Oncologist at the National Cancer Institute. He co-Directs immunotherapy trials at the Cancer Therapy Evaluation Program (also known as CTEP) and serves as an attending physician in NCI's Developmental Therapeutics Clinic. As part of his work in immunotherapy drug development, he has made a major effort to advance the understanding of immune-related adverse events, including the establishment of the Alliance-NIH irAE Biorepository. Dr. Naqash, is an Oncologist with a focus on Early phase clinical trials, drug development and biomarkers in Immunotherapy. He is currently an Assistant professor of Medicine at the Oklahoma Health Stephenson Cancer Center.
Learn from the experts about the latest in immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologist Dr. Kerry Reynolds, and expert neurologists Drs. Amanda Guidon and Leeann Burton from Massachusetts General Hospital for an informative and high yield discussion.
Learn from the experts about the clinical diagnosis and multidisciplinary management of autoimmune Type 1 Diabetes. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and endocrinologists Dr. Ole-Petter Hamnvik and Dr. Le Min from Brigham and Women's Hospital Harvard Medical School and Dana Farber Cancer Institute for an informative and high yield discussion. 
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with resident physicians Dr. Harsh Patolia, Dr. Nathan Hirshman and Dr. Michelle Ferriera who share their experience and tips for fellow residents in training on managing immune mediated adverse events.
Learn from the experts about immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Neurologist Dr. Andrew Mammen.  Andrew Mammen, M.D., Ph.D., joined NIAMS as Muscle Disease Unit Leader in the Laboratory of Muscle Stem Cells and Gene Regulation in 2014. He obtained his medical degree and Ph.D. in neuroscience at Johns Hopkins in 2000, where he subsequently completed his medicine internship, neurology residency, and neuromuscular fellowship. Prior to his appointment at NIH, he was Associate Professor of Neurology and Medicine at the Johns Hopkins University School of Medicine. He co-founded the Johns Hopkins Myositis Center in 2007, where he continues to see myositis patients as an adjunct faculty member. Dr. Mammen and his colleagues at Hopkins discovered a novel form of autoimmune myopathy associated with statin use and autoantibodies recognizing HMG-CoA reductase, the pharmacologic target of statins. In addition to clinical studies involving myositis patients, his current laboratory research interests include defining pathogenic mechanisms in the various forms of autoimmune myopathy and understanding the role of myositis autoantigens in muscle regeneration.
Learn from the experts about the latest in Immune Mediated Liver Toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Transplant Hepatologist Dr. Lindsay King. Dr. King is a Hepatologist, Assistant Professor of Medicine at Duke University School of Medicine.
Hosts: Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Adela Rambi Cordones. Dr. Cordones is a Dermatologist, Associate Professor of Dermatology at Duke University School of Medicine. She leads the Immunodermatology Clinic at Duke and is clinician investigator with an expertise in Autoimmune Skin Disease and Cutaneous Drug reactions. 
Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Meenal Kheterpal. Dr. Kheterpal is a Dermatologist, Assistant Professor of Dermatology at Duke University School of Medicine. She also directs clinical research in Melanoma and Non - Melanoma Skin Cancer at Duke Dermatology.
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Oncologist, Dr. Jarushka Naidoo about the complex and challenging diagnosis of Immune mediated Pneumonitis.  Dr. Jarushka Naidoo is currently a thoracic oncologist at Beaumont Hospital, Royal College of Surgeons of Ireland and she is also the national lead for lung cancer for Cancer Trials Ireland, and serves as an adjunct professor at Johns Hopkins University. She also serves on the NCCN guidelines committee for the management of immune-related toxicity, and runs an institutional multidisciplinary team for immune toxicity management.
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert Dr. Javid Moslehi, MD, Cardiologist, Associate Professor of Medicine and an expert in immune-mediated cardiotoxicities at Vanderbilt University. Dr. Moslehi is also the Director of Cardio-Oncology at Vanderbilt.
Learn from the experts about the latest in scientific trials and novel therapies in the pipeline for management of Immune Mediated Colitis. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- Medical Oncologist- Dr. Kerry Reynolds, Gastroenterologist/ Immunologist- Dr. Micheal Dougan from Massachusetts General Hospital and rising star resident- Dr. Nazli Dizman from Yale for an informative and high yield discussion.
Learn from the experts about the clinical diagnosis and multidisciplinary management of Immune Mediated Colitis. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologist Dr. Kerry Reynolds and Gastroenterologist/ Immunologist Dr. Micheal Dougan from Massachusetts General Hospital for an informative and high yield discussion.
Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and rheumatologists Dr. Leonard Calabrese and Dr. Cassandra Calabrese from Cleveland Clinic and Dr. Alexa Meara from Ohio State University about budding collaborations and scientific discovery in Immune Mediated Rheumatic Adverse Events
Hosts: Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Rheumatologist Dr. Sophia Weinmann about the complex and challenging diagnosis of Immune mediated Myositis and Myalgia’s.
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