Razib Khan's Unsupervised Learning

On this episode of Unsupervised Learning Razib talks to Aaron Renn. Renn is a writer, consultant, and urban analyst known for his work on the challenges facing American cities and religious institutions in the 21st century. He is a contributor to The American Reformer and the author of Life in the Negative World, a book exploring the cultural shifts regarding Christianity in America. Renn previously served as a Senior Fellow at the Manhattan Institute for five years and as a contributing editor for City Journal, having established his voice on urban policy through his widely cited blog, The Urbanophile. Prior to his career in public policy and journalism, he spent 15 years in management and technology consulting, including a tenure as a partner at Accenture. Before getting into the meat of the discussion, Renn and Razib discuss management consulting and the value that a firm like Accenture provides a corporation. Razib wonders whether consultants are simply brought in to rubber-stamp what management has already concluded, but is aiming to pin the blame on an external actor (e.g., layoffs). Renn argues that this is not the case, and in fact, though he acknowledges that management consultants provide an outsider view unencumbered by internal politics that allows them to be taken more seriously. They also discuss the impact of AI on some services that management consultants provide, and the future of white-collar work. Then Renn goes on an extended riff on the rise and fall, and possible new rise, of the Midwestern social and economic landscape. A native of southern Indiana, Renn has spent time in Chicago and New York before settling down in the affluent suburb of Carmel, Indiana. Razib and Renn discuss the decline of the Northeast and the industrial Heartland, and what makes the Midwest unique, with its origins as part of the original early American republican frontier. Renn discusses candidly the upsides and downsides of living in "flyover country," from its peace and tranquility, to the reality that Midwestern metropolitan areas do not have the same intellectual and cultural dynamism as coastal cities. Finally, Razib asks Renn, a Protestant Christian who identifies as evangelical, about the cultural and theological shifts occurring on what was once called the Religious Right. Renn argues that this movement's peak was really in the mid-1990's, and the whole thirty-year period since has seen retreat and retrenchment. He believes that Christians have lost control of the cultural narrative and have to accept a position as outsiders. Renn also addresses the decline of premillennial dispensationalism, most famously illustrated in the Left Behind series of the 1990s and early 2000s, and the rise of Christian nationalism, and in particular, the role of Reformed pastor Doug Wilson in this shift.

On this episode of Unsupervised Learning Razib talks to Daniel Tabin, a 5th-year Ph.D. student in David Reich's lab in the Department of Human Evolutionary Biology. His research focuses on using ancient and modern DNA to answer questions about human history. Tabin completed a degree in Computer Science and Math and Master's in Computer Science from Rensselaer Polytechnic Institute. He Ph.D. project involves the population genetic history of Central and East Asia. First, Razib and Tabin discuss a recent paper he co-authored that looks at problematic results in the paleogenetic literature due to contamination and DNA damage. Tabin reviews all the processes and analyses that paleogeneticists go through to validate that the ancient DNA data they have is truly ancient, rather than recent contamination, from wet-lab precautions to downstream analysis. Then they dig into the empirical results over the last 15 years from the field of ancient DNA, from what we know (or don't) of the out-of-Africa bottleneck, early modern humans in Asia and how we think about persistent mysteries like "Population Y" in the New World (Population Y is more closely related to Papuans and Andamanese than Northeast Asians).

On this episode of Unsupervised Learning Razib talks to Peter Nimitz about the rise of the Slavs. His Substack, titled Nemets, explores world history through the lenses of archaeology, paleogenetics, and historical processes. His writing focuses on "deep history," such as the Bronze Age Collapse and the migration of Indo-European peoples, while connecting these ancient shifts to broader patterns of civilizational rise and fall. Nimitz often integrates technical data from genetics and climate science to challenge traditional narratives about nomadic tribes and early state formations across Eurasia. Beyond antiquity, the newsletter also touches on modern geopolitical developments and regional studies, ranging from the war in Ukraine to the cultural history of the Americas. Razib and Nimitz explore the thousands of years of Slavic history and prehistory, from their fragmentary mentions in antiquity, to their explosion in the Middle Ages. Nimitz discusses the many archaeological cultures in northeastern Europe that might be candidates for the proto-Slavs as they emerged from the Corded Ware Culture during the Bronze Age, as well as the historical, cultural and genetic effects of the Slavic migrations that impacted Christian Europe after 600 AD. He also addresses the role of Slavs as one of Europe's preeminent ethnolinguistic configurations in early modern Europe.  

On this episode Razib talks to Jesse Arm, VP of external affairs at the Manhattan Institute. His writing and commentary have appeared in the New York Times, Wall Street Journal, The Atlantic, New York Post, Fox News, City Journal and Jerusalem Post. Arm graduated with honors from the University of Michigan, where he majored in international political economy, and studied language and international affairs at Tel Aviv University. He has also worked for Senator Tom Cotton and Representative Dan Benishek, and the analytics arm of American Continental Group, a major lobbying firm. Razib and Arm discuss the perceptions and attitudes of Gen Z Republicans, focusing on a group of 18-29-year-olds in Nashville, TN. Arm notes that while Gen Z feels economic anxiety, they are also entrepreneurial and comfortable with the world of social media. Gen Z Republicans are religious, like previous generations, but less likely to be married or have long-term partners at the same age as earlier cohorts. They express a desire for politics to be entertaining, similar to reality TV. The conversation also touches on the influence of social media on their views, the power of influencers like Nick Fuentes, and the potential for future political figures to emerge from the creator class. Arm also addresses the impact of intergenerational wealth transfer on political attitudes.

On this episode of Unsupervised Learning, Razib talks to Davide Piffer, whose Substack examines genetic differences between populations. Piffer has been publishing on human genetic variation for a decade, and recently started a Substack, Piffer Pilfer, exploring similar issues in detail over a series of posts. Razib asks Piffer about the difficulties in analyzing polygenic scores from quantitative traits in ancient DNA samples. How does he do in technical terms, from genome quality to imputation to ancient populations from modern ones? Then, they discuss some of Piffer's findings, in particular, his work on pigmentation. Piffer talks about how he discovered that modern European pigmentation, and in particular, light complexion, is the product of both admixture from different populations with different characteristics and natural selection over the millennia. Piffer talks about how he discovered that selection for lighter pigmentation continued into the Iron Age.

Today Razib talks to Aneil Mallavarapu, a scientist and technology leader based in Austin, Texas, whose career bridges the fields of biochemistry, systems biology, and software engineering. He earned his doctorate in Biochemistry and Cell Biology from the University of California, and has held academic positions at Harvard Medical School, where he contributed to the Department of Systems Biology and developed the "Little b" programming language. Mallavarapu has transitioned from academic research into the tech and venture capital sectors, co-founding ventures such as Precise.ly and DeepDialog, and currently serving as a Managing Partner at Humain Ventures. He remains active in the scientific community through local initiatives like the Austin Science Network. Most of the conversation centers around Mallavarapu's arguments outlined in his Substack The Case Against Conscious AI - Why AI consciousness is inconsistent with physics. The core of his argument rests on the "Simultaneity Problem" and the "Hard Problem of Physics," which involve non-locality and the memorylessness of artificial intelligence phenomena. Though Mallavarapu believes that artificial intelligence holds great promise, and perhaps even "artificial general intelligence" (AGI) is feasible, he argues that this is a distinct issue from consciousness, which is a property of human minds. Razib also brings up the inverse case: could it be that many organisms that are not particular intelligence, also have consciousness? What does that imply for ethics of practices like eating meat?

On this episode Razib, talks to Richard Hanania, a returning guest to the podcast. Hanania holds a Ph.D. from UCLA, a J.D. from the University of Chicago, and an undergraduate degree from CU Boulder in linguistics. He is a regular contributor to the Boston Globe and UnHerd, and has his own newsletter. Hanania is also the author of The Origins of Woke: Civil Rights Law, Corporate America, and the Triumph of Identity Politics. Razib and Hanania talk about his new book Kakistocracy: Why Populism Ends in Disaster, and his developing views on populism and immigration. They highlight the rise of populism on the Right, the rejection of cognitive elitism, and the impact of social media on political discourse. Hanania criticizes the far-right's nativism, particularly against Indian immigrants, and the rise of anti-Semitism, both as a feature of low-IQ populism. They also touch on foreign policy, noting the failures of authoritarian regimes like Russia and China, and the potential for democratic systems to prevail. Hanania brings up cultural differences, particularly in Asia, and the impact of personality traits on success. They talk about the Big Five personality traits, and note that disagreeableness and low neuroticism are linked to professional success, especially in men. Razib also brings up the 2017 James Damore Google memo controversy, highlighting the cultural and political implications down to the present. Hanania reflects on his experiences with cancel culture and the evolving acceptance of diverse viewpoints. They also discuss the role of Substack in promoting free speech and the challenges faced by platforms in maintaining this principle.

On this episode, Razib talks to returning guest, Francis Young, a historian who teaches at Oxford. Young specialises in the history of religion and belief from ancient times to the present day, and provides expert indexes for academic books and translates medieval and early modern Latin. He holds a PhD from Cambridge University and is the author, editor or co-author of over 20 books. On his last visit to the podcast, he discussed his book Pagans in the Early Modern Baltic, an account of the practices and persistence of Baltic paganism down to the 16th-century, the age of the Renaissance and Reformation. Today he discusses his new book, Silence of the Gods: The Untold History of Europe's Last Pagan Peoples. Razib and Young first discuss what it means to be "pagan" in a European context, first during Classical Antiquity, but more recently in Northern Europe down to the early modern period. Young discusses how it is difficult to understand and define paganism without reference to Christianity, which was a major force in shaping the nature of pagan religion in Northern Europe. Razib asks about the specific nature of northeast Baltic paganism, and in particular, the late survivals of pre-Christian religion among Lithuanians and Estonians, and the differences between the two groups. Young explains his understanding of different religious practices and the various forms of non-Christian practice that persisted among different groups, including mixed "creole" identities. Razib also inquires about the Mari El, a Finnic group in the Urals that might be the only continuously officially pagan people in Europe, as well as evidence Young reports that Estonian peasants were never truly fully Christianized.

On this episode of Unsupervised Learning, Razib again talks to George Washington University archaeologist Eric Cline. The author of 1177 B.C. - The Year Civilization Collapsed and After 1177 B.C. - The Survival of Civilizations, Cline has a new book out, Love, War, and Diplomacy: The Discovery of the Amarna Letters and the Bronze Age World They Revealed. While 1177 B.C. closed with the end of the first global civilization, that of the Eastern Mediterranean at the end of the Bronze Age, and After 1177 B.C. tells the story of those who picked up the pieces, Love, War, and Diplomacy puts the spotlight on the Late Bronze Age at its peak. Razib and Cline discuss the two major threads in Love, War, and Diplomacy: the decipherment of cuneiform and the emergence of the field of Assyriology, and the diplomatic world of Bronze Age Great Powers. Cline addresses the reality that 19th-century archaeology was not an idealized enterprise, and scholars had to compete with treasure hunters, and negotiate difficult nationalist sensitivities. He also explains how they deciphered cuneiform decades after hieroglyphs, providing an alternative view of the earliest antiquity. The discussion then focuses on the intricate and tense relationship between Egypt, Assyria, the Hittites, and the Mitanni. Cline also highlights the reality that the Amarna Letters also shed light on the bickering between the petty states of the Levant and their relationship to their hegemon, Egypt.

On this episode of Unsupervised Learning Razib talks again with Washington Post columnist and repeat guest Shadi Hamid (listen to previous episodes). A native Pennsylvanian of Egyptian ethnic background and Islamic faith, Hamid completed his Ph.D. in politics at Oxford University. He is co-host of the Wisdom of Crowds podcast and website with Damir Marusic, and now the author of his own Substack and a recent book, The Case For American Power. Hamid is also the author of The Problem of Democracy: America, the Middle East, and the Rise and Fall of an Idea. , Temptations of Power: Islamists & Illiberal Democracy in a New Middle East and Rethinking Political Islam. Before moving the discussion to The Case For American Power, Razib asks Hamid about his current positioning on the American political landscape with the emergence of the hard-right during the second Trump administration. Hamid admits that during the "woke era" he wasn't sure about his place on the Left as a progressive due to his misgivings with racial identarianism, but with the rise of white nationalism on the Right and the executive decisions of the Trump administration Hamid finds himself more comfortable saying he is a progressive. Racism and the passions unleashed by the Israel-Palestine conflict since 10/7 have made Hamid reevaluate the virtues of some level of wokeness. Pivoting to foreign policy, Razib and Hamid discuss his new book, and its positioning within a political landscape that ranges from neconservatism, liberal internationalism and isolationism of all sorts. Despite Hamid's misgivings of some aspects of American culture and the nation's past political sins, he asserts (unlike the far Left) that overall America is a force for good, and that it should exercise its power to spread its vision of morality across the world. The Case For American Power is an attempt to articulate a liberal and progressive internationalist vision for 2025, decades after the failed Iraqi intervention. Hamid also addresses the sea-change on the progressive side of American politics when it comes to Israel, admitting he feels much freer to express skepticism or critiques of Israeli policy than he had in previous eras.

On this episode, Razib talks to Vishal Ganesan and Anang Mittal, two Indian-American Hindus who have been thinking about the role of their faith in the present, and past, of the American social landscape. Ganesan is a California-based attorney and writer who focuses on the history, identity, and representation of the Hindu diaspora in the United States. He is best known for his project "Hindoo History" and his writing on the "Frontier Dharma" platform, which attempts to conceptualize what an American, as opposed to Indian, "Hinduism" might look like. Anang Mittal is a DC-based political communications professional who recently worked for Senator Mitch McConnell. Mittal grew up in India before moving to the US at a young age about 25 years ago. Ganesan, in contrast, was born to an earlier generation of Indian immigrants to the US. He grew up north of Austin, TX. Though their perspectives differ, they both believe that Hinduism and Indian-American identity cannot simply be ported over with no changes into the American cultural landscape. The conversation is centered on two essays, Ganesan's The Meaning and Limits of "Hinduphobia" Discourse in the Diaspora and Mittal's What Hindu Americans Must Build. While Ganesan explores and articulates what it means to be Indian-American and Hindu today in America, and what might mean in the future, Mittal's argument is framed by a deep understanding of American history and how Hindus fit into the bigger arc of history. Razib, Ganesan and Mittal discuss the past, present, and potential future of Hindus and Indians, two separate categories, in America over the course of two hours. Their discussion was triggered by the online controversy over the fact that Vice President J. D. Vance's wife is a Hindu, and he has encouraged her to convert to his Roman Catholic religion (in which their children are being raised). But the discussion extends far beyond matters of contemporary politics, probing what it means to be American, and what it could mean to be a Hindu.

On this very special episode, Razib talks to paleoanthroplogists John Hawks and Chris Stringer. Hawks is a paleoanthropologist who has been a researcher and commentator in human evolutionary biology and paleoanthropology for over two decades. With a widely read weblog (now on Substack), a book on Homo naledi, and highly cited scientific papers, Hawks is an essential voice in understanding the origins of our species. He graduated from Kansas State University in 1994 with degrees in French, English, and Anthropology, and received both his M.A. and Ph.D. in Anthropology from the University of Michigan, where he studied under Milford Wolpoff. He is currently working on a textbook on the origins of modern humans in their evolutionary context. Hawks has already been a guest on Unsupervised Learning three times. Chris Stringer is affiliated with the Natural History Museum in London. Stringer is the author of African Exodus. The Origins of Modern Humanity, Lone Survivors: How We Came to Be the Only Humans on Earth and Homo Britannicus - The Incredible Story of Human Life in Britain. A proponent since the 1970's of the recent African origin of modern humans, he has also for decades been at the center of debates around our species' relationship to Neanderthals. In the 1980's, with the rise to prominence of the molecular model of "mtDNA Eve," Stringer came to the fore as a paleoanthropological voice lending support to the genetic insights that pointed to our African origins. Trained as an anatomist, Stringer asserted that the fossil evidence was in alignment with the mtDNA phylogenies, a contention that has been broadly confirmed over the last five decades. Razib, Hawks and Stringer discuss the latest work that has come out of Yuxian, China, and how it updates our understanding of human morphological diversity, and integrate it with the newest findings about Denisovans from whole genome sequencing. They talk about how we exist at a junction, with more and more data, but theories that are becoming more and more rickety in terms of explaining the patterns we see. Hawks talks about the skewing effect of selection on phylogenetic trees, while Stringer addresses the complexity of the fossil record in East Asia.

Today Razib talks to Sean Trende. He is a prominent American political analyst who currently serves as the Senior Elections Analyst for RealClearPolitics, a position he has held since 2010. He is also a Fellow at the American Enterprise Institute (AEI) and a lecturer at The Ohio State University, where he earned his Ph.D. in political science in 2023. Before transitioning to full-time political analysis, Trende practiced law for eight years at firms including Kirkland & Ellis LLP and Hunton & Williams LLP, holding a J.D. and M.A. from Duke University and a B.A. from Yale University. Known for his expertise in election forecasting, redistricting, and political demographics, he authored the book The Lost Majority (2012), co-authored The Almanac of American Politics 2014, and served as a court-appointed special master to redraw Virginia's legislative districts in 2021. Trende and Razib first talk about the elections in the fall of 2025 in Virginia and New Jersey, and what they tell us about the elections next year. They also discuss the election of Zohran Mamdani in New York City, and the rise of populism on the Left and Right. Razib asks Trende about why political commentary often assumes single-party rule is about to happen, only to be refuted by the reality of the opposition's resurgence once these claims are made. They also talk about Trende's distinctive personal background, and his perspective as a more centrist-libertarian commentator and professor in the political analyst field.

This week on the Unsupervised Learning Podcast, Razib talks to returning guest Alex Young of UCLA and Herasight. Trained originally as a mathematician, Young studied statistics and computational biology at the University of Cambridge before doing a doctorate in genomic medicine and statistics at the Wellcome Trust Centre for Human Genetics, University of Oxford, under Peter Donnelly. He also worked at deCODE Genetics in Reykjavik and at Oxford with Augustine Kong, developing methods in quantitative and population genetics. Razib and Young talk extensively about what we know about heritability and genomics in 2025, four years after their first conversation. In particular, they discuss what larger sample sizes, high-density genotype-arrays and whole-genome sequencing have told us about heritability and the ability to predict traits in individuals from their sequence. They discuss quantitative and behavioral traits like height, intelligence and risk of autism, and the differences between classical statistical genetical methods utilizing twins and modern molecular genomic techniques that attempt to fix specific physical markers as causal factors in characteristics of interest. In addition to his academic work, Young has also been consulting for the polygenic embryo-screening company Herasight, working on cutting-edge methods for genomic prediction in the context of in vitro fertilization. They dig deep into the new method Young and colleagues worked on that helps democratize embryo selection using genomics, ImputePGTA.

Today on Unsupervised Learning Razib talks to Zineb Riboua, a research fellow and program manager of Hudson Institute's Center for Peace and Security in the Middle East. She specializes in Chinese and Russian involvement in the Middle East, the Sahel, and North Africa, great power competition in the region, and Israeli-Arab relations. Riboua's pieces and commentary have appeared in the Wall Street Journal, Foreign Policy, the National Interest, the Jerusalem Post and Tablet among other outlets. She holds a master's of public policy from the McCourt School of Public Policy at Georgetown University. She did her undergraduate studies in France, where she attended French preparatory classes and HEC Paris' Grande Ecole program. Her Substack is Beyond the Ideological. Razib and Riboua discusses two pieces on her Substack today, Zohran Mamdani, Third-Worldism, and the Algerian Revolution and Zohran Mamdani and Islam as Language, American Third-Worldism. Riboua explains that contrary to some assertions Mamdani is not an Islamist, but neither is a standard-issue class-based socialist or an identitarian in the woke model that was ascendent a few years ago. Rather, Riboua's contends that Mamdani, a "Third-Culture Kid," emerges out of the post-colonial world that reframes the Marxist framework into a Western vs. non-Western dyad. Rather than the Islamist Iranian Revolution of 1979, she traces Mamdani's intellectual lineage, that of anti-colonial Third-Worldism, to the Islam-inflected Algerian Revolution of the early 1960s. With conventional racial and gender identitarianism exhausted, Riboua contends that Third-Worldism is likely going to be the most potent force in the American Left over the next decade.

Today Razib talks to Ed West, a British journalist and author. He has served as deputy editor of UnHerd and The Catholic Herald, and has written columns for The Spectator and The Daily Telegraph. He runs the Substack newsletter Wrong Side of History, where he explores culture, politics, and the longue durée of Western history. West is the author of books including Small Men on the Wrong Side of History and The Diversity Illusion, as well as popular-history titles such as 1066 and Before All That. A previous podcast guest, West and Razib revisit the topic of British decline three years on. They discuss Britain's economic transformation, from one of the standout economies of Europe a generation ago, to a laggard. Razib probes why the British seem so attached to their welfare state, and why the state has embraced anti-growth policies along with high migration rates. They also discuss the tensions within Britain's large Muslim minority, and the cultural environment that allowed for mass migrant inflows despite their political unpopularity.

Today Razib talks to Noah Smith, an American economist-turned-blogger known for his commentary on economics and public policy. His blog, Noahpinion, is one of the most popular on Substack. He earned a PhD in economics at University of Michigan and served as an assistant professor of finance at Stony Brook  University before leaving academia to become a full-time writer. He wrote a column for Bloomberg until 2021, when he turned his focus entirely to independent writing and his Substack newsletter. Smith is based out of San Francisco but spends part of the year in Japan. An enthusiast for Japanese culture, he is also one of the central nodes in English-speaking rabbit-twitter. First, Razib and Smith talk about the current cultural and political situation in Japan. In particular, how did Japan transform itself from a country with non immigration to one with a non-trivial number of migrants? Additionally, Razib asks Smith about the new Prime Minister, Sanae Takaichi, the first woman in that role. Smith elucidates her relationship to the politics of two of her most prominent predecessors, Shinzo Abe and Junichiro Koizumi. Razib also asks, is she as far right as some people are saying? Then Smith and Razib discuss the "vibe shift" in American culture over the last five years, from the peak period of wokeness around 2020, to the current political ascendancy of MAGA and how Democrats are reconfiguring their politics.

Today, Razib talks to Coltan Scrivner, a behavioral scientist, horror entertainment producer, and author, whose work centers on the psychological and evolutionary roots of our fascination with darkness, horror, and true crime. He is affiliated with the Department of Psychology at Arizona State University. Scrivner also serves as the executive director of the Nightmare in the Ozarks Film Festival and founded the Eureka Springs Zombie Crawl. He has been featured in The New York Times, CNN, The Wall Street Journal, NPR, TIME Magazine, National Geographic, Scientific American and Forbes. He is the author of Morbidly Curious: A Scientist Explains Why We Can't Look Away, where he explores how our fascination with horror functions as a survival-oriented, yet deeply human, impulse. Though working in psychology and behavior, Scrivner's original training is in biological the sciences, and Razib first probes him on the possible evolutionary origins of our persistent interest in horror, and why we might actually be attracted to the phenomenon in the first place. Scrivner also explains how the horror genre differs from other narrative forms, in particular, the power imbalance that makes heroic action and tension much more difficult. Horror, in fact, primarily leverages our intuitions about how predator and prey interact, more than a battle between peers. Scriver also discusses the relationship between fear and our dreams, and the various psychological and evolutionary theories for why we might have so many nightmares.

Today Razib talks to Nate Soares the President of the Machine Intelligence Research Institute (MIRI). He joined MIRI in 2014 and has since authored many of its core technical agendas, including foundational documents like Agent Foundations for Aligning Superintelligence with Human Interests. Prior to his work in AI research, Soares worked as a software engineer at Google. He holds a B.S. in computer science and economics from George Washington University. On this episode they discuss his new book, If Anyone Builds It, Everyone Dies: Why Superhuman AI Would Kill Us All, co-authored with Eliezer Yudkowsky. Soares and Yudkowsky make the stark case that the race to build superintelligent AI is a "suicide race" for humanity. Razib and Soares discuss how AI systems are "grown" rather than deliberately engineered, making them fundamentally opaque and uncontrollable. They explore a concrete extinction scenario, explain why even minimally misaligned goals could lead to human annihilation. Soares urges immediate cooperative action to prevent such a worst-case outcome.

On this episode of Unsupervised Learning, Razib talks to Alexander Cortes. Cortes is a trainer, fitness influencer and entrepreneur. He is the co-founder, along with his wife, of Ferta, a company that aims to "optimize your reproductive health and conceive naturally." Born and raised in California, Cortes began his career in the fitness industry as a personal trainer in 2010. Over the next few years he expanded his efforts online, writing about fitness and nutrition from a science-informed perspective. Cortes developed a following by offering practical advice on strength training, muscle building, and the psychological aspects of fitness to the interested general public, translating the wisdom-of-the-gym for the person on the street. In the first part of the podcast, Razib and Cortes talk about "broscience," and how it differs from "quantified self" and other movements geared toward self-optimization. They discuss how "bros" arrived on the importance and utility of peptides long before the ozempic revolution, and how the iterative and experimental methods of gym-addicted amateurs predated and anticipated what would later become conventional wisdom. Razib also explores how Cortes' particular style of broscience differs from that of others, with its stronger empirical basis and analytical orientation (and aversion to fads like "raw food"). They discuss the "peptide revolution" and how online fitness and health influencers discovered it earlier, the utility of the macromolecules in health and wellness, and what the online community discovered already that is likely to come down the clinical pipeline. In the second part of the discussion, Cortes introduces his new company, Ferta, and its situates its position in the fertility space. He explains the origin of his firm as he and his wife began to attempt to conceive in their 30s, and how difficult or easy the process was conditional on the optimizations they engaged in. Cortes explains many people struggle because they do things wrong, and don't maximize their chances by being healthy and fertile.