What's Your Problem?

Kevin Murach is a professor who studies muscle cells at the University of Missouri. Kevin's problem is this: Can we understand what's going on in our cells when we lift weights – and can we use that knowledge to help people stay healthier as they age? In this episode, Kevin explains:  The technology lets scientists watch individual muscle nuclei during exercise The significance of a cancer gene called Myc that is activated after lifting weights  How Myc may be linked to cellular age reversal Why muscle responds less to exercise with age Connect with us: Follow Jacob Goldstein on LinkedIn, X and Instagram  Email us at [email protected]  Follow Pushkin on Instagram, LinkedIn or X  Listen to Jacob’s other show, Business History  To listen to the show ad free, sign up for Pushkin+  See omnystudio.com/listener for privacy information.

Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple, Spotify or wherever you get your podcasts. With the news of Warren Buffett stepping down as chairman of Berkshire Hathaway, we are revisiting an episode from our two-part series on Buffet. Warren Buffett rose from obscurity to become the richest person in the world - and he did it in a unique way. As a boy in Omaha he collected information obsessively - writing down car license numbers and hoarding bottle caps. As a young man, Buffett turned his focus on scouring business accounts to find companies that had hidden value no one else could spot. We tell the story of young Warren Buffett as he quietly worked building up the expertise and accumulating the wealth that would allow him to become the most famous investor of our age.See omnystudio.com/listener for privacy information.

Circadian rhythm isn’t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells.  Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she’s a leading expert on circadian rhythm in muscle cells. Karyn's problem is this: How does the circadian rhythm in muscle cells change as we age, and how does exercise help keep our system in sync? In this episode, Karyn explains:  How every cell in your body has a clock in it How muscle clocks prepare cells for work and schedule recovery during rest How age affects these clocks’ ability to regulate effectively  Why exercise can improve clock function  Why jet lag and late-night eating can put your body clocks out of sync  Connect with us: Follow Jacob Goldstein on LinkedIn, X and Instagram  Email us at [email protected]  Follow Pushkin on Instagram, LinkedIn or X  Listen to Jacob’s other show, Business History  To listen to the show ad free, sign up for Pushkin+  See omnystudio.com/listener for privacy information.

Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple, Spotify or wherever you get your podcasts. William Shockley was an electronics genius - he even won a Nobel Prize - but he was an awful boss. Shockley was a cruel, paranoid micromanager. And this annoyed the staff of brilliant young engineers he'd assembled in a quiet town in Northern California. In fact, they quit and set up a company of their own inventing silicon chips.  Robert Noyce, Gordon Moore and the rest of "The Traitorous Eight" transformed computing, but also blazed a trail for the tech founders who would flock to Silicon Valley and change the world. Members of "The Traitorous Eight" set up Intel and AMD, while also funding businesses such as Google and Slack.  Connect with us: Follow Business History on Instagram and TikTok Follow Jacob Goldstein on LinkedIn, X and Instagram  Follow Robert Smith on Instagram and X Email us at [email protected]  Follow Pushkin on Instagram, LinkedIn and X  To listen to the show ad free, sign up for Pushkin+  See omnystudio.com/listener for privacy information.

Note: Today’s show is sponsored by PayPal. Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for a world where their customers include AI agents? In this episode, Kartik explains: Why trust in agentic shopping will arrive category by category, not all at once How a single old Reddit post erased a thriving brand from ChatGPT’s recommendations Why someone needs to take on the liability risk when purchases go wrong How treating AI as just another sales channel is the mistake the movie studios made with Netflix How to get a language model to pay attention to your brand Connect with us: Follow Jacob Goldstein on LinkedIn, X and Instagram  Email us at [email protected]  Follow Pushkin on Instagram, LinkedIn or X  Listen to Jacob’s other show, Business History  To listen to the show ad free, sign up for Pushkin+ See omnystudio.com/listener for privacy information.