Your Complex Brain

In 1995, actor Christopher Reeve was injured in a horseback riding accident, leaving him quadriplegic - paralyzed from the shoulders down. He became a tireless advocate and a passionate supporter of research. Christopher’s dream was for those living with spinal cord injuries to have a better quality of life, and one day to walk again. More than 25 years later, thanks to advances in surgical approaches, neuroprotective drugs, and gene therapy using stem cells, that dream is becoming closer to reality.Featuring: Dr. Laureen Hachem is a Senior Neurosurgery Resident and PhD Candidate at UHN’s Krembil Brain Institute and the University of Toronto. Dr. Michael Fehlings is a Neurosurgeon and Senior Scientist at UHN’s Krembil Brain Institute and a Professor of Neurosurgery at the University of Toronto. Dr. Fehlings also holds the Campeau-Tator Chair in Brain and Spinal Cord Research at UHN.John Ruffolo is the Founder and Managing Partner of Maverix Private Equity, a private equity firm focused on technology-enabled growth and disruption investment strategies. He is currently living with a spinal cord injury.Additional resources: UHN’s Spinal Cord Injury ClinicDr. Fehlings’ Laboratory for Neural Repair and Regeneration websiteDr. Fehlings interview on Season 1 of Your Complex Brain, ‘Revolutionary Advances in Spinal Cord InjuryPSI Foundation feature story on Dr. Laureen HachemToronto’s Top Grad Dreams Big – Toronto.com feature story on Dr. Laureen Hachem as a high school studentThe Globe and Mail feature story on John RuffoloThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

In the time that it takes to say this sentence – three seconds – someone in the world will develop dementia, a group of symptoms impacting memory, thinking, mood, behaviour and the ability to complete everyday tasks. Alzheimer’s is the most common form of dementia.With people living longer, even into their 90s and beyond, dementia is becoming the biggest and most consequential global health threat of our time. But, according to a landmark study in The Lancet medical journal, there are 12 modifiable risk factors that can reduce your chances of getting dementia at any age – by up to 40%. In this episode of Your Complex Brain, we discuss which of those risk factors are most impactful to lower – or even reverse – your risk of dementia, with a focus on the latest science looking at the benefits of exercise.Featuring: Maria Martinez has been a social worker nearly 25 years. Most recently, she has worked with the team at UHN’s Memory Clinic, helping patients living with Alzheimer’s and dementia, and their families, navigate their diagnosis and community supports.Dr. Carmela Tartaglia is a Neurologist and a Clinician Scientist with UHN’s Krembil Brain Institute, as well as co-Director of UHN’s Memory Clinic and an Associate Professor at the University of Toronto.Dr. Laura Middleton is an associate professor and the Schlegel Research Chair in Dementia and Active Living, at the University of Waterloo. She is also an Affiliate Scientist at KITE, the research arm of UHN’s Toronto Rehabilitation Institute. Additional resources: Dr. Carmela Tartaglia’s interview on EP 1 of Your Complex Brain – ‘The Quest to Solve the Concussion Problem’Risk Factors for Alzheimer’s and Dementia (video)UHN Memory ClinicSchlegel-UW Research Institute for Aging (RIA)Dr. Laura Middleton’s research project - DREAM (Dementia Resources for Eating, Activity, and Meaningful InclusionDr. Laura Middleton’s research project - DICE (Dementia Inclusive Choices for Exercise)The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

In a sweeping 2023 report, the US Surgeon General, Vivek Murthy, declared loneliness an epidemic and a public health emergency. According to the report, loneliness and isolation can lead to a significant increase in mental health disorders, such as anxiety and depression, as well as a nearly 30% increased risk of heart disease, stroke and among older adults, a 50% risk of dementia.Around the world, there are efforts to help people cope with loneliness. In the Netherlands, one grocery store chain has introduced ‘chat check outs’ where customers can take their time and socialize – part of a government initiative to address the growing issue of isolation.There are also a number of apps to help introduce you to your neighbours anywhere you live in the world.And a recent story in The Globe and Mail profiled a woman who rents her time out to those needing a dinner companion, a study buddy, or a listening ear. She’s seen more than 60 clients so far. Today’s episode focuses on the health impact of loneliness on the brain, why social media seems to be making us lonelier even as it’s meant to connect us, and how each of us can learn to exercise our social muscle, and improve our overall health.Featuring: Dr. Jaideep Bains – Director of the Krembil Research Institute at UHN and co-Director and Senior Scientist with UHN’s Krembil Brain Institute. Dr. Hayley Hamilton – Associate Director and Senior Scientist with the Institute for Mental Health Policy Research at the Centre for Addiction and Mental Health (CAMH).Additional resources: UHN’s Krembil Brain InstituteDr. Jaideep Bains’ public talk – ‘Is My Stress Your Stress?’ The Centre for Addiction and Mental Health (CAMH)The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

We are once again bringing you inside UHN’s Krembil Brain Institute, one of North America's largest and most innovative neurological centres, to meet the scientists & physicians advancing discovery, the patients who inspire us, and the care teams who support them. This season, we’re exploring some big new research in brain health, including: What young women need to know about preventing a stroke, Can loneliness re-wire your brain? And how YOU can reduce YOUR chances of Alzheimer’s. We’ll also take you to the forefront of AI powered brain science, dive into the link between genetics and reading disabilities  and find out why getting a good night’s sleep is crucial for brain health.There are a million amazing things to know about your complex brain – and we couldn't be more excited to explore them with you. Season 3 launches March 19, with episodes every other Tuesday. Subscribe to Your Complex Brain so you don’t miss a thing.The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

From new Alzheimer’s drugs, to novel treatments for brain cancer, to chronic pain, many of us feel overwhelmed by the sheer volume of health news in the media and confused about what to believe - and how it applies to our own health.In this special episode of Your Complex Brain - our last of the season - we bring back five of our featured UHN brain experts to weigh in on the top, science-based, evidence-backed tips for keeping your brain fit and healthy as you age (and some of their answers may surprise you!)Host Heather Sherman also introduces the Your Complex Brain production team and asks what they each do to keep their brains happy and healthy.Featuring: Drs. Andrea Furlan, Jaideep Bains, Mary Pat McAndrews, Donald Weaver and Aleksandra Pikula.  Additional resources (5-6): Dr. Andrea Furlan’s YouTube Channel Dr. Jaideep Bains’ public talk – ‘Is My Stress Your Stress?’ Dr. Mary Pat McAndrews’ discussing her science journey & why she studies memory Dr. Donald Weaver’s Your Complex Brain Season 1 podcast episode – ‘What’s it Going to Take to Solve Alzheimer’s?’ Dr. Aleksandra Pikula’s Your Complex Brain Season 1 podcast episode – ‘The Rise of Stroke in Young Adults’ The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

More than eight million Canadians are currently living with the effects of debilitating chronic pain.In this episode, we discuss the connection between chronic pain and the brain, including the latest & most effective treatments, the stigma - how do you study and treat something that you often can’t see? And, is there a way to build ‘pain resilience’?We’ll speak with Dr. Andrea Furlan, a senior scientist & physiatrist with the KITE Research Institute and Dr. Anuj Bhatia, an anesthesiologist and clinician investigator with the Krembil Brain Institute.We’ll also hear from Lara Pingue, about her personal experience living with chronic pain.Featuring: Dr. Anuj Bhatia - Anesthesiologist and pain medicine physician who is the Director of the Comprehensive Integrated Pain Program at UHN, a clinician investigator with the Krembil Brain Institute, and a Professor at the University of Toronto.Dr. Andrea Furlan - Senior Scientist at The KITE Research Institute and a physiatrist with the Toronto Rehabilitation Institute, at UHN. Lara Pingue - Editor for the Globe and Mail. She lives with her husband and children in Toronto.Additional resources:Comprehensive Integrated Pain Program at UHN‘The Krembil Brain Institute’s chronic pain experts are using novel treatment approaches – and returning people to meaningful lives’ – Article in 2021 KBI Magazine, featuring Drs. Anuj Bhatia & Hance ClarkeDr. Andrea Furlan’s KITE Research Institute pageDr. Andrea Furlan’s Youtube ChannelDr. Andrea Furlan interviewed on UHN’s ‘Behind the Breakthrough’ podcastThe Krembil Brain Institute’s ‘Your Complex Brain’ podcast episode about Trigeminal Neuralgia – ‘The Most Painful Brain Disease You’ve Never Heard Of’ featuring Dr. Mojgan HodaieThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

When Brynn Ladley was born, she was a smiling, happy and healthy baby, hitting all of her developmental milestones. Then, at six weeks old, she began having seizures and eventually was diagnosed with CDKL5, a rare and debilitating genetic disorder that has no cure. Upon Brynn’s diagnosis, her mother Natalie became an advocate and connected with Dr. James Eubanks, a Senior Scientist at the Krembil Brain Institute, who has made it his life’s mission to pioneer advanced research looking at how brain function is altered in specific rare, neurodevelopmental conditions, such as CDKL5 and Rett SyndromeHe is also developing new therapeutic strategies to better treat, or one day even cure, these diseases. We’ll also hear from Brynn’s mother Natalie and from Richard Logan, Dr. Eubanks’ long-time lab manager, who are optimistic about advances in this research, in the years to come.Featuring: Dr. James Eubanks – Senior Scientist and Research Division Head at the Krembil Brain Institute, part of UHN.Natalie Ladly – President of CDKL5 Canada and mother to seven year-old Brynn Ladly, who is living with CDKL5.Richard Logan - Lab manager and senior technologist for Dr. Eubanks’ lab at the Krembil Brain Institute.Additional resources: CDKL5 CanadaOntario Rett Syndrome AssociationKrembil Brain Institute magazine article featuring Dr. EubanksUHN Foundation’s ‘Know Your Heroes’ article featuring Dr. EubanksCollingwood Today article about Bryn Ladley & her familyCanadian Organization for Rare Disorders The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Every year, 40 million people worldwide sustain a concussion – a type of traumatic brain injury caused by a hit or jolt to the head.We often hear about concussions in the context of sports, but most occur as a result of everyday life, from running or biking, accidental falls and motor vehicle accidents.While the vast majority of those who suffer a concussion recover in time, there are many who experience lasting symptoms. Researchers and clinicians want to know why - including Dr. Charles Tator, who's made it his life's mission to educate the public and the healthcare community about the impact of concussion, and to advocate for change in youth and professional sports.In this episode, we speak with Dr. Tator, a neurosurgeon and researcher at the Krembil Brain Institute, and Fran Rider, an athlete and a leader in women's hockey. Featuring: Dr. Charles Tator - Neurosurgeon and researcher with the Krembil Brain Institute, as well Director of the Canadian Concussion Centre, at UHN. Fran Rider – Co-founder, President and CEO of the Ontario Women's Hockey Association. Additional resources: Canadian Concussion Centre (CCC)The Hull-Ellis Concussion and Research Clinic at UHNCCC Concussion Safety Webinar Series‘The Quest to Solve the Concussion Problem’ – Your Complex Brain podcast featuring Dr. Carmela TartagliaToronto Star article – “Four high-profile Canadians to donate their brains for research into concussion effects in women”The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

When you think about your favourite memories, what comes to mind?Is it the championship win at your high school football game? Your child’s first words? Or the lyrics to a song you loved? In this episode, our experts tackle the big & thought-provoking questions, such as: How does our brain log & store memories? Where do memories go as we age? And why do we remember some things, and not others? Most importantly, are there any proven methods or tactics to help improve memory? The episode features neuropsychologists Dr. Mary Pat McAndrews and Dr. David Gold, as well as Dr. Samantha Audrain, a Postdoctoral fellow & trainee graduate from Dr. McAndrews’ lab.Featuring: Dr. Mary Pat McAndrews - Clinical neuropsychologist and senior scientist at the Krembil Brain Institute. She is also Division Head of Clinical and Computational Neuroscience at UHN. Dr. McAndrews’ work focuses on investigating memory and language in patients with memory disorders, including epilepsy and Alzheimer’s disease. Dr. David Gold - Neuropsychologist and clinician investigator with the Krembil Brain Institute. Dr. Gold primarily works with patients living with epilepsy and also regularly consults with UHN’s Memory and Neurosurgery clinics, as well as the Canadian Concussion Centre. Dr. Samantha Audrain - Postdoctoral fellow at the National Institute of Mental Health, and a former graduate student of the University of Toronto and UHN. Her research focuses on understanding how long-term memories are formed and stored in the brain and how that process is disrupted in patients experiencing memory dysfunction.Additional resources: UHN Neuropsychology ClinicUHN Memory ClinicUHN News story – ‘How to make a memory’How being curious led Dr. Mary Pat McAndrews to a career in scienceInt’l Day of Women and Girls in Science event - Dr. Mary Pat McAndrews presents about her research into memory (@23:40)ECHOEpilepsy series – Dr. David GoldThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

What happens when a vision researcher has a chance meeting with a pediatric oncologist and that collaboration leads to unexpected and promising results?In Episode 5 of Your Complex Brain, we’re talking about a homegrown vision rehabilitation program helping young brain cancer survivors, whose sight has been impacted by their tumours, improve their vision.The program, developed at University Health Network in Toronto, uses virtual reality to effectively retrain parts of the brain, allowing them to better perceive objects and obstacles.Joining us on the podcast today is neurobiologist, Dr. Michael Reber, and pediatric oncologist, Dr. Eric Bouffet. We’ll also hear from 18 year-old Jack Conway, one of the research participants in the study.Featuring: Dr. Michael Reber - Senior Scientist at the Donald K. Johnson Eye Institute, part of the Krembil Research Institute, at University Health Network, and Associate Professor in the Department of Ophthalmology and Vision Sciences at the University of Toronto.Dr. Eric Bouffet - Past director of the Pediatric Neuro-Oncology program at the Hospital for Sick Children in Toronto, and the first Garron Family Chair in Childhood Cancer Research.Jack Conway - High school student who is passionate about video games, theme parks, and politics. Jack was diagnosed with an optic pathway glioma brain tumour as an infant, and recently was a research participant in the Vision Rehab Study.Additional resources: Donald K. Johnson Eye Institute at UHNDr. Reber’s lab websiteThe Hospital for Sick ChildrenUHN Foundation story on this Vision Rehab StudyDr. Reber interviewed on UHN’s ‘Behind the Breakthrough’ podcastDr. Bouffet addresses United NationsThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Whether as a patient, a caregiver, a neighbour or a friend, chances are, one day, we will all be touched by Alzheimer’s or dementia. This disease steals our memories and cruelly robs us of our loved ones, often when we need them the most. But, there is hope and momentum in the world of Alzheimer's research. In fact, a new theory suggests that Alzheimer’s could even be an autoimmune disease. In this episode of Your Complex Brain, we speak with Dr. Donald Weaver and Dr. Saskia Sivananthan. We’ll also hear from Lindsay Bongard-Batori, who lost her mother Barbara to Alzheimer’s. Featuring: Dr. Donald Weaver – Neurologist, medicinal chemist & Senior Scientist with the Krembil Brain Institute at UHN. Dr. Weaver is an internationally recognized research leader in university-based drug design and discovery for neurological disorders. Dr. Saskia Sivananthan – Neuroscientist & Chief Science and Knowledge Translation Officer at the Alzheimer Society of Canada, overseeing the Alzheimer Society Research Program, a dementia research priority setting leader. Lindsay Bongard-Batori - Lost her beloved mother Barbara to Alzheimer’s in 2020, and hopes her story will help others caring for their loved ones.Additional resources: Dr. Donald Weaver’s lab websiteUHN – Dementia & Neurodegenerative DisordersAlzheimer Society of Canada (for information on latest research awards, patient stories, help for caregivers, provincial chapters)Alzheimer Society of Canada HotlineLandmark Study: Navigating the Path Forward for Dementia in Canada(VIDEO) A New Theory of Alzheimer’s (featuring Dr. Weaver)(VIDEO) Living with Dementia: A Caregiver’s Perspective(VIDEO) Risk Factors for Alzheimer’s and Dementia(PODCAST) What is it Going to Take to Cure Alzheimer’s (featuring Dr. Weaver + Patty Kim)The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Deep brain stimulation (DBS) is complex brain surgery in which electrodes are placed at strategic, predetermined targets within a patient's brain. The electrodes are then connected to a battery pack which is surgically inserted under the skin of the chest, like a pacemaker.When DBS was first introduced as a treatment option for people living with Parkinson’s disease more than 20 years ago, it was a game changer.In this episode of Your Complex Brain, we’ll speak with Krembil Brain Institute neurosurgeon, Dr. Suneil Kalia, and neurologist, Dr. Alfonso Fasano, about the future of DBS – and how it could be used to help many more patients improve their quality of life, including those living with other neurological diseases.We’ll also hear from CBC journalist Harry Forestell about his DBS journey.Featuring: Dr. Suneil Kalia – Neurosurgeon & Senior Scientist at the Krembil Brain Institute & Associate Professor in the Division of Neurosurgery, Department of Surgery, University of Toronto. As a stereotactic and functional neurosurgeon, Dr. Kalia focuses on the surgical management of movement disorders, epilepsy and pain. He holds the R.R. Tasker Chair in Stereotactic and Functional Neurosurgery.Dr. Alfonso Fasano – Neurologist & Clinician Investigator with the Edmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, at the Krembil Brain Institute (Toronto Western Hospital). Dr. Fasano is a Professor of Medicine, Department of Neurology, at the University of Toronto. He holds the Chair in Neuromodulation at UHN. Harry Forestell – Long-time CBC journalist who has reported on some of the biggest stories of our time, and is the current host of CBC News New Brunswick at 6. At the age of 53, Harry was diagnosed with Parkinson’s disease and subsequently had DBS surgery. Harry is first and foremost a family man; he is married to Jennifer and they have two beautiful daughters.Additional resources: Krembil Brain Institute’s Movement Disorders Clinic (Toronto Western Hospital)Krembil Brain Institute’s DBS Surgery Information PageCBC story about Harry Forestell’s DBS experience & surgeryVIDEO – Harry Forestell story ‘See the instantaneous effects oThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Women make up nearly half of the world's population and have higher rates of neurological disorders, yet there is still a gap when it comes to better understanding and treating women living with brain-related illnesses. Many women also face systemic barriers and biases when they seek help, often leading to a delay in diagnosis and treatment.Featuring: Dr. Esther Bui - Neurologist and clinician educator at UHN’s Krembil Brain Institute and assistant professor at the University of Toronto. Her research includes the creation of Canada’s first accredited Women’s Neurology Clinic and training program.  Find her on Twitter: @womensneurologyDr. Mary Angela O'Neal - Director of the Women's Neurology program at the Brigham and Women's Hospital in Boston, and an assistant professor of neurology at Harvard University. Dr. O’Neal also directs a Harvard Medical School course in Women’s Neurology and Psychiatry.Nikki Ashworth – Experiencing seizures since she was a child, Nikki was only diagnosed with temporal lobe epilepsy in her 30s. Her seizures may come without warning, but she's been turning her experience into an art form with her dark and honest unintentional comedy. Find Nikki on IG: @strange_missRoshan Malhan - A second-year medical student at the University of Toronto’s Temerty Faculty of Medicine, where he acts as a co-director for the Anesthesia Interest Group and Emergency Medicine Interest Group. He is currently exploring his interests in a number of medical specialties and looking forward to gaining additional insights during clerkship. Additional resources: UHN Epilepsy ClinicUHN Foundation ‘Know Your Heroes’ Q&A with Dr. BuiCanadian Leader in Neurology: Dr. BuiBrigham and Women’s Hospital Women’s Neurology ProgramWomen’s Health in Neurology – Dr. O’Neal (video)The Lullaby Project (Massey Hall & Roy Thomson Hall)“My epilepticThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

In a world that appears to be becoming more and more divisive, there's one thing we can all agree on. As a society, we are stressed out. Whether it's financial pressures, family or work obligations, or even just finding time for yourself in a never-ending tornado of to-do lists, stress is everywhere and it's not going away. We often talk about the physiology of stress and how it affects us physically and mentally, but in this episode of Your Complex Brain, we delve much deeper to talk about the science of stress - what's actually happening in our brain and our body when the stress response is activated, and how these insights could lead to new approaches and therapies for treating disease. We’ll speak with internationally renowned neuroscientist, Dr. Jaideep Bains, about his research looking at how the brain processes, activates, and adapts to stress, and whether stress is contagious. We’ll also hear from clinical psychologist, Dr. Kathryn Curtis, about the power of mindfulness and mindful breathing to help decrease stress, and we’ll have a first-hand account of dealing with stress and burnout from Farrah Schwartz. Featuring: Dr. Jaideep Bains - Director of the Krembil Research Institute and a Senior Scientist with the Krembil Brain Institute at UHN. For the past two decades, Dr. Bains has led a successful research team at the University of Calgary, making many important discoveries that have provided insights into how the brain adapts to stress.  Dr. Kathryn Curtis – a Clinical Psychologist at the Comprehensive Integrated Pain Program at UHN, where she provides psychological services to individuals living with chronic pain. Dr. Curtis’ research evaluates mind-body interventions, such as yoga and mindfulness, for populations experiencing chronic pain and mobility restrictions.Farrah Schwartz - Manager of Patient Education and Engagement, at UHN. Farrah has worked in the patient education field for more than 15 years and regularly teaches and presents on the impact of health literacy on health outcomes and experience. After 15 years as a mother, Farrah still learns new things most days, and feels it is vitally important to talk about the challenges of parenting openly to build support and reduce the stigma of mother/parent burnout and stress. Additional resources: Dr. Jaideep Bains’ lab website Dr. Jaideep Bains’ public talk – ‘Is My Stress Your Stress?’ Dr. Jaideep Bains onThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Well, it’s no surprise. Since last season, our brains haven’t gotten any less complex! But that just means there are even more stories to share about the mysteries, myths and science behind how our brains work, and what keeps our brains healthy and fit. On Season 2 of our podcast Your Complex Brain, we’ll highlight the latest research, technology and innovations in brain science by speaking with thought leaders & experts, as well as patients, their families and the dedicated care teams on the front lines of keeping our brains healthy - and fixing them when illnesses arise. This season, we’ll be looking for answers to some pretty big questions – such as, ‘Is stress contagious?’ ‘Why are many women living with brain disease experiencing a delay in diagnosis?’ And, ‘How could advances in technology improve outcomes for patients who undergo deep brain stimulation?’And those are just the first three episodes!There are a million amazing things to know about your complex brain – and we couldn’t be more excited to explore them with you.The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

We’ll be launching Season 2 of the Your Complex Brain podcast next spring and we are so excited to bring you even more fascinating topics and inspiring stories about the most complex and fascinating organ in your body – your brain.Until then, please check out our friends at Behind the Breakthrough, a podcast hosted by Christian Cote, showcasing the ground breaking research and the people behind it, at University Health Network, in Toronto.  Behind the Breakthrough is on all major streaming platforms and Season 4 is not to be missed!The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

It’s been more than two years since Susie Goulding contracted COVID-19. But, like many others experiencing long COVID, her ordeal is far from over.On today’s episode of Your Complex Brain, Heather explores what the medical and science communities are learning about the long-term impacts of COVID-19 – and all the mysteries that remain. After hearing a first-hand account from Susie, Heather meets with three researchers and clinicians at UHN, all of whom are investigating COVID’s enduring brain-related symptoms, such as headaches, brain fog and memory issues. They discuss what is currently being studied, the latest insights into what may be causing these symptoms, and how to provide effective treatments.Featuring:Dr. Carmela Tartaglia, a Cognitive Neurologist and Clinician Investigator with Krembil Brain Institute. Dr. Tartaglia is also co-Director of UHN’s Memory Clinic. She is currently involved in a number of studies looking at the cognitive and neuropsychiatric impact of long COVID on patients, as well as sex and gender differences in long COVID. Dr. Angela Cheung is an Internal Medicine Specialist and Senior Scientist at UHN. Dr. Cheung is the co-Lead Investigator of the Canadian COVID-19 Prospective Cohort Study, also known as CANCOV, which is designed to better understand the short and long-term outcomes for patients with long COVID and their caregivers. Dr. Abdu Sharkawy is an Internal Medicine & Infectious Diseases Specialist at UHN. Under the mentorship and support of Dr. Cheung, he has become an active and dedicated consultant to UHN’s Long Covid Clinic. Dr. Sharkawy is also a trusted public figure who is regularly called upon by media, to comment on the latest COVID-19-related news and information. Special thanks to Susie Goulding for sharing her story.Additional Resources:The Canadian COVID-19 Prospective Cohort Study (at UHN)Toronto Rehab Long Covid Clinic COVID Long Haulers Facebook Support Group CanadaCOVID Long Haulers CanadaListen to Dr. Angela Cheung on UHN’s Behind the Breakthrough podcast Listen to Susie Goulding on The Big Story The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Imagine not being able to brush your teeth, eat a sandwich or cuddle your children because of the intense pain. That’s the reality for many people living with trigeminal neuralgia, an unrelenting form of chronic facial pain. For many of these patients, a smile, a kiss, or even a gust of wind can unleash a throbbing so severe, some describe it as a ‘lightning bolt to the face.’Because trigeminal neuralgia is so rare and so misunderstood, some physicians have never even heard of it. Luckily, many patients here in Canada and from around the world find their way to Dr Mojgan Hodaie, a Neurosurgeon and Senior Scientist with Krembil Brain Institute. Dr. Hodaie is an internationally renowned expert in trigeminal neuralgia.In this episode, Dr. Hodaie talks about her quest to better understand where the pain originates from in trigeminal neuralgia, and where it travels within the brain, so that she can develop new and more personalized treatment options for patients.  She also discusses her groundbreaking research and advanced imaging techniques that may also help those suffering with other types of chronic pain disorders.Featuring:Dr. Mojgan Hodaie is a Neurosurgeon and Senior Scientist with Krembil Brain Institute, as well as the Greg Wilkins-Barrick Chair in International Surgery at UHN, Surgical co-Director of the Joey & Toby Tanenbaum Family Gamma Knife Centre, and the Education Lead at Krembil Brain Institute, traveling the world to teach and mentor the next generation of neurosurgeons. Dr. Hodaie is also a Professor in the Department of Surgery at the University of Toronto.Dr. Hodaie’s clinical treatment is focused primarily on the management of facial pain. Her research team has a particular interest in advanced MR technology approaches for the study of facial neuropathic pain.Special thanks to Josh Johnston and Asma Naheed for sharing their stories.Additional Resources:Dr. Mojgan Hodaie’s Lab at Krembil Brain InstituteUHN’s Comprehensive Integrated Pain ProgramKBI Magazine story featuring Josh Johnston “I genuinely believed I was about to die”Trigeminal Neuralgia Association of CanadaThe Facial Pain AssociationCBC Story – “Toronto Neurosurgeon Marks 1000th OpeThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

More than 100,000 Canadians are living with Parkinson's, a progressive brain disease that can impact mobility, cognitive function and speech. In this episode, Heather explores what it means to not just live with Parkinson’s, but to ‘live well,’ with meaning and purpose. She meets with two patients currently living with Parkinson’s, who are on a mission to help others on the same journey, and a neurologist and scientist, who sees Parkinson’s patients and researches new approaches to treatment. The guests are all members of the Patient Advisory Board (PAB) at Krembil Brain Institute's world-renowned Movement Disorders Clinic. The PAB’s mandate is to help improve the quality of research, communication, and the overall patient experience within the clinic, and to redefine how healthcare professionals and patients communicate with each other, in the hopes that this novel approach to patient partnership could help move the Parkinson's field forward and improve patient outcomes.Featuring: Hugh Johnston is a retired professional accountant who spent many years as a strategic advisor to several of Canada’s top foodservice companies, helping to streamline operations and boost efficiency. Hugh’s business expertise came in very handy as the founding Chair of the Patient Advisory Board at Krembil Brain Institute’s Movement Disorders Clinic.Dr. Soania Mathur is Chair of the Research Committee of the PAB, as well as Co-Chair of the Patient Council and a member of the Executive Science Advisory Board of the Michael J. Fox Foundation for Parkinson's Research. She is also one of the founders of PD Avengers, a global alliance of people with Parkinson's who are advocating for change, and the Founder of UnshakeableMD, a virtual platform helping to educate and engage those with Parkinson's to live full and productive lives. Dr. Alfonso Fasano is a neurologist and a Clinician Investigator at Krembil Brain Institute (KBI), working primarily with patients living with Parkinson’s. He also holds the Chair in Neuromodulation and is co-Director of the Surgical Program for Movement Disorders at KBI, as well as Medical Advisor to the PAB. Additional Resources:Krembil Brain Institute Movement Disorders Clinic Movement Disorders Clinic Speaker Series (featuring Hugh & Soania)Parkinson Canada UnshakeableMD PDAvengers The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

More than 50 years after emerging as a potential treatment for anxiety and depression, addiction, post-traumatic stress disorder and other chronic illnesses, psychedelics appear to be making a comeback. But where does the research stand currently on psychedelics and what do we really know about how these compounds may affect the brain?With the number of people living with mental health conditions on the rise and the re-emergence of psychedelics as a possible therapy, this topic is very timely. Some may call it a “perfect storm” – one the medical and scientific communities will need to carefully navigate, in order to tap the potential of psychedelics, safely and cautiously.Featuring:Dr. Susan Abbey is Psychiatrist-in-Chief at the University Health Network (UHN), and a Clinician Investigator with the Toronto General Hospital Research Institute.  She is also a Professor in the Department of Psychiatry at The University of Toronto and the inaugural Director of the Nikean Psychedelic Psychotherapy Research Centre at UHN.Dr. Lakshmi Kotra is a Medicinal Chemist and Senior Scientist with Krembil Brain Institute and a Professor of Medicinal Chemistry at The University of Toronto. He is also an academic entrepreneur with three decades of expertise in drug discovery, development, and pharmaceuticals, and the co-founder and CEO of Lucid Psycheceuticals.Additional Resources:Nikean Psychedelic Psychotherapy Research Centre at UHNFirst-of-its-kind research centre will bring psychedelic psychotherapy to UHN The Revival of Psychedelic Research – ORT Times articleLucid PsycheceuticalsThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!