MDS Podcast

Dr. Divyani Garg speaks with Dr. Hubert H. Fernandez about tavapadon, a once-daily selective dopamine D1/D5 receptor agonist, and what the TEMPO clinical development program tells us about its potential role in Parkinson’s disease (PD). They discuss the rationale for D1/D5 stimulation, findings from other TEMPO programs, the magnitude and clinical meaning of the motor benefit, flexible dosing, and the important tolerability and discontinuation findings from TEMPO-2. The conversation also explores where tavapadon might fit relative to levodopa and conventional D2/D3 dopamine agonists, and its potential role across different stages of PD. Read the article.

Prof. Jeffrey Kordower and Prof. Franziska Richter Assêncio join Prof. Tiago Outeiro to discuss the historical use of animal models in the field of Parkinson's disease. Together they review ethical issues, the value of different types of models, and their relevance to the field.

In this new episode of the Hot Topic 'Prodromal synucleinopathies' Dr. Eva Schäffer joins Dr. Eduardo de Pablo Fernández to discuss recent advances, future challenges, and practical clinical advice in prodromal Parkinson's disease.

In this episode, Dr. Kathryn Yang discusses a case of a young girl with subacute-onset jerky movements with an interesting finding on oculomotor examination, and explores the etiological diagnosis of this peculiar syndrome. Read the article.

Sleep Specialist Dr. Laura Pérez-Carbonell joins Dr. Eduardo de Pablo Fernández to discuss a wide range of topics related to REM sleep behaviour disorder as a prodromal synucleinopathy.