Life Optimized

This week, I speak with Dr. Elizabeth Sharp, M.D., IFMCP. She is a board-certified Internal Medicine Physician, Institute for Functional Medicine Certified Practitioner and the founder and CEO of Health Meets Wellness. Elizabeth started Health Meets Wellness to make functional medicine more accessible, combining her expertise in healthcare with physical activity, specifically yoga. She is dedicated to helping her patients reach their wellness goals and developed the Health Meet Wellness method with Troy Flanagan, Ph.D. and Susie Parker-Simmons, RDN, specifically to help patients with weight management.  In addition to her innovative practice, she is an Assistant Professor at Mount Sinai Hospital. We chat about her holistic approach to health and wellness, focusing on the integration of medicine, exercise, and nutrition to optimize overall well-being and treat autoimmune diseases.In this episode you will:Understand the importance of a personalized approach in treating health conditions.Recognize the role of diet, exercise, and nutrition in optimizing health.Be able to Identify the potential triggers and root causes of autoimmune conditions.Know what questions to ask your provider for the most comprehensive assessmentLearn the key pillars to holistic health Connect with Dr. Elizabeth Sharp:Website: https://healthmeetswellness.com/Instagram: https://www.instagram.com/dr.elizabethsharp/Use code Paulvin10 for a gift!

In today’s episode, I speak with Dr. Kamal Obbad, the co-founder of Nebula Genomics. Kamal is a Harvard and Gates-Cambridge Scholar with research experience at Google. Recognizing a gap in the consumer market for Whole Genome Sequencing (WGS), he co-founded Nebula Genomics to democratize access to comprehensive genomic data. Kamal aims to make personal genomics mainstream and accessible. We chat about the significance of whole genome sequencing and its potential to improve health and wellness. Kamal gives us a lesson on what the genome is, the importance of studying the whole genome sequence for health optimization, and why it has previously been so cost prohibitive to secure whole genome sequencing. In this episode you will learn:- Understand the concept of personal genomics and its potential impact on health and wellness.- Learn about the difference between whole genome sequencing and other genetic tests.- Gain knowledge about the complexity of DNA and the importance of non-coding regions in genetic analysis.- Recognize the limitations and concerns associated with genetic testing and the need for genetic counseling.- Explore the future possibilities of DNA sequencing and its role in personalized medicineLearn more about Nebula Genomics and Kamal’s work: nebula.org

In today’s episode, I talk with Kirsty Godso, Nike trainer and entrepreneur, about optimizing workouts and diet for maximum results. We discuss what women need to know when looking at their workout planning, the role of supplementation in fitness, and the impact of nutrition on overall health. Kirsty shares her personal journey in the fitness industry and highlights the need for trainers to adapt their programs to individual needs. We also touch on the benefits of high-intensity workouts, the challenges of balancing hormones in active females, and the importance of outdoor time for mental health. Show Highlights:The key ratio for high-intensity workouts to see results What women need to know about high-intensity workoutsThe latest in supplementation for muscle recovery and performance enhancementHow to integrate new routines to enhance sleep and reduce brain fogConnect with Kristy:madeof.comkirstygodso.comConnect with Dr. Paulvinhttps://doctorpaulvin.com/

Schlidt is the cofounder and managing partner at Palo Santo, a venture capital fund focused exclusively on the advancement of psychedelic therapies for the treatment of mental health disorders and beyond. Based on his own experience with severe depression as a teenager, Schlidt's goal is to steward the most efficacious psychedelic therapies towards FDA approval so that patients may safely, legally, and affordably access these medicines. He has deployed $25 million into 20 companies including Gilgamesh, Journey Clinical and Sensorium.Show Highlights:-The potential of psychedelics for mental health treatment.-Tim's story leading to investment in psychedelics.-Why to practice safe and supervised use of psychedelics in treatment.-Legal and ethical considerations around the use of psychedelics.-What are challenges in developing psychedelics?-Predicitons for psychedelics in mainstream medicine.-Psychedelics for therapeutic and personal growth.

Katrine is a health practitioner, author, researcher, and heavy metals detoxification specialist. After growing up in Russia and being negatively affected by radiation fallout from Chernobyl, she had to find her own path to health. She gained a wide knowledge of natural methods for detoxifying and rebuilding the body. Now she helps individuals achieve their own health goals through the combination of state-of-the-art technology, nutrition, and holistic healing. Show Highlights:  -Katrine’s journey of personal transformation in health.  -How to prepare for radiological tests. -The current rise of bioregulators.  -A deep dive into the future of supplements.  -What are the long-lasting effects of neurofeedback? -Analyzing brain wave patterns.  

Summary Join me in conversation with Hannah Went, a leading figure in epigenetics research, as we explore the science behind biological age testing and its potential impact on personalized healthcare.  Hannah attended the University of Kentucky and graduated with a degree in Biology. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation-based age diagnostics and started TruDiagnostics in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers. Since TruDiagnostic’s inception, they have created one of the largest private epigenetic health databases in the world with over 30,000 patients tested to date. Hannah has since created Everything Epigenetics where she shares insights on how DNA regulation has an impact on your health.    Show Highlights:  -What factors influence how your cells age? -Lifestyle tips to promote healthy cellular aging.  -What makes one aging test special compared to others? -Misconceptions about biological age clocks. -What is the future of epigenetics?  

In today's show, I talk to Jonah Rosner, former NFL sports scientist turned running scientist and high-performance coach. At 25 he was one of the youngest sports scientists in NFL history for the Houston Texans. He also worked across Major League Soccer at Austin FC, the NBA, and NCAA college basketball at University of Texas where he also received his master’s degree in exercise physiology. Jonah specializes in using the latest sports science technology and testing to individualize strength and endurance training programs.Show HighlightsHow to improve your VO2 Max.The best supplements to enhance athletic performance.Will nitrates really improve your endurance?How to use Blood Flow Restriction to boost your training.What is biomechanical feedback and how does it help?The best wearables for performance data.ResourcesFollow Jonah - https://www.instagram.com/rosnerperformance/Connect with Dr. Paulvinhttps://doctorpaulvin.com/

In today's show I talk to Pamela Gold, the founder of PRTL (formerly HACKD Fitness) NYC's first biohacking fitness studio, author of Find More Strength: 5 Pillars to Unlock Unlimited Power and Happiness and forthcoming book Timeless in Less Time: 12 Weeks to Optimized Fitness for Life, creator of Peace Power Parenting, an online course to support conscious parenting. Pam is an expert in integrated (physical, mental and energetic) fitness, minimum effective dose fitness, and biohacking. Show Highlights:Why you need to practice self-awareness and learn to listen to your body.The positive impact of a daily meditation practice.How to balance work, family, and personal well-being.The unique needs of women in biohacking.How to optimize your health with a data-driven approach.Tools and strategies for more effective workouts.Learning to trust yourself without relying on other people’s opinions.It’s never too early to teach self-awareness to children.ResourcesVisit PRTL: https://prtl.com/Connect with Dr. Paulvinhttps://doctorpaulvin.com/

In today's show I talk to Wade Lightheart, 3-Time Canadian Natural Bodybuilding Champion, and one of the world's premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition, and exercise which have sold in over 80 countries. Wade is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels.Show Highlights:Why bodybuilding is the original biohacking.The biggest three factors that affect your outcomes in health and fitness.How to lose weight sustainably.The connection between resistance training and your metabolism.Why do many people fail with their diets?Ways to extend your lifespan to 100 years old.How to use your unique psychological, emotional, and genetic makeup to your advantage.ResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

We're continuing the mini-series on Alzheimer's disease, this time with a focus on specific steps you can take to evaluate and reduce your risk of contracting the sickness. Unfortunately, there isn't yet a specific treatment for the disease, but that doesn't mean you can't take action now.Show Highlights:How to test for Alzheimer's before it's too lateLifestyle and nutrition changes you should make immediatelySurprising ways Low Dose Naltrexone can helpWhy you should care about your MicrogliaHow increasing antioxidants in your body may prevent diseaseSupplements that may reduce your risk of Alzheimer'sResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

In this episode, we're going to discuss the latest insights and biohacking techniques to help improve brain health, with a focus on Alzheimer's disease. Learn about new medicines, supplements, and technology that can help optimize your brain performance.Show Highlights:What causes Alzheimer's disease?Which lab tests can help evaluate potential brain issues and signs of inflammation.What factors can lead to neurodegenerative symptoms.Why memory loss is a common symptom of brain issues.The latest medicines and supplements for treating Alzheimer's diseaseRecommendations for technology you can use in your own home to optimize brain performance.How you can reduce your risk of developing Azheimer's disease.ResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

In this episode of the Life to Optimize Podcast, Dr. Neil Pop discusses two main topics: bioregulators and a new peptide called SS-31 (or Elamipretide). Bioregulators, which have been around since the Cold War, are small proteins that work on specific DNA sites to regulate gene expression and DNA methylation, promoting health and longevity. SS 31 is a mitochondrial peptide with antioxidant and anti-inflammatory properties, currently undergoing extensive research. It shows promise in heart health, tendon and joint healing, and potential benefits for Alzheimer's and brain health. Show Highlights:What are bioregulators?Ideal dosages and duration for taking bioregulators.The best place to get bioregulators and peptides.What is SS-31 and how can it help you?Can Elamipretide help your brain and prevent Alzheimer's?The surprising benefits of SS-31 and other similar peptides.ResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

Today’s episode is all about fertility. We’ll be discussing various techniques to boost fertility, and the potential negative effects of birth control pills on female hormones. Cutting-edge stem cell treatments and other advancements are also discussed. We'll also cover the impact of inflammation and insulin resistance on mitochondrial function, and what that means for fitness and overall health. Show Highlights:How to reduce inflammation in your body.What can women do to boost fertility?Do stem cell treatments help with infertility?The latest advancements in female fertility treatments.How do birth control pills affect female hormones and fertility?Which lifestyle choices and supplements optimize women's sexual health?ResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

Today’s episode is all about supplements. We’ll be discussing different kinds of supplements, which ones you should stay away from, and what makes supplements the way they are.  Listen and find out about Spermidine, Urolithin A, and more supplements that can help you in the future.Show Highlights:What are supplements?What kind of supplements are out there?Which one’s are good and bad?What’s Spermidine?Urolithin A and why it’s a strong supplement.What’s Butyrate?The two supplements that improve overall health and longevityHow sleep influences supplemental careSupplements mentioned in this episode:SpermidineUrolithin AButyrateResveratrolApigeninMetforminResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

Dr. Hill is one of the top peak performance coaches in the country. He holds a Ph.D. in Cognitive Neuroscience from UCLA’s Department of Psychology and continues to do research on attention and cognition. Research methodology includes EEG, QEEG, and ERP. He has been practicing neurofeedback since 2003.In addition to founding Peak Brain Institute, Dr. Hill is the host of the Head First Podcast with Dr. Hill and lectures at UCLA, teaching courses in psychology, neuroscience, and gerontology.Show Highlights:Learn how you can use neurofeedback to optimize brain functionCan neurofeedback treat ADHD?How does Neurofeedback work?Discover the science behind brain mapping and how it can identify areas of the brain that need attention.How long do the benefits of neurofeedback last?Is it possible to train your brain for higher achievement?What does AI mean for the future of neurofeedback?How to be the best version of yourselfPeak Brain InstitutePeak Brain Institute - Brain Gym & Peak Performance CenterResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/

Ryan Smith received a BA in biochemistry from Transylvania University before heading to medical school in 2013. After passing USMLE Step 1, he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US and grew to 80 million in revenue within 3 years. Ryan exited Tailor Made in 2020 to create TruDiagnostic. TruDiagnostic is a CLIA certified lab and health data company which specializes in understanding and reporting insights found through Epigenetic methylation data. TruDiagnostics has also led research in the field with over 30+ clinical trials investigating the best ways to reverse these markers through diet, lifestyle, and prescription interventions. Currently, TruDiagnostic is working with collaborators from Duke, Harvard, Yale, UCSF, Ohio St. and more to uncover new insights from the methylome. TruDiagnostic is also the only commercial company on the market to offer 2nd or 3rd generation aging algorithms which have shown to be more predictive and precise than 1st generation aging clocks.Show Highlights:The current state of anti-aging medicineWhy it's important to measure biological age accurately The best measurement tools for anti-agingWhy you should start testing your biological age as early as possibleWhat data can tell us about the health of an individual beyond agingWhich lifestyle changes will be most helpful for optimizing your health spanResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/TruDiagnostic™ | Advanced Epigenetic Testing

In today's show I talk to Dr. Jay T. Wiles about Heart Rate Variability. We go really deep into all the aspects of HRV. From measuring it accurately to optimizing the factors that affect it. Everything you need to know and more!Dr. Jay T. Wiles is a clinical health psychologist, currently working as the Health Behavior Coordinator at WJB Dorn VA Medical Center in Columbia, SC and the Greenville Outpatient VA Clinic. He has specialized training in health behavior coaching, health assessment, nutritional interventions for mental and physical health, Motivational Interviewing, applied psychophysiology, and consultation. Dr. Wiles works as a consultant for companies/organizations, practitioners, and individual patients on nutritional psychology, health behavior change, applied psychophysiology, and health promotion/disease prevention via complementary and integrative practices.Show Highlights:What is Heart Rate Variability, and why should you measure it?How to measure your Heart Rate VariabilityThe common problems with wearable technologyOptimal ranges for your HRVHow to interpret your biometric dataWhat affects your HRV both positively and negativelyThe surprising connection between HRV and mental healthResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/Home - Hanu Health, Inc. - Use code DRPAULVIN for 20% off

Today’s episode is a deep dive into peptides. There has been a lot of hype in the Biohacking community around these amazing products. Research is quickly evolving, and keeping up with the latest developments can be difficult. Listen and learn how you can get the most out of peptides to help with your healing and recovery.Show Highlights:What are peptides?How should you take peptides?The best peptides for pain and recoveryAre there risks to taking peptides?The Wolverine Stack – the ultimate in regenerative healingHow to use peptides to lower inflammationWhy you need to pay attention to mitochondrial peptidesPeptides discussed in this episode:Thymosin Alpha 1ThymulinBPC157CJC 1295Melanotan 1 & 2Thymosin Beta 4 (TB4)TB5GHK CopperPentosan PolysulfateAOD9204P21M677TesamorelinKPVMOTS-CSS 31Resources:Connect with Dr. Paulvinhttps://doctorpaulvin.com/

Today’s show is a deep dive into exogenous ketones. You’ll learn about the latest advances and products, what the benefits are, and what to expect from the upcoming research in this exciting field. I’m joined by Frank LLosa, the CEO and founder of KetoneAid. He’s an expert on all things ketones, and I’m excited to have him on today’s show to help us learn more!Show Highlights:What are exogenous ketones?Your body’s fuel source: glucose or ketonesWhy we should beware of the misinformation in the world about products related to ketones and ketosisHow to understand ketone esters, BHB, and what they do for the bodyThe top benefits of using a ketone product: recovery, mental cognition, and sleepHow exogenous ketones should be taken (Too much of a good thing is NOT good!)What to expect from exogenous ketones in brain activityHow following the keto diet differs from taking exogenous ketonesWhat exogenous ketones can do for high-performance athletes and average athletesHow to be an educated consumer in today’s ketone marketWhere the future is headed in the field of exogenous ketonesAn overview of products available at KetoneAid (including their upcoming ketogenic, gluten-free beer!)Where ketone science is headed for the futureResources:Connect with Dr. Paulvinhttps://doctorpaulvin.com/Connect with Frank and KetoneAidwww.ketoneaid.com, Instagram, Facebook, and YouTube

We are diving deep into some of today’s most popular scientific breakthroughs in the field of health optimization. My expert guest shares real-life applications from his wealth of knowledge and experience. Join us to learn more about feeling better, looking better, and adding years to your health span!Dr. John Sottery is a Ph.D. scientist who believes that “aging normally” is a disaster. As a 63-year-old with young children, he is incredibly focused on maximizing his health and lifespan. His goal is to teach others how to outperform their chronological age through mitochondrial and cardiovascular health, and he focuses his research on ways to turn on the body’s genes that will drive protection and repair. After obtaining his doctorate in chemistry from Duke University, he led project development teams at Procter & Gamble before leaving to start several companies of his own. Through his work today, he attacks problems to understand them at a molecular level to maximize health span, slow down the damage, and accelerate repair in the body. Show Highlights:What is most important to know in optimizing mitochondrial healthWhy we need to understand what damages mitochondria, how to get rid of the damaged ones, and how to create new mitochondria from undamaged onesDr. John’s #1 tip for mitochondrial health: Don’t eat within three hours of going to bed.How to push your mitochondria with ice baths, saunas, or HIIT workouts–so that your body knows how to recycle defective mitochondriaHow to understand the basics of intermittent fasting, autophagy, antioxidants, and free radicalsWhy broccoli sprouts are good for us–and other foods that turn up Nrf2How the body’s phase 2 toxification enzymes work to eliminate carcinogensDr. John’s take on getting vital nutrients from food vs. relying on supplementsHow to get the most nutrition out of the broccoli you eatHow fasting, exercise, Resveratrol, and spermidine help turn up autophagyHighlights of the overall benefits of spermidine, including recent research about preventing colon cancer and osteoporosisSources and benefits of ergothioneine (an amino acid found primarily in mushrooms)Why copper can be the difference between mild cognitive impairment and full-blown Alzheimer’s (Eat your mushrooms!)Why YOUR body has its own recipe for optimal healthDr. John’s final thoughts about how excess fructose, alpha tocopherols, and omega-6 fats are harming peopleResourcesConnect with Dr. Paulvinhttps://doctorpaulvin.com/Connect with Dr. Johnwww.johnsottery.com, Facebook, and YouTubeMentioned in this episode: Dr. Guido Kroemer on YouTube, Nature Wants Us to Be Fat by Dr. Richard Johnson and Drop Acid by Dr. David Perlmutter