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Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine and have special guests talking about their area of expertise! This podcast is made for educational purposes. The content provided in this podcast, and in any linked materials, is not intended and should not be construed as medical advice and should not be used to diagnose or treat any medical condition. We try to stay away from opinions but all opinions represent our own and not of any entity we work for. Please keep this in mind as you enjoy the podcast!
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Send us a Text Message (please include your email so we can respond!) Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM. SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/ SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502 SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/ SBT Timin...
Send us a Text Message (please include your email so we can respond!) We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025 PIC (pubmed): https://pubmed.ncbi.nlm.ni...
Send us a Text Message (please include your email so we can respond!) Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/ UK-RO...
Send us a Text Message (please include your email so we can respond!) Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018. FLUID: https://pubmed.ncbi.nlm.nih.gov/405...
Send us a Text Message (please include your email so we can respond!) Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one! Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/ JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276 Editorial: https:...
1Send us a Text Message (please include your email so we can respond!) Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM. RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/ PROMIZING (pubmed): h...
Send us a Text Message (please include your email so we can respond!) Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial". Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode! Pubmed: https://pubmed.ncbi.nlm.nih...
Send us a Text Message (please include your email so we can respond!) Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference! If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon...
Send us a Text Message (please include your email so we can respond!) Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/ AJRCCM: https://www.atsj...
Send us a Text Message (please include your email so we can respond!) Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding! Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/ Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/ Transfusion threshold (NEJM): htt...
Send us a Text Message (please include your email so we can respond!) Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025. Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be su...
Send us a Text Message (please include your email so we can respond!) Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014. PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/ PEITHO: https://...
Send us a Text Message (please include your email so we can respond!) Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedetomidine articles was in Lancet Respiratory medicine, rather, it was published in eClinical Medicine part of...
Send us a Text Message (please include your email so we can respond!) Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How I do it" series from CHEST. Auto-PEEP (NEJM): https://www.nejm.org/doi/full/10.1056/NEJM199307153290322 Extuba...
Send us a Text Message (please include your email so we can respond!) Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al both published in CCM in 2025. PROACTIVE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982178/ PROACTIVE (CCM):...
Send us a Text Message (please include your email so we can respond!) Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We then frustrate Todd with questions from our mailbag, a good episode! TRAUMOX2 (pubmed): https://pubmed.ncbi.nlm.nih...
Send us a Text Message (please include your email so we can respond!) Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure" published in NEJM May 2015 RENOVATE (pubmed): ht...
Send us a Text Message (please include your email so we can respond!) Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A long episode but a lot of good discussion SCREEN (pubmed): https://pubmed.ncbi.nlm.nih.gov/39658862/ SCR...
Send us a Text Message (please include your email so we can respond!) Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis" published by Dark et al in JAMA 2024 and presented at the CCR Down Under Conference. ADAPT-Sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39652885/ ADAPT-Sepsis (JAMA): https:/...
Send us a Text Message (please include your email so we can respond!) Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy! TIGHT K: https://pubmed.ncbi.nlm.nih.gov/39215972/ PROPHY VAP: https://pubmed.ncbi.nlm.nih.gov/38262428...
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