Sapio with Buck Joffrey

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat. Show Notes: 00:47 Is It Fine That I Sleep Too Much? 08:08 The 40hz Gamma Frequency and How It Relates to Brain Health 13:28 The Anti-Aging Effects of Human Growth Hormone 20:31 Reconsideration of How to Fast 29:22 Potentially Harmful Effect of NMN 33:08 Visceral vs Subcutaneous Fat  

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet. Show Notes:  01:10 Types of Fasting 03:31 Why Fasting is Beneficial From a Cellular Level 07:00 Intermittent Fasting VS Fast Mimicking Diet 14:05 How Does Fasting Help Cancer Patients 20:37 What Is in the Fast Mimicking Diet 33:38 Pills and Supplements for Fasting Mimicking Diet 41:23 Time-Restricted Feeding Based on Circadian Rhythm  

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health. Show Notes: 01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment 04:14 When Did People Start to Take Metabolic Syndrome Seriously? 08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint? 10:21 The Balance Between Building and Breaking Down in the Metabolic System 14:41 Time-Restricted Feeding and Ketogenic Diet 28:31 The Role of Medications and Supplements 30:51 Lifestyle and Exercise as Intervention  

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment. Show Notes: 00:58 What Really is Healthspan? 05:06 Biological Age VS Chronological Age 07:41 The Factors that Determine Biological Aging 12:08 What Happens When You Artificially Suppress These Factors 16:58 What is Phenomics and how can it predict diseases? 24:21 How Can You Do Self Tests?

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information. Show Notes: 02:01 Intermittent fasting vs caloric restriction 06:57 Why Intermittent Fasting Improves Metabolic Health 10:19 Intermittent fasting while maintaining a healthy diet 12:32 The study 19:35 What does this study mean to Buck?  

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets. Show Notes: 02:14 The definition of stress 13:16 Why does stress disrupt circadian rhythms and sleep 16:08 How do we treat stress? 21:23 Nootropics 24:39 Vagal nerve stimulator 28:34 Digital detox and meditation 33:02 Diet for stress  

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer’s disease. Show Notes: 1:27 Is it true that the testosterone in men in general has gone down? 02:43 Common symptoms of low testosterone 05:15 Normal level of testosterone 07:19 Testosterone and metabolic syndrome 12:49 Testosterone replacement therapy and cancer 16:03 Downside of testosterone replacement therapy 19:18 Different options to supplement testosterone 29:03 What’s on the horizon? 32:50 ED and cardiovascular diseases 38:35 Should all 40+ men be on daily Cialis? 40:43 Penile pump  

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns. Show Notes: 2:55 A plant-based diet for better health? 11:53 Balancing nutritions for the plant-based diet 20:39 Accessibility of the plant-based diet 22:30 Processed plant-based food  

Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine. Show Notes: 00:43 Near-Death Experience and Shift in Perspective 07:04 The Three Minds Framework 23:03 Reevaluating the Model of Human Anatomy 27:20 The Four Engines: Nutrition, Movement, Connection, and Rest 39:24 The Four Engines of Health and Healing 41:01 Harnessing the Placebo Effect and Self-Healing  

In this episode, Buck addresses questions from listeners. Topics include: 00:34 What is a healthy range in your weight? 04:28 The dangerous kind of fat 07:53 Male hormone replacement and cancer 13:12 How long does it take for the circadian rhythm to adjust to a new time zone? 18:35 The risk of cell phones?  

Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues. Show Notes: 02:59 What is musicality? 04:47 What is tonality? 07:05 How does music affect the brain? 11:20 Music as treatment for mental health 22:22 Does music sharpen our intellect? 27:05 Musical vs pharmaceutical interventions 30:38 How to get started on music therapy

Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation. Show Notes: 00:48 What is oxidative stress? 04:12 What is an antioxidant and how does it work?  10:24 Glutathione and its relationship to longevity 29:12 Dr. Patel’s Auro Wellness

Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy. Topics include root causes of food allergy, prevention, diagnosis, and treatment. Show Notes: 04:33 Does where you live affect your allergies? 06:46 How do you know you have an allergy and not something else? 09:40 Life-threatening allergies explained 13:41 Does allergy develop from childhood? 16:28 What makes some foods trigger allergies? 20:22 Rising gluten sensitivity 23:03 Are restrictive food policies increasing cases of allergies 26:20 The relationship between eczema and allergy 29:00 Microbiome 32:43 Desensitizing allergies  

Buck Joffrey, M.D. discusses metabolic syndrome which affects 1/4 of the global adult population and how it underlies the development of virtually every other major cause of death. Show Notes: 00:13 Understanding Metabolic Syndrome 05:29 Criterias of Metabolic Syndrome 23:40: Insulin Resistance and Hyperinsulinemia 24:49: Metabolic Syndrome and Diabetes 37:49: Recommended Lab Tests 42:05: The Health Implications of Liposuction 50:42: The Importance of HSCRP  

Buck talks about the common cold. He discusses the etiology, the role of cold weather, prevention and treatment of this common and frustrating problem.

Buck interviews Dr. Corey Frucht, MD, PhD, a board-certified dermatologist on the topic of aging skin and skin cancer. This episode explores the causes of aging skin and skin cancer, as well as what we can do to combat the inevitable effects of skin aging. Show Notes: 00:00:50:12 How and why can skin look young or old? 00:03:51:20 Why does the skin of people of color age slower? 00:05:14:09 How exactly does UV light damage your skin? 00:07:05:01 Sunscreen 101 00:11:41:08 Physical blockers vs chemical blockers 00:13:41:00 Can you get tan without damaging your skin? 00:14:16:06 How to keep your skin young 00:29:24:14 Skin Cancer

In this special New Year episode, Buck reviews some of the concepts discussed on the show in 2023.  

In this episode, Buck addresses questions from listeners. Topics include oral hygiene, Alzheimer’s disease, and Matthew Perry’s ketamine-related death.