This Week In Medicine

Here are the  articles   from Kidney International reportsA New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After TransplantationIntroductionThe interferon gamma (IFN-γ) enzyme-linked immunosorbent spot is a highly sensitive immune assay that enables the assessment of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) and can identify at-risk transplant patients of CMV infection; however, its clinical implementation remains elusive.ConclusionWe developed a robust CMV-PrognosTIC score to quantify the risk of CMV infection in SOT, which may be readily implemented in clinical transplantation to personalize CMV preventive therapies.Self-Reported Outcome of Living Kidney Donation Correlates With Perioperative Complications not With Surgical TechniquesIntroductionThe German health care system lacks data on surgical complications and self-reported outcomes (SROs) of living donors. The prospective German Living Kidney Donor Registry, SOLKID-GNR aims to improve the assessment of donors’ medical and psychosocial risks.ConclusionAlthough the surgical technique does not directly affect donors' QoL shortly after donation, minimally invasive procedures result in shorter hospital stays and a quicker return to work. Self-reported complications have a greater impact on mental QoL than those documented by transplant centers, highlighting the importance of subjective experiences during recovery.

Hi, This Week in Medicine, we will be discussingFirst we will be discussing articles in New England Journal of Medicine Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 DiabetesOral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation  Journal of  American Medical AssociationPrediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia  Annals of Internal MedicineThe Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity British Medical JournalSecond cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016 LancetPaclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2): a multicentre, participant-masked, registry-based, randomised controlled trial  JAMA oncology Established Cancer Predisposition Genes in Single and Multiple Cancer DiagnosesFalls Among Individuals With Systemic Lupus Erythematosus: An Observational StudyJournals of the American College of CardiologySafety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation  JAMA CardiologyOne-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST ElevationAn Individual Patient Data Meta-Analysis Journal of Clinical Endocrinology & MetabolismAssociation Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018 Diabetes careA Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.   NeurologyAssociation of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging  ChestInvestigating the Long-Term Effects of COVID-19 Infection on Health Care Utilization in Individuals With COPD The American Journal of Respiratory and Critical Care MedicineMolecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation Clinical Journal of American Society of NephrologySodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD: A Meta-Analysis of Kidney Outcome TrialsKidney International reportsProspective Pilot Study of Plasma Cell–Targeted Therapy With Bortezomib in Refractory IgA NephropathyCommunity-Acquired Acute Kidney Injury and Late Kidney Dysfunction in Survivors of COVID-19 Hospitalization 

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy Multidomain Rehabilitation for Older Patients with Myocardial Infarction  Journal of  American Medical AssociationBiparametric vs Multiparametric MRI for Prostate Cancer DiagnosisThe PRIME Diagnostic Clinical Trial  Annals of Internal MedicineExposure to CT and Pregnancy Outcomes  British Medical JournalSecond cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016  LancetBenefit–harm trade-offs of intensive blood pressure control versus standard blood pressure control on cardiovascular and renal outcomes: an individual participant data analysis of randomised controlled trialsJAMA oncology Debt, Bankruptcy, and Credit Scores After Cancer Diagnosis  Journal of Clinical Rheumatology Pilot Study: Development and Evaluation of Validity Evidence of a Low-Cost, Low-Fidelity Hand Model to Teach Clinical Assessment of Small Joint Swelling in Inflammatory Arthritis  Journals of the American College of CardiologyTrajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease JAMA CardiologyPolygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events  Journal of Clinical Endocrinology & MetabolismYAP1 Is a Prognostic Marker and Its Inhibition Reduces Tumor Progression in Adrenocortical Tumors Diabetes careGlucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease   NeurologyAssociation of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors   ChestAssociation of Timely Spirometry With Lower All-Cause Mortality  Risk Factors for Patient-Important Upper Gastrointestinal Bleeding Clinical Journal of American Society of NephrologyPregnancy and Long-Term Kidney Function in CKD: A Systematic Review and Meta-Analysis Kidney International reportsMeta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus A Systematic Review of Sleep Hygiene Strategy in CKD 

Hi, This Week in Medicine, we will be discussingFirst we will be discussing articles in New England Journal of Medicine Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma  Journal of  American Medical Association Annals of Internal MedicineMeasurement Error and the Cost-Effectiveness of Intensive Blood Pressure Targets Effect of lateral versus supine positioning on hypoxaemia in sedated adults LancetSpironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial JAMA oncology Sintilimab Plus Axitinib for Advanced Fumarate Hydratase–Deficient Renal Cell CarcinomaA Phase 2 Nonrandomized Clinical Trial  Clinical Infectious Diseases  Journal of Clinical Rheumatology Noninfectious Uveitis in Pediatric Rheumatology: Long-term Follow-up at Tertiary Centers CirculationA Nationwide Factorial Randomized Trial of Electronic Nudges to Patients With Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial  Journals of the American College of CardiologyPaclitaxel-Coated Balloon for the Treatment of Multilayer In-Stent Restenosis: AGENT IDE Subgroup Analysis JAMA CardiologyPolygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events Journal of Clinical Endocrinology & MetabolismAssociation Between Urinary Phthalate Metabolites and Sarcopenia in US Adults From NHANES 2011-2018 Diabetes careIn Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth   NeurologyUse of Disease-Modifying Therapies in Patients With Late-Onset Multiple    ChestNormosol-R vs Lactated Ringers in the Critically Ill  The American Journal of Respiratory and Critical Care MedicineMechanically Affected Lung and Progression of Emphysema  Clinical Journal of American Society of NephrologyPopulation Health Management Impact on Healthcare Utilization and Costs in CKD: Post Hoc Analysis of the Kidney Coordinated HeAlth Management Partnership TrialSex Differences in the EXerCise Introduction to Enhance Performance in Dialysis Trial Kidney International reportsEconomic Evaluation of System-Wide Implementation of Kidney Supportive Care Impact of Improved Diagnosis and Treatment on Holistic CKD Burden 

Hi, This Week in Medicine, we will be discussingNew England Journal of Medicine Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline  Journal of  American Medical Association Dalbavancin for Treatment of Staphylococcus aureus Bacteremia Annals of Internal MedicineGeographic Variation in Receipt of Care by Specialized Oncologists British Medical JournalGlobal, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic  LancetExtending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy JAMA oncology Integrating Quality of Life and Survival in Systemic Therapy for Advanced Hepatocellular CarcinomaA Network Meta-Analysis  Clinical GastroenterologyNoninvasive Disease Assessment in Eosinophilic Esophagitis With Fractionated Exhaled Nitric Oxide, Blood, and Fecal Biomarkers  Clinical Infectious Diseases  Journal of Clinical Rheumatology Validation of the ANCA-Associated Vasculitis Patient-Reported Outcomes Questionnaire in a Latin American Vasculitis Cohort  CirculationAssociation of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease Journals of the American College of CardiologyRecurrent Events Analysis of MASTER DAPT: Total Ischemic and Bleeding Events After Abbreviated vs Prolonged DAPT in HBR Patients  JAMA CardiologyEarly Childhood Food Insecurity and Cardiovascular Health in Young Adulthood  Journal of Clinical Endocrinology & MetabolismTrends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022 Diabetes careLack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy  NeurologyReal-World Evidence of Brexpiprazole Use and 6-Month Mortality, Hospitalization, and Emergency Department Visits Among Persons With Dementia ChestContinuous Glucose Monitoring for Hyperglycemia in Critically Ill PatientsA Randomized Controlled Trial The American Journal of Respiratory and Critical Care MedicineEndotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4) Clinical Journal of American Society of NephrologyCore Outcome Measure for Life Participation in Patients with CKD: Standardized Outcomes in Nephrology Workshops Report Frailty in Adults with CKD and Validation of the Kidney Failure Risk Equation in Frailty Subgroups Kidney International reportsA Systematic Review of Treatment for Acute Interstitial Nephritis Double-Icodextrin Dose Randomized Controlled Trial of a Double Icodextrin Dose for Older Patients on Incremental Continuous Ambulatory Peritoneal Dialysis 

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of Medicine Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer Journal of  American Medical AssociationAlteplase for Acute Ischemic Stroke at 4.5 to 24 Hours  Annals of Internal MedicineEfficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain: A Randomized Controlled Trial  JAMA oncology Modeling Population-Level Impacts of Cell-Free DNA Screening for Colorectal Cancer in Canada  Journal of Clinical OncologyRandomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer journal of HepatologyA phase IIb randomised-controlled trial of the FFAR1/FFAR4 agonist icosabutate in MASH   GastroenterologyRisk of Gastric Adenocarcinoma After Eradication of Helicobacter pylori Clinical Gastroenterology Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders Clinical Infectious DiseasesTarget Trial Emulation of SARS-CoV-2 Infection Versus No Infection and Risk of Post–COVID-19 Conditions in the Omicron Variant Versus Prior Eras  Rheumatology Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease  CirculationAbelacimab Versus Rivaroxaban in Patients With Atrial Fibrillation on Antiplatelet Therapy: A Prespecified Analysis of the AZALEA-TIMI 71 Trial  Journals of the American College of CardiologyUsing Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial JAMA CardiologyCumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk  Journal of Clinical Endocrinology & MetabolismTrends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022 Diabetes careLack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy  NeurologyStatin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020: A Target Trial Emulation Study  The American Journal of Respiratory and Critical Care MedicineEndotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4) Clinical Journal of American Society of NephrologySodium-Glucose Cotransporter-2 Inhibitor Therapy and Longitudinal Changes in Kidney Function among Veterans with Autosomal Dominant Polycystic Kidney Disease Here are the  articles   from Kidney International reportsA Systematic Review of Treatment for Acute Interstitial Nephritis 

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery Journal of  American Medical AssociationImpact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures in Veterans Annals of Internal MedicineSocial Determinants of Health and Long COVID  British Medical JournalSex related differences in efficacy and safety of antithrombotic therapy in patients with coronary artery disease  LancetAdjuvant chemotherapy and hormonotherapy versus adjuvant hormonotherapy alone for women aged 70 years and older with high-risk breast cancer based on the genomic grade index (ASTER 70s): a randomised phase 3 trial JAMA oncology First-Line Therapy For Advanced Non–Clear Cell Renal Cell CarcinomaA Systematic Review and Meta-Analysis journal of HepatologyCarvedilol vs. propranolol for the prevention of decompensation and mortality in patients with compensated and decompensated cirrhosis Gastroenterology Mebeverine and the Influence of Labeling in Adolescents With Irritable Bowel Syndrome or Functional Abdominal Pain Not Otherwise Specified: A 2 × 2 Randomized, Placebo-Controlled Trial Clinical Gastroenterology Association Between the Inflammatory Potential of Diet and Constipation Among Adults in the United States: A Cross-sectional Study  CirculationNonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy Journals of the American College of Cardiology10-Year Outcome of Complete or Infarct Artery-Only Revascularization in STEMI With Multivessel Disease: The DANAMI-3-PRIMULTI Study JAMA CardiologyMode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection FractionThe FINEARTS-HF Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismTumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer Diabetes careAssociations of AMH in Midreproductive Years with Bone Mineral Density and Turnover Markers in Midlife NeurologyRisk of Ventricular Arrhythmia and Sudden Cardiac Arrest Among Older Patients Using Lamotrigine for Epilepsy ChestTrajectories of Interferon-Gamma Release Assay Results Over 2 Years in Independent Cohorts From China, South Africa, Tanzania, and the United States The American Journal of Respiratory and Critical Care MedicineIloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial  Clinical Journal of American Society of NephrologyDecision Readiness and Determinants of KRT among Veterans with Advanced CKD  Kidney International reportsLow Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) 

Hi, This Week in Medicine, we will be discussingFirst we will be discussing articles in New England Journal of Medicine Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy Ivermectin to Control Malaria — A Cluster-Randomized Trial Journal of  American Medical AssociationTelehealth and Online Cognitive Behavioral Therapy for Chronic Pain Annals of Internal MedicineGlucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes   British Medical JournalGlobal, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic   JAMA oncology Nivolumab and Ipilimumab Combination Treatment in Advanced Ovarian and Endometrial Clear Cell CancersA Nonrandomized Clinical Trial  journal of HepatologyAll-cause and cause-specific mortality in patients with chronic hepatitis B and concurrent steatotic liver disease GastroenterologyCapsule Endoscopy–Guided Proactive Treat-to-Target Versus Continued Standard Care in Patients With Quiescent Crohn’s Disease: A Randomized Controlled Trial Clinical Gastroenterology Real-world Clinical Effectiveness and Safety of Vedolizumab and Adalimumab in Biologic-naive Patients With Crohn’s Disease: Results From the EVOLVE Study  CirculationEfficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial  Journals of the American College of CardiologyBiolimus-Eluting Biomatrix Stent vs a Dual-Therapy Sirolimus-Eluting Stent in PCI: The SORT OUT XI Randomized Trial JAMA CardiologyOCT vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified LesionsThe CALIPSO Randomized Clinical Trial  Journal of Clinical Endocrinology & MetabolismThe Role of Whole Food Plant-Based Food Intake on Postprandial Glycemia in Type 1 Diabetes Diabetes careAssociations of Concurrent Hypertension and Type 2 Diabetes With Mortality Outcomes: A Prospective Study of U.S. Adults  ChestClinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma The American Journal of Respiratory and Critical Care MedicineDeep Learning Estimation of Small Airway Disease from Inspiratory Chest Computed Tomography: Clinical Validation, Repeatability, and Associations with Adverse Clinical Outcomes in Chronic Obstructive Pulmonary Disease  Clinical Journal of American Society of NephrologyUnveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization Here are the  articles   from Kidney International reportsCharacterization of Monogenic Kidney Disease in Older Patients With CKD 

Hi, This Week in Medicine, we will be discussingNew England Journal of Medicine Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin  Journal of  American Medical AssociationHepatitis C Screening in Emergency DepartmentsThe DETECT Hep C Randomized Clinical Trial Annals of Internal MedicineVaporized Nicotine Products for Smoking Cessation Among  British Medical JournalGlobal, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic LancetSafety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial  Journal of Clinical OncologyAcalabrutinib Plus Bendamustine-Rituximab in Untreated Mantle Cell Lymphoma  GastroenterologyElectroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial Clinical Gastroenterology Budesonide Versus Mesalamine in Microscopic Colitis: A Comparative Meta-analysis of Randomized Controlled Trials  CirculationPulsed Field Ablation of Persistent Atrial Fibrillation With Continuous Electrocardiographic Monitoring Follow-Up: ADVANTAGE AF Phase 2 Journals of the American College of CardiologyImpact of Optical Coherence Tomography-Based Post-PCI Physiology Assessment to Predict Clinical Outcomes: An ILUMIEN-IV Substudy  JAMA CardiologyEmergency Department–Based Education and mHealth Empowerment Intervention for HypertensionThe TOUCHED Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismClomiphene Citrate Medication for Infertility and Risk of Stillbirth or Neonatal Death: A Population-based Cohort Study  Diabetes careComparison of Serum Creatinine– and Cystatin C–Based eGFR at Baseline and Their Prediction of Incident Moderate Albuminuria in Individuals With Type 1 Diabetes   NeurologyLamotrigine and Cardiac Arrhythmias: A Target Trial Approach ChestModified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical VentilationmThe American Journal of Respiratory and Critical Care MedicineAirway Scaffolds for Emphysema-related Hyperinflation: Six-Month Results from the BREATHE Trial Clinical Journal of American Society of NephrologyThe Emerging Nephrology Physician Workforce in the United States: Defining an Impending Shortfall Kidney International reportsPoint-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India 

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine As-Needed Albuterol–Budesonide in Mild Asthma Global Effect of Cardiovascular Risk Factors on Lifetime Estimates Intravenous Tenecteplase before Thrombectomy in Stroke Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast CancerJournal of  American Medical AssociationObesity Variation Among Asian, Native Hawaiian or Pacific Islander Adults in the USAnnals of Internal MedicineDevelopment and Validation of Body Mass Index–Specific Waist Circumference Thresholds in Postmenopausal Women British Medical JournalGlobal, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic LancetMitapivat in adults with non-transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE): a phase 3, international, randomised, double-blind, placebo-controlled trial  JAMA oncology Adjuvant Chemoradiation and Immunotherapy for Extrahepatic Cholangiocarcinoma and Gallbladder CancerA Randomized Clinical Trial Journal of Clinical OncologyUse of Low-Value Cancer Treatments in Medicare Advantage Versus Traditional Medicarejournal of HepatologyModeling the health and economic impact of pharmacologic therapies for MASLD in the United States  Gastroenterology Diagnostic Accuracy of Timed Barium Esophagram for Achalasia  Clinical Gastroenterology  Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders  Rheumatology Association of Soluble Immune Checkpoint Molecules PD1 and 4-1BB With CTLA-4Ig Treatment Response in Early Rheumatoid Arthritis Circulation Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study Journals of the American College of CardiologyPlaque Vulnerability and Cardiovascular Risk Factor Burden in Acute Coronary Syndrome: An Optical Coherence Tomography Analysis  JAMA CardiologyCumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk Journal of Clinical Endocrinology & MetabolismEffects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes Diabetes careEconomic Costs Attributed to Diagnosed Diabetes in Each U.S. State and the District of Columbia: 2021 NeurologyNeighborhood Socioeconomic Status and the Functional Outcome of Patients Treated With Endovascular Thrombectomy for Ischemic Stroke  ChestProlonged Mechanical Ventilation in Critically Ill Patients he American Journal of Respiratory and Critical Care MedicinePrevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with BiologicsClinical Journal of American Society of NephrologyHigh Heat Exposure and Medical Utilization among the CKD PopulationKidney International reportsHolistic Impact of CKD: A Clinical, Economic, and Environmental Analysis by IMPACT CKD

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine Structured Exercise after Adjuvant Chemotherapy for Colon Cancer Tirzepatide as Compared with Semaglutide for the Treatment of Obesity Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer  Journal of  American Medical AssociationLorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension: The Launch-HTN Randomized Clinical Trial Annals of Internal MedicineRisk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary DiagnosesA Retrospective Cohort Study  British Medical JournalGlobal, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic  LancetSurgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial  Gastroenterology Noncontrast Magnetic Resonance Imaging vs Ultrasonography for Hepatocellular Carcinoma Surveillance: A Randomized, Single-Center Trial  Clinical Gastroenterology Esophageal Expert Development of a Preliminary Question Prompt List for Adults With Eosinophilic Esophagitis: A Modified Delphi Study  Clinical Infectious DiseasesGlucocorticoid Dosing and Implications for Vaccination: Evolution of Global Definitions Journal of Clinical Rheumatology Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)  CirculationFMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1  Journals of the American College of CardiologyLong-Acting Factor XI Inhibition and Periprocedural Bleeding: An Analysis From AZALEA-TIMI 71  JAMA CardiologyCardiomyopathy-Associated Gene Variants in Atrial Fibrillation Journal of Clinical Endocrinology & MetabolismCost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism Diabetes careImpact of Islet Transplantation on Diabetes Complications and Mortality in Patients Living With Type 1 Diabetes NeurologyAssociation of Predicted Visceral Fat Percentage With Dementia Risk in Older Adults: The Role of Genetic Risk and Lifestyle ChestVentilator-Associated Pneumonia in Low- and Middle-Income vs High-Income Countries The American Journal of Respiratory and Critical Care MedicineEarly versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation Clinical Journal of American Society of NephrologyHigh Heat Exposure and Medical Utilization among the CKD Population Kidney International reportsEffect of Sleep Characteristics on Rapid Estimated GFR Decline in Adults with Normal Kidney Function 

Hi, This Week in Medicine, we will be discussing New England Journal of Medicine Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve ImplantationEfruxifermin in Compensated Liver Cirrhosis Caused by MASHJournal of  American Medical AssociationComplete AI-Enabled Echocardiography Interpretation With Multitask Deep LearningAnnals of Internal MedicineRisk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary DiagnosesBritish Medical JournalEffect of UK Quality and Outcomes Framework pay-for-performance programme on quality of primary carejournal of HepatologyHistological severity, clinical outcomes and impact of antiviral treatment in indeterminate phase of chronic hepatitis B: A systematic review and meta-analysisClinical Gastroenterology The Tissue Systems Pathology Test Objectively Risk-Stratifies Patients With Barrett’s Esophagus: Results From a Multicenter US Clinical Experience StudyDelayed Perforation After Endoscopic Resection of Upper Gastrointestinal Tumors: CT Findings to Identify Patients Requiring SurgeryClinical Infectious DiseasesAntimicrobial Stewardship and Beyond: The Many Essential Roles of Infectious Diseases Pharmacists  CirculationLymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF Journals of the American College of CardiologyBalloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension:  JAMA CardiologyAsundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant UseA Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismDecreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence Diabetes careCellular Versus Acellular Matrix Products for Diabetic Foot Ulcer Treatment: The Dermagraft and Oasis Longitudinal Comparative Efficacy Study (DOLCE)—A Randomized Clinical Trial  NeurologyNoninvasive Assessment of the Risk Features of Hemorrhage in Moyamoya Disease Using 7T MRI ChestPreserved Ratio Impaired Spirometry Prevalence, Risk Factors, and Outcomes The American Journal of Respiratory and Critical Care MedicineElastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome Clinical Journal of American Society of NephrologyEfficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with and without Advanced CKD: Systematic Review and Meta-AnalysisKidney International reportsDotinurad Treatment for Patients With Hyperuricemia Complicating CKD 

Hi, This Week in Medicine, we will be discussing New England Journal of MedicinePhase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes  Journal of  American Medical AssociationClinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer Annals of Internal MedicineEffects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery  LancetComparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial  Journal of Clinical OncologyExplaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study  journal of HepatologyUtility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH   Gastroenterology Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease  Clinical Gastroenterology The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation Clinical Infectious DiseasesAssociation Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes Rheumatology Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases  Journals of the American College of CardiologyDisentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction  JAMA CardiologySex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis  Diabetes careCardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials   NeurologyAssociation of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study  ChestClinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis The American Journal of Respiratory and Critical Care MedicineImpact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial  Clinical Journal of American Society of NephrologyClinical Implications of Slope of GFR in Clinical Trials of CKD Progression Kidney International reportsNephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists 

Hi, This Week in Medicine, we will be discussing New England Journal of MedicineSotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis Journal of  American Medical Association Add-On Treatment With Zilebesiran for Inadequately Controlled HypertensionThe KARDIA-2 Randomized Clinical Trial Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill PatientsThe A2B Randomized Clinical Trial  Annals of Internal MedicineTrends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States  British Medical JournalA village doctor-led mobile health intervention for cardiovascular risk reduction in rural China  LancetNegative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial journal of HepatologyUtility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH Gastroenterology Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease Clinical Gastroenterology The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation Rheumatology Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease Journal of Clinical Rheumatology Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis CirculationExploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension   Journals of the American College of CardiologyDisentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction  JAMA CardiologyClinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration  Journal of Clinical Endocrinology & MetabolismFetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study  NeurologyStability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years ChestVideo vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest  The American Journal of Respiratory and Critical Care MedicineImpact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial Clinical Journal of American Society of NephrologyHigh-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD Kidney International reportsKidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease 

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineOveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1 Second-Line Antiretroviral Therapy for Children Living with HIV in Africa Journal of  American Medical AssociationDexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease Annals of Internal MedicineComparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide British Medical JournalEffects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial LancetEfficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial  Gastroenterology Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort Clinical Gastroenterology The Lactulose Breath Test Can Predict Refractory Gastroesophageal Reflux Disease by Measuring Bacterial Overgrowth in the Small Intestine Rheumatology A Catalog of “Knee Friendly” Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey Journal of Clinical Rheumatology Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)  CirculationOutcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry Journals of the American College of CardiologyEffect of Empagliflozin on the Mechanisms Driving Erythropoiesis and Iron Mobilization in Patients With Heart Failure: The EMPEROR Program JAMA CardiologyLong-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity  Journal of Clinical Endocrinology & MetabolismRisk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome Diabetes careEarly Fasting Serum Glucose or Weight Reduction With Tirzepatide and Metabolic Outcomes in People With Type 2 Diabetes: A Post Hoc Analysis of the SURPASS Trials NeurologyRisk of False Acetylcholine Receptor Autoantibody Positivity by Radioimmunoprecipitation Assay in Clinical Practice ChestLow-Dose Melatonin for Prevention of Delirium in Critically Ill Patients The American Journal of Respiratory and Critical Care MedicinePopulation-Based Screening for Chronic Obstructive Pulmonary Disease Using the St. George’s Respiratory Questionnaire in Resource-Limited Settings  Clinical Journal of American Society of NephrologyPredicting Kidney Outcomes in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Biomarker Analysis Kidney International reportsProspective Cohort Study in Alport Syndrome Patients Under Standard Therapy 

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineTolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis Journal of  American Medical AssociationSpironolactone vs Amiloride for Resistant Hypertension  Annals of Internal MedicineMedical, Societal, and Ethical Considerations for Directed Blood Donation in 2025  British Medical JournalUse of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study LancetClinical presentation and epidemiological assessment of confirmed human mpox cases in DR Congo: a surveillance-based observational study  journal of HepatologyA new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD  Gastroenterology Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares Clinical GastroenterologyReproducibility of the AGREE II Tool for Assessing the Methodological Quality of Clinical Practice Guidelines for the Management of Antithrombotic Agents in Patients Undergoing GI Endoscopy CirculationGenetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes Journals of the American College of CardiologyIschemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial JAMA CardiologyTrajectory of Cardiovascular Health Across Childhood and Adolescence Journal of Clinical Endocrinology & MetabolismRenal Protective Effect of Metformin in Type 2 Diabetes Patients Diabetes careEfficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease   NeurologyEndovascular Thrombectomy for Large Ischemic Core Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials  ChestEffect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes The American Journal of Respiratory and Critical Care MedicineClinical and Biological Features of a Thickened Basement Membrane Zone in Asthma  Clinical Journal of American Society of NephrologyDialysis Dependence in Standard versus Accelerated Initiation of KRT in AKI: A Post Hoc Analysis Kidney International reportsScoping Review of Kidney Patients and Providers Perspectives on Disaster Management 

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of MedicineLepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) Identification of Hepatic-like EPO as a Cause of Polycythemia Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1 Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype Journal of  American Medical AssociationMidurethral Sling vs OnabotulinumtoxinA in Females With Urinary IncontinenceThe MUSA Randomized Clinical Trial  Annals of Internal MedicineSexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans British Medical JournalUse of gabapentinoid treatment and the risk of self-harm  LancetOral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study Journal of Clinical OncologySupervised Exercise for Patients With Metastatic Breast Cancer  journal of HepatologyMetabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B Gastroenterology Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood Journal of Clinical Rheumatology Salivary β2-Microglobulin, Na+, and Cortisol Levels, and Salivary Glands' Uptakes in Sialoscintigraphy in Sjögren Disease  CirculationNrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2 Journals of the American College of CardiologyNonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves: Exposure Response in 2.39 Million Patients From JAMA CardiologySalt Substitution and Recurrent Stroke and DeathA Randomized Clinical Trial  Journal of Clinical Endocrinology & MetabolismDigital Voice Analysis as a Biomarker of Acromegaly   ChestTreatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived IndicesThe Lactel Randomized Multicenter Study  Next we will be discussing articles In the field of Nephrology Here are the  articles   from Kidney International reportsImproving Blood Pressure in High-Risk Patients With CKD Using an Interdisciplinary Remote Hypertension Program Outcomes for Patients With a Deceased Donor Kidney Offer in the New Allocation System 

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineEfficacy and Safety of Obinutuzumab in Active Lupus Nephritis Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation Fidanacogene Elaparvovec for Hemophilia B — A Multiyear Follow-up Study Journal of  American Medical AssociationUse of Life Support and Outcomes Among Patients Admitted to Intensive Care Units Annals of Internal MedicinePatterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023 British Medical JournalFirearm availability and firearm incidents: quasi-experimental analysis using start of US hunting seasons  LancetEffect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial Journal of Clinical OncologyTrastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer journal of HepatologyPNPLA3 rs738409, environmental factors and liver-related mortality in the US population Gastroenterology ERBB2 Comprehensive Profiling and Prognostication in Stage III Colon Cancer: Findings From PETACC8 and IDEA-France Cohorts  Clinical GastroenterologyHistological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials Rheumatology Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis  Journal of Clinical Rheumatology Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan  Circulation Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group Journals of the American College of CardiologyGenetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women JAMA CardiologyTreatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and LesothoA Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismEfficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial Diabetes careLongitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus  NeurologyInvestigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis  ChestSarcoidosis Treatment Patterns in the United States he American Journal of Respiratory and Critical Care MedicineNasal High Flow to Modulate Dyspnea in Orally Intubated PatientsKidney International reportsRandomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan 

Hi, This Week in Medicine, we will be discussing New England Journal of MedicineExtended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation Assessment of a Polygenic Risk Score in Screening for Prostate Cancer  Journal of  American Medical Association Invasive Group A Streptococcal Infections in 10 US States Annals of Internal MedicineInsurer-Level Estimates of Revenue From Differential Coding in Medicare Advantage  British Medical JournalEvolution of reported patient and public involvement over time in randomised controlled trials in major medical journals and in their protocols  LancetEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials  Cancer Journal for CliniciansCancer statistics for African American and Black people, 2025 Journal of Clinical OncologyMinimal Residual Disease–Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials  journal of HepatologyAssociation of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study Gastroenterology Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial Clinical Gastroenterology Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials Rheumatology Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials  Journal of Clinical Rheumatology Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies  CirculationEvidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting  Journals of the American College of CardiologyCardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis  JAMA CardiologyDefault Bulk Ordering and Text Messaging to Enhance Outreach for Lipid ScreeningA Randomized Clinical Trial Journal of Clinical Endocrinology & MetabolismMBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-In-Human, Randomized Trial   Diabetes careDiabetes Risk After Treatment for Childhood and Young Adult Cancer   NeurologyNeurodegeneration and Demyelination in the Multiple Sclerosis Spinal Cord: Clinical, Pathological, and 7T MRI Perspectives  ChestEstimation of Expiratory Function in Infants With Passive Expiration From Total Lung Capacity  The American Journal of Respiratory and Critical Care MedicineTemporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts  Kidney International reportsReal-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD 

Hi, This Week in Medicine, we will be discussing New England Journal of MedicineTwice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons Left Atrial Appendage Closure after Ablation for Atrial Fibrillation Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours The Genetic Architecture of Congenital Diarrhea and Enteropathy Journal of  American Medical AssociationCardiac Arrest During Long-Distance Running Races Annals of Internal MedicineThe Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial British Medical JournalEffects of intensive blood pressure treatment on orthostatic hypertension LancetPharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study Journal of Clinical OncologyEfficacy and Safety of Denileukin Diftitox-Cxdl, an Improved Purity Formulation of Denileukin Diftitox, in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma  journal of HepatologyAssociation of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study Gastroenterology Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial Clinical Gastroenterology Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection   Clinical Infectious DiseasesPeer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Tria  Rheumatology Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis  Journal of Clinical Rheumatology Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies  CirculationClinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry  Journals of the American College of CardiologyNew Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals  JAMA CardiologyIntravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes  Journal of Clinical Endocrinology & MetabolismMBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug Diabetes careDiabetes Risk After Treatment for Childhood and Young Adult Cancer   NeurologyAssociations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study  ChestImplementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma The American Journal of Respiratory and Critical Care MedicineTemporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts Clinical Journal of American Society of NephrologyPerformance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers  Kidney International reportsSystematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD