DiscoverON CRISPR: The Story of Jennifer Doudna with Walter Isaacson
ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson
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ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

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Description

A single scientific breakthrough changed the future of humanity, setting off the third great revolution of modern times. As with any revolution, things didn’t happen neatly or quietly. One figure stood at the center of it all: Jennifer Doudna, the Nobel Prize-winning biochemist who co-created CRISPR. Her invention signified the arrival of a newfound ability to edit our genes, as simply as we edit a sentence, with a word processor.


From Walter Isaacson - the bestselling biographer behind Musk, Einstein and Steve Jobs – and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Jennifer Doudna.


Her personal trajectory, and that of her collaborators and competitors, tells the story of how we arrived at this new frontier of gene editing. It’s a story filled with global stakes and fiery competition. And a story that touches upon the ethical considerations that gene editing brings.


Season 2: 


He didn’t have a role in Hamilton, but America wouldn’t be the same without him! 


From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Mastermind, co-host of the beloved Longform podcast) comes a behind the scenes look at the story of Ben Franklin, and how his genius shaped our national character. 


From Franklin’s adventures as a mischievous apprentice, to his evolution over 84 years into America’s best writer, inventor,scientist, diplomat, and business strategist… as well as Founding Father, Isaacson covers everything from the wit behind Poor Richard’s Almanac to the wisdom behind the Declaration of Independence; not to mention, how a former slave owner evolved into the shepherd of a near-perfect Constitution. 


In this intimate behind the scenes interview, Isaacson provides a look at how he came to understand Franklin’s remarkable life, how it shaped America’s national identity, and why Ben Franklin matters so much right now. 


Season 1: 


What is it like to shadow Elon Musk for two years? To sit courtside as he builds a rocket? Or tears apart an engineer? Or couch surfs at the homes of billionaires? And how on earth do you make sense of it all? Walter Isaacson is the biographer of giants: DaVinci, Franklin, Doudna, Jobs...and now Musk, former enfant terrible, rocket launcher, electric car innovator, and Twitter—er, X—disruptor, to put it gently. 


In this four-part series, author Evan Ratliff (“Mastermind,” “Longform” Podcast) sits down with Isaacson to draw out the behind-the-scenes stories of this epic biography, and what the writer has learned as an outsider inside Silicon Valley.  

18 Episodes
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NEW FROM THE BUILDERS: Elon Musk: "Humans Won't Be in Control" When AI Becomes Smarter Than Us

NEW FROM THE BUILDERS: Elon Musk: "Humans Won't Be in Control" When AI Becomes Smarter Than Us

2026-10-2948:00

Elon Musk has spent his career turning improbable ideas into companies that reshape the world. To some, the entrepreneur behind Tesla and SpaceX is an engineering genius whose ambitions have transformed electric cars and space travel. To others, his politics and extraordinary influence raise serious questions about the future he is building. Either way, the world’s first trillionaire is betting Tesla’s future on AI and humanoid robots, and SpaceX’s on life beyond Earth. In this season’s debut episode, Walter asks Musk about DOGE regrets, why he believes robots will solve America’s national debt, and the dark politics that have consumed his own platform, X. Along the way, Musk shares why living in a simulation demands that we all be less boring. A candid conversation about the imagination, drive and contradictions of a man determined to turn his vision into our future. Interview taped August 6, 2026. And be sure to pick up Walter Isaacson’s The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution, wherever fine books are sold. ABOUT THE HOSTWalter Isaacson is the bestselling author of biographies of Elon Musk, Jennifer Doudna, Leonardo da Vinci, Steve Jobs, Benjamin Franklin, and Albert Einstein. He is a professor of history at Tulane University and previously served as CEO of the Aspen Institute, chair and CEO of CNN, and editor of Time. He was awarded the National Humanities Medal in 2023. IN THIS SEASONElon Musk (Tesla, SpaceX, xAI)Peter Thiel (Founders Fund, PayPal, Palantir)Mustafa Suleyman (Microsoft AI, DeepMind)Dario Amodei and Daniela Amodei (Anthropic)and more!See omnystudio.com/listener for privacy information.
ON CRISPR Episode 5: The Conversation

ON CRISPR Episode 5: The Conversation

2025-10-0801:07:36

In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doudna explain how CRISPR blossomed from an idea to a phenomenon, and the challenges scientists faces in this politically fraught moment.See omnystudio.com/listener for privacy information.
ON CRISPR Episode 4: Franken Monsters

ON CRISPR Episode 4: Franken Monsters

2025-10-0144:50

As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity.  Walter Isaacson sits down with Evan and tells him why the field has always been ripe with ethical questions, and how the COVID-19 pandemic pushed researchers to recalibrate their priorities.See omnystudio.com/listener for privacy information.
ON CRISPR Episode 3: Patent Wars

ON CRISPR Episode 3: Patent Wars

2025-09-2435:25

Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer.  Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work for humans, and getting the credit for it.See omnystudio.com/listener for privacy information.
ON CRISPR Episode 2: The Discovery

ON CRISPR Episode 2: The Discovery

2025-09-1738:57

Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Their curiosity would prove to be the foundation for a history altering discovery: the ability to edit our genetic code.  See omnystudio.com/listener for privacy information.
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