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DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.
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Welcome to the November 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2025 issue of Diabetes. 6:00 In the first segment, our hosts are joined by Kaylia Reynolds, MS and Nora Franceschini, MD, MPH, FAHA, both of the Department of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina. Their paper, "Diabetes Genetic Clusters and Clinical Outcomes in American Indians," is available for free at doi.org/10.2337/db25-0322. 20:40 To discuss the latest Paper of the Month, our hosts are joined by first author Stephanie K. Holm, a postdoctoral student in the Clemmensen group, and Christoffer Clemmensen, Associate Professor in the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. Their paper, "Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice," is available for free at doi.org/10.2337/db24-1056. 38:15 In the latest edition of "Sweet Talk," Kevin and Kirk speak with Banting Medal recipient Jens Juul Holst, MD, DMSc, of the University of Copenhagen, whose work with incretin hormones laid the foundation for therapies now used around the world. His article, "Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture," is available for free at doi.org/10.2337/dbi21-0026. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the October 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2025 issue of Diabetes. 5:50 In the first segment, our hosts are joined by Tessa M. Cacciottolo, PhD, a Chain Florey TTI Fellow in the MRC Laboratory of Medical Sciences at Imperial College London. She is the first author of the article "Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis," available for free at doi.org/10.2337/db25-0209. 22:15 In honor of last month being Childhood Obesity Month, in this month's edition of "Sweet Talk", our hosts speak with Kristen Nadeau, MD, MS, a professor of pediatrics at the University of Colorado Anschutz Medical Campus, and Bethany Cartwright, MD, PhD, an Assistant Instructor in the Department of Pediatrics at UT Southwestern Medical Center. They discuss the complications children with obesity can face, as well as the stigma and weight biases that accompany these diagnoses. Cartwright's article, "Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity," is available for free at doi.org/10.2337/dbi24-0044. 49:10 In a special segment, Nadeau and Cartwright take questions directly from kids of various ages on the topics of diabetes and obesity. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes. 5:25 In the first segment, our hosts are joined by Carmelo Quarta, PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of "GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice," available for free at doi.org/10.2337/db24-1071. 27:30 Next, Darleen and Kirk speak with Willa A. Hsueh, MD, Professor of Medicine in the Division of Endocrinology at the Ohio State University College of Medicine. She is a corresponding author on this month's Paper of the Month, "The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism," available for free at doi.org/10.2337/db24-0861. 46:20 Lastly, in this month's edition of "Sweet Talk," Kevin and Darleen are joined by Alexander R. Nectow, MD, PhD. A recipient of the American Diabetes Association's Pathway to Stop Diabetes Award, Dr. Nectow lab at Columbia University studies the dorsal raphe nucleus (DRN) and its relation to metabolism. His article, "The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes," is available for free at doi.org/10.2337/dbi24-0015. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
In this special crossover episode, recorded live at the American Diabetes Association's 85th Scientific Sessions in Chicago, the hosts of ADA's professional podcasts—Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio—come together to discuss key highlights and groundbreaking research presented at the 2025 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year's findings mean for clinical practice and future research. Available now across all ADA professional podcast channels. Featured Podcasts: DiabetesBio – From ADA's flagship research journal, Diabetes Diabetes Care "On Air" – From ADA's clinical research journal, Diabetes Care Diabetes Core Update – ADA's podcast for primary care Join the Discussion with: Alice Cheng, MD – Co-host of Diabetes Care "On Air" Kirk Habegger, PhD – Co-host of DiabetesBio Michael Rickels, MD, MS – Co-host of Diabetes Care "On Air" Darleen Sandoval, PhD – Co-host of DiabetesBio Neil Skolnik, MD – Co-host of Diabetes Core Update and Diabetes Day by Day Kevin Williams, PhD – Co-host of DiabetesBio 🔗 Learn more about ADA's full podcast portfolio: https://diabetesjournals.org/journals/pages/podcasts Subscribe to Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio on Apple Podcasts, Amazon Music, Spotify, or your preferred platform.
Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month's episode, a special extended edition of "Sweet Talk," exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by Daniel J. Drucker, OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association's (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with Jonathan Campbell, PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, "Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies," available for free at doi.org/10.2337/db25-0393. 42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, "A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity," available for free at doi.org/10.2337/dbi24-0026, and a counterpoint article titled "GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale," also available for free at doi.org/10.2337/dbi24-0027. And don't forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts! To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July's Paper of the Month, titled "Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis." They're joined by corresponding authors Dr. Takayoshi Suganami, professor in the Department of Molecular Medicine and Metabolism, the Research Institute of Environmental Medicine at Nagoya University in Nagoya, Japan, and Miyako Tanaka, a lecturer in the same department. This article is available for free at doi.org/10.2337/db24-0762. 22:25 Our hosts speak with Richard M. Watanabe, PhD, Professor of Population and Public Health Sciences in the Department of Population and Public Health Sciences at the University of Southern California Keck School of Medicine. His paper, "Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver," is available at doi.org/10.2337/db24-0923. 46:50 In this month's edition of "Sweet Talk," our hosts are joined by Barbara B. Kahn, MD, recipient of the American Diabetes Association's Albert Renold Distinguished Career Award, to discuss her work uncovering key molecular mechanisms contributing to type two diabetes and the role of adipose tissue in regulating systemic insulin sensitivity. Dr. Kahn is the George Richards Minot Professor of Medicine at Harvard Medical School and Vice Chair for Research Strategy at Beth Israel Deaconess Medical Center in Boston. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and "Sweet Talk" with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes. 4:40 In the first interview segment, our hosts discuss June's Paper of the Month, titled "Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk." They're joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at doi.org/10.2337/db24-0958. 17:25 Our hosts speak with Greg M. Kowalski, PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University's Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, "The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans," available for free at doi.org/10.2337/db24-0388. 33:55 In this month's edition of "Sweet Talk," our hosts are joined by Shingo Kajimura, PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA's 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes. 6:25 In the first interview segment, our hosts discuss May's Paper of the Month, titled "β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation." They're joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729 25:30 It's a special two-part edition of "Sweet Talk." In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They're joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year's Scientific Sessions programming committee. 48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association's Banting Medal for Scientific Achievement, and he discusses his landmark paper, "Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function," available for free at doi.org/10.2337/diab.42.11.1663. They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes. 6:30 In the first interview segment, our hosts discuss an article titled "Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice." They're joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419. 25:20 Our hosts discuss the latest Paper of the Month, entitled "An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target." They're joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497. 38:55 In the special edition of "Sweet Talk," our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They're joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD, professor at UT Southwestern Medical Center in Dallas, Texas. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the March 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2025 issue of Diabetes. 3:20 In the first interview segment, our hosts discuss the Paper of the Month, "Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays." They're joined by Anne Gresch, PhD, a postdoctoral fellow at the University of Colorado's Anschutz Medical Campus, and Prof. Dr. Martina Düfer, from the Department of Pharmacology at the University of Munster Pharmaceutical and Medicinal Chemistry in Munster, Germany. This article is available for free at doi.org/10.2337/db23-0870. 22:40 Our hosts discuss an article from the February issue of Diabetes, entitled "Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes." They're joined by lead author Delnaz Roshandel, PhD, Senior Research Associate, and Andrew Paterson, MD, both of the Genetics and Genome Biology Program at the Hospital for Sick Children in Toronto, Canada. This article is available for free at doi.org/10.2337/db24-0340. 36:20 In the special edition of "Sweet Talk," our hosts welcome Jeffrey S Flier, MD, former Dean of Harvard Medical School and past recipient of the ADA's Banting Medal, as well as Christopher Bang Newgard, PhD, leader in pancreatic islet biology and metabolic disease at Duke University School of Medicine and previous recipient of the ADA's Outstanding Scientific Achievement Award. They discuss an article by Diabetes editor-in-chief, David A. D'Alessio, on the historic development of the insulin radioimmunoassay, available for free at doi.org/10.2337/dbi24-0055. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the February 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2025 issue of Diabetes. 3:55 In the first interview segment, our hosts our joined by Francis C. Lynn, BSc PhD, Associate Professor in the Department of Surgery and School of Biomedical Engineering at the University of British Columbia in Vancouver. He is the corresponding author of the article "Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line." The article is available for free at doi.org/10.2337/db24-0756. 18:25 Darleen, Kevin, and Kirk speak with David C. Wraith, PhD, Emeritus Professor of Immunology, and Michael J. Price, PhD, a research fellow, both at the Institute of Immunology and Immunotherapy at the University of Birmingham in the UK. They discuss their article, "Pre-clinical development of a tolerogenic peptide from glutamate decarboxylase as a candidate for antigen-specific immunotherapy in type 1 diabetes," available at doi.org/10.2337/db23-0996. 35:50 In the latest edition of "Sweet Talk," our hosts welcome Bret H. Goodpaster, PhD, Scientific Director and Senior Investigator at the AdventHealth Translational Research Institute for Metabolism and Diabetes in Orlando, FL, and Professor of Medicine at Johns Hopkins University. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes. 2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature. 3:35 In part one of this special Sweet Talk segment, our hosts are joined by Philipp Scherer, PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and Joel Elmquist, DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA's Outstanding Scientific Achievement Award, and Scherer recently received the ADA's Banting Medal. They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases. 33:00 In part two, our hosts speak with Jonathan Flak, PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA's Pathway to Stop Diabetes Award. He discusses his work on the brain's role in glucose regulation, energy balance, and bodyweight control. His article, "Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes," can be found in the January 2025 issue of Diabetes. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes. 0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include: Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445 Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388 Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172 Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020 Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827 Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175 6:15 Darleen is joined by Lukas Stilgenbauer of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as Mariana Sadagurski, associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University. They discuss their article "Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling." This article is available for free at doi.org/10.2337/db24-0110 33:45 Kirk and Kevin dive into the December issue's Paper of the Month, "Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes." They're joined by lead author Max Petersen, an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at doi.org/10.2337/db24-0083. 47:20 Finally, this month's edition of Sweet Talk focuses on work funded by the American Diabetes Association's Pathway to Stop Diabetes initiative. Kathleen Alanna Page, Associate Professor of Medicine at the University of Southern California's Keck School of Medicine, and Jasmin Alves, a postdoctoral research fellow with Page, stop by to discuss Page's study, "Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes." The article is available at doi.org/10.2337/dbi24-0012 To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes. 3:45 After a quick rundown of our hosts' Halloween plans, this month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024! 5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article "Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior." This article is available for free at doi.org/10.2337/db24-0207. 27:05 Our hosts discuss the November issue's Paper of the Month, "Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy." They're joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at doi.org/10.2337/db24-0107. 50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month's Sweet Talk segment features Dr. Giles Yeo, a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:05 This month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024! 5:15 Darleen and Kirk speak with Dr. Magnus Grøndahl, faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, "Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis." This article is available for free at doi.org/10.2337/db24-0305. 19:05 Our hosts discuss a featured article entitled "Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function." They're joined by the study's lead author, Dr. Jessie Barra, and corresponding author—as well as Barra's mentor—Dr. Holger Russ. This study is available at doi.org/10.2337/db24-0346. 35:00 Finally, just in time for National Vision Awareness Month, a Sweet Talk segment first: a discussion on the important topic of diabetic retinopathy. Dr. Siddharth Sunilkumar and Dr. Michael Dennis discuss their Perspectives article, "REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes," funded by the ADA Pathway to Stop Diabetes Initiator Award, which was given to Dr. Dennis in 2014. This article is freely accessible at doi.org/10.2337/dbi24-0013. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:20: Darleen and Kirk are joined by Jose A. Ortiz and Hsun Teresa Ku, first and last authors of "Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0490. 25:07: Kirk and Darleen talk to Adrian Vella, last author of "The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans." This article is also an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db24-0192. 50:21: In this month's Sweet Talk segment, Kevin chats with Matthew J. Webber, a 2019 Pathway to Stop Diabetes Accelerator Award winner, about his research on materials that can sense and respond to changing glucose. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to a very special episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care "On Air," acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care "On Air"; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care "On Air," DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer. This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the "bench-to-bedside" spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.) Correction: •Dr. Carmella Evans-Molina is from the Indiana University School of Medicine •Dr. Lou Philipson is from the University of Chicago To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes. 2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled "Glucose Transporters Are Key Components of the Human Glucostat." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508. 27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of "Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676. 50:21: In this month's Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent "Classics in Diabetes" feature, named "Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/dbi24-0025. The original "Classics" article is freely accessible at https://doi.org/10.2337/diab.42.11.1678. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the July 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2024 issue of Diabetes. 4:31: Darleen and Kirk are joined by Dr. Jordan J. Wright, first author of the Paper of the Month, entitled "Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0009. 17:23: Kirk and Darleen then chat with Dr. Lisa Smeehuijzen, first author of the article "Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0970. 20:26: In a very special Sweet Talk segment, Kevin is joined by cohosts Darleen and Kirk for an interview with Dr. Rury R. Holman, the winner of the 2024 Banting Medal for Scientific Achievement. More details about this award can be found at https://professional.diabetes.org/awards/banting-medal-scientific-achievement-award. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Welcome to the June 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2024 issue of Diabetes. 2:27: Darleen and Kirk are joined by Dr. Ralph A. DeFronzo, senior author of the article "Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects." This article is freely accessible at https://doi.org/10.2337/db23-0457. 20:26: In this month's Sweet Talk segment, Kevin and Kirk highlight this month's Point-Counterpoint feature on whether a new model is needed on the regulation of β-cell KATP channels in glucose metabolism. First, they talk to Drs. Matthew J. Merrins and Richard G. Kibbey, authors of the Counterpoint, titled "Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!" This article is freely accessible at https://doi.org/10.2337/dbi23-0032. 35:00: Kevin next is joined by Drs. Guy A. Rutter and Ian R. Sweet, authors of the Point article, titled "Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?" This article is freely accessible at https://doi.org/10.2337/dbi23-0031. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
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