DiscoverMeSsy with Christina Applegate & Jamie Lynn Sigler
MeSsy with Christina Applegate & Jamie Lynn Sigler
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MeSsy with Christina Applegate & Jamie Lynn Sigler

Author: Wishbone Production

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On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
147 Episodes
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Jack Osbourne

Jack Osbourne

2026-11-0354:03

This week, Christina and Jamie are joined by Jack Osbourne for an honest conversation about growing up in the spotlight, getting sober at 17, and being diagnosed with MS at just 26. Jack opens up about how he's navigated life's challenges, the importance of perspective, and what he's learned about resilience, fatherhood, and living with a chronic illness.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.Honeylove  - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepodBlissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at https://blissy.com/MESSY.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
This week, Christina and Jamie read listener emails and discuss navigating life without a diagnosis, the challenges of parenting teenagers, learning to accept help, and the realities of getting older.Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.OneSkin 0 Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpodMyAlloy - With Alloy, your best hair isn’t behind you. Visit https://MyAlloy.com and use the code MESSY to get 20 percent off your first order. Your menopause-specialized doctor will tailor your care to your needs — plus, you get zero dollar unlimited messaging with your doctor. This code is valid on products only.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.Send us an email: https://www.messythepodcast.com/contactExecutive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.Ridge - One thing to pack, five ways to power! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messyNOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months.Send us an email: https://www.messythepodcast.com/contactExecutive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.ZocDoc - Head to https://Zocdoc.com/messy to get started and check that appointment off your to-do list! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Novartis in neuroscienceOur ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.Jones Road - Use code MESS  at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #adK18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code [MESSY]Blissy - Wake up with clearer skin, smoother hair, and cooler sleep. Use code MESSY for an extra 30% off at blissy.com/MESSY. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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