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Intelligent Medicine
Intelligent Medicine
Author: Dr. Ronald Hoffman
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© 2025 Ronald L. Hoffman MD, PC. All Rights Reserved
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Pioneering complementary medicine practitioner Dr. Ronald Hoffman takes a cutting-edge approach to health, wellness, and aging. He covers both conventional and alternative modalities, as well as nutrition, exercise, and supplements.
757 Episodes
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Nutrient Deficiencies and Their Link to Alzheimer’s Disease and Diabetes Risk in Night Owls: Nutritionist Leyla Muedin discusses research findings linking nutrient deficiencies to Alzheimer's disease and how diet and supplementation can play a crucial role in prevention. She highlights the importance of antioxidants like lutein, zeaxanthin, and lycopene for brain health and their potential to reduce Alzheimer's risk. Leyla also delves into the connection between evening chronotypes ('night owls') and an increased risk of diabetes, emphasizing the role of lifestyle factors and offering suggestions for healthier sleep habits. She encourages listeners to maintain a diet rich in carotenoids for better cognition and eye health, and to adjust sleeping patterns for overall well-being.
Thanksgiving and overindulgenceA food poisoning incidentObservations on health at ThanksgivingWhat do you think of online sites offering prescriptions for hair loss via a questionnaire?
My granddaughter suffers from menstrual cramps. Do you have any suggestions?Do you recommend nicotinamide daily to prevent recurrence of basal cell cancers?What works best to lower fibrinogen?I've been on Ozempic for a year and have diarrhea every morning!Is bypass surgery still being done?Would you recommend Bergamot for fatty liver?
Water Quality and Filtration: Cydian Kauffman, CEO of Pure Water Northwest, delves into the intricacies of water quality and filtration. Kauffman, an expert in making water quality understandable and accessible, discusses the various methods to test and improve water quality, the efficacy of different water filtration systems, and common misconceptions about water contaminants. They explore the advantages and limitations of carbon filters and reverse osmosis systems, address concerns about municipal water safety, and consider the presence of microplastics and forever chemicals in tap water. Practical advice is provided for consumers on selecting appropriate filtration systems and understanding the importance of regular water testing. This insightful discussion also touches on broader water quality issues, including potential health impacts and future water supply challenges.
Dr. Hoffman continues his conversation with Cydian Kauffman, CEO of Pure Water Northwest.
Alan Frost, founder of Flava Naturals, and Dr. Joseph C. Maroon, MD, FACS, clinical professor and vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center, and author of "The Science of Cocoa," detail recent scientific findings on the cardiovascular and cognitive benefits of cocoa flavanols, the importance of sourcing and processing cocoa, and how cocoa can enhance athletic performance and brain health. The episode also covers the benefits of cocoa for skin health, fighting inflammation, and even mitigating some of the effects of sitting. Dr. Maroon elaborates on his protocols for concussion recovery, including the use of omega-3 fish oil, creatine, and CBD. The episode concludes with a discussion on how cocoa impacts mood and a special discount offer for Flava Naturals products. Just go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide, plus get free shipping on all orders over $30.
Dr. Hoffman continues his conversation with Alan Frost, founder of Flava Naturals, and Dr. Joseph C. Maroon, MD, FACS, clinical professor and vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center, and author of "The Science of Cocoa."
New weight loss drugs may portend end of “Fat Acceptance” movement; Celebs and Southerners embrace GLP-1s; Trump clears path for more access to diet drugs; Mid- and late-life exercise slash dementia risk; “Ethicists” urge more tick-borne meat allergy to save planet—as alpha-gal syndrome claims first fatality; What’s wrong with the melatonin study that claims it leads to heart failure? How to detox 9-11 first-responders? Can weekend warriors obtain same benefits as regular exercisers?
Can natural herbs aid recovery from anorexia? What an analysis of Hitler’s DNA tells us about how genes shaped his personality; Can surgical anesthesia accelerate memory loss? Bananas could be interfering with your smoothie’s health benefits; Not just sun, but pesticides and herbicides increase risk for melanoma; Chemical residues on produce impair male fertility; Proliferation of fast-paced social media videos are dumbing us down; Doctors aren’t less resilient, the demands of medicine are just fostering unprecedented levels of physician burnout.
Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's. The episode delves into lifestyle interventions such as ketogenic diets, fasting, and nutritional impacts to manage and potentially reverse the detrimental shift in microglial behavior.
Soup in cold weatherStudy: No benefit from beta-blockers post heart attack, but vitamin D cuts risk of 2nd heart attack in half!New study links oxalic acid to gadolinium side effects and toxicityMore on the assault on young people's brains
What can I do about a hip labrum tear?Are there any specific water filters that you recommend?What say you about lead levels in dark chocolate?
Clinical Pharmacist, Author, Board-Certified Clinical Nutritionist, and Health Expert Jim LaValle details the many health benefits of aged garlic extract, particularly its impact on periodontal disease. He reveals exciting new research findings that show Kyolic Aged Garlic Extract supplements can significantly reduce periodontal pocket depth -- a key indicator of gingivitis and periodontal disease progression. He also highlights the role of aged garlic extract in reducing inflammation and improving gum health, which in turn has significant implications for cardiovascular and cognitive health. The conversation also touches on various formulations of aged garlic extract available from Kyolic, the importance of integrative approaches to health and wellness, and updates on the latest trends in anti-aging medicine, including peptides and GLP-1 agonists.
Dr. Hoffman continues his conversation with clinical pharmacist, author, board-certified clinical nutritionist, and health expert Jim LaValle on the many health benefits of aged garlic extract.
Nathan Jones, CEO of Xlear, Inc., details the benefits of xylitol in dental and respiratory health products such as nasal sprays and chewing gums under the Spry brand. Nathan advocates for the FDA to allow anti-cavity claims for xylitol and other compounds despite the current monopoly of fluoride in such claims. They question the efficacy and potential downsides of fluoride, and explore alternative dental health interventions. The episode also covers xylitol’s role in preventing tooth decay, respiratory health benefits during the COVID-19 pandemic, and ongoing legal challenges with the FTC. Discussions highlight the potential implications of oral health on systemic diseases like cardiovascular disease and Parkinson’s, and emphasize the importance of nasal hygiene alongside dental care.
Dr. Hoffman continues his conversation with Nathan Jones, CEO of Xlear, Inc.
“Study” that’s not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore dr’s advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance. Give the gift of healthy chocolate! Go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide. Plus get free shipping on all orders over $30.
The FDA belatedly liberates women’s hormone replacement; Beta-blockers now deemed passé for routine heart attack aftercare; After most breast cancer surgery, adjuvant radiation brings no survival benefits; Can you drink caffeinated coffee if you have atrial fibrillation? Ignore frequent falls without attention to balance and stability training at your peril; Is it reasonable to contemplate a knee replacement surgery at 88?
Navigating the Complexities of Antinutrients in Your Diet: Leyla Muedin, a registered dietitian nutritionist, delves into the controversial topic of antinutrients. Responding to a question from a listener named Deanna, Leyla explains the different types of antinutrients—such as phytates, oxalates, tannins, lectins, goitrogens, and phytoestrogens—and their potential impacts on nutrient absorption. She discusses the dual nature of these compounds, highlighting their possible negative effects along with their roles in health benefits like gut microbiota support and anti-cancer properties. Leyla also shares practical food preparation tips for mitigating the adverse effects of antinutrients and emphasizes the importance of dietary variety.
Are children's IQs going down?An overview of medical reversalsCan you comment on the melatonin and heart failure study?Result of a prostate artery embolization




Weren't the young people who died of Spanish flu the so called "les sans gueule" or "the shell shocked" coming from the WW I ?!
#nicotinamideRiboside increases energy output in the #mitochondria. Other #supplements to improve performance and healthy aging are discussed as well.