IJGC conversations

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Drs. Robert Wenham and Angeles Alvarez Secord to discuss Pembrolizumab and weekly paclitaxel for platinum-resistant ovarian cancer.   Dr. Robert Wenham is a gynecologic oncologist and Chair of the Gynecologic Oncology Program at Moffitt Cancer Center.  Dr. Wenham has a strong interest in research and is a principal investigator for numerous clinical trials to improve cancer care for women.  His research activities include the use of novel drugs for the treatment of gynecologic cancers.  He has received the Molly Cade Ovarian Cancer Research Award from the Gynecologic Cancer Foundation.  Dr. Wenham enjoys the challenge of helping women with complex issues and the opportunity to offer them cutting-edge therapies, from the latest chemotherapy approaches to biologically targeted therapies, minimally invasive surgery, and clinical trials.  He is also an expert in pelvic exenteration surgery, a very complex operation that offers hope of a possible cure for certain patients with gynecologic cancer.  Clinically, he prefers a more collaborative approach where the patient plays an active role in decisions as he guides them through the pros and cons of their options.     Angeles Alvarez Secord, MD, MHSc, is a professor in the Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Duke University Heath System. She received her undergraduate degree with honors from Carroll College in Helena, Montana and graduated AOA with honors from the University of Washington School of Medicine in Seattle, Washington. Dr. Secord completed her residency in obstetrics and gynecology and her fellowship in gynecologic oncology at the Duke University Medical Center in Durham, North Carolina. Upon completing her fellowship in 2001, she joined the Division of Gynecologic Oncology at Duke. She is currently Director of Gynecologic Oncology Clinical Trials, Associate Director of Clinical Research, Gynecology Oncology, and one of the Principal Investigators for NRG Oncology at the Duke Cancer Institute. Dr. Secord serves on the GOG Foundation Board of Directors. She is passionate about mentoring the next generation of investigators and serves as the GOG Foundation Education and Mentoring Chair and the NRG Oncology Investigator and Career Development Committee Vice-Chair. Dr. Secord is a fellow of the American College of Obstetricians and Gynecologists and an active member of American Society of Clinical Oncology, American Gynecological & Obstetrical Society, Society of Gynecology & Oncology, and International Gynecologic Cancer Society as well as other professional organizations.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Roni Nitecki Wilke to discuss Risk-reducing Salpingectomy with Delayed Oophorectomy.   Dr. Nitecki Wilke is a gynecologic oncologist and assistant professor at the department of gynecologic oncology and reproductive medicine at the University of Texas MD Anderson Cancer Center.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Drs. Alex Melamed and René Pareja to discuss De-escalation in Gynecologic Oncology.   Alex Melamed, MD, MPH, is a gynecologic oncologist and clinical outcomes researcher in the Department of Obstetrics and Gynecology at Mass General Hospital and an Associate Professor at Harvard Medical School. He co-directs the Inference Lab in MGH's Vincent Department of Obstetrics and Gynecology. Dr. Melamed's research focuses on applying methods that provide meaningful insights from observational data. In particular, his work explores how focusing on temporal and spatial variation in clinical practice can help to uncover how health care affects patient outcomes. Some of his research focuses on increasing understanding of how surgical care affects the lives of cancer patients. Dr. Melamed is an associate editor of the International Journal of Gynecologic Cancer.    Dr. René Pareja is a Gynecologist and Obstetrician, graduated from Universidad Pontificia Bolivariana in Medellín, Colombia in 2000; he finished his training in Gynecologic Oncology in 2003, from Pontificia Universidad Javeriana and Instituto Nacional de Cancerología in Bogotá, Colombia. He is a minimally invasive surgeon, graduated from Corporación de Estudios de la Salud (CES) in 2013. He currently works at Astorga Oncology Clinic in Medellín and at National Cancer Institute in Bogotá, Colombia. Dr. Pareja serves as a reviewer for more than 20 journals. He has authored or co-authored nine book chapters and more than fifty publications in peer-reviewed journals. Currently he is an Associate Editor of the International Journal of Gynaecological Cancer and is a Council member of the International Gynecological Cancer Society Council. He also serves as an international mentor for the Hospital General San Juan de Dios in Guatemala through the IGCS Global Curriculum & Mentorship Program.Some of his research has influenced how gynecologic oncologists treat cancer and has been published in important medical journals, like the New England Journal of Medicine, JAMA, and Journal of Clinical Oncology.

In this episode of the IJGC podcast, the IJGC editorial fellows are joined by Dr. Reitan Ribeiro. Dr. Ribeiro is an Assistant Professor in the Department of Obstetrics & Gynecology and the Department of Oncology at McGill University. He is an attending Gynecologic Oncologist and Surgical Oncologist at the Cedars Cancer Center, McGill University Health Center, where he practices as both a clinician and scientist. A pioneer in laparoscopic and robotic surgery, Dr. Ribeiro developed the uterine transposition technique, enabling fertility preservation for patients undergoing pelvic radiation therapy. His work has earned national and international recognition, and he has shared his technique with oncologists worldwide, teaching it at prestigious cancer centers such as the Houston Methodist Hospital (USA), and international societies such as the European Society of Gynecological Oncology (ESGO). He has also led landmark clinical trials in the field of gynecology oncology, including Keynote 001, LACC, and SGNTV-003. His contributions have been recognized with several prestigious awards, including an Honorable Mention from the Chamber of Deputies of Paraná, Brazil, and the National Medical Treatment Innovation Award (VEJA), best video award from the American Society of Gynecology Oncology (SGO), and the 2025 Outstanding Achievement in Gynecologic Oncology Surgery Award by the International Gynecologic Cancer Society (IGCS) .

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Giorgio Bogani to discuss Uterine Leiomyosarcoma.   Prof. Bogani serves as a consultant in gynecologic oncology at the Fondazione IRCCS Istituto Nazionale dei Tumori di Milano in Milan, Italy. He completed a research fellowship at the Mayo Clinic in Rochester, MN, USA, with a focus on endometrial cancer and gynecologic oncology. Currently, his expertise is centered on gynecological surgery and experimental medicine. 

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Alex Melamed to discuss Neoadjuvant Chemotherapy: Mortality in Low- vs High-Volume Centers. Alex Melamed, MD, MPH, is a gynecologic oncologist and clinical outcomes researcher in the Department of Obstetrics and Gynecology at Mass General Hospital and an Associate Professor at Harvard Medical School. He co-directs the Inference Lab in MGH's Vincent Department of Obstetrics and Gynecology. Dr. Melamed's research focuses on applying methods that provide meaningful insights from observational data. In particular, his work explores how focusing on temporal and spatial variation in clinical practice can help to uncover how health care affects patient outcomes. Some of his research focuses on increasing understanding of how surgical care affects the lives of cancer patients. Dr. Melamed is an associate editor of the International Journal of Gynecological Cancer. 

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Alessandro D. Santin to discuss Mirvetuximab in Low-Grade Ovarian Cancer.   Dr. Alessandro D. Santin, a native of Italy, graduated with honors from the University of Brescia, Italy and received his postgraduate training in Obstetrics & Gynecology at the same University. He served a fellowship in Gynecologic Oncology at the University of California, Irvine and an International Fellowship in the Division of Gynecologic Oncology at the University of Arkansas for Medical Sciences, Little Rock, Arkansas. Dr. Santin joined the faculty in the Section of Gynecologic Oncology in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale University as Professor as of July 2008. Dr. Santin has more than 400 original research and peer-reviewed publications including multiple review articles and book chapters and he has written extensively on various topics, including cancer of the ovary, endometrium and cervix as well as on tumor immunology and immunotherapy. Dr. Santin's clinical interests include the use of immunotherapy in ovarian, cervical and endometrial carcinoma patients with disease resistant/refractory to standard treatment, therapeutic vaccines against Human Papillomavirus (HPV) infected genital tumors, and the development of personalized treatment modalities including monoclonal antibodies and antibody-drug-conjugates (ADC) against chemotherapy resistant gynecologic tumors.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Stephanie Gill to discuss ICG Angiography for Bowel Anastomosis Evaluation.   Stephanie J. Gill, MD, FRCSC, MSc, MScHSE, is a second-year Gynecologic Oncology Fellow at the University of Toronto in Toronto, Canada, with clinical appointments at Princess Margaret Cancer Centre and the Odette Cancer Centre. She holds two Master’s degrees in Medical Sciences—focused on biostatistics and epidemiology—and Health Sciences Education, with a particular interest in robotic surgery training and competency-based assessment. Her research interests include surgical innovation and enhanced recovery after surgery, outcomes in rare gynecologic malignancies such as vulvar cancer and gestational trophoblastic neoplasia, and quality improvement in gynecologic oncology.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Mariana Scaranti to discuss ESMO 2025 Highlights: Top Studies In Gynecologic Oncology.   Mariana Scaranti, MD, is a Brazilian medical oncologist dedicated to gynecologic oncology. She practices at Hospital 9 de Julho in São Paulo and is the National Lead for Gynecologic Oncology at Rede Américas, Brazil. She serves as Research Director of Grupo EVA, the Brazilian Gynecologic Oncology Group, and is a member of the Gynecologic Tumors Committee of the Brazilian Society of Clinical Oncology (SBOC). She previously trained as a fellow at The Royal Marsden NHS Foundation Trust in London

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Nicole Concin to discuss ESGO-ESTRO-ESP 2025 Endometrial Cancer Guidelines.   Professor Concin serves as the Chair of the Department of Gynaecology and Gynaecological Oncology and as Director of the Department of Obstetrics and Gynaecology at the Medical University of Vienna. She is President of the Austrian Network of Gynaecologic Oncology (AGO Austria), Executive Committee member of the European Society of Gynaecological Oncology (ESGO), immediate Past-President of the ESGO, Board of Directors member of GCIG Gynaecologic Cancer InterGroup (GCIG), education faculty member for gynaecological cancer of the European Society of Medical Oncology (ESMO) and Board member of the International Federation of Gynaecology and Obstetrics (FIGO) Committee on Women’s Cancer. Professor Concin’s clinical, research and teaching focus is gynaecological oncology. She has led multiple translational and clinical research projects worldwide and provided her expertise in >100 international clinical trials in gynaecological oncology, several of which she served as Principal or Global Coordinating Investigator. She has authored >150 research articles inhighly ranked peer-reviewed Journals. Her most cited article is the European multidisciplinary guidelines for the management of patients with endometrial carcinoma (Concin N. et al, IJGC Dec 2020; >1300 citations). In recognition of Professor Concin’s ability and achievements, she has received multiple grants and awards including the award of the Austrian Society for Cancer Aid, i.e. the Univ. Prof. DDr. Karl Fellinger Award. Her recent article in Lancet Oncology, “ESGO–ESTRO–ESP guidelines for the management of patients with endometrial carcinoma: Update 2025,” presents the latest revision of the guidelines, building upon the previous version published in 2021.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Drs. Cristina Taliento and Giuseppe Vizzielli to discuss ctDNA & diagnosis of ovarian cancer.   Cristina Taliento is a gynecologist and PhD candidate in a joint PhD program at the University Hospital of Ferrara, Italy, and KU Leuven, Belgium, associated with the International Ovarian Tumour Analysis (IOTA) Group. She completed a Research Fellowship at the European Institute of Oncology in Milan. She recently started her Fellowship Training in Gynecologic Oncology at the University Hospital of Heidelberg, Germany. Her PhD research focuses on clinical and translational studies in the diagnosis and management of adnexal tumors, with a particular interest in circulating tumor DNA in ovarian cancer.   Giuseppe Vizzielli is an associate professor of gynecology and obstetrics at the Department of Medicine, University of Udine, and Chief of the Gynecologic Oncology Unit at University Hospital of Udine, Italy. He completed his Ph.D. studies in molecular pathology in gynaecological oncology at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma. He is a member of the European Society of Gynaecological Oncology (ESGO) and a member of the Italian Society of Gynaecological Endoscopy (SEGI), affiliated with the ESGE. He was the principal investigator of the national research project,  Longitudinal genomic and transcriptomic analysis on ovarian cancer organoids. He serves as an official reviewer of many indexed international journals as well as Lancet Oncology, the International Journal of Gynecological Cancer, the European Journal of Surgical Oncology, World Journal of Surgical Oncology, European Journal of Obstetrics and Gynecology and Reproductive Biology, Archives of Gynecology and Obstetrics, and BMC Cancer, and he is an associate editor of BMC Cancer, Cancers and the World Journal of Surgical Oncology. His recent publication in IJGC focuses on Circulating tumor DNA in the diagnosis of ovarian cancer.      

In this episode of the IJGC conversations 2025 December Editor's Choice, Editorial Fellow Itziar Villagrá, Joannie Neveu, and Mathilde Del discusses the contents of the 2025 December issue of IJGC.   

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Bradley Monk to discuss ctDNA: Results from CALLA Trial.   Bradley Monk, MD, FACOG, FACS is a board-certified gynecologic oncologist with Florida Cancer Specialists & Research Institute and medical director of the Late-Stage Clinical Research Program. He provides care to patients at the FCS West Palm Beach location. Dr. Monk has extensive leadership experience in practice-changing clinical research and the development of clinical research programs in community oncology settings. His research special interests are primarily focused on the prevention and treatment of gynecologic cancers. As a principal investigator, Dr. Monk has been involved in numerous groundbreaking studies throughout his career. Dr. Monk is a co-founder of the GOG-Partners (GOG-P) Foundation® (GOG-F), a nonprofit organization committed to advancing clinical and scientific research in the field of gynecologic malignancies. The organization was instrumental in establishing a national gynecologic clinical trials network. He has presented his findings at hundreds of national and international forums and authored more than 400 peer-reviewed articles and more than 35 book chapters focused on the prevention and treatment of gynecologic malignancies and patient reported outcomes. Dr. Monk is a past recipient of the esteemed Ernst Wertheim Award for his research in cervical cancer. Prior to joining FCS in 2024, Dr. Monk served as director and principal investigator for HonorHealth at the Virginia G. Piper Cancer Center in Scottsdale, Arizona, where he also served as the site research leader for Sarah Cannon Research Institute. Among his numerous academic appointments, he most recently served as a professor on the Clinical Scholar Track at the University of Arizona College of Medicine.

In this IJGC podcast, Dr. Pedro Ramirez discusses RAMP 201 Results: Avutometinib and Defactinib in Low-Grade Serous Ovarian Cancer with Susana N Banerjee and Rachel N. Grisham. Prof Susana Banerjee MBBS MA PhD FRCP is a Consultant Medical Oncologist and Research Lead for the Gynaecology Unit at The Royal Marsden NHS Foundation Trust, London. She is also Professor in Women’s Cancers at the Institute of Cancer Research. Dr Banerjee specialises in ovarian cancer and the systemic treatment of endometrial and cervical cancers. Prof Banerjee is President of the Royal Society of Medicine Oncology Section. Prof Banerjee graduated with a 1st class in Physiology from St John’s College, University of Cambridge. She was president of the Cambridge Medical Society in 1996-1997. She completed her medical training in 2000 at The Royal Free/University College London Medical School where she was a University of London Gold Medal finalist. Dr Banerjee gained a PhD from The Institute of Cancer Research in 2009, University of London and was awarded the San Antonio Breast Cancer Symposium Novartis Oncology Basic Science Award for her research. Other prizes include the Association of Cancer Physicians McElwain Prize, the Sir Antony Driver Prize and the Pfizer British Oncology Association Young Investigator Award (highly commended). She received The Fellow of ESMO (FESMO) Award in 2023. Prof Banerjee has served in international specialist groups including the European Organization for Research and Treatment of Cancer (EORTC) Executive Steering Committee for Gynaecological Cancers, ESGO (European Society of Gynaecological Oncology) Congress Faculty and International Gynecologic Cancer Society Scientific Program Committee. Prof Susana Banerjee was elected to serve on the European Society of Medical Oncology (ESMO) Executive Board as Director of Membership (2020-2022). She was Track Chair for Gynaecological Cancers for the ESMO Congress 2018, Scientific Co-Chair for ESMO Asia 2018 and Co-Chair of the ESMO Gynaecological Cancers Congress 2021-2024. She is currently co-chair of the Gynecological Cancer InterGroup (GCIG) Rare Cancers Committee. She is a Theme Lead (Cancer Treatment Effects) for the National Institute for Health and Care Research (NIHR) Biomedical Research Centre (BRC) at The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research. Prof Banerjee is an author of over 200 peer-reviewed publications including in the New England Journal of Medicine, Lancet, Lancet Oncology, Journal of Clinical Oncology and Annals of Oncology. Her research interests include individualisation of patient treatment, targeted therapies (including PARP inhibitors) and rare gynaecological cancers. Prof Banerjee has Global and UK Chief Investigator roles of over 30 national and international clinical trials. She led the ENGOTov60/GOG3052/RAMP201 trial globally which resulted in FDA accelerated approval for avutometinib and defactanib - the first approved therapy specifically for low grade serous ovarian cancer.   Dr. Rachel N. Grisham is a medical oncologist and internationally recognized expert in gynecologic cancers, with a particular focus on low-grade serous ovarian carcinoma (LGSOC) and rare ovarian malignancies. She has played a leading role in advancing systemic therapy for ovarian cancer through clinical trials, translational research, and national guideline development. Dr. Grisham has been at the forefront of evaluating novel targeted therapies for LGSOC, including MEK inhibitors, avutometinib, and defactinib, as well as hormone-directed strategies and combinations with novel agents. She has served as principal or co-investigator on multiple pivotal trials, including ENGOT-OV60/GOG-3052/RAMP 201 and RAMP 301, which are shaping the future treatment landscape for recurrent LGSOC. Her work extends to biomarker-driven approaches, exploring MAPK pathway alterations, homologous recombination deficiency, and folate receptor alpha expression, with the goal of developing precision oncology strategies in ovarian cancer. In addition to clinical trials, Dr. Grisham has published extensively on the molecular landscape and clinicopathologic features of ovarian tumors, treatment paradigms for granulosa cell tumors and clear cell carcinoma, and the management of rare gynecologic neoplasms such as mesonephric-like adenocarcinomas. She is a co-author of the NCCN Guidelines for Ovarian, Fallopian Tube, and Primary Peritoneal Cancers, reflecting her leadership in shaping standards of care. Her scholarly contributions include over a decade of influential publications in Journal of Clinical Oncology, Clinical Cancer Research, Gynecologic Oncology, International Journal of Gynecological Cancer, and Cancer. She has also authored consensus statements and state-of-the-science reviews that provide critical guidance for clinicians worldwide. Through her clinical research, teaching, and collaborative international work, Dr. Grisham has made significant contributions to improving outcomes for women with gynecologic cancers, particularly those with low-grade serous ovarian cancer, a historically under-researched disease.

In this IJGC podcast, Dr. Pedro Ramirez discusses SENTIX Trial with David Cibula. Dr. David Cibula graduated from the First Faculty of Medicine at Charles University in Prague in 1992. Since 2003, he has served as the Chair of the Gynecological Oncology Center at the University Hospital in Prague, and in 2022, he became the head of the Department of Gynecology, Obstetrics, and Neonatology. He is a former President of the European Society of Gynecologic Oncology and previously led the International Group for Guidelines and Quality Indicators in Cervical Cancer. He is the founder and chair of the Central and Eastern European Group for Clinical Trials in Gynecologic Oncology, a member of ENGOT. Dr. Cibula has also established two charitable organizations supporting patients with gynecologic cancers and promoting research in the field. He is the author or co-author of hundreds of scientific publications. His recent article in Nature Cancer presents the final results of the SENTIX study on sentinel lymph node biopsy in early-stage cervical cancer.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Dr. Frédéric Amant to discuss ESGO/INCIP 2025 Guidelines for Cancer in Pregnancy.   Frédéric Amant (MD, PhD) received his medical degree from the University of Leuven (KU Leuven), Belgium in 1992, completed his specialty training as an obstetrician/gynecologist in 1998 and his subspecialty training in gynecologic oncology in 2000. He defended his thesis on uterine sarcomas in 2002 at the KU Leuven. He is specialist at the UZ Leuven in Belgium. He is professor at the KU Leuven in Belgium and at the University of Amsterdam in the Netherlands, and honorary professor at the university of Pretoria, South Africa. Since 2024 he is council member of the European Society of Gynecologic Oncology. Frédéric Amant heads the Gynecologic Oncology research section at the University of Leuven, Belgium and at the Netherlands Cancer Institute. In 2005 he founded the “International Network on Cancer, Infertility and Pregnancy” (INCIP)(www.cancerinpregnancy.org), and chairs this network up till now. Since 2014, INCIP also registers young women who aim to preserve their fertility. In 2021 he launched the Advisory Board Cancer Infertility Pregnancy (ABCIP) under the umbrella of INCIP. In addition, Frédéric Amant founded Trace, the tumor xenograft platform at the KU Leuven and the Fund for Innovative Research at the KU Leuven. He co-founded ENITEC, the European Network on Individualized Treatment of Endometrial Cancer. Since 2024 he is member of the research council at the KU Leuven.

In this IJGC podcast, Dr. Pedro Ramirez discusses SUROVA Study: Surgery vs Neoadjuvant Therapy in Ovarian Cancer with Luis Chiva.   Prof. Luis M. Chiva, MD, PhD, is Chair of Obstetrics and Gynecology and Professor of Gynecology and Medical Ethics at the University of Navarra in Pamplona, Spain. An internationally recognized leader in gynecologic oncology, he is renowned for his expertise in complex pelvic oncologic surgery and his commitment to advancing surgical quality and patient-centered care. A graduate of the University of Madrid, Dr. Chiva completed his gynecologic oncology fellowship at Rush-Presbyterian–St. Luke’s Medical Center in Chicago. He later directed the Gynecologic Oncology Department at MD Anderson Cancer Center Madrid and established educational collaborations with MD Anderson Houston. Dr. Chiva has authored over 100 peer-reviewed publications, delivered more than 300 invited lectures, and spearheaded key educational initiatives such as the international “Meet the Surgeon” program. He has held major leadership roles within ESGO, including serving as council member, chair of the Quality Assurance and Certification Committee, and Editor-in-Chief of the ESGO e-Academy platform. He was presented for Honorary Fellowship in the American College of Surgeons in 2021.  

In this IJGC podcast, Dr. Pedro Ramirez discusses Updates in Radiotherapy in Gynecologic Cancers with Junzo Chino.   Dr. Chino is an Associate Professor of Radiation Oncology and Director of Brachytherapy at the Duke Cancer Center. He has authored over 100 publications in the peer reviewed literature, and his research interests are concentrated in radiation therapy for gynecologic cancer, as well as health services and disparities. He was lead author of the ASTRO guidelines task force for cervical cancer, and served as the GYN section editor at the International Journal of Radiation Oncology Biology and Physics and Associate Editor of the International Journal of Gynecological Cancer. His recent article published in Cancer focuses on Recent advances in gynecologic radiation oncology. 

In this episode of the IJGC conversations 2025 November Editor's Choice, Editorial Fellow Paula Mateo-Kubach and Matteo Loverro discusses the contents of the 2025 November issue of IJGC. 

In this IJGC podcast, Dr. Pedro Ramirez discusses Results of the MoST-CIRCUIT Trial with Oliver Klein.   A/Prof Klein is a clinician-scientist at the Austin Hospital and the ONJCRI with a 20-year experience in the field of cancer immunotherapy and a particular interest in the treatment of rare gynaecological malignancies. Dr Klein pioneered clinical trials using checkpoint blockade in patients with advanced rare cancers including gynaecological malignancies. These trials demonstrated unprecedented clinical outcomes in this patient population of major unmet medical need. Next to his clinical research, Dr Klein participates and leads translational research investigating biological correlates of response to immunotherapy.