DiscoverDDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson
DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson
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DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson

Author: Drew Donaldson | Performance Enhancement Coach

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DDT Method Podcast is for serious athletes and advanced lifters who want accurate information on compounds, protocols, fat loss, and the performance strategies that actually deliver results.

Drew Donaldson has spent years coaching serious athletes at every level, building protocols from the ground up alongside the practitioners, researchers, and competitors doing the same work. If you're serious about performance enhancement and want advice from someone operating at this level, this is your show.

Topics include: peptides, hormone optimization, performance enhancement biohacking and training.
102 Episodes
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Join my Enhancement Education Community → https://ddtmtd.co/skoolImplement the protocols → https://ddtmtd.co/applyNationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyNeed reliable, third-party tested research compounds: Janus Optimize Code DDTSkoolTen of the most repeated safety beliefs about TRT and steroids don't hold up, and internal medicine physician Dr. Christopher Bronson explains why. Some of these myths make TRT look riskier than it is. Others make steroid use look safer than it is. Drew and Dr. Bronson go through hematocrit and blood donation, blood pressure, ApoB and cholesterol, statins, echocardiograms and calcium scores, and why the rules for a medical TRT patient and a steroid user aren't the same.If you're on TRT, you might be donating blood you don't need to and draining your iron in the process. If you use steroids, a normal morning blood pressure reading and a zero calcium score can tell you you're fine when you aren't. The tests that look reassuring are often the ones that miss the problem, and the two things that actually lower your risk are cheap and easy to get. So if your bloodwork looks good, your calcium score is zero and your blood pressure is normal every morning, are you actually safe?Dr. Christopher Bronson is an internal medicine physician whose telehealth practice focuses on testosterone therapy, including many patients with obesity and diabetes. He founded TRTFacts.com and is writing a book on testosterone therapy.5 Key TakeawaysHigh hematocrit doesn't thicken your blood. What it actually does changes how much you should worry.Why over-donating may raise the very clot risk you were donating to prevent.Why daytime blood pressure isn’t the whole picture for enhanced athletes.Why controlling blood pressure, ApoB and hematocrit alone doesn't make steroids safe.How a zero calcium score can be the most dangerous result a steroid user gets.Chapters00:00 The Biggest Mistake Starting TRT 05:40 Who Is Dr. Bronson 11:11 Is High Hematocrit Actually Dangerous? 20:30 Why Hematocrit Stays High 28:15 How Tightly to Control Hematocrit 35:59 Blood Pressure: Morning Readings vs the 24-Hour Test 44:51 Blood Pressure and ApoB Targets for Enhanced Users 51:56 The Heart Damage You Can't Medicate Away 59:06 Why Calcium Scores Mislead Steroid Users 1:04:37 Cholesterol Targets on Medical TRT 1:07:47 Final ThoughtsConnect with Dr. Christopher BronsonWebsite: https://trtfacts.comInstagram: https://instagram.com/cbronsmdTikTok: https://tiktok.com/@cbronsonmdYouTube: https://youtube.com/@cbronsonMDAll links: https://linktr.ee/cbronsonmd
Nationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyReliable, third-party tested research compounds: Janus Optimize Code DDTSkoolJoin my Enhancement Education Community → https://ddtmtd.co/skoolHire me as your coach → https://ddtmtd.co/applyA month and a half ago my heart started skipping beats, and after an EKG, an ER visit, and a cardiologist, the answer was stress, not PEDs.Nothing was wrong with my heart.Everything was wrong with how I was running my life.So this is the first solo episode of the DDT Method Podcast, and it's the whole plan that came out of it. The training, nutrition and… all the compounds I’m taking and what I’m leaving behind.About me: I'm Drew Donaldson, founder of DDT Method. I spent fifteen years as a pro wrestler including time in WWE developmental, I ran MI40 Gym as head trainer and general manager under Ben Pakulski, and have been using peptides since 2010. I coach, I run the DDT Method School Group, and I'm in a lifelong argument with absolutist fitness advice.5 Key TakeawaysThe three things that were wrong when my heart started skipping beats, and none of them was my heart.Why a calcium score of zero at 38 didn't let me off the hook, and the test that finds what it can't.The two blood markers most guys on gear have never heard of, and the one that should keep you off steroids entirely if it's high.The announcement: my testosterone dose for the rest of my life, and why I'm done with everything above it.How to use fat loss tools by the day instead of by the cycle: which days get BAM15, which get ATX-304, and why they never overlap.Chapters0:05 First solo episode: what this is2:22 A thousand right ways, a million wrong ways4:41 Comic books, WWE developmental, 250 pounds, and MI409:08 Why I learn the mechanism: ATP, ROS, AMPK, mTOR15:29 The goal: the biggest 200 pounds humanly possible18:30 The heart scare: skipped beats, stress, a gallon of sweat a day24:16 Thick blood, and the EKG with the leads on backwards27:30 Calcium score zero at 38, and why that's not enough31:05 ApoB and Lp(a): the numbers guys on gear don't know35:29 Soft plaque, the contrast scan, the echo, and the Holter38:40 Phase one: macros, water, four hypertrophy sessions42:14 Steps, four cardio sessions, weighted vests, two HIIT sessions46:33 Norwegian 4x4s and the four functional sessions51:00 Hematocrit management and daily injections53:14 The announcement: replacement dose for life, nothing anabolic on top56:40 Taurine, TUDCA, senolytics, and the mitochondrial stack1:03:30 Tirzepatide over retatrutide1:04:11 SS-31: an Iron Man suit for the cell1:09:00 Plasmalogens, omegas, carbon 60, glutathione, BPC and TB-5001:13:01 Bioregulators: Thyrogen, Chelohart, Livagen, Vesugen1:14:30 The problem with 23-year-old educators1:18:30 Tesamorelin and the start of the fat loss phase1:20:40 MBD1 and the futile creatine cycle1:24:21 BAM15, DNP, and ATX-304: tools by the day, not by the cycle1:30:58 Epitalon, and FLGR-242 as the January finisher1:34:30 The tech: multi-wave oscillator, PEMF, CO2, red light, face plunge1:39:53 You can do cool shit without the hardcore levers1:42:20 Coaching, consult calls, and the School Group
Nationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyReliable, third-party tested research compounds: Janus Optimize Code DDTSkoolJoin my Enhancement Education Community → https://ddtmtd.co/skoolImplement the protocols → https://ddtmtd.co/applyIf it hurts, stop doing it. That's Joe DeFranco's advice for every man over 40 who's still training like he's 25, and he says he could end the podcast right there. We're glad he didn't, because the next hour is the system behind the most famous rebuild in strength and conditioning: Triple H at 40, body breaking down, one injury after another, willing to trade his physique for function. Joe told him he'd look the same or better. Three months without a heavy back lift, face pulls and band pull-aparts instead of 150-pound dumbbell rows, and his tailor measured his upper back bigger. Sixteen years later they still train together. On this episode of the DDT Method Podcast Drew gets the whole method: no mandatory exercises, upper/lower over the bro split, unilateral lower body, and relative-strength goals like a weighted push-up 10RM that you can't improve while carrying extra body fat.5 Key TakeawaysThe one piece of advice Joe says could end the podcast, and why most men over 40 ignore it every time they lift.Why Joe would make every online coach train people in person for five years first, and the one-in-fifty problem research can't solve.The exact changes that rebuilt Triple H, including the three months his tailor noticed before he did.The bodyweight above which every one of Joe's health markers goes bad, and the mindset shift that got him under it at 51.The weekly template for being good at everything: how many lifts, how many steps, how much zone 2, and the only HIIT session you need.Chapters0:00 Where men over 40 are dropping the ball0:47 If it hurts, stop: listen to your body, not the internet4:03 From a 500-square-foot storage closet to the New York Giants9:44 Train people in person for five years before you coach online18:38 Joe's transformation at 40: satisfied not full, 7.5/10 workouts, move more23:18 What goes wrong in your 40s even when you do everything right26:16 Bigger is not better after 40: leaner and stronger30:18 Good at everything: the pro wrestler problem33:48 No mandatory exercises: concurrent programming and relative-strength goals43:32 How Joe rebuilt Triple H: three months without a heavy weight53:07 The upper/lower split, two-minute mobility, and the unused home gym1:00:35 Cardio: don't start with Norwegian 4x41:04:48 The weekly template: lifts, steps, zone 2, and one HIIT session1:07:01 Where to find JoeConnect with Joe DeFrancoInstagram – https://www.instagram.com/defrancosgym/Website – https://www.defrancostraining.comYouTube – https://www.youtube.com/joedefrancoPodcast – The Industrial Strength Show
Nationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyReliable, third-party tested research compounds: Janus Optimize Code DDTSkoolJoin my Enhancement Education Community → https://ddtmtd.co/skoolImplement the protocols → https://ddtmtd.co/applyYou have peptide fatigue. We love PEDs, peptides, and small molecules as much as anyone, and we've watched the space go from hunting for Masteron to every person with a phone taking 87 things for every condition they think they have. So on this episode of the DDT Method Podcast Drew brings in Braydon Barrett, a strength coach of 13 years who studied pharmacodynamics and biochemistry on top of exercise physiology, and asks him which peptides are the real needle movers. Braydon answers with a question: what's your biological bottleneck? Because for most people it isn't a peptide. It's the mitochondria, and the things that build mitochondria are the things you're skipping. Two hard cardio sessions a week on top of heavy lifting. Heat. Sleep, which he calls the biggest mitochondrial uncoupler we have, and it's free. MOTS-c and 5-Amino-1MQ sit at the very bottom of his list. Peptides are the essential amino acids. Training is the steak.5 Key TakeawaysThe one question Braydon asks before he'll name a single peptide, and why most people's honest answer isn't a peptide at all.His ranked list for building mitochondria, from the thing no supplement can touch down to where MOTS-c and 5-Amino-1MQ actually land.The engine analogy that finally separates biogenesis, mitophagy, and efficiency, and which one you need right now.The four-block training system behind Look Like You Lift, and the one macro that moves with every block.The number Braydon checks before your body weight in a fat loss phase, and what he does the morning it drops.Chapters 0:00 Peptide fatigue: when everyone with a phone can buy anything1:21 Why peptides are the future of medicine, and the counterfeit problem4:31 A 13-year overnight success: strongman, powerlifting, Look Like You Lift9:33 Rigidity in training creates rigidity in thinking13:07 Start with the biological bottleneck, not the peptide17:08 The best-case peptide candidate: lean, optimized, and still wants more17:50 Mitochondria are not just the powerhouse of the cell19:25 What actually builds mitochondria (and where MOTS-c lands)23:56 Peptides are the amino acids, training is the steak24:51 The V8 engine: more cylinders, cleaner fuel, better firing30:29 Reactive oxygen species: redlining the electron transport chain34:13 The Look Like You Lift system: four training blocks40:45 Why dedicated blocks beat doing everything at once42:16 Carbs are the lever that moves with each block48:06 Your body is a thermostat, not a calculator51:20 Waking body temp: the number that gives you permission to push57:29 Cardio: two hard sessions a week, zone 2, and the HIIT you're not doing1:05:36 Where to find Braydon
Implement my protocols → https://ddtmtd.co/applyNationwide Bloodwork, no doctor visit → https://ddtmtd.co/AmplifyReliable third-party tested research compounds: Janus Optimize Code DDTSkoolJoin my Enhancement Education Community → https://ddtmtd.co/skoolYou're collecting peptides like Pokémon. That's Dr. Gabriel Alizaidy's diagnosis in the first ninety seconds of this episode of the DDT Method Podcast, and the next hour is the cure: pick the right tool for the right job, run one or two things at a time, dose low and slow, and let someone who isn't you make the call. Drew's intake forms went from three entries to forty-seven. Both of them have been guilty. Nobody gets to feel superior here.The section people will replay is mitochondria. SS-31 is physical therapy for your mitochondria. MOTS-c is exercise. Run them in the wrong order and you get the pattern Gabe sees constantly: two great injections, then tired all the time. He explains mitochondria the way he'd explain them to his mom (miles per gallon, exhaust, scrap the broken car), why diet, sleep, and training come before anything goes in a syringe, why MOTS-c works better with exercise instead of replacing it, and the MOTS-c doses he won't touch. Then the wide-angle stuff: red light therapy and nitric oxide, oxytocin as the peptide he uses before public speaking, myostatin inhibitors and FLGR from a safe distance, how Drew finds new compounds before they hit Instagram, why phase 3 trials for BPC-157 and TB-500 aren't coming, and the decision-fatigue conversation that lands where wealthy people already live: get an advisor for this part of your life. First peptide or fifteenth, this is the episode about how to choose.About the guest: Dr. Gabriel Alizaidy (MD; MS in Precision Health, University of Chicago) came up through CAR-T cancer research at UChicago, runs clinical R&D for a performance-medicine telehealth company, and sat on the FDA's Pharmacy Compounding Advisory Committee that voted this summer to move BPC-157, TB-500, KPV, and MOTS-c toward compounding pharmacies.5 Key TakeawaysThe one-line diagnosis an FDA panel doctor gives for how most people use peptides.Why SS-31 is physical therapy and MOTS-c is exercise for your mitochondria.The number of compounds Drew is actually running right now, even though he has vials of everything.Why phase three trials for BPC-157 and TB-500 aren't coming, and what a clinical researcher says should stand in for them.The reason Gabe says even a knowledgeable person shouldn't build their own stack, and the kind of advisor he thinks belongs in your corner.Chapters 0:00 Welcome, and how to work with DDT Method1:24 The #1 peptide mistake: collecting like Pokémon3:13 Who Gabe is: CAR-T research, telehealth R&D, and the FDA peptide panel8:17 The new fat-loss compounds, and why he won't rush them12:53 Mitochondria explained: miles per gallon and exhaust16:59 The non-negotiables before you inject anything20:24 SS-31 is physical therapy, MOTS-c is exercise: which comes first22:58 A word from Amplify Wellness and Janus Optimize25:33 Low and slow: the doses he won't touch28:30 Folate, AMPK, and cardiolipin: what the two peptides actually do33:04 Red light therapy and nitric oxide38:08 Oxytocin: the peptide for public speaking and connection42:52 Myostatin inhibitors and FLGR: watching, not touching47:55 A word from Amplify Wellness, Janus Optimize, and the Skool group50:09 How Drew finds new compounds, and why RCTs aren't coming55:56 Less is more: Drew's medicine cabinet confession1:00:32 Decision fatigue: put the call in an expert's hands1:06:42 Where to find GabeConnect with Dr. Gabriel AlizaidyInstagram – @gabrielalizaidyLinkedIn – https://www.linkedin.com/in/galizaidy/YouTube – https://www.youtube.com/channel/UCiOE4LyFDVoSuQLSLX7SM8A
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