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MCAT Basics (from MedSchoolCoach)
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MCAT Basics (from MedSchoolCoach)

Author: MedSchoolCoach

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Join us as we detail MCAT exam topics. Each podcast covers several MCAT sections with lessons based on review material put out by the AAMC, such as practice tests and question banks. Sam also interviews MCAT tutors and experts who share tips on how premed students can raise their score to get into medical school.
76 Episodes
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Social norms and deviance as covered in the MCAT is a fascinating topic, and in this episode, we'll break down the intersection of social norms—folkways, mores, taboos, and laws—how they play a crucial role in shaping societal values, and what happens when these norms break down, a concept known as anomy. Plus, we'll delve into collective behavior phenomena such as fads, mass hysteria, moral panic, and riots, touching on some real-life examples and historical comparisons.   Expect a comprehensive overview, with real-world relevance and plenty of examples to help solidify your understanding.    Visit MedSchoolCoach.com for more help with the MCAT. Jump into the conversation: [00:00] Introduction to the MCAT Basics [04:57] Breaking social norms is not a big deal. [09:00] Jeffrey Dahmer was a serial killer. [12:41] Breaking social norms, deviance explained in theories. [14:03] Biking under influence leads to deviant identity. [19:02] Weak community ties breed crime, social disorganization theory. [20:20] Cultural deviance theory explains lower class deviance. [23:39] Social control theory emphasizes individual responsibility for deviance. [26:58] Orson Welles's 1938 radio drama causes hysteria.  
In this episode, we’ll nail down all that is needed for the MCATB in relation to fat and protein metabolism. Two critical processes for gaining energy and maintaining cellular functions in the body. We'll learn about the intricate details of beta-oxidation, where fatty acids are broken down in the mitochondrial matrix to produce energy-rich molecules like NADH, FADH2, and acetyl CoA. From protein catabolism, where proteins are broken down into amino acids that feed into gluconeogenesis and ketosis pathways, to protein anabolism, where these amino acids are incorporated into new proteins. You'll get insights into the role of amino acids in synthesizing other compounds like serotonin and nucleotides. Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: 00:00 Introduction to MCAT Basics 01:25 Fat metabolism 02:00 Fat absorption 06:45 Breakdown of fats 08:30 Lipolysis 10:15 Transport of fatty acids 11:20 Beta oxidation pathway 13:40 Energy yield from beta-oxidation 16:00 Odd-chain and unsaturated fatty acids in beta-oxidation 20:00 Differences in energy production and pathways. 22:29 Fatty acid synthesis 25:15 Ketone body formation and usage 28:00 Protein breakdown (catabolism) 31:45 Glucogenic and ketogenic amino acids 35:00 Protein synthesis (anabolism)  
Work and Energy

Work and Energy

2026-01-2733:13

In this episode, we cover the topic of work and energy. We’ll start off by talking about work, which includes the mathematical and conceptual definitions and the sign convention of work. We’ll also talk a little bit about mechanical advantage and also path dependency. Moving on to energy, we’ll talk about the general definition of energy, we’ll compare and contrast energy in work and the different types of energy that includes kinetic energy, potential energy, thermal energy, and total mechanical energy. Lastly, we’ll talk about energy transfer, specifically heat transfer, and the three types of convection, conduction, and radiation. Visit MedSchoolCoach.com for more help with the MCAT.   Jump Into the Conversation: 00:00 Introduction 05:27 Summary: Limits of equation for work and force 08:39 Positive work: force and displacement in same direction 09:32 Comparison of mechanical and thermodynamic work sign conventions 12:50 Work changes kinetic energy of moving objects 16:32 Friction and energy 22:25 Pitching 27:10 Kinetic and potential energy relation  32:14 Sun and heat transfer  
The Endocrine System

The Endocrine System

2026-01-2238:48

In this episode, we’ll cover crucial aspects such as hormones, their origins and mechanisms of action, and the various structures within the endocrine system. We'll also decode complex cell-to-cell communication and distinguish between different hormone types—peptide, protein, steroid, and lipid-derived.   Furthermore, we'll explore key endocrine disorders like diabetes and hyper- and hypogonadism, discussing their causes, symptoms, and relevance to the MCAT. In addition, we'll touch upon the functions and hormones of several glands, including the pituitary, thyroid, adrenal glands, and pancreas.   Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: 00:00 Introduction to the MCAT Basics Podcast with host, Sam Smith 03:34 Exosomes act as information carriers for cells. 09:00 Large, charged substances dissolve in blood easily. 10:30 Protein kinase A activates multiple molecules quickly. 15:57 Podcast discusses prostaglandin, thromboxins, leukotrienes and glands. 18:22 Hormones explained: flat peg and pineal gland. 23:15 Endocrine diseases: hyperthyroidism, hypothyroidism, hyperinhypogonadism, diabetes. 26:33 Autoimmune disorder characterized by overactive thyroid production. 29:28 Hypothalamus role in hormone production and disorders. 34:01 Type 1 diabetes: Genetic and environmental factors. 35:47 Diagnosis and causes of type two diabetes. 39:18 Med School Coach elevates your application level.  
This episode is packed with essential high-yield information for your MCAT prep, covering the biological, physiological, and psychological aspects of sleep. We’ll explore various sleep theories, like the Memory Consolidation and Brain Plasicticity Theories, and even discuss the controversial “Sleeping When You Die” theory. We’ll also delve into dream theories, including Freud’s interpretations and the Activation Synthesys Hypothesis. Plus, we’ll address common sleep disorders such as insomnia, sleep apnea, and narcolepsy, alongside the effects of different drugs on your sleep patterns.    We’ll cover critical brain structures involved in sleep, such as the hypothalamus and the suprachiasmatic nucleus, and break down the stages of sleep measured through EEG, EMG, and EOG.    Visit MedSchoolCoach.com for more help with the MCAT.   [00:00] Introduction to the MCAT Basics podcast with host, Sam Smith [04:05] Pineal gland, amygdala, basal forebrain in sleep. [07:40] Measuring postsynaptic potential, not action potentials. EEG waves distinguish sleep stages. EMG records muscle electrical activity. [10:46] Alpha waves awake, theta waves asleep. Hallucinations in stage N1 sleep. [15:01] Unconfirmed sleepwalking. Stages of sleep explained. [18:18] Sleep cycles lengthen REM stage, diagrams illustrate. [19:50] We don't remember all our dreams. [23:55] Shifting circadian rhythms due to changes in light. [29:10] Blind people's melatonin release entrained with light. [29:41] Cortisol secretion cycle follows a circadian rhythm. [35:09] Freud: Dreams represent unconscious desires; manifest vs latent. [38:53] Divorce dreams related to spouse thinking time. Broad sleep disorder categories: insomnia, breathing, hypersomnolence. [41:18] Hypersomnia, narcolepsy, drugs' impact on sleep. [44:14 Brief primer on drug effects on sleep.  
The Excretory System

The Excretory System

2026-01-1529:28

In this episode, we're covering the anatomy and physiology of key organs such as the kidneys, liver, skin, lungs, and large intestine, and discuss the crucial role they play in eliminating waste products from our bodies. From the structure of the hepatic lobules in the liver to the sweat glands in our skin and the alveoli in our lungs, we'll cover how each component functions to maintain homeostasis. We'll also delve into the metabolic breakdown processes and the excretion of waste molecules such as urea, electrolytes, and gases like carbon dioxide.  Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] Introduction to the MCAT Basics Podcast with host, Sam Smith [04:50] Kidney, adrenal glands, nephrons filter blood. Bladder stores waste connected to kidneys. [09:57] Liver has lobes and functional hepatic lobules. Skin excretes through sweating. [12:20] Lung anatomy: trachea, bronchi, alveoli, gas exchange. [16:54] Urea cycle energy requirement, deamination of amino acids. [20:35] Urea density calculates volume of small ice cube. [24:15] Carbon dioxide is a metabolic byproduct. [27:46] Liver metabolizes drugs into water-soluble compounds.
Common Hormone Axes

Common Hormone Axes

2026-01-1338:01

In this episode, we'll explore three crucial hormone axes: the hypothalamic-pituitary-adrenal (HPA) axis, the hypothalamic-pituitary-gonadal (HPG) axis, and the renin-angiotensin-aldosterone (RAAS) system. We'll decode the complex interplays among the hypothalamus, pituitary gland, and various peripheral organs, focusing on how these hormone systems regulate everything from stress responses and reproductive functions to blood pressure and fluid balance. We'll break down the HPA axis and its pivotal role in stress response, featuring hormones like corticotropin-releasing hormone (CRH) and cortisol. Next, we’ll navigate through the HPG axis to understand the hormonal orchestration behind testosterone, estrogen, and progesterone production. Lastly, we’ll zero in on the RAAS system, demystifying its essential function in blood pressure regulation and electrolyte balance. Visit MedSchoolCoach.com for more help with the MCAT.  Jump into the conversation: [00:00] Introduction to the MCAT Basics Podcast with host, Sam Smith [03:11] Hypothalamus: brain section, regulates hormones, monkey bread. [08:57] Hypothalamus releases hormones to stimulate pituitary gland. [12:12] Cortisol is a crucial stress response hormone. [13:12] Steroid hormones need carrier proteins for transport. [17:05] Hypothalamic pituitary gonadal axis involves important structures. [21:01] Hypothalamus releases gonadotropin hormone for sex development. [27:14] Sex hormones regulate important body functions through feedback. [28:31] Juxtaglomerial cells respond to changes in blood pressure. [33:20] Angiotensin III and IV stimulate aldosterone release. [35:36] Renin angiotensin system increases sodium, blood pressure.  
In this episode, we’ll talk about  ATP or adenosine triphosphate. We will begin with a detailed examination of ATP's structure and composition as a nucleotide, followed by an explanation of the metabolic pathways involved in its production—both aerobic and anaerobic. We will also cover the pivotal process of ATP hydrolysis, emphasizing its energy release and crucial role in various cellular processes, including the sodium-potassium pump and protein phosphorylation. Additionally, we will address the limitations of ATP supplementation and the broader implications of ATP in biological transport and biosynthesis processes. This episode promises to provide a clear and thorough understanding of ATP's essential functions, ensuring you are well-prepared for your MCAT studies. Visit MedSchoolCoach.com for more help with the MCAT.   Jump Into the Conversation: [00:00] Intro into Adenosine Triphosphate, otherwise known as ATP [2:09] The structure of ATP  [06:48] Where and how ATP is produced [24:04] Thermodynamics of ATP [35:16] The functions of ATP [35:31] Sodium-potassium pump or the sodium-potassium ATPase [39:45] Protein kinases and protein phosphorylation [42:48] ATP binding cassette transporter protein or ABC transporter proteins  
Biological Membranes

Biological Membranes

2026-01-0644:24

This MCAT Basics podcast covers biological membranes. First, the podcast introduces a few topics regarding membranes: what they are, how they are formed, their presence in the cell, and cell-to-cell junctions. Second, it addresses transport through the membrane, including simple diffusion, active vs. passive transport, and transport membrane proteins. Next, the discussion moves to membrane proteins, including receptors, transporters, and the differences between integral, peripheral, and lipid-anchored proteins. Finally, the podcast covers membrane dynamics, such as endocytosis and the transmembrane system, and discusses membrane potential.   Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the Conversation: [00:00] Intro into MCAT Basics [01:08] Introducing Biological Membranes [01:53] What is a membrane and what is its structure [15:33] Cell to cell junctions and the involvement of plasma membranes [17:16] Transport through a membrane [26:49] Membrane proteins [31:05] Membrane dynamics and potential  
Electrochemistry

Electrochemistry

2026-01-0146:49

In this episode of MCAT Basics, we’ll cover Electrochemistry. We start with the role of salt bridges in electrochemical cells and cover the intricacies of cell notation. We’ll also discuss how ions maintain charge balance, the importance of reduction and oxidation potentials, and how these elements come together in galvanic and electrolytic cells. We’ll also take a closer look at concentration cells and the critical Nernst equation, which helps us understand cell potentials under non-standard conditions. Visit MedSchoolCoach.com for more help with the MCAT. Jump into the Conversation: [00:00] Introduction to MCAT Basics [01:09} Introduction to Electrochemistry [03:20] Concentration cell: same metal, different ion concentrations [13:05] Visualizing galvanic cells using royal analogy [22:19] Reduction potential, oxidation potential, cell potential explained [30:47] Electrochemical cells, Gibbs free energy, and Nernst equation [41:16] Electroplating and electric current to coat metals [45:40] Electrochemistry in Nanobiology: measuring oxidation of molecules  
The Digestive System

The Digestive System

2025-12-3049:32

In this episode, we'll break down the intricate processes of nutrient digestion and absorption, from the mechanical and chemical digestion in the stomach to the vital role of the small and large intestines. We'll also discuss the regulatory mechanisms involving hormones and nervous innervation and the essential structures like the liver, gallbladder, and pancreas. And don't forget, this episode is packed with tips on everything you need to know about this high-yield topic for the MCAT. So grab your notes, get comfortable, and let's embark on this fascinating journey through the digestive system. Stay tuned for a deep dive into how our bodies turn food into the vital nutrients we need to thrive. Visit MedSchoolCoach.com for more help with the MCAT. Jump into the conversation: [00:00] Introduction to the MCAT Basics [05:11] Digestive system involves mechanical and chemical processes. [06:55] Food travels through digestive system over time. [10:48] Small intestines: duodenum, jejunum, ileum, enterocytes crucial. [14:38] Sphincters in digestive system control food movement. [16:26] Podcast discusses physiology of digestive system structures. [20:57] Salivary enzyme breaks down starch into glucose. [23:46] Muscle contractions propel food through digestive system. [27:40] Lipase enzyme breaks down fats in stomach. [29:11] Stomach doesn't absorb nutrients, protects itself. [32:55] Enzymes linked to cells for carbohydrate breakdown. [38:05] Bile emulsifies fat, chylomicrons enter lymphatic system. [41:35] Gut bacteria metabolize cellulose, form fatty acids. [45:02] Living without large intestine; regulation of digestion. [46:50] CCK stimulates pancreatic juice release, important digestion. [49:57] Prepare for MCAT and excel with us!  
This podcast focuses on the eye. It begins with a brief overview of the eye's anatomy and physiology. The discussion then shifts to rods, cones, and the phototransduction pathway. The final section addresses perception. Key topics include visual field processing, differences between binocular and monocular cues, and feature detection (covering both Magno and Parvo pathways).  Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] MCAT Tutoring from MedSchoolCoach [00:34] Welcome to MCAT Basics [01:06] Topics covered in this episode [02:10] Anatomy & physiology of the eye [16:02] Phototransduction pathway [26:59] Perception  [28:13] Visual field processing [31:34] Binocular versus monocular queues [35:02] Visual feature detection - Gestalt principles [38:18] Parallel Processing [39:12] Parvo versus Magno pathways  
Sound and Hearing

Sound and Hearing

2025-12-2329:04

In this episode, we focus on the physiology of sound and hearing. We begin by exploring sound-related concepts, including sound waves, pitch, ultrasound, and the decibel system. Next, we delve into the anatomy and physiology of the ear, providing a clear understanding of how we perceive sound. This material will appear in two of the four MCAT sections: the Bio/Biochem and Physics/Chemistry sections. Visit MedSchoolCoach.com for more help with the MCAT.   [00:00] Introduction [01:50] Physics of sound waves [06:07] Wavelength and frequency equation [08:08] Equation for the speed of sound [11:01] Overall takeaway for the MCAT [11:15] Ultrasound imaging [14:23] The decibel system [18:05] Anatomy and physiology of the ear
Redox reactions or reduction and oxidation are reactions in which electrons are simultaneously transferred from one chemical species to another. This episode begins with exploring this concept, including an in-depth look at oxidizing and reducing agents and the factors determining a compound's effectiveness as an oxidizing agent.  It also covers the oxidation states of molecules and functional groups, common redox reagents in organic chemistry, and the role of redox in biological systems. The episode also addresses numerical concepts from general chemistry related to redox, such as determining oxidation numbers and understanding electrochemical cells. Visit MedSchoolCoach.com for more help with the MCAT.   [00:00] Introduction [01:09] What is the conceptual definition of redox [06:22] What is an oxidizing agent, and what is a reducing agent? [08:50] What makes a molecule better than another at being an oxidizing agent or a reducing agent? [13:58] Which oxidation reduction reagents should you know and what do they [21:44] Redox in biological systems [35:01] How to determine the oxidation state [41:16] The application of oxidation-reduction in electrochemical cells  
Intelligence

Intelligence

2025-12-1634:49

In this episode, we explore the topic of intelligence, which is primarily featured in the psychology and sociology section of the MCAT. We cover several key theories, including entity vs. incremental theory, general intelligence theory, two-factor theory, multiple intelligences theory, Triarchic theory, CHC theory, and biological theories. Additionally, we examine the nature vs. nurture debate on hereditary intelligence factors and discuss how intelligence is measured. Visit MedSchoolCoach.com for more help with the MCAT.   Jump Into the Conversation: [00:00] Intro to Intelligence [02:47] Entity vs. Incremental Theory [06:36] G Factor Theory [10:26] Multiple Intelligences Theory [12:18] Triarchic Theory [14:39] CHC Theory [18:58] Theories of Intelligence [21:01] Hereditary factors of intelligence  [28:33] How intelligence is measured [32:06] Why intelligence tests can be problematic  
This episode of MCAT Basics covers the world of circuits. We will explore electrical circuits and their fundamental principles. We’ll start with dissecting the essential parameters that form the backbone of circuits: voltage, current, resistance, and power. These are the building blocks upon which all circuit dynamics are based. Next, we'll explore a variety of circuit elements, from resistors to batteries, capacitors, and switches. Each of these components plays a vital role in shaping the behavior of circuits and understanding their functionality. Finally, we'll delve into Ohm’s Law and Kirchhoff’s Law, two fundamental principles that govern circuit behavior. By grasping these laws, you'll gain essential insights into how circuits operate and how to analyze their dynamics effectively. Visit MedSchoolCoach.com for more help with the MCAT and use promo code PODCAST to receive a five percent discount on your first session. Jump into the conversation: [00:00] MCAT Tutorig from MedSchoolCoach [00:34] Welcome to MCAT Basics [01:07] Topics covered in this episode [02:14] Circuit Variables - voltage, current resistance, power [22:59] Circuit Elements - resistors, sources of voltage, capacitors, and switches [44:28] Ohm's Law [45:24] Kirchhoff's Law  
This episode of MCAT Basics covers several separation and purification techniques you may see on the MCAT. We’ll cover these techniques in three distinct categories: small molecules, proteins, and cells.  Within the small molecule category, we’ll discuss extraction, crystallization and recrystallization, and chromatography (TLC and HPLC). For proteins, we cover SDS-page, precipitation, soelectric focusing, and chromatography variations. Lastly, we’ll explain, within the world of cells, centrifugation, flow cytometry, and microfluidics.    Visit MedSchoolCoach.com for more help with the MCAT.    Jump into the conversation: [00:00] MCAT Tutorig from MedSchoolCoach [00:34] Welcome to MCAT Basics [01:07] Topics covered in this episode [02:24] Techniques for small molecules - extraction, crystallization and recrystallization, and chromatography (TLC and HPLC) [28:24] Techniques for proteins - SDS-page, precipitation, isoelectric focusing, and chromatography variations [54:47] Techniques for cells - centrifugation, flow cytometry, and microfluidics.   
Innate Immune System

Innate Immune System

2025-11-2147:09

The immune system is split up into two main categories - the adaptive immune system and the innate immune system.  This episode will cover the intricacies of the innate immune system beginning with an overview of its constituent cells. We will then explore three pivotal elements of the system: anatomical barriers, the general inflammatory response, and the complement system. This will show up in the bio/biochem section of the MCAT. For additional reading on this topic, you can refer to the NIH’s Innate Immune System paper. Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] MCAT Tutoring from MedSchoolCoach [00:34] Welcome to MCAT Basics [01:06] Topics covered in this episode [02:09] The goal of the innate immune system [04:57] The cells that make up the innate immune system [11:47] Anatomical barriers to the innate immune system [19:53] General inflammatory response of the innate immune system [42:49] Complement system [45:33] MCAT Advice of the day - take as much time as you need to study for the MCAT  
Adaptive Immune System

Adaptive Immune System

2025-11-1942:42

To continue our discussion on the immune system, in this episode, we will cover the second type of immune system – the adaptive immune system.    We start with covering some vocabulary that you’ll need to know to understand the immune system, then we move into the cells that make up the adaptive immune system. Then we break down the two branches of the adaptive immune system -  humoral immunity including the discussion of B cells and cell-mediated immunity highlighting T cells.   Don’t miss our previous episode on the other type of immune system, the innate immune system.    Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] MCAT Tutoring from MedSchoolCoach [00:34] Welcome to MCAT Basics [01:06] Topics covered in this episode [02:01] Review on the difference between innate vs. adaptive immue system [02:32] General Vocabulary terms for the adaptive immune system [07:05] The cells that make up the adaptive immune system [13:09] The humoral immune system and B cells [26:07] Cell mediated immunity and T Cells [34:38] Antigen activation  
Renal Physiology

Renal Physiology

2025-11-1352:54

Understanding the kidneys' role in the body’s balance is essential for the MCAT and beyond. In this episode, host Sam Smith discusses renal physiology, covering everything from kidney anatomy to the nephron’s critical functions in filtration, reabsorption, secretion, and excretion. You’ll explore the roles of the renal cortex and medulla, learn about the loop of Henle, and uncover the importance of ions, plasma volume, and pH regulation in kidney function. Plus, we’ll examine hormones like ADH and aldosterone and their impact on fluid balance, as well as essential measurements like glomerular filtration rate (GFR) for assessing kidney health. Visit MedSchoolCoach.com for more help with the MCAT.  Jump into the conversation: (00:00) Intro to renal physiology (02:43) Kidney anatomy overview (08:38) Nephron structure and function (09:50) Six key functions of the kidney (12:03) Nephron Processes: Filtration (17:32) Nephron Processes: Reabsorption and secretion (22:51) The Loop of Henle (26:05) Understanding osmolarity in the Loop of Henle (26:55) Ion transport in the ascending limb (32:04) The role of the collecting duct (37:18) Hormonal regulation of the nephron (46:50) Key measurements of renal function (50:15) MCAT Advice of the Day
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Comments (1)

dchamberss dchamberss

This was a very good episode. Good breakdown and explanation. Give the course name, e.g. biochem I. It was hard to relate the quiz questions to the lecture topic, but I still liked the segment because you explained the answer well. A lot of content for the time. U listened twice. Thanks for respecting our time.

Aug 10th
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