Clinical Data Talks

Sylvain Berthelot welcomes Dr. Marek Wasiluk, CEO of ClinMark. With a career that spans from CRA to leading a global CRO, Marek brings a unique perspective on how clinical research organizations can embrace innovation while safeguarding trial quality. Together, they explore the fine balance between adopting new technologies and managing operational risk. Marek shares how his background in medicine, quality assurance, and clinical operations shapes his approach to implementing digital solutions that not only meet regulatory expectations but also bring real value to sponsors and patients. Sylvain and Marek discuss why CROs must be both cautious and bold when evaluating new tools, how to build trust with clients while innovating, and the importance of curiosity and adaptability in driving meaningful change. Tune in to hear how CROs can move beyond “shiny new objects” and take a thoughtful, balanced approach to innovation in clinical trials.

Join Sylvain Berthelot as he welcomes Mats Sundgren, Senior Advisor at the European Institute for Innovation through Health Data. A pioneer in implementing eSource during his years at AstraZeneca, Mats shares how this approach is transforming clinical research. Together, they explore what eSource really means and why reducing duplicate data entry at site level is such a game-changer. Mats highlights findings from a recent study with Memorial Sloan Kettering Cancer Center, which revealed the heavy time burden manual data entry places on coordinators, and how eSource can dramatically improve efficiency and data quality. The discussion also covers the promise and challenges of scaling eSource adoption: from interoperability standards like HL7 FHIR, to dealing with unstructured data using natural language processing. Mats emphasizes the role of AI as an assistant rather than a replacement, and why true progress requires aligning value across sponsors, hospitals, vendors, and regulators. Tune in to learn more about eSource, the cultural shifts needed for sustainable adoption, and the guiding principles Mats applies – rooted in Nash equilibrium.

Sylvain Berthelot sits down with Joe Erato, Chief Operations Officer at Spaulding Clinical. Together, they explore what it really takes to run early phase studies without paper – and why the transition to fully electronic systems can be both challenging and transformative. Joe shares how Spaulding Clinical was founded with a vision to “take clinical research into the next generation using technology,” and what it meant to implement paper-free processes from the very beginning. He reflects on the steep learning curve, the risks of being first to adopt, and the operational upheaval required to shift an entire unit away from legacy methods. Sylvain and Joe discuss the importance of integration to reduce manual entry, how real-time data capture accelerates decision-making and improves quality, and why designing systems around the patient experience is critical to compliance and study success. Tune in to hear how Spaulding Clinical built its operations from the ground up, the lessons learned along the way, and what going truly paper-free means for the future of clinical trials.

In this episode of Clinical Data Talks, Sylvain Berthelot welcomes Tanya Du Plessis, Chief Data Strategist and Solutions Officer at Bioforum. Together, they unpack what data surveillance really means and how to make it a practical reality in today’s clinical trials. With over two decades of experience in clinical data management, Tanya shares how the evolving regulatory landscape – including ICH E8 and ICH E6(R3) –  is pushing sponsors to adopt a more holistic, risk-based view of data. Rather than reacting to problems at the end of a study, she explains how data surveillance empowers teams to identify risks earlier, address root causes, and protect trial integrity. Sylvain and Tanya discuss why regulators intentionally avoid a rigid definition of data surveillance, how cross-functional collaboration between statisticians, medics, and data managers is key, and why proactive strategies ultimately save both time and cost.  Tune in to explore how data surveillance is reshaping the role of data managers, the culture of oversight, and the future of trial success.

Join host Sylvain Berthelot and Sébastien Coppe, CEO and co-founder of One2Treat, to explore a patient-focused approach to redefining clinical endpoints. Drawing from his background in optimizing clinical supply chains and his passion for involving patients more deeply in trial design, Sébastien shares how One2Treat is using technology to bring the patient’s voice into the earliest stages of clinical development. The discussion touches on the limitations of traditional endpoints, the value of co-designing studies with patients, and the promise of tools that capture lived experiences to define outcomes that truly matter. Sébastien emphasizes the need to rethink how we measure success in trials, through real-world impact and patient relevance. Tune in to discover how new statistical approaches are enabling a more meaningful way to define what good looks like in clinical research.

The evolving role of data managers with Kelly Forester Sylvain Berthelot sits down with Kelly Forester, a clinical data management expert with 30 years’ experience. Kelly shares personal stories from her journey in clinical research, including how she transitioned from early roles in data entry to leading global data strategies. They both reflect on the shifting expectations for data managers, from scripted technical execution to strategic thinking. In an increasingly digital and decentralized clinical trial landscape, they discuss the need for adaptability as ever evolving technologies reshape the industry. The conversation also dives into career development, mentorship, and the growing importance of soft skills and cross-functional collaboration. Tune in to discover how data managers are not just keeping pace with change but driving it.   Clinical Data Talks is a podcast brought to you by CRScube, a leader in eClinical technology solutions.

For the first episode of Clinical Data Talks, host Sylvain Berthelot welcomes industry expert Doug Bain to explore the intricate journey of clinical data - from its initial collection to final submission. With a background spanning software development and leadership roles at eClinical vendors and CRO, Doug brings a wealth of experience and sharp industry insights. Together, they discuss the evolving challenges of managing clinical data efficiently, the impact of new technologies on data workflows, and the importance of standardization in the world of clinical data. Doug also shares his perspective on how the industry can address persistent issues like data fragmentation and interoperability while embracing innovations that enhance data integrity and usability. Tune in to learn more about the clinical data life cycle and what’s shaping its future.   Clinical Data Talks is a podcast brought to you by CRScube, a leader in eClinical technology solutions.

Applying real world evidence to clinical trials with Cristina Chang In the final episode of season 1, Sylvain Berthelot welcomes Dr. Cristina Chang, Chief Medical Officer at HiRO, to unpack the growing importance of real-world evidence (RWE) in clinical development. With decades of experience across global pharmaceutical companies, Cristina shares her deep insights into how real-world data is being applied to clinical trials to enhance patient outcomes, regulatory submissions, and post-marketing strategies. She discusses the practical considerations for using RWE, from data collection challenges to ensuring scientific rigor, as well as how the regulatory landscape is evolving to support these efforts. Cristina also reflects on cultural and organizational changes needed to integrate RWE into clinical development successfully, and how emerging technologies and cross-functional collaboration can drive this transformation. Join us as we explore how real-world evidence is shifting from a buzzword to a critical component of evidence generation in modern clinical research.

In this episode of Clinical Data Talks, Sylvain Berthelot welcomes Brian Barnes, Director of Risk Management Strategy at BioNTech, to explore the human and strategic dimensions of risk-based quality management (RBQM). Drawing from his rich experience across CROs, technology vendors, and now a sponsor organisation, Brian shares how his role as a “risk assessment facilitator” reflects a broader cultural shift: developing a company-wide risk-focused mindset and moving risk management upstream into study design and operational planning. Sylvain and Brian talk about building risk frameworks from the ground up, demonstrating return on investment for RBQM and confronting resistance and misconceptions. Brian offers practical insight into why RBQM is less about the tools and more about people, collaboration, and culture. Tune in to discover what “good” risk management looks like and how to make it stick –across teams, trials, and organisations.

In this episode of Clinical Data Talks, host Sylvain Berthelot welcomes industry veteran Joe Dustin to explore the evolving landscape of eClinical technology and the impact of AI in clinical trials. With decades of experience across eClinical vendors and the sponsor side, Joe shares his insights into the major transformations shaping the industry - from paper-based processes to electronic data capture, on-premise systems to cloud platforms, and now, the rise of AI-driven solutions. Together, they discuss the current challenges of interoperability and fragmentation in clinical data, the potential of AI to enhance data management and trial design, and how standardization efforts like the USDM (Unified Study Definitions Model) are paving the way for faster and more efficient studies. This conversation is packed with valuable perspectives on where clinical technology is heading.   Clinical Data Talks is a podcast brought to you by CRScube, a leader in eClinical technology solutions.