Signal and Symptoms Podcast

Why do brilliant healthcare products fail before they ever reach patients? Sally Ann Frank, who leads Microsoft's worldwide strategy for health startups, exposes the fatal mistake and her proven protocol to avoid it.In this episode, Sally Ann Frank, Global Lead for Health & Life Sciences at Microsoft for startups, breaks down her proven Startup Protocol framework to achieve healthcare AI startup success in an agentic AI era. Drawing from her work with hundreds of early-stage companies, Sally emphasizes the critical mistake first-time founders make: investing all their energy in building a great product without doing customer discovery to prove anyone will actually pay for it. As AI agents transform healthcare delivery, she argues the conversation must shift from talking about AI capabilities to obsessively documenting the tangible value it creates—whether that's saving clinician time, improving patient outcomes, or streamlining administrative workflows.This episode provides Sally's tactical playbook for documenting value so convincingly that doing nothing becomes your customer's riskiest choice. From ideation to scale, her framework delivers the strategic clarity founders need to transform breakthrough ideas into fundable, sustainable businesses.What You Will Discover:- Sally Ann Frank: Her Mission In Action- Why Startups Fail Before Launch- How to Document End-User Value in Agentic AI era- Who Validates Value Before Scaling- The Unicorn Protocol- The No Free Pilots Rule- The Founder Mindset that Wins- Your Biggest Competitor: Customers Doing Nothing- A No Is Never Final Referenced in the show:🖇️ "The Start Up Protocol: A Guide for Digital Health Startups to Bypass Pitfalls and Adopt Strategies That Work" by Sally Ann Frank – https://www.amazon.com/Startup-Protocol-Startups-Pitfalls-Strategies/dp/103263944X/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1699382769&sr=8-8 🖇️ “The Unicorn Protocol: Digital Health Unicorns, How They Got There and What You Can Learn From Them” – https://www.amazon.com/Unicorn-Protocol-Digital-Health-Unicorns/dp/1032711019/?_encoding=UTF8&pd_rd_w=G2PgE&content-id=amzn1.sym.0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_p=0fb2cce1-1ca4-439a-844b-8ad0b1fb77f7&pf_rd_r=135-3915937-9293427&pd_rd_wg=HIDM6&pd_rd_r=dfd48b8a-14cb-42ef-98fc-b91d305d282c&ref_=aufs_ap_sc_dsk Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - a...

Healthcare is at a critical crossroads where clinicians are increasingly sidelined by administrative weight and third-party interests. The path forward isn't just surviving a broken system—it’s reclaiming our roles as primary stakeholders and system architects through a unified, "Doctor-to-Doctor" movement.Joining us to lead this conversation is Dr. Kianor Shah, a Southern California-based oral surgeon with 20 years of clinical experience and founder of the Global Summit Institute. Dr. Shah argues that the integration of medicine and dentistry is the next frontier of patient care, with AI serving as the "divine tool" to bridge these historical silos. By leveraging predictive analysis and peer-to-peer collaboration, we can move beyond the administrative burdens that cause burnout and return our focus to clinical excellence. This mission culminates in the 2026 Global Medical Dental AI Summit in London, a landmark effort to set rigorous, doctor-led standards for AI implementation. Together, we explore how transitioning from a service-provider mindset to a stakeholder mindset allows us to get around industry challenges and restore the oral-systemic health connection.What You Will Discover:- On Building the Doctor-to-Doctor movement- The Entrepreneurial Mindset- Bridging the Medical-Dental Gap- 2026 Global Medical Dental AI Summit- The Strategic Formula (0.5%) for Healthcare Transformation- Does a 3-5 Year Timeline Matter for Physician Leadership?- AI as the Unifying Catalyst, Not the End GoalAbout the Conference:2026 Global Medical Dental AI Summit📍 Leonardo Royale Hotel, London Tower Bridge📅 May 14-16, 2026🎤 100+ speakers | 3 tracks (Medical, Dental, Business) | 700 attendeesExclusive offer for Signals & Symptoms listeners:Use the discount code VIP20 for a special offer🔗 https://top100doc.com/london/ Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Kianor Shah DMD, MBS, Founder, Global Summits Institute💼LinkedIn -

The FDA stepped back. Now, organizational governance is the only thing standing between innovation and liability.At CES 2026, the FDA officially announced it won't regulate wellness devices or Clinical Decision Support tools—removing approval bottlenecks and accelerating innovation. But this regulatory shift transfers responsibility to healthcare organizations themselves. Who builds the frameworks for data management when there's no FDA requirement? How do health systems justify physician time reviewing continuous patient streams without reimbursement pathways? And where does liability fall in this new landscape?In this episode, Dr. Junaid and Ed tackle the AI governance vacuum, exploring how healthcare AI agents can scale care, from filtering patient data to managing population health. They share J.P. Morgan Healthcare Conference updates on why organizational trust, rather than just regulatory stamps, is the key to successful AI in healthcare.What You Will Discover:- What changed in the regulatory landscape?- How the shift affects clinician workflows- Who should pay for clinical data platforms?- JPM Conference Insights- The importance of governance and trust- Biologics, biosimilars, and China competition- Practical strategies for continuous learningReferenced in the show:🖇️ "Supercharging a New FDA: Marty Makary on Science, Power & Patients" – https://www.youtube.com/watch?v=DBlOJpT9Y1Y 🖇️A Field Guide to Deploying AI Agents in Clinical Practice – https://mitsloan.mit.edu/shared/ods/documents?PublicationDocumentID=10789 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamd📑Substack - https://substack.com/@junaidkaliamd2025?Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=en📑Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxVisit our website:

AI transformation in healthcare isn't something happening to physicians—it's an evolution physicians can actively shape and lead.In this episode, we introduce our host, Dr. Junaid Kalia, a practicing neurologist who experienced healthcare's systemic failures firsthand and decided to build the solution himself. As founder of SaveLife.AI, his journey embodies physician-led innovation: combining clinical expertise with entrepreneurial action to create real transformation. Joining the conversation are his sister, Dr. Saira Kalia (academic program director), and close friend, Dr. Danish Bhatti (angel investor/advisor), as they discuss the evolution from clinician to innovator—and why "action bias" matters more than perfect planning.Join our panel of a private sector entrepreneur, an academic program director, and an angel investor/advisor for a peer-to-peer reality check on the barriers, breakthroughs, and lessons learned.What You Will Discover:- Meet the Panel: Neurologist, Psychiatrist, and Their Unconventional Journeys- Why They Stepped Outside the Traditional Clinical Pathway- The Reality of Physician-Entrepreneurship- Reason Behind Execution Failure- The Resistance & Barriers They Didn’t ExpectConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Saira Kalia, MD, Associate Professor, Arizona & Pediatric & Perinatal Psychiatry💼LinkedIn - https://www.linkedin.com/in/saira-kalia-md-60685a132/overlay/about-this-profile/ Danish Bhatti, MD, Serial Entrepreneur and Angel Investor in Healthcare Startups💼LinkedIn - https://www.linkedin.com/in/danish-bhatti/ Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/

Drug development today forces patients to fit standard medications—but what if we could reverse that paradigm and design treatments tailored to each patient's unique biology?This episode explores how specialized AI cloud infrastructure is transforming drug discovery and healthcare research–not as a distant future possibility, but as tools available to researchers today. Joining the conversation is Dr. Ilya Burkov, who shares how the right computational foundation and HPC tools accelerate scientific breakthroughs at AI speed.The conversation reveals a significant shift in accessibility: junior researchers without specialized training now achieve 80-90% success rates in complex CRISPR experiments using agentic AI systems. These results once required years of expertise. Small research teams and startups can now access the same cutting-edge infrastructure as major pharmaceutical companies. This democratization directly impacts clinical practice: drug development timelines are compressing from decades to months, which means personalized treatments tailored to individual biology could become available within your career timeline.It's not just about raw infrastructure efficiency. It's about the combination of technology, accessibility, domain expertise, and white-glove support that together transform what's possible in healthcare innovation. What You Will Discover:- Dr. Burkov: Bridging Biology and AI Infrastructure- Nebius: AI Cloud for Drug Discovery, Genomics, Health Tech- Scaling Personalized Patient Medicine- Expert Support vs. Generic Clouds- AI Success for Junior Researchers- AI in Drug Discovery- Nebius On Democratizing Latest GPU Access- Future: Predicting Individual Patient OutcomesReferenced in the show:🖇️ "CRISPR-GPT for agentic automation of gene-editing experiments" – https://pubmed.ncbi.nlm.nih.gov/40738974/ Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Dr. Ilya Burkov, Global Head of Healthcare & Lifesciences at Nebius💼LinkedIn -

The most dangerous assumption in healthcare AI today is that we have time to "wait and see" how tools develop. With the state-of-the-art for AI models now shifting every 7 days, the traditional 3-year implementation cycle isn't just slow—it’s stagnating clinical transformation.In this episode, Dr. Khan Siddiqui (Radiologist and Founder of Hoppr AI) joins the panel to reveal why the future of medicine isn’t about choosing the "perfect" tool. Instead, it’s about building a sustainable system that can keep pace with technology improving at 1,600 times the speed of human practice. This conversation moves beyond theory to address a raw, systemic crisis facing modern medicine: where radiologists must read 145 cardiac CT scans in a single shift—roughly 5.5 images per second. This unsustainable pace leaves physicians exhausted and their families suffering the collateral damage of clinical burnout. Dr. Siddiqui breaks down how the collision of massive workforce shortages and declining reimbursements has moved AI from a "luxury" to a baseline requirement for survival. To meet this challenge, the episode explores the critical shift in a clinician-led innovation, frictionless workflow, and dynamic regulation.What You Will Discover:- From Clinician to AI Visionary- The Microsoft Origin of Hoppr- The True Cost of Clinical Burnout- The Systemic Collapse: Workforce Gaps- Why Augmentation is Survival- Ending Static AI Governance- Dr. Siddiqui’s Vision for the Future of Medicine- AI Without the Tech Tax- Why the FDA Model is FailingConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Khan Siddiqui, MD, Radiologist, Founder of HOPPR💼LinkedIn - https://www.linkedin.com/in/khansiddiqui/ 🏥Hoppr AI - ​​https://www.hoppr.ai/ Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:a...

This Holiday Special brings together 15 healthcare leaders, technologists, and innovators to tackle the biggest questions facing medicine in 2026. AI tools are proliferating across hospitals, but can healthcare systems integrate them effectively?Healthcare stands at a crossroads in 2026. AI is everywhere—from radiology to clinical decision support—but critical questions remain. Will it lower costs for patients? Can hospitals keep pace with innovation? And most importantly: who's steering this transformation? Our diverse panel of physicians, educators, consultants, and entrepreneurs shares their frontline perspectives on what's working, what's failing, and what must change.Tune in to discover practical steps for upskilling, embedding AI into workflows, and ensuring the next generation enters the workforce ready to leverage these technologies for better patient outcomes.What You Will Discover:- What's Coming in Healthcare AI 2026- Breakthrough Technologies & AI in Practice- What's Holding Healthcare Back- What You Can Do NowConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest:Avinash Jayaswal, MD, MS, MSc,💼LinkedIn - https://www.linkedin.com/in/avinash-jayaswal-md-ms-msc-464a5a2/Jim Pollock💼LinkedIn - https://www.linkedin.com/in/jimdpollock/Dipu Patel, DMSc, MPAS, ABAIM, PA-C💼LinkedIn - https://www.linkedin.com/in/dipu-patel-dmsc-pa-c-695000b/ Arlen Meyers, MD, MBA💼LinkedIn - https://www.linkedin.com/in/ameyers/ Kianor Shah DMD, MBA💼LinkedIn - a...

The future of AI-enabled care is massive and available, but the question remains: will we be the ones leading it?In this episode, Dr. Robert Pearl – Former CEO of Permanente Medical Group (Kaiser Permanente), Author of "ChatGPT, MD", Forbes Contributor – joins the panel to challenge the core of how we practice medicine today. Medical students are entering training with AI capabilities that their professors don't possess. But beneath this technological evolution lies a clinical crisis: 400,000 deaths annually from misdiagnosis, intermittent care for chronic diseases, and a system that could eliminate up to $2 trillion in wasteful spending.The conversation addresses why AI integration advances rapidly in other countries, yet the US lags, not from lack of technology, but from cultural resistance and misaligned financial incentives. Dr. Pearl reveals the solution he's witnessed work at scale that allows a delivery system to have smarter chronic disease management and better doctor-patient interaction.This discussion connects directly to what matters most in clinical practice: better diagnostic accuracy, continuous disease monitoring that actually works, and care delivery that doesn't burn out physicians while delivering superior results. The paradigm can shift from the traditional trade-off between quality, access, and cost to a model where increasing quality and access genuinely lowers cost.What You Will Discover:- The Era of Smarter Students: AI Skills Professors Don't Have- The Clinical Crisis: 400,000 Deaths From Misdiagnosis- How 24/7 AI Monitoring Reduces Heart Attacks & Strokes by 30-50%- Why Singapore & Dubai Lead While the US Lags- Why Current Incentives Block AI Adoption- The Fee-for-Service Problem: Rewarding Volume Over Outcomes- How AI will Impact Pharmaceutical innovations- Flipping the Paradigm: Lower Cost Through Higher Quality & AccessReferenced in the show:🖇️ "ChatGPT, MD: How-AI Empowered Patients & Doctors Can Take Back Control of American Medicine" – https://www.amazon.com/dp/B0CWCV9DVZ 🖇️ “Mistreated: Why We Think We’re Getting Good Health Care – And Why We’re Usually Wrong” – https://www.amazon.com/Mistreated-Think-Getting-Health-Usually/dp/1610397657/ Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=enEdward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - a...

If healthcare AI is truly evolving, why are there still gaps between what technology can do and what healthcare organizations are actually doing? These gaps aren't just inefficiencies. They're creating real clinical risks that directly impact patient outcomes.This year-end roundtable brings together three healthcare AI experts—Dr. Harvey Castro, Dr. Junaid Kalia, and Edward Marx—following their appearance at AIMed 2025 to share their key takeaways from deploying AI in the messy reality of hospital systems. They synthesize insights across policy, culture, and implementation: how cost disruption reshapes hospital innovation budgets, what Singapore's mandatory retraining model signals about workforce transformation, and where CMS guidelines create strategic inflection points for health systems. They demonstrate what continuous collaborative learning looks like in practice: completing advanced certifications, testing tools hands-on in their own workflows, and building AI systems for acute care environments.Whether you're a clinician evaluating AI tools for your practice, an executive planning institutional strategy, or a founder building healthcare AI solutions, this episode helps you separate signal from noise and position yourself strategically in this transformation.What You Will Discover:- Introduction & ABIM Course Discussion- Ed's 3 Key Learnings for AI-Driven Transformation- Harvey's 3 Takeaways: Martec's Law & The Culture Problem- Junaid's 3 Lessons from Building AI Solutions- Why Nurses Are Being Left Behind in AI Adoption- Deep Seek Impact: How AI Costs Dropped 99%- Who Should Pay for AI? Government vs. Private Investment- Singapore's Approach: Mandatory AI Retraining PolicyReferenced in the show:🖇️ “2025 Agenda: Advancing Healthcare with Expert-Led AI” – https://aimed.swoogo.com/aimed25/8350420 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx   Visit our website:https://signalandsymptoms.com/Get advisory insights about...

Innovation signals are everywhere, but what matters are those that move from laboratory potential to measurable clinical impact.Joining the conversation are Jim Pollock and Tom Meese from LumenAstra, demonstrating how clinical insight, technical capability, and strategic execution bridge the gap between healthcare innovation and patient outcomes. The discussion explores how their innovative work in developing non-invasive internal body temperature measurement technology will transform the future of AI development, enhance predictive models, and drive the creation of new clinical applications, all while leveraging the interdisciplinary nature of healthcare technology.This isn't promotional & theoretical. Just the evidence of what happens when we measure the right interventions and act on them wisely.What You Will Discover:- Introduction to Lumen Astra & Its Mission- Innovative temperature measurement technology- Why has technology only emerged now- How real-time brain temperature improves clinical decisions - Dr. Kalia's compassion fatigue story in Neuro-ICU - Building through customer discovery over assumptions- Closing: AI, evidence, and futureConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx  Connect With Our Guests:Jim Pollock - Co-founder, LumenAstra💼LinkedIn - https://www.linkedin.com/in/jipollock/ Tom Meese - Co-founder, LumenAstra💼LinkedIn - https://www.linkedin.com/in/tom-meese-615ab35/ For clinical collaboration or investment inquiries📧 - info@lumenastra.io 🔗 - https://www.lumenastra.io/  Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:

What if the biggest barrier to better cancer care isn't technology—it's how physicians approach treatment with ego?In this episode, we sit down with Dr. Talia Baker, a transplant surgeon who walked away from clinical practice to solve a problem she witnessed firsthand: the liver cancer patient journey is fundamentally broken.Dr. Baker introduces the Lori MDT project, a vision for reshaping how patients navigate fragmented cancer care. But the real conversation goes deeper—into the uncomfortable truths about institutional incentives, the care gaps between diagnosis and treatment, and why even the best academic centers are limited by their own biases. Her core argument: fragmented cancer care demands interdisciplinary collaboration and technology-driven process re-engineering. The era of incremental improvements is over. The future belongs to integrated services that cut across specialties—not siloed excellence in labs or imaging alone.What You Will Discover:- How the system's fragmentation and silos fail patients today- Why 75% of cancer patients don't get multidisciplinary care- The hardest problem: physician hubris, not technology implementation- The wisest surgical lesson—knowing when not to operate- Why we lost sight of focusing too much on product quality over service integration- Building mosaics of superpowers before digital twins take overThis isn't about replacing clinicians with AI—it's about collaboration across clinicians, technologists, patients, and systems to augment what we can do together.Referenced in the show:🖇️ "OpenTSLM: Time-Series Language Models for Reasoning over Multivariate Medical Text- and Time-Series Data" – https://arxiv.org/abs/2510.02410 🖇️ “Artificial intelligence should genuinely support clinical reasoning and decision making to bridge the translational gap ” – https://www.nature.com/articles/s41746-025-01725-9 🖇️Chain-of-Influence: Tracing Interdependencies Across Time and Features in Clinical Predictive Modelings – https://arxiv.org/abs/2510.09895 🖇️“Large language models forecast patient health trajectories enabling digital twins” –https://www.nature.com/articles/s41746-025-02004-3 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram -

What if we're running a sick care system pretending to be healthcare? AI promises to change that by improving access for patients and reducing burden for providers, but only if we have leaders who know how to guide the transformation. The challenge: healthcare offers no structured pathway for developing these leaders.Joining today's expert panel: Arlen Meyers, MD, MBA, President & CEO of the Society of Physician Entrepreneurs, and Muhammad Siddiqui, Chief Digital & Information Officer at Reid Health. Together, they reveal why this leadership gap exists across four levels (personal, organizational, systemic, and societal) and what's actually working on the front lines.The conversation moves beyond theory into practical realities: why the traditional triple threat model (clinician-researcher-educator) must evolve into something new, how real implementation success shows up in physician quality of life before ROI spreadsheets, and why sustainable AI adoption ultimately requires changing the rules that shape our current healthcare system. The missing piece isn't just technology. It's a culture of continuous learning that prepares physicians to bridge clinical expertise, technological fluency, and entrepreneurial thinking.What You Will Discover:- Introduction & Episode Overview- The Four Barriers to AI Adoption- Why Physicians Aren't Becoming Tech Entrepreneurs- The New Triple Threat in Medical Career- Building AI IQ of Healthcare Through Education- The Leadership Development Gap- Bridging Clinical Innovation and Business Value- The Complexity of Healthcare Sales- Actionable Advice for Healthcare Leaders- Reframing the Problem: Changing the RulesReferenced in the show:🖇️ "There is no Chief Healthcare AI Officer School" – https://arlenmeyersmdmba.substack.com/p/there-is-no-chief-healthcare-ai-officer 📚 Digital Health Entrepreneurship (Health Informatics) by Arlen Meyers - https://www.amazon.com/Digital-Health-Entrepreneurship-Informatics-dp-3031339010/dp/3031339010/ref=dp_ob_title_bk Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website -

If AI is the future of healthcare, why is its adoption moving at a glacial speed?In this episode, Sherri Douville, CEO of Medigram and Chair of the Trustworthy Technology and Innovation Consortium (TTIC), argues the true bottleneck is not technology, but a crisis of accountability. She explains that systems—even those that are FDA-approved and cyber-secure —stall because hospital leadership lacks robust governance frameworks to properly evaluate solutions and grant final approval for patient care. The panel reveals how to establish trust infrastructure and why elevating AI governance to the same rigorous level as finance and clinical quality is the only path to scalability. This structural shift from treating AI as an "innovation experiment" to a reliable "system of record" is the only way to manage risk, ensure accountability, and accelerate safe, effective deployment.What You Will Discover:- Deploying AI Safely and Effectively: Her Mission- Why the C-Suite Cannot Evaluate AI- The CIO's Dilemma: Clinical Risk Approval- Founder's Advice: Investor-Client Compatibility- Govern AI Like Finance and Clinical Quality- Mindset is the Biggest Limiting Factor- Hospitals Face Audits Q2 Next Year- Human Resilience Gives the Most HopeTune in for an actionable roadmap to accelerate your AI transformation, complete with frameworks for executive oversight, ethical deployment, and securing your future investments.Books Mentioned:📚Mobile Medicine by Sherri Douville – https://www.amazon.com/Mobile-Medicine-Overcoming-Culture-Governance/dp/0367651505 📚Advanced Health Technology by Sherri Douville – https://www.amazon.com/Advanced-Health-Technology-Managing-Acceleration/dp/1032391480 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/about-ed-marx📹YouTube - https://www.youtube.com/@EdwardMarx  Special Guest:Sherri Douville💼LinkedIn -...

What if the biggest threat to the future of medicine isn't AI—but our refusal to use it?That's exactly what keeps Dr. Anthony Chang up at night. As founder of Intelligence-Based Medicine (AIMed) and a pioneering pediatric cardiologist, he's dedicated his career to a singular mission: ensuring clinicians aren't left out of healthcare's AI revolution.In this episode, Dr. Chang joins us to outline the new paradigm where AI serves as the great equalizer—amplifying the reach of elite institutions while empowering rural hospitals with the same capabilities. He shares his vision for a future driven by clinical leadership, data science, and the most revolutionary tool in modern medicine: the Digital Twin, which will soon become routine for personalized care.What You Will Discover:- Introduction & AIMed Conference preview- Digital Twins: The end of "1x research" in medicine- The real barriers to AI adoption- Why AI is the great equalizer for rural hospitals & developing countries- The bilingual clinician imperative- How physicians’ critical thinking and judgment will remain essentialLearn the practical skills and strategic knowledge to lead the AI revolution at the premier event for Artificial Intelligence in Medicine.🔗Register for AIMed25 Global Summit: https://aimed.swoogo.com/AIMed25 🔗Explore the American Board of AI in Medicine: https://abaim.org/ 🔗Catch Dr. Harvey Castro's upcoming TEDx talk on AI in healthcare at TEDxSouthlake 2025🔗Discover cutting-edge AI applications at the AI for Healthcare Leaders ConferenceArticle reference:🖇️ "If A.I. Can Diagnose Patients, What Are Doctors For?" – https://www.newyorker.com/magazine/2025/09/29/if-ai-can-diagnose-patients-what-are-doctors-for Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website -

Artificial Intelligence is being hailed as the Fourth Industrial Revolution, but if you're a clinician or a healthcare executive, it might feel more like a permanent roadblock. You’re past the hype, but still wrestling with the paradox: Why does technology that can predict diseases days in advance get stuck in endless, expensive pilot programs?Join physician-founder Dr. Junaid Kalia and international advisor Dr. Harvey Castro as they diagnose the true state of AI in healthcare. They argue that the friction you feel trying to implement a new tool is merely a symptom of a much larger, global tension—one that is fundamentally cultural, economic, and geopolitical. We explore the deep regional divide on AI adoption, contrasting Western healthcare's inherent caution with Asia's rapid acceptance, and expose the mounting pressure on US-based AI. International models are closing the performance gap while costing as little as one-tenth of the price, creating a crucial strategic dilemma for every strategic budget. Finally, we confront the regulatory landscape: is increased US regulation genuine oversight, or a strategic form of "protectionism" designed to slow down nimble innovators?This episode offers more than just diagnosis—it delivers the actionable foresight needed to lead. The hosts strip away the philosophical debate on whether AI can truly "think" and refocus on the only thing that matters: creating workflows that solve critical problems. What You Will Discover:- The Fourth Industrial Revolution: Understanding AI's threat to current healthcare labor models.- AI in Action: The shift to embedded systems and autonomous life- Geopolitics and Price Wars: How global competition creates a strategic dilemma on costs- Regulation as Protectionism: Is increased US governance designed to protect patients or to safeguard market interests?- The Workflow Revolution: Why it matters for clinical impactReferenced in the show:🖇️ "The state of AI: How organizations are rewiring to capture value” – https://www.mckinsey.com/capabilities/quantumblack/our-insights/the-state-of-ai 🖇️ “The 2025 AI Index Report” – https://hai.stanford.edu/ai-index/2025-ai-index-report 🖇️ “BIG IDEAS 2025” – https://www.ark-invest.com/big-ideas-2025 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram -

What happens when breakthrough technology arrives before the infrastructure to support it? Healthcare organizations face AI transformation without the policies, governance, or strategic frameworks to implement it effectively. The gap creates a vacuum that patients are filling on their own—forcing leaders to rethink their approach.In this episode, Dr. Zayna Khayat joins the conversation as a health futurist—not to predict what's coming, but to help healthcare leaders make strategic decisions that create their desired future rather than react to an uncertain one. Alongside physicians and executives navigating innovation from different vantage points, she explores why proven innovations stall in approval cycles, and how leaders shift from reactive deliberation to strategic action.The episode demonstrates what that shift requires: deciding what percentage of organizational choices align with future vision versus current crises, building governance infrastructure before deploying innovation, and using collapse scenarios as speculative tools to change how leaders decide today. Organizations engaging in this work now shape their evolution. Those seeking certainty first may find patients and entrepreneurial outsiders have already moved forward.What You Will Discover:- How applied futurism helps make strategic bets on emerging futures- The market infrastructure innovators must build- Future visioning with leadership as the prerequisite for innovation adoption- The Collapse Scenario: AI-empowered patients dissolving primary care modelsConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/about-ed-marx Special Guest:Zayna Khayat, Ph.D., Health Futurist💼LinkedIn - https://www.linkedin.com/in/zaynakhayat/  Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/ 

Can AI-powered wearables and sophisticated diagnostic algorithms truly change clinical practice? Or are we mistaking technological capability for clinical readiness?In this episode, our hosts bring a dual perspective as physicians and healthcare AI futurists to a critical analysis. They examine emerging hardware and diagnostic approaches that could reshape real-time workflows, scrutinize what benchmark studies actually reveal about AI performance, and articulate a vision grounded in a simple but profound truth: while the physician's eye is limited to the visible spectrum, AI can process extensive multimodal data in real time.This isn't about diminishing the role of physicians. It's about what happens when AI is designed as an extension of physician capability rather than a substitute for it. The episode offers a concrete vision of how this partnership could work in practice, and what a human-AI partnership means for clinical practice.What You Will Discover:[00:34] Intro[00:54] How AI-powered glasses could reshape real-time clinical workflows[05:45] What radiology benchmarks reveal about AI's clinical readiness[07:45] Why human perception has fundamental limits and how AI fills that gap[09:26] How lack of regulation could amplify health inequities in the AI era[10:19] Envisioning the need for physician-algorithm specialists[12:06] Shaping a more capable, present, and human-centered practiceReferenced in the show:🖇️ “The algorithmic consultant: a new era of clinical AI calls for a new workforce of physician-algorithm specialists” – https://www.nature.com/articles/s41746-025-01960-0 🖇️ “Radiology’s Last Exam (RadLE): Benchmarking FrontierMultimodal AI Against Human Experts and a Taxonomy ofVisual Reasoning Errors in Radiology” – https://arxiv.org/abs/2509.25559 🖇️“Analog in-memory computing attention mechanism for fast and energy-efficient large language models” – https://www.nature.com/articles/s43588-025-00854-1 🖇️ “New Meta Ray-Ban AI-Powered Display Glasses & Neural Band” – https://www.meta.com/ai-glasses/meta-ray-ban-display/?srsltid=AfmBOorJFTa87uJM8WpBm-rGtISfvdb-LGADG99BHMZfDIH-Ijj7Pzz6 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram -

What if AI could have detected your patient's serious condition earlier than your current best practice protocols, potentially avoiding a complex intervention? For Ed Marx, this isn't hypothetical—he lived it. This episode dives into the clinical realities of AI as a tool for early diagnosis, demonstrating how it's transforming the clinician-patient partnership and challenging providers to rethink workflows to keep pace with AI-empowered patients. Drawing from 20 years of digital transformation leadership and deeply personal healthcare experiences, Ed Marx shares powerful personal case studies of AI's success in diagnostics and overcoming access bottlenecks for specialized care. This episode provides a grounded analysis necessary to examine the immediate strategic implications for practitioners and the necessity for administrators to reorganize primary care delivery models.The future of care requires collaboration—where clinicians leverage AI not as a replacement, but as a tool to enhance early detection, improve access, and extend their reach.What You Will Discover:- From Digital Charts to AI Charts: Healthcare's Third Evolution- Why Concierge AI Is Nothing Like Dr. Google- Ed's Prostate Cancer Story: How AI Could Have Changed Everything- “December Is Too Late”: Bypassing Specialist Wait Times with AI- Why 40% of Patients Are Skipping Visits- How AI Empowers Rather Than Replaces- From Resistance to Action: Strategic Steps for Healthcare LeadersReferenced in the show:🖇️”The algorithmic consultant: a new era of clinical AI calls for a new workforce of physician-algorithm specialists” – https://www.nature.com/articles/s41746-025-01960-0 🖇️ “If A.I. Can Diagnose Patients, What Are Doctors For?” https://www.newyorker.com/magazine/2025/09/29/if-ai-can-diagnose-patients-what-are-doctors-for Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/about-ed-marx  Visit our website:

The question isn't whether AI works in clinical practice—it's about dismantling the bottlenecks that keep proven innovations trapped in academic papers instead of integrated into daily care.In this episode, our panel of experts cuts through the noise to ask: What's actually preventing healthcare from closing the implementation gap—and what can we do moving forward? Because we need more healthcare professionals who not only recognize AI's potential but also implement it in a way that improves patient outcomes. Hear from three voices who bring this challenge to life: a clinician-founder who's navigated the frustration of having evidence without approval, a clinician and international AI advisor offering global insight on building trust and navigating governance, and a healthcare executive confronting the daily tension between operational demands and strategic transformation. Through peer-to-peer dialogue, they challenge conventional wisdom about innovation hierarchies, experimentation, and what leadership truly entails in the age of AI.What You’ll Discover:- The Seven-Year Evidence Gap- Why Culture (not Capability) is the Real Barrier- The Operational Trap: Why There's No Time to be Strategic- How Transparency Builds Trust in AI- Why Fear of Failure and Over-Governance Kill Innovation- Innovation Hierarchy: The Danger of Hiring Another Chief.- How to Remove Yourself from the Grind and Think about the Future- Board-Level Education: The Need for Tech-Advanced Leadership- Strategic Framework: A 5-Question for C-suite’s AI ReadinessMost importantly, you'll walk away with a five-question evaluation framework that CMOs, CFOs, and CEOs can use immediately to assess AI readiness and drive meaningful implementation.This isn't just theory—it diagnoses the real barriers and prescribes practical solutions. Referenced in the show:🖇️ "Accelerating clinical evidence synthesis with large language models" – https://www.nature.com/articles/s41746-025-01840-7 Book mentioned:📚Healthcare Digital Transformation: How Consumerism, Technology and Pandemic are Accelerating the Future - https://a.co/d/86uLRxw Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  a...

Healthcare AI is in its Wild West phase—messy, undefined, and full of potential. In this episode, our panel takes a step back to ask: where are we on this path to innovation, and how do we prepare for what's next?The conversation explores where healthcare AI sits on the hype cycle. While some are just discovering what AI can do, others are already navigating the trough of disillusionment. Our hosts discuss why innovation appears messy right now, how that's actually normal, and what the barriers to adoption reveal about the future trajectory.What You Will Discover:- Why controlling the 'mess' too much stifles progress?- What is the current stage of Healthcare AI in the Hype Cycle?- Who will pay for AI?- How to create a safe space for experimentation?From the struggle to legally define what AI even is, to the careful balance hospital leaders must strike between enabling innovation and ensuring patient safety—this episode is about distinguishing value from hype. Join our panel of experts for a peer-to-peer reality check on where we are, where we're headed, and how to navigate the uncertainty in between.Referenced in the show:🖇️ "The algorithmic consultant: a new era of clinical AI calls for a new workforce of physician-algorithm specialists" – https://www.nature.com/articles/s41746-025-01960-0 🖇️ “Unprepared and overwhelmed: A case for clinician-focused AI education” – https://www.sciencedirect.com/science/article/abs/pii/S0933365725001873 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/about-ed-marx  Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/