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Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
74 Episodes
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We’ve had one difficult coagulation topic yes, but what about second difficult coagulation topic? We are joined by the fantastic Dr Caroline Dix today to take us through not one but TWO challenging scenarios in thrombosis. First we’ll be revisiting Cerebral Venous Sinus Thrombosis but this time with someone who knows what they are doing. After that we’ll cover anticoagulating people when some very fundamental parts of the system are broken - the management of antithrombin deficiency. This epi...
Sometimes something comes along that puts a chill down the spine of every doctor. Any conversation that starts with "Oh hey do you remember that patient you saw...?". Mystery meat day in the cafeteria. Dealing with hospital executives. For these times in life you need a guide. Today we'll be covering one of those spine-chilling clinical scenarios with our very apt guide consultant haematologist Dr Sara Ng. Over forty minutes Sara will un-chill your spine with her practical approach to managin...
Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent films. Look - we go outside and experience the full gamut of popular culture. Oh and we finish up our discussion of thrombophilia testing in the lab - looking this week at activated protein C resistance testing, molecular Factor V Leiden assessment and Prothrombin gene mutations. TIMESTAMPS 1:06 - P...
Lions and tigers and… thrombosis? Oh my! Join the Bloody Minded Crew on the yellow brick road to visit the emerald laboratory and see the wonderful wizard of clots - your friendly laboratory coagulation scientist! Put on your blood red ruby slippers and join us for this bumper lab episode as we learn about how exactly we test for Protein C, S and antithrombin deficiencies as well as lupus anticoagulants. By the end of it you’ll have a brain for coags, a heart full of of love for thrombosis an...
“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing. ...
We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!) Timestamps: 0:58 - ROADTRIP 4:07 - CVST 11:07 - CVST - Treatment 15:36 - Lemierre's 17:50 - CRVO 24:36 - Splanchnic Thrombi 34:45 - Renal Vein Thrombi 39:41 - Uterine Vein Thrombus 42:09 - Ovarian Vei...
It's said that beauty is skin deep but you know what else lurks just under your epithelium - CLOTS! Nick, Cale and Bashar head very slightly under our outer layer to the peripheral vasculature in this increasing tortured metaphor as we learn on our shortest episode to date about what to do when those not so deep vessels fill with thrombus. Timestamps 2:12 - Where are superficial veins? 5:23 - What's the deal with thrombophlebitis 7:34 - MONDOOORS (To the tune of Trogdor) 9:11 - Risk Fac...
D-ismayed by D-readful D-ressing D-owns by your D-emonstrably D-eplorable registrar? . Join de Bloody Minded Crew for a Tour D-Force of D-Dimer D-rama as we D-issect and D-iscuss this most D-ifficult of D-iagnostic tests! Timestamps 2:14 - What is a D-Dimer and where does it come from? 6:57 - FXIII and D-Dimer 7:49 - Fibrinolysis and other degradation products 10:18 - D-Dimer Assays - LIA 14:22 - D-Dimer Units - Important! 15:39 - D-Dimer Assays - ELISA / ELFA 16:59 - D-Dimer Assays - POCT 18...
“Give me a 2cc bolus of clot stat Emma. No wait - not there!” But it was too late, and Em-Bolused the 2cc of clot straight to the lungs”. Join the Bloody Minded Crew as they get to the heart… no get to the lungs of the topic of Pulmonary Embolism. VanQuish the V/Q and CriTically aPprAise the CTPA with these acronyms that are just as bad as a cardiology trial and half as useful. Sadly the Top Gun soundtrack is copyrighted but nothing will stop you playing Berlin over the background of the intr...
Calves, thighs, arms and more, Clots can form inside them all! Join your hosts Cale, Bashar and Nick as they take a deep (hah) dive into the nitty-gritty things you should know about managing DVTs of the extremities TIMESTAMPS 0:54 - Intro to Extremity Clots 3:49 - Veins of the Lower Limb 5:54 - History & Exam Lower Limb 10:54 - Phlegmasias 15:52 - Investigations 21:27 - Below Knee DVTs 26:41 - Proximal Lower Limb 29:40 - May-Thurner 33:04 - PTS 34:33 - Upper Limb 41:15 - How long...
Rudolf the red nosed physician Wrote a very cool triad And if you ever saw it you would even say ‘Egad!’ All of the other physicians used to laugh and call him dumb They never let poor Rudolf join in the MDT fun Then one foggy clinic day a patient came to say “Rudolf with your triad so smart won’t you describe to me the pathophysiology of clotting in a way that both makes sense and fits inside the metre of this children's song” But he couldn’t, so welcome back to our next batch...
Philip K. Dick once wrote, “Perhaps if you know you are insane then you are not insane. Or you are becoming sane, finally. Waking up.” Waking up, that is, not to the alternative history universe where the Axis won WWII but rather, to a new bonus episode on Castleman disease! Join Cale, Bashar and Nick as we explore one of Haem’s most zebra diagnoses, and do whatever we can to put off Nick’s clot season for just a bit longer. TIMESTAMPS: 00:53 - Holiday to Bavaria 04:12 - Basics of Castleman D...
Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse? Why does everyone freak out when these patients are febrile? Why is everyone so hung up about handwriting? What are these weird drugs? It's OK – we are here once more to demystify the acronyms – and help you know what we are giving, why we are giving it and how to manage complications of Bi-Specific and CAR-T...
Bamboozled by basophils bountiful booty of granules? Let’s begin brilliantly with a basophil based bonanza. Buckets and buckets of brazenly basophil related bonus banter. You beauty! But, beware the bawdy, boisterous boys babbling brobdignagian-ly about BASOPHILS. It sounds better if you read it in Hugo Weaving’s voice and it’s the 5th of November I swear. TIMESTAMPS 3:07 - What are basophils? 6:54 - Snapping turtle trivia 7:55 - Role of basophils 9:42 - Basopenia &...
The mighty eosinophil had triumphed. The last parasitic worm lay vanquished beneath his granule-studded pseudopodia. For years, he’d battled helminthic scourge, a hero in mucus armor. But now, with no foes left to smite, he grew restless. He turned his sharp gaze to pollen, peanuts, and pet dander. "Troublemakers," he muttered, unsheathing his cytotoxic arsenal. With righteous zeal, he charged into the sinuses and skin, sparking sneezes and wheals in his wake. “A threat is a threat,” he decla...
Put on your monocles and kimonos and hop on the monorail to our episode composed of monotonous monologues, monogamously dedicated to that most monolithic and sometimes monoclonal of mononucleated cells. We are monobviously talking about the monocyte. TIMESTAMPS 0:57 - Mono-Cyte! 2:50 - What is a monocyte? 4:20 - Monocyte subclasses 6:00 - Role of monocytes 8:10 - Causes of Monocytopenia 9:43 - Hairy cell leukaemia 12:42 - Reactive monocytosis &n...
Behold the field in which I grow my cells and see that it is barren. It’s out of the frying pan and into the aplastic fire with not a cell in sight. Join Nick, Cale and Bashar without two neutrophils to rub together as we talk about an approach to that most concerning of FBC features - pancytopenia. TIMESTAMPS 2:22 - Definition of pancytopenia 4:23 - Spurious pancytopenia 6:04 - Cutoffs (arbitrary as usual) 9:43 - Acquired aplastic anaemia 15:30 - Inherited b...
Once again the Bloody Minded Crew have ventured out of the lab to find and trap another haematology registrar from the wards and convince them to come back to the show and talk about cells. Join haematology registrar Dr Lise Kempler as she teaches the team about what to do when that lymphocyte number just creeps up and up and up. TIMESTAMPS 2:34 - Aspiring to be a lymphocyte 5:44 - What are lymphocytes? 9:52 - Cutoffs (arbitrary as usual) 13:09 - Infective causes &n...
Whilst most of haematology is spent looking forlornly into the empty neutrophil cupboard like old Mother Hubbard post chemotherapy, the pendulum can also swing to the other extreme. Join us as we unpack the reactive and not-so-reactive causes of a neutrophilia so you don’t get too left-shifted on the wards. TIMESTAMPS 2:18 - Apologies to the Welsh 3:07 - Cutoffs (arbitrary as usual) 4:46 - Left-shift 7:02 - Spurious neutrophilia 7:44 - Reactive neutrophilia ...
A lone neutrophil stands alone against a horde of gram negative bacteria. He is the last of his kind, the single granulocyte rising from the ashes of a marrow once verdant with haematopoiesis, now overrun with blasts. As the endotoxin rushes towards him, he smiles, for on the horizon he can see the glimmer of tazocin rushing through the blood vessels like Gandalf leading the Rohirrim to Helm’s Deep. While the Bloody Minded Cinematic Universe remains in pre-production, you can sate your appeti...
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