NEI Podcast

Originally released in 2024, this episode features the late Dr. Vladimir Maletic in conversation with Drs. Andy Cutler and Stephen Stahl about the clinical significance and neurobiology of anhedonia. They discuss its different dimensions, how it differs from emotional blunting, its relationship to functioning and treatment response, and practical approaches to assessment and treatment. The episode highlights why recovery from depression requires restoring interest, motivation, and pleasure—not simply reducing negative symptoms.  Vladimir Maletic, MD, MS, was a clinical professor of psychiatry and behavioral science at the University of South Carolina School of Medicine in Greenville and a consulting associate in the Division of Child and Adolescent Psychiatry at Duke University. Board certified in psychiatry and neurology, his areas of expertise included the neurobiology of mood disorders, schizophrenia, pain, and sleep–wake regulation.  Stephen M. Stahl, MD, PhD, DSc (Hon.), is a psychiatrist, psychopharmacologist, and internationally recognized educator in clinical neuroscience and psychopharmacology. He is the author of widely used educational resources, including Stahl's Essential Psychopharmacology and Stahl's Prescriber's Guide, and his work focuses on translating complex neurobiology and treatment mechanisms into practical clinical concepts for mental health clinicians.  Andrew J. Cutler, MD, is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and EMA Wellness. He is a Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.   Fall Congress  Get $100 off NEI Fall Congress registration with code POD26. Go to https://nei.global/fall to sign up today!  Membership  As a valued NEI Podcast listener, Dr. Cutler's offering you 20% off new NEI Membership with code CUTLER20. Go to https://nei.global/member and join now!  Never miss an episode!🎙SUBSCRIBE to the NEI Podcast – available on all your favorite platforms: https://nei.global/podcast  Interested in Psychopharmacology? Learn about the NEI Master Psychopharmacology Program: https://nei.global/mpp   Stay updated with email alerts and join our conversations on social. Follow us on:  YouTube: https://nei.global/youtube  Instagram: https://nei.global/instagram  LinkedIn: https://nei.global/linkedin  Facebook: https://nei.global/facebook  X: https://nei.global/twitter

In this episode, Dr. Andy Cutler speaks with Dr. Tim Wilens about the complex relationship between attention-deficit/hyperactivity disorder (ADHD) and substance use disorders. They discuss how to distinguish ADHD from substance-related cognitive symptoms, determine when co-occurring conditions should be treated concurrently, and select appropriate ADHD medications based on the substance involved. Dr. Wilens also examines stimulant misuse and diversion, the role of nonstimulants, what is known about centanafadine's abuse potential, and practical approaches to monitoring treatment without undermining the therapeutic relationship.  Timothy E. Wilens, MD, is chief of the Division of Child and Adolescent Psychiatry and is co-director of the Center for Addiction Medicine at Massachusetts General Hospital. He is the MGH Trustees Chair in Addiction Medicine and a professor of psychiatry at Harvard Medical School. Dr. Wilens' research interests include the relationship among ADHD, bipolar disorder, and substance use disorders, embedded health care models, and the pharmacotherapy of ADHD across the lifespan.     Andrew J. Cutler, MD, is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and EMA Wellness. He is a Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.  Fall Congress   Get $100 off NEI Fall Congress registration with code POD26. Go to https://nei.global/fall to sign up today!   Membership  As a valued NEI Podcast listener, Dr. Cutler's offering you 20% off new NEI Membership with code CUTLER20. Go to https://nei.global/member and join now!  Never miss an episode!🎙SUBSCRIBE to the NEI Podcast – available on all your favorite platforms: https://nei.global/podcast  Interested in Psychopharmacology? Learn about the NEI Master Psychopharmacology Program: https://nei.global/mpp   Stay updated with email alerts and join our conversations on social. Follow us on:  YouTube: https://nei.global/youtube  Instagram: https://nei.global/instagram  LinkedIn: https://nei.global/linkedin  Facebook: https://nei.global/facebook  X: https://nei.global/twitter

Originally released in 2021, this episode features Dr. Thomas Schwartz discussing common mistakes in psychopharmacology and how psychiatric clinicians can recognize and manage them. He explores diagnostic uncertainty, medication dosing, informed consent and monitoring, and rational versus irrational polypharmacy. He also considers how clinicians can reassess inherited diagnoses, learn from prescribing errors, and preserve the therapeutic relationship when mistakes occur.   Thomas L. Schwartz, MD, is a Distinguished Teaching Professor at Norton College of Medicine, SUNY Upstate Medical University in Syracuse, New York. He is an award-winning educator deeply involved in medical student and resident training, as well as the development of continuing medical education in psychiatry.  Fall Congress  Get $100 off NEI Fall Congress registration with code POD26. Go to https://nei.global/fall to sign up today!  Membership  As a valued NEI Podcast listener, Dr. Cutler's offering you 20% off new NEI Membership with code CUTLER20. Go to https://nei.global/member and join now!  Never miss an episode!🎙SUBSCRIBE to the NEI Podcast – available on all your favorite platforms: https://nei.global/podcast  Interested in Psychopharmacology? Learn about the NEI Master Psychopharmacology Program: https://nei.global/mpp   Stay updated with email alerts and join our conversations on social. Follow us on:  YouTube: https://nei.global/youtube  Instagram: https://nei.global/instagram  LinkedIn: https://nei.global/linkedin  Facebook: https://nei.global/facebook  X: https://nei.global/twitter

In this episode of PsychopharmaPearls, Dr. Andy Cutler and Dr. Will Sauvé discuss what clinicians need to know about kratom. They review why patients use it, signs of misuse, dependence, or withdrawal, and key pharmacologic and safety concerns. The conversation also offers practical guidance for discussing kratom use and incorporating it into treatment planning.  William Sauvé, MD, is a board-certified psychiatrist and Chief Medical Officer at Osmind. He has extensive experience in interventional psychiatry, including TMS and esketamine, and previously served for 11 years as an active-duty Navy psychiatrist. He also serves on the faculty of the Neuroscience Education Institute.  Andrew J. Cutler, MD, is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and EMA Wellness. He is a Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.   Fall Congress  Get $100 off NEI Fall Congress registration with code POD26. Go to https://nei.global/fall to sign up today!   Membership  As a valued NEI Podcast listener, Dr. Cutler's offering you 20% off new NEI Membership with code CUTLER20. Go to https://nei.global/member and join now!  Never miss an episode!🎙SUBSCRIBE to the NEI Podcast – available on all your favorite platforms: https://nei.global/podcast  Interested in Psychopharmacology? Learn about the NEI Master Psychopharmacology Program: https://nei.global/mpp   Stay updated with email alerts and join our conversations on social. Follow us on:  YouTube: https://nei.global/youtube  X: https://nei.global/twitter  Instagram: https://nei.global/instagram  Facebook: https://nei.global/facebook  LinkedIn: https://nei.global/linkedin

In this episode, Dr. Andy Cutler is joined by Drs. Stephen Stahl and Jeffrey Strawn to discuss deprescribing practices in psychiatry. They explore why deprescribing is an essential clinical skill, how to determine whether a patient still needs a medication, dose, or combination, and how to approach tapering in a way that balances relapse prevention, withdrawal risk, and patient-centered care. The conversation also covers practical considerations for deprescribing antidepressants, antipsychotics, benzodiazepines, and sedative-hypnotics, with attention to common pitfalls and strategies for safer, more intentional medication management.  Stephen M. Stahl, MD, PhD, DSc (Hon.), is a psychiatrist, psychopharmacologist, and internationally recognized educator in clinical neuroscience and psychopharmacology. He is the author of widely used educational resources including Stahl's Essential Psychopharmacology, Stahl's Prescriber's Guide, and Stahl's Deprescriber's Guide, and his work focuses on translating complex neurobiology into practical clinical concepts for mental health clinicians.  Jeffrey R. Strawn, MD, FAACAP, is a Professor of Psychiatry, Pediatrics, and Clinical & Translational Pharmacology at the University of Cincinnati, Ohio. He is Director of the UC Anxiety Disorders Research Program and Associate Vice Chair of Research in the Department of Psychiatry & Behavioral Neuroscience at UC, and he is the author of Stahl's Deprescriber's Guide.  Andrew J. Cutler, MD, is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and EMA Wellness. He is a Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.  Resources  Strawn, JR, Stahl SM. Stahl's Deprescriber's Guide. Cambridge University Press; 2026. https://doi.org/10.1017/9781009642187  Fall Congress   Get $100 off NEI Fall Congress registration with code POD26. Go to https://nei.global/fall to sign up today!   Membership  As a valued NEI Podcast listener, Dr. Cutler's offering you 20% off new NEI Membership with code CUTLER20. Go to https://nei.global/member and join now!  Never miss an episode!🎙SUBSCRIBE to the NEI Podcast – available on all your favorite platforms: https://nei.global/podcast  Interested in Psychopharmacology? Learn about the NEI Master Psychopharmacology Program: https://nei.global/mpp   Stay updated with email alerts and join our conversations on social. Follow us on:  YouTube: https://nei.global/youtube  Instagram: https://nei.global/instagram  LinkedIn: https://nei.global/linkedin  Facebook: https://nei.global/facebook  X: https://nei.global/twitter