The Catalysts

Can the trillions of microbes in our gut hold the key to transforming cancer treatment? Through relentless persistence, Saman Maleki, PhD, is pioneering research that uses the gut microbiome and fecal microbiota transplants (FMT) to boost the power of cancer-fighting immunotherapy. In this episode, he shares the science, the challenges, and the hope driving a new frontier in cancer care.  With Saman Maleki, PhD  Associate Professor, Departments of Pathology & Laboratory Medicine, Oncology, and Medical Biophysics, Schulich School of Medicine & Dentistry, Western University  Scientist, Ontario Institute for Cancer Research (OICR)  Scientist, Verspeeten Family Cancer Centre, London Health Sciences Centre Research Institute  Saman Maleki's Poop Pills   FMT Phase 1 Trials  FMT at Work 

 What if your body already held a secret weapon to beating cancer? Mansour Haeryfar, PhD, is tapping into MAIT cells — a rare type of immune cell that can be supercharged with bacterial molecules to hunt down tumours. His research suggests these cells could form a basis for powerful, universal therapies that work across patients. In this episode, he'll reveal how this cutting-edge science could transform cancer treatment and how the inspiration to fight against malignancy came from an unexpected source.    With Mansour Haeryfar, PhD   Professor, Departments of Microbiology & Immunology, Medicine, Surgery, and Oncology, Schulich School of Medicine & Dentistry, Western University  Scientist, Lawson Research Institute of St. Joseph's Health Care London Past President, Canadian Society for Immunology    Robert Pope: the Artist  MAIT Cells Fighting Cancer Tumors  The Haeryfar Laboratory 

Imagine if doctors could send tiny, living medicine straight to a tumor — and then watch it move through the body in real time. That's the work of imaging scientist John Ronald, PhD. From eureka moments, to using firefly genes to track cells, in this episode he tells us how curiosity and creativity are leading to cancer treatment breakthroughs, and opening new frontiers in cancer treatment — one where therapies can be monitored, adjusted, and optimized as scientists track their progress inside the body with unprecedented resolution.     With John Ronald, PhD  Associate Professor, Medical Biophysics Director, Imaging Laboratories, Robarts Research Institute Schulich School of Medicine and Dentistry Western University     John Ronald's Lab Cell Tracking Research Imaging Reporter Genes Monitoring Cell Therapies 

When it comes to cancer drug treatments, one size doesn't fit all. That's because our unique genetics determine how our body reacts to certain drugs, which can turn a life-saving treatment into a side-effect nightmare. This is the problem Dr. Richard Kim has spent his career solving. He's championed pharmacogenomics: using genetics to match the right drug to the right patient. His persistence helped make Ontario one of the first provinces to adopt genetic testing that prevents severe chemotherapy side effects, saving lives and reshaping cancer care. In this episode, Dr. Kim explains why "one-size-fits-all" medicine is outdated and how innovations in technology are turbocharging genomics and precision medicine.    With Richard B. Kim MD, FRCPC, FCAHS, FRSC Wolfe Medical Research Chair in Pharmacogenomics Professor of Medicine, Physiology & Pharmacology, and Oncology  Chair, Division of Clinical Pharmacology Department of Medicine Schulich School of Medicine & Dentistry, Western University  Attending Physician, London Health Sciences Centre Scientist, London Health Sciences Research Institute   Personalized Medicine at Schulich  Groundbreaking Drug Testing  Wolfe Medical Research Chair in Pharmacogenomics  Pharmacogenomics in the Clinic   

Every cancer journey begins with images—CT scans, MRIs, X-rays. For most of us, they're snapshots that confirm what's already there. But for Sarah Mattonen, PhD, at Schulich School of Medicine & Dentistry, those images hold untold stories. She's uncovering hidden patterns in scans—clues that can reveal if a tumor might come back, or if treatment could cause side effects before patients feel them. With the power of AI, she's turning medical images into roadmaps for truly personalized cancer care. In this episode, we explore how her work is transforming cancer treatment today, and what it means for the future of oncology.  With Sarah Mattonen, PhD   Assistant Professor of Medical Biophysics and Oncology, Schulich School of Medicine & Dentistry, Western University  Scientist, London Health Sciences Centre Research Institute    Cancer Imaging at the Baines Centre  Alumni profile   Paper in International journal of Radiation Oncology, Biology, Physics  Paper in the Journal of Thoracic Disease  Paper in the International Journal of Medical Physics Research and Practice 

Cancer can feel like a battle fought in darkness - but what if you could turn on the lights? In this episode, Dr. David Palma, a radiation oncologist and clinician-scientist, explains how he's changing the way patients understand and fight their diagnosis. He's transformed personal loss into a mission to empower patients to become the heroes of their own medical stories. As well, as a leading expert in precision radiotherapy, he'll discuss how he's pushing  the boundaries of how radiation can treat advanced cancers. With a bestselling book and decades of expertise, Dr. Palma will reveal how every patient can turn their cancer diagnoses into a roadmap to hope.    With Dr. David Palma   Professor, Department of Oncology , Schulich School of Medicine & Dentistry, Western University  Radiation Oncologist, Verspeeten Family Cancer Centre, London Health Sciences Centre   Taking Charge of Cancer, by David Palma  Sapiens, by Yuval Noha Harari  Precision Radiation  Bio 

Join us as we delve into the groundbreaking work of 2024 Taylor Prize Laureate Professor Rusty Gage, whose landmark discovery transformed our understanding of the brain by showing that humans continue to generate new neurons well into adulthood and even as we age. In this episode, we explore the latest research in the field of neurogenesis and learn how Professor Gage and his team are unlocking innovative approaches to revitalizing the aging brain. We'll also get a glimpse into the inspirations behind his work—from systems theory to intriguing concepts in astrophysics—revealing how these ideas drive his pioneering research in neuroscience.

Why do some older adults in their 80s, 90s and even 100s age well? What's the secret to their excellent cognition? Is it genetics or environmental factors? Join us as we take a sneak peek into the world of the SuperAgers. In this episode, Western Professor Angela Roberts flips the aging problem on its head and looks at why some age exceptionally well. Discover what makes the Canadian cohort of SuperAgers extra special – a diverse group of older adults with exceptional cognition, an unquenchable thirst for life and adventure, and to top it all, resilience against time and adversity.

Tune in to learn how VR can transform the aging experience – from enhancing social connections to creating mystical experiences. In this episode, Western professor Paul Andrew Frewen shares insights from his research on virtual reality, psychiatry, and psychology. Discover how wearable VR technology is being harnessed to enhance mental well-being, promote social connection, revolutionize mental health interventions and create profound experiences for the aging population.

As Canada marks six years of cannabis legalization, we explore the shifting landscape of cannabis use among older adults, the fastest-growing group of consumers. In this episode, Western professor Jibran Khokhar, PhD, delves into the latest research on edibles, oils, THC, CBD, and even psychedelics, examining their potential effects on the aging body and brain. Are older adults use cannabis for medicinal purposes or it is just for recreation? Are the effects of cannabis real or could it simply be a placebo effect? Tune in to find out.

Tune in to explore the link between gait and cognition, and learn how the right dose of physical exercise and cognitive training can delay the onset of dementia. In this episode of The Catalysts, renowned Western University geriatrician Dr. Manuel Montero-Odasso, discusses the connection between falls, frailty and mobility issues, and cognitive decline in older individuals. Dr. Montero-Odasso shares how his research using motor biomarkers, dual-task gait testing and innovative interventions, such as the SYNERGIC Trials, is proving effective in delaying dementia in individuals with mild cognitive impairment. Tune in to learn about the vital role of mobility in aging and the promising strategies to maintain cognitive and physical health as we grow older.

Learn how the TRIDENT Platform is Revolutionizing Drug Discovery for Neurodegenerative Diseases Like Alzheimer's and Parkinson's In this debut episode of The Catalysts, we explore the cutting-edge, open-source TRIDENT research platform, that's revolutionizing and de-risking the drug discovery pipeline for neurodegenerative diseases by focusing on "failing faster" — a strategy designed to save time and money, and ultimately lives. Join Schulich School of Medicine & Dentistry and Robarts Research Institute scientists Dr. Lisa Saksida and Dr. Ravi Menon as they discuss how this innovative approach led by an interdisciplinary team of scientists at Western University is key to finding the most promising drugs and therapies for age-related diseases like Alzheimer's, Parkinson's, and dementia while sparing patients from false hope.

Here is your sneak peek to the Catalysts miniseries on the science of aging, featuring fascinating talks with top scientists and clinicians transforming the field, plus an exclusive conversation with the 2024 Taylor Prize laureate. This miniseries is in association with the J. Allyn Taylor International Prize in Medicine — one of Canada's most prestigious medical research awards — awardded by the Schulich School of Medicine & Dentistry and Robarts Research Institute, Western University.