BetterHealthGuy Podcast

🎧 Episode Summary In this episode, Andrew Heyman, MD, MHSA, continues exploring complex chronic illness through the broader framework of the Cell Danger Response and his five-phase treatment model. Building on Part 1, he examines Actinobacteria, endotoxins, MARCoNS, fungal colonization, detoxification, phospholipid replacement, hidden infections, the microbiome, and nervous system regulation as part of moving through CDR1. The conversation then explores CDR2 and CDR3, including mitochondrial and metabolic restoration, immune regulation, safety signaling, VIP, and strategies for rebuilding resilience and supporting a return to health. 🧭 In This Episode - Actinobacteria exposure and its role within the CIRS model - Environmental and gut-derived endotoxins as drivers of inflammation - Detoxification strategies for chemicals, pesticides, and heavy metals - Phospholipid replacement for detoxification, cell membranes, and mitochondrial support - RG3 (Synapsin) for neuroinflammation and microglial activation - Pathogen reduction for Lyme disease, Candida, SIBO, parasites, and reactivated viruses - MARCoNS and nasal dysbiosis in chronic inflammatory illness - Fungal colonization and the use of natural and pharmaceutical antifungals - Gut permeability, microbiome diversity, fiber, probiotics, and immunoglobulins - EMDR, limbic retraining, and autonomic regulation for hyperreactivity - CDR1 treatment gates for progressing through trigger removal, pathogen reduction, and gut repair - CDR2 metabolic and mitochondrial restoration for rebuilding cellular energy production - Mitochondrial testing for personalizing CDR2 treatment - CDR3 safety signaling, VIP, and restoring immune regulation - Autoimmunity and restoring balance between innate and adaptive immunity - Graded exercise, fasting, hormesis, and rebuilding resilience in CDR3 👤 About the Guest Andrew Heyman, MD, MHSA, is an internationally recognized expert in integrative and metabolic medicine. He is currently the Fellowship Director of Integrative Medicine at The George Washington University and is responsible for overseeing graduate education and multiple degree programs.  Dr. Heyman created the first master's degree in Integrative Medicine in the United States within a major academic center and developed additional graduate curricula in nutrition, metabolic medicine and performance, men's health, biotoxin exposure and neurodegeneration, and administrative health services in wellness settings.  Dr. Heyman has held board certifications in Family Medicine, Integrative Medicine, and Anti-Aging and Regenerative Medicine. He also served as the Director of Academic Affairs for the American Academy of Anti-Aging Medicine for a decade, overseeing all educational programs globally.  Since 2014, Dr. Heyman has maintained a clinical and research focus on biotoxin illnesses and exposure to water-damaged buildings. He has published almost two dozen papers in peer-reviewed academic journals on the subject and edited the first medical textbook on the subject.  Dr. Heyman is considered one of the world's leading experts in this area, having presented his work to Congress, testified in dozens of mold-related legal cases, and provided professional education to countless practitioners globally.  He is the founder of Beyond Mold, a complete medical and health resource for individuals and families suffering from mold illness.  Dr. Heyman has been featured on the Discovery Channel, Martha Stewart Living, Ladies' Home Journal, and Natural Health Magazine. He has appeared in many other television and print venues and is a widely sought-after and celebrated speaker around the world on many integrative medicine topics. Connect With the Guest Website - https://BeyondMold.com YouTube - https://www.youtube.com/@BeyondMold Facebook - https://www.facebook.com/profile.php?id=61587620336794 Instagram - https://www.instagram.com/beyond_mold TikTok - https://www.tiktok.com/@beyondmold Interview Date: September 3, 2026 🔗 Related Resources A Clinical Operationalization of the Cell Danger Response: Outcomes of a Five-Phase Treatment Protocol in 100 Patients with Chronic Post-Exposure Illness - https://esmed.org/MRA/mra/article/view/7633 Andrew Heyman, MD, MHSA, presents a five-phase Cell Danger Response treatment protocol and clinical outcomes from 100 patients with chronic post-exposure illness. SameHere Global - https://samehereglobal.org SameHere's mission is to normalize society's perception of mental health and make it part of our everyday conversation. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep240 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

🎧 Episode Summary In this episode, Andrew Heyman, MD, MHSA, explores mold-related illness, CIRS, and complex chronic illness through the broader framework of the Cell Danger Response. Drawing on his clinical experience, research, and personal journey with Lyme disease and mold illness, he explains how mitochondrial responses to threat may connect CIRS with conditions such as ME/CFS, Long COVID, and other chronic illnesses. The conversation explores total toxic and infectious load, resilience, CDR1, testing strategies, mitochondrial function, and an evolving approach to understanding and treating patients whose bodies remain stuck in a state of cellular defense. 🧭 In This Episode - Dr. Heyman's personal experience with Lyme disease and mold-related illness - CIRS within the broader Cell Danger Response model - Chronic illness triggers, total load, and mitochondrial resilience - CDR1, CDR2, and CDR3 as stages of cellular defense and recovery - Trauma-based illness, hyperreactivity, and cellular danger signaling - Testing strategies for assessing the Cell Danger Response - GENIE findings and their relationship to mitochondrial signaling and exposure - HLA-DR genetics, illness susceptibility, and total load - GDF15 and FGF21 as markers of mitochondrial stress - Direct mitochondrial function testing with Seahorse and citrate synthase assays - Persistent alarm signaling and abnormal test results after triggers are removed - Cellular mosaicism and different Cell Danger Response states within the same person - Five danger-sensing pathways and their response to mold, Lyme, Actinobacteria, endotoxins, and beta-glucans - Treatment timing across CDR1, CDR2, and CDR3 - CDR1 treatment phases for trigger removal, inflammation, detoxification, and microbial recovery 👤 About the Guest Andrew Heyman, MD, MHSA, is an internationally recognized expert in integrative and metabolic medicine. He is currently the Fellowship Director of Integrative Medicine at The George Washington University and is responsible for overseeing graduate education and multiple degree programs.  Dr. Heyman created the first master's degree in Integrative Medicine in the United States within a major academic center and developed additional graduate curricula in nutrition, metabolic medicine and performance, men's health, biotoxin exposure and neurodegeneration, and administrative health services in wellness settings.  Dr. Heyman has held board certifications in Family Medicine, Integrative Medicine, and Anti-Aging and Regenerative Medicine. He also served as the Director of Academic Affairs for the American Academy of Anti-Aging Medicine for a decade, overseeing all educational programs globally.  Since 2014, Dr. Heyman has maintained a clinical and research focus on biotoxin illnesses and exposure to water-damaged buildings. He has published almost two dozen papers in peer-reviewed academic journals on the subject and edited the first medical textbook on the subject.  Dr. Heyman is considered one of the world's leading experts in this area, having presented his work to Congress, testified in dozens of mold-related legal cases, and provided professional education to countless practitioners globally.  He is the founder of Beyond Mold, a complete medical and health resource for individuals and families suffering from mold illness.  Dr. Heyman has been featured on the Discovery Channel, Martha Stewart Living, Ladies' Home Journal, and Natural Health Magazine. He has appeared in many other television and print venues and is a widely sought-after and celebrated speaker around the world on many integrative medicine topics. Connect With the Guest Website - https://BeyondMold.com YouTube - https://www.youtube.com/@BeyondMold Facebook - https://www.facebook.com/profile.php?id=61587620336794 Instagram - https://www.instagram.com/beyond_mold TikTok - https://www.tiktok.com/@beyondmold Interview Date: September 3, 2026 🔗 Related Resources A Clinical Operationalization of the Cell Danger Response: Outcomes of a Five-Phase Treatment Protocol in 100 Patients with Chronic Post-Exposure Illness - https://esmed.org/MRA/mra/article/view/7633 Andrew Heyman, MD, MHSA, presents a five-phase Cell Danger Response treatment protocol and clinical outcomes from 100 patients with chronic post-exposure illness. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep239 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

🎧 Episode Summary In this special episode, Neil Nathan, MD and Dr. Ritchie Shoemaker, MD come together to share their distinct perspectives on mold-related illness and Chronic Inflammatory Response Syndrome (CIRS).  Drawing on decades of clinical experience and research, they explore where their approaches converge and differ across diagnosis, urine mycotoxin testing, MARCoNS, GENIE, environmental assessment, Actinobacteria, nervous system regulation, VIP, treatment approaches, and overall recovery.  The conversation offers two evolving perspectives on complex chronic illness with a shared goal of helping patients regain health and resilience. 🧭 In This Episode - Treatment models for mold illness and CIRS, including key drivers and foundational pillars of recovery - HLA-DR testing and its role in susceptibility, clinical decision-making, and recovery potential - Biotoxin blood markers for diagnosis, treatment planning, and monitoring progress - Urine mycotoxin testing, including accuracy, interpretation, limitations, and clinical utility - VCS, NeuroQuant, GENIE, and organic acids as tools for clinical assessment and treatment direction - MARCoNS, the sinubiome, and their potential significance in mold-related illness and CIRS - Environmental assessment using ERMI, HERTSMI-2, air sampling, and indoor environmental professionals - Nervous system dysfunction involving the limbic system, vagus nerve, dysautonomia, and mast cell activation - Coagulation abnormalities and their potential significance in CIRS - Prescription and natural binders and their role in treatment - Fungal colonization and the role of antifungal treatment - Actinobacteria and endotoxins as potential contributors to CIRS - VIP and its potential role in treatment - Recovery endpoints and the factors involved in restoring health and resilience 👥 About the Guests Neil Nathan, MD is a leading clinician in the treatment of mold illness, Lyme disease, chemical sensitivities, and other complex chronic conditions, and is the author of several books including Toxic and The Sensitive Patient's Healing Guide. Connect With the Guest Website - https://neilnathanmd.com Ritchie Shoemaker, MD is a pioneer in the field of biotoxin illness and the developer of the Chronic Inflammatory Response Syndrome, or CIRS, model.  He is the author of several books including Mold Warriors and Surviving Mold. Connect With the Guest Website - https://www.cirsx.com Interview Date: August 13, 2026 🔗 Related Resources Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome - https://pubmed.ncbi.nlm.nih.gov/23580077 Biochemical Markers in the Urine Associated with Gastrointestinal Mold-Overgrowth Are Linked with Elevated Urinary Mycotoxins in Patients with Suspected Mold Illness - https://townsendletter.com/biochemical-markers-in-the-urine-associated-with-gi-mold-overgorwth-shaw-and-pratt-hyatt Clearance of multiple antibiotic-resistant coagulase-negative staphylococci is selectively associated with higher circulating α-melanocyte stimulating hormone in patients evaluated for chronic inflammatory response syndrome - https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1728408/full Pitfalls of Mycotoxin Testing: Evidence-Based Findings Confirm Mycotoxin Assays Using Antibody Testing and Urinary ELISA Are Based on Flawed Science - https://esmed.org/MRA/mra/article/view/7260 Transcriptomic Parkinson's Prodrome and its Correction by Vasoactive Intestinal Polypeptide in Chronic Inflammatory Response Syndrome - https://esmed.org/MRA/mra/article/view/7608 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep238 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

🎧 Episode Summary Emily Gutierrez, DNP, C-PNP, CCN, IFMCP, FMAPS explores the brain-folate connection and the role of cerebral folate deficiency in autism, PANS/PANDAS, and neurodevelopmental health. She explains how folate supports DNA synthesis, myelination, neurotransmitter production, and other critical functions in the brain, while highlighting how blood folate levels may appear normal even when folate availability in the central nervous system is inadequate. The conversation examines folate receptor alpha autoantibodies and the mechanisms that can interfere with folate transport into the brain. Dr. Gutierrez discusses their significant overlap with autism and PANS/PANDAS, the potential contributions of mitochondrial dysfunction and genomic variants, and the use of the Folate Receptor Antibody Test (FRAT) to identify blocking and binding autoantibodies. She explores dietary, inflammatory, and immune factors that may influence folate receptor autoimmunity and cerebral folate availability. Dr. Gutierrez discusses folinic acid and prescription leucovorin as strategies to increase folate availability in the brain, including dosing, titration, potential side effects, and factors that may influence treatment response. She explains how higher doses may utilize alternative folate transport mechanisms, why addressing inflammation, infections, and nutrient cofactors may be important, and how restoring adequate folate availability may support language, development, neurological function, and resilience. 🧭 In This Episode - Cerebral folate deficiency and impaired folate availability in the brain - Folate receptor alpha autoantibodies and their effect on folate transport - Autism and PANS/PANDAS prevalence in cerebral folate deficiency - Mitochondrial dysfunction and energy-dependent folate transport - FRAT testing for folate receptor alpha autoantibodies - Blocking, binding, and soluble folate receptor findings and clinical severity - Folate receptor autoantibodies and fluctuations in folate transport - Genomic variants and their relationship to folate metabolism and FRAT positivity - Dietary folic acid and dairy considerations with folate receptor autoantibodies - Inflammation, infections, nutrient cofactors, and preparation for high-dose folinic acid - Leucovorin dosing and clinical response to folinic acid - Folinic acid side effects and its relationship to tetrahydrobiopterin - High-dose folinic acid and alternative folate transport mechanisms - Immune dysregulation and folate receptor autoimmunity in autism 👤 About the Guest Emily Gutierrez, DNP, C-PNP, CCN, IFMCP, FMAPS is a doctorally prepared nurse practitioner and nationally recognized expert in functional medicine. With advanced clinical training in both pediatric and adult care, she brings a root-cause, evidence-based approach to optimizing neurological and mental health across the lifespan. As a Doctor of Nursing Practice (DNP) from Johns Hopkins University, Dr. Gutierrez specializes in translational medicine; applying the latest scientific research to real-world patient care. She has served as adjunct faculty at Johns Hopkins University for six years, teaching integrative and functional health. She is a Fellow of the Medical Academy of Pediatric Special Needs (MAPS), an Institute for Functional Medicine Certified Practitioner (IFM-CP), a Certified Clinical Nutritionist (CCN), and a Primary Care Mental Health Specialist (PCMHS). Her clinical background includes extensive training in neuronutrition, genomics, and integrative strategies to support complex mental health and neurodevelopmental conditions. In her role as Chief Scientific Medical Liaison and Formulator for Neuro Nutrients, she develops clinically informed, research-backed supplements that support brain function, mood balance, and overall neurological resilience; designed for both pediatric and adult populations. Connect With the Guest Website - https://neuronutritionassociates.com YouTube - https://www.youtube.com/@neuronutritionassociates184 Facebook - https://www.facebook.com/neuronutritionassociates Instagram - https://www.instagram.com/neuronutritionassociates Interview Date: August 7, 2026 🔗 Related Resources Neuro Nutrients - https://www.neuronutrients.com In her role as Chief Scientific Officer and Formulator for Neuro Nutrients, Dr. Gutierrez develops clinically informed, research-backed supplements that support brain function, mood balance, and overall neurological resilience. Folate Receptor Antibody Test - https://www.fratnow.com FRAT® was developed in the lab of Dr. Edward Quadros at the State University of NY (SUNY Downstate) and is the only assay available that can screen for both blocking and binding folate receptor autoantibodies. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep237 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

🎧 Episode Summary Jason Hawrelak, ND, PhD explores the central role of the gut microbiome in shaping human health, explaining how the trillions of microorganisms that inhabit the gastrointestinal tract influence immunity, metabolism, brain function, inflammation, and resilience. Drawing on more than two decades of research and clinical experience, he discusses how modern lifestyles, antibiotic exposure, processed foods, and environmental factors have altered the diversity of the human microbiome and contributed to the growing burden of chronic disease. The conversation examines the balance between beneficial microbes, pathobionts, and pathogens, highlighting the importance of microbial diversity, short-chain fatty acid production, intestinal pH, and ecological balance rather than simply eliminating unwanted organisms. Dr. Hawrelak shares practical insights into microbiome testing, comparing culture, PCR, 16S sequencing, and shotgun metagenomics while explaining how these tools can guide personalized interventions to restore healthier microbial ecosystems. Dr. Hawrelak also discusses the microbiome's role in conditions such as IBS, SIBO, inflammatory bowel disease, Candida overgrowth, and systemic inflammation. He explains how dietary strategies, prebiotics, probiotics, herbal medicines, and targeted microbiome support can improve gut ecology, reduce inflammatory burden, optimize digestive function, and promote lasting health throughout the body. 🧭 In This Episode - The evolution of microbiome research over the past 25 years - Why the gut microbiome functions like another human organ - Microbial diversity, richness, and ecosystem resilience - The microbiome's influence on immunity, inflammation, and brain health - Dysbiosis, leaky gut, and the roots of chronic disease - Butyrate, short-chain fatty acids, and microbial metabolites - Beneficial microbes, pathobionts, and microbial balance - Akkermansia, Proteobacteria, Bacteroides, and gut ecology - Prebiotics, dietary fiber, polyphenols, and microbiome restoration - Lactulose as a powerful microbiome-modulating prebiotic - SIBO, methane, motility, and the migrating motor complex - Shotgun metagenomics, 16S sequencing, PCR, and stool testing - Crohn's disease, ulcerative colitis, and microbiome-targeted therapies - Candida, the mycobiome, and fungal overgrowth - Colonic pH, digestive health, and ecological balance - Practical strategies for optimizing the microbiome and overall health 👤 About the Guest Jason Hawrelak, ND, PhD is a researcher, educator, Western herbalist, and naturopathic physician with over 25 years of clinical experience.  He earned his PhD examining the capacity of probiotics, prebiotics, and herbal medicines to modify the gastrointestinal microbiota and teaches worldwide on the topics of microbiota modification and gut health. He has published extensively in these areas, including 20 textbook chapters. Dr. Hawrelak serves on the Medical Nutrition Council of the American Society for Nutrition and is a Fellow of both the American College of Nutrition and the Naturopaths and Herbalists Association of Australia.   Dr. Hawrelak maintains a busy telehealth practice as lead clinician at the Hawrelak Gut and Microbiome Clinic.  Dr. Hawrelak is Chief Research Officer at Probiotic Advisor, which offers a searchable database that enables evidence-based prescribing of probiotic products. Dr. Hawrelak also founded and serves as Lead Educator at the Microbiome Restoration Center, an online educational platform devoted to training health professionals to become microbiome clinicians through its flagship courses, Naturopathic and Functional Medicine Approaches to Gastrointestinal Disorders and Advanced Microbiome Manipulation. Connect With the Guest Website - https://microbiomerestorationcenter.com Facebook - https://www.facebook.com/probioticadvisor Instagram - https://www.instagram.com/probioticadvisor Interview Date: June 21, 2026 🔗 Related Resources Probiotic Advisor - https://www.probioticadvisor.com ProbioticAdvisor.com provides independent, unbiased, evidence-based information on probiotics, their potential risks, and documented benefits. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep236 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.