Claim OwnershipHistamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
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© 2026 Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
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The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.
Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.
43 Episodes
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In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fatigue, insomnia, and “wired but tired” patterns. We also discuss slow COMT activity, the link betwee...
In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms. H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrow...
In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your st...
In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms. She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break histamine down. You’ll learn why antifungals alone often fail, how gut “terrain” factors like lo...
In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Hista...
In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure. After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares how targeted support using sulforaphane, digestive enzymes, and Epsom salt baths helped stabili...
In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey...
In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms. Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protec...
In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health. Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is often overlooked, how genetic variations can impact B12 utilization, and why choosing the correct ...
In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation. This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react badly to methylated B vitamins, and how over-methylation can drive symptoms such as anxiety, irrita...
Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement Therapy (HRT) in supporting women’s health. They explore what actually happens during hormone fluctuations in perimenopause, how to recognize estrogen dominance, and the benefits and risks of estrogen, progesterone, and testosterone therapy. Rachel shares practical insights...
Is your home secretly affecting your health? In this episode of The Histamine Well Podcast, Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnetic fields (EMF), and poor indoor air quality. Jo shares her journey into building biology and explains how unseen environmental factors—like hidden mold spores or constant EMF exposure—can impact your immune system, mood, and energy levels. Together, they break down what you can...
In this episode of The Histamine Well Podcast, Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood forms of Small Intestinal Bacterial Overgrowth (SIBO). Together, they break down how Hydrogen Sulfide SIBO differs from hydrogen- and methane-dominant SIBO, exploring the unique bacteria and biochemical pathways involved. Rosaria shares her step-by-step naturopa...
In this episode of The Histamine Well Podcast, Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness. You’ll learn how the limbic system, vagus nerve, neuroplasticity, and brain retraining techniques play a vital role in recovery from conditions influenced by trauma, mold exposure, and stress. Jacqui shares her journey from traditional physiotherapy to a holistic, trau...
In this episode of The Histamine Well Podcast, Joanne is joined by colleague Melanie and patient Tracy, who shares her powerful story of navigating the challenges of oxalates, histamine intolerance, adrenal fatigue, and blood sugar imbalances. Tracy’s journey highlights the complex relationship between oxalates, adrenal and blood sugar imbalances, and oxalate dumping symptoms. With support from Melanie, she has worked through paradoxical reactions to magnesium and B6, learned strategies for m...
In this episode of The Histamine Well Podcast, host Joanne Kennedy and guest Mariella Gebhardt unpack the nuances of medical testing in functional medicine—and why lab results alone don’t always tell the full story. From histamine intolerance and methylation issues to gut health, Candida, mold exposure, and hormone imbalances, Joanne and Mariela explore the limitations and benefits of testing while emphasizing the importance of case history, symptoms, and environmental factors in shaping trea...
Could mold be the missing link in your chronic health puzzle? In this episode of The Histamine Well Podcast, Joanne speaks with Melanie Peers about the hidden impact of mold illness and how it can silently drive histamine intolerance, food sensitivities, and long-term inflammation. You’ll discover how mold exposure can: Raise histamine levels and trigger mast cell activationDisrupt methylation and detoxification pathwaysCause oxalate buildup and sulfur imbalancesLead to neurological, digestiv...
Perimenopause isn’t just a physical transition — it’s an emotional, spiritual, and energetic shift. In this empowering episode of The Histamine Well Podcast, Joanne speaks with Claire Tait, a holistic kinesiologist and intuitive energy healer, about how to navigate perimenopause with greater balance, calm, and self-awareness. Claire shares her expertise on how kinesiology, reiki, acupressure, yoga, and other holistic practices can support women during this powerful life stage. You’ll learn ho...
Can histamine be the hidden reason behind your anxiety? In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop. Whether you're a practitioner treating patients with anxiety or someone who’s tried everything to feel better — this episode gives you a deeper...
We break down how disrupted sulfur metabolism can mimic histamine symptoms—severe bloating, crushing fatigue, joint pain, brain fog, skin flushing—and why reactions to garlic, onions, eggs, brassicas, NAC, and glutathione are key clues. You’ll learn the roles of sulfite/sulfide vs. sulfate, SUOX + molybdenum, B12, mitochondria, hydrogen sulfide overgrowth, and environmental drivers like mold and oxalates. We also cover testing pointers (homocysteine, stool, OAT), why low-sulfur diets are onl...
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