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Harmony Hub Health

Author: Michele

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Functional Medicine, Hormone Health and Weight Loss with Michele Postol, CRNP 

88 Episodes
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A simple question at a noisy gym—“What’s that?”—sparked a full reset on how we explain regenerative care. We zoom out from jargon and get practical about what regenerative medicine is, who it helps, and why pairing it with functional medicine can create the conditions for real healing. Instead of managing symptoms, we focus on restoring function, structure, and cellular health in the tissues that often stall: tendons, ligaments, joints, nerves, and chronically inflamed areas. We walk through...
Feeling “fine” on paper while your body says otherwise is exhausting. We dive into why 2025 marked a turning point for functional medicine and how smarter tools, clearer metrics, and cellular-first thinking finally closed the gap between normal labs and not-normal lives. We start with mitochondrial medicine—the unsung engine behind energy, cognition, hormones, and aging. As NAD+ declines and oxidative stress rises with time, many people experience daily fatigue without an obvious diagnosis. ...
You can chug from the biggest water bottle on the planet and still be dehydrated. We unpack why real hydration is about getting water into your cells—and why minerals, osmosis, and aquaporins matter more than ounce counts. Michelle breaks down the difference between extracellular and intracellular water, then walks through the science of how sodium, potassium, chloride, and magnesium create the osmotic pull that lets water cross the cell membrane. If that mineral signal is weak, or if stress ...
Feeling tired isn’t a character flaw; it’s a signal your cells are sending for help. We take you inside a functional lens on energy and show why caffeine, stimulants, and quick shots may mask the problem while the real drain continues. Starting with a clear story—needing Adderall to focus, coffee to function, and B12 to get through the day—we flip the script from chasing highs to restoring steady power. We unpack the seven most common drivers of fatigue we see in our clinic: blood sugar swin...
December doesn’t just crowd your calendar; it floods your body with inflammatory signals that drain energy, cloud thinking, and disrupt sleep. We unpack a year-end functional medicine reset designed to calm the immune system, rebuild mineral balance, and restore true resilience so you can end the year clear and start the new one strong. We walk through a data-first roadmap: a consultation and metabolic blood panel to assess inflammation and detox status, IgG food sensitivity testing to pinpo...
Your brain has a reset button, and it might look like a sleek white pod filled with warm, magnesium-rich water. We take you inside the science and the experience of floating to show how sensory withdrawal and Epsom salt saturation can lower cortisol, reduce inflammation, and move the body from fight or flight into real repair. If you’ve been running on fumes, battling pain, or chasing sleep that never sticks, this is a practical roadmap to relief that blends neuroscience and functional medici...
A 20-year misunderstanding just lost its grip. We break down why the FDA removed the black box warning from most menopausal hormone therapy and what that means for safety, confidence, and real-world results. The conversation starts with how the WHI study was interpreted in 2002—older participants, higher baseline risk, and reliance on synthetic formulations—and moves into the clear distinctions between bioidentical hormones and conventional HRT. We explain why molecule choice, timing near men...
Your body is not broken, it’s brilliantly adaptive. We unpack Ehlers-Danlos syndrome through a whole-body lens, showing how connective tissue shapes every system and why symptoms that seem random are often smart compensations. By tracing the common triad of EDS, POTS, and MCAS, we reveal how unstable collagen stresses circulation and the autonomic nervous system, which then primes mast cells to overreact. Seen together, dizziness, gut issues, fatigue, skin sensitivity, and “anxiety” stop feel...
What if your body isn’t breaking down so much as it’s missing the right signals to rebuild? We explore a practical roadmap for true repair—skin that thickens and brightens, joints that move with less pain, hair that regrows, and metabolism that finally wakes up. No fluff, just clear guidance on when to use PRP, exosomes, Wharton’s jelly, polynucleotides, and targeted peptides to match the state of your tissue and your goals. We start with skin because that’s where most people first notice ag...
A stronger life starts with better signals, not bigger effort. We pull back the curtain on heart rate variability and show how those tiny beat-to-beat changes reveal your real-time capacity to handle stress, recover deeply, and perform with clarity. Instead of chasing perfect sleep hours or a single “ideal” number, we focus on the story your HRV trends tell about autonomic balance, mitochondrial energy, and hormone stability. I share how my view shifted from bedside EKG calipers to modern we...
If your “healthy” meals still leave you bloated, foggy, or flaring days later, your immune system may be reacting to foods on a delay. We break down how IgG food sensitivities differ from classic IgE allergies, why leaky gut turns dinner into an inflammatory trigger, and how genetics can steer immune fallout toward your gut, skin, thyroid, or joints. You’ll hear a candid story of living with celiac, moving from dozens of reactive foods to just a few, and the surprising culprits that often fly...
A scary cholesterol panel can either trigger panic or spark a smarter plan. We chose the latter. After my husband’s labs lit up with sky-high triglycerides and lackluster HDL, we went all-in on a functional strategy—no statins, no guesswork. The result? A 237-point drop in triglycerides and better lipid ratios powered by high-quality omega-3s, the newly recognized essential fatty acid C15, and a commitment to testing what matters. We break down the real story behind “healthy fats”: why omega...
Hunger shouldn’t feel like a constant negotiation. We take you inside a practical, plant-based approach to appetite control that taps the gut’s own language—bitter signaling—to lift satiety hormones and make smaller portions feel natural, not forced. Drawing on clinical research and hands-on protocols, we unpack how a delayed‑release hops extract (amarosate) interacts with TAS2R receptors to elevate GLP‑1 and CCK within an hour, slow gastric emptying, and reduce cravings without stimulants or...
Your immune system might be a drama queen, and that's not just a metaphor. When mast cells—powerful defenders designed to protect you from threats—become hyperreactive, they create a storm of inflammation affecting everything from your skin to your digestive system to your brain. This phenomenon, known as Mast Cell Activation Syndrome (MCAS), leaves countless patients struggling with mysterious symptoms that conventional medicine often misses or dismisses. The symphony of symptoms can be bew...
Have you been celebrating those dramatic drops on the scale? Think twice before popping the champagne. As a Nurse Practitioner specializing in metabolic health, I'm pulling back the curtain on why rapid weight loss might be sabotaging your long-term success. When a patient proudly announced losing nine pounds in just one week, my reaction wasn't congratulatory – it was concern. That dramatic number likely represented water weight, muscle loss, and a flood of stored toxins entering the bloods...
Gluten — that innocent-looking protein in wheat, barley, and rye — stirs up heated debates in both medical circles and dinner table conversations. But what's the real story behind the gluten-free movement? Is it just another wellness fad, or is there legitimate science backing the millions who claim sensitivity? This episode takes you on a deeply personal journey through my own struggle with gluten sensitivity and eventual celiac disease diagnosis. From being dismissed by doctors to enduring...
Most of us know the basics of Lyme disease – tick bite, bullseye rash, antibiotics. What rarely makes headlines is the devastating reality when Lyme transforms from a simple infection into a complex, multi-system condition that conventional medicine struggles to recognize and treat effectively. This transformation happens when Lyme crosses a critical threshold from acute to chronic. During those early days post-tick bite, the bacteria remain vulnerable, largely confined to the bloodstream wh...
Ever found yourself staring blankly at the wall of magnesium supplements, feeling more confused than enlightened? You're not alone. In this eye-opening exploration of "the master mineral," we demystify the complex world of magnesium supplementation and reveal why choosing the right form matters more than you might think. Magnesium isn't just another supplement—it's involved in over 300 biochemical reactions throughout your body. From calming your nervous system to energizing your cells, supp...
Methylene blue represents one of the most fascinating evolutions in medical therapeutics - from a simple blue dye used to stain microscope slides in the 1800s to a powerful mitochondrial medicine today. Remember seeing it used during surgeries simply to check for leaks? That same compound is now at the frontier of functional medicine as a cellular energizer. The science behind methylene blue is remarkable yet straightforward. Your mitochondria - those cellular power plants that create energy...
A century-old medication suddenly deemed unsafe? The FDA's unexpected crackdown on desiccated thyroid extract (DTE) has left 1.5 million Americans questioning their treatment options and wondering about the true motivations behind this regulatory move. Desiccated thyroid extract—ground-up pig thyroid glands turned into pill form—has been helping patients feel human again since the late 1800s. These natural thyroid medications contain both T4 and T3 hormones, making them particularly valuable...
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