Healio Rheuminations

In this episode of Rheuminations, host Adam J. Brown, MD, untangles the confusing serologies of lupus by learning about their discoveries from the beginning. He answers questions like what's the deal with immunofluorescence patterns, why does SSA/SSB have two names (Ro/LA), and is double-stranded DNA antibody really attracted to both strands? ·       The story of antibodies in lupus. 3:27 ·       The "LE" factor. 10:11 ·       The changing fluorescent patterns of the staining of the nucleus/ENAs. 18:50 ·       The anti-Smith antibody. 24:51 ·       The mysteries of SSA and SSB. 28:52 ·       Double-stranded DNA. 36:32 ·       Crithidia luciliae. 40:30  We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Aarden LA, et al. Ann NY Acad Sci. 1975;doi:10.1111/j.1749-6632.1975.tb29197.x Alspaugh MA, et al. Arthritis Rheum. 1976;doi:10.1002/art.1780190214 Aslpaugh MA, et al. J Clin Invest. 1975;doi:10.1172/JCI108007 Arana R, et al. J Clin Invest. 1967;doi:10.1172/JCI105677 Clark G, et al. J Immunol. 1969;PMED:4179557 Dubois EL, et al. Blood. 1957;doi:10.1182/blood.V12.7.657.657 Friou GJ, et al. J Immunol. 1958;doi:10.4049/jimmunol.80.4.324 Hargraves MM. Proc Staff Meet Mayo Clin. 1949;doi:10.1016/S0025-6196(25)08519-2 Haserick JR, et al. Am J Med Sci. 1950;doi:10.1097/00000441-195006000-00010 Rowell NR, et al. Arch Dermatol. 1963;doi:10.1001/archderm.1963.01590200064012 Tan EM, et al. J Clin Invest. 1966;doi:10.1172/JCI105479 Tsokos GC. J Immunol. 2006;doi:10.4049/jimmunol.176.3.1295

In this episode of Rheuminations, guest host Leonard H. Calabrese, DO, sits down with David Chernoff, MD, chief medical officer of SetPoint Medical, to discuss the vagus nerve and recent developments in immune mediated disease. ·       The story of Kevin Tracey, MD. 5:08 ·       Going from cytokines to the vagus nerve to immune mediated inflammatory disease. 7:23 ·       The ups and downs of non-surgically implanted devices. 13:28 ·       The pivotal studies. 15:35 ·       Gadolinium MRI. 24:03 ·       The gut-brain immune axis. 29:35 We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Leonard H. Calabrese, DO, can be reached at [email protected]. Follow him @LCalabreseDO.

In this episode of Rheuminations, host Adam J. Brown, MD, will walk you through the history of pleural effusions in rheumatoid arthritis. He discusses topics ranging from fascinating case studies to how pleural effusions are treated today.  ·        Diving into pleural effusions. 2:38 ·        What's in the fluid? 12:01 ·        When did pleural effusions become linked to RA? 15:18 ·        The glucose talk. 27:04 ·        Green effusions. 32:40 We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

Not all jaw claudication is giant cell arteritis. Hear some interesting cases and learn about things to look for in the labs to suspect an alternative diagnosis along with co-host Leonard H. Calabrese, DO. ·        When GCA isn't GCA, walking through mimic cases 2:43 ·        Infectious mimics 14:36 ·        Large vessel involvement cases 16:47 ·        GCA as a medical emergency 22:05 ·        Erdheim-Chester disease 23:40 We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

In this week's episode we interview Kinanah Yaseen, MD, a rheumatologist from Cleveland Clinic's department of rheumatic and immunologic diseases about using ultrasound for giant cell arteritis. ·        Intro by Adam J. Brown, MD 0:12 ·        Dr. Brown's recent patient 1:34 ·        History of ultrasound and GCA 3:20 ·        Episode overview 7:05 ·        History of echolocation; how bats helped us invent ultrasound 8:00 ·        What is a bat bomb? 14:56 ·        How the Titanic helped us invent ultrasound 16:48 ·        Neurologists bring ultrasound to medicine 20:09 ·        OB/GYN is next to use ultrasound 23:11 ·        Ultrasound image quality becomes better 26:32 ·        Ultrasound use in giant cell arteritis 28:44 ·        Welcome Kinanah Yaseen, MD 33:49 ·        Using ultrasound in the clinic 34:25 ·        Can you walk us through an ultrasound of the axillary and vertebral arteries? 37:16 ·        Can you tell us why we stopped looking for sites to biopsy by finding narrowing of the vessels?  38:19 ·        Tell us about the halo sign 39:10 ·        How do you validate your ultrasound skills? 40:20 ·        If we start a patient on steroids, how useful is an ultrasound? 42:35 ·        Episode summary 44:20 ·        Thank you for listening 45:57 We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Kinanah Yaseen, MD, is a is a staff member of Cleveland Clinic's department of rheumatic and immunologic diseases. References: Friedman, G, et al.Isr J Med Sci. 1988 Kaproth-Joslin K A, et al. Radiographics. 2015 ;doi:10.1148/rg.2015140300 Puéchal X, et al. Lancet. 1995;doi:10.1016/s0140-6736(95)92626-7 Schmidt W A, et al. Lancet. 1995;doi:10.1016/s0140-6736(95)93005-1 Sigel B. Ultrasound Med Biol. 1998;doi:10.1016/s0301-5629(97)00264-0 Editor's Note: This has been updated to include references.