Metascience Matters

Florian Naudet is a Professor of Therapeutics at Rennes University. As a metascientist and psychiatrist, his research interests lie in developing and evaluating methodological solutions to treatment assessment, primarily but not exclusively for mental health conditions. His work has also made inroads to quantifying and understanding research waste and the prevalence of substandard data-sharing practices.CONTACT RANDY:Feedback: metasciencematters@gmail.comEPISODE LINKS:Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trialshttps://link.springer.com/article/10....Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysishttps://link.springer.com/article/10....Pharmageddon (book) https://davidhealy.org/pharmageddon-i...A manifesto for reproducible sciencehttps://www.nature.com/articles/s4156...Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trialhttps://pmc.ncbi.nlm.nih.gov/articles...OUTLINE:0:00 - Introduction0:36 - Florian's origin story as a psychiatrist and metascientist4:46 - How Florian became interested in metascience11:55 - Systematic review of clinical trials of Esketamine for depression28:45 - Publishing this study as a registered report40:49 - Vibration-of-effects analysis of double-blind randomized controlled trials assessing nalmefene and/or naltrexone for treating alcohol use disorders59:58 - Advice for listeners interested in pursuing research like Florian's 1:03:38 - Outro

Chirag Patel is an Associate Professor of Biomedical Informatics at Harvard Medical School, renowned for his expertise in using computational methods to understand human health and disease from high-throughput data streams. He specializes in understanding the role in the intersection of genetics and environmental exposures (the exposome) in human health, as well as various disease areas such as diabetes, cardiovascular disease, and Alzheimer’s disease.CONTACT RANDY:Feedback: metasciencematters@gmail.comEPISODE LINKS:Chirag’s Lab: https://www.chiragjpgroup.org/TEDx talk on the exposome:    • Exposome: decoding human health and diseas...  OUTLINE:0:00 - Introduction0:37 - How do you decide what to work on?1:57 - Where does metascience fit into your work?3:57 - Vibration-of-effects analysis6:41 - How does VoE change how we see existing scientific work?9:22 - The biggest challenges in the replication crisis within biomedical informatics11:48 - Environment-wide association study of Type 2 diabetes15:04 - The exposome17:30 - Policy vs. precision medicine applications of the exposome20:09 - The patient exposome22:38 - HBA1C for diabetes as a bridge to the exposome23:54 - Broader metascientific issues of the exposome25:01 - The effects of extreme weather events on human health29:35 - AI for biomedical informatics, the exposome, metascience31:19 - Advice for listeners interested in pursuing research like Chirag’s 32:53 - Outro