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The Big Brain Podcast
The Big Brain Podcast
Author: The Block
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© 2026 The Block
Description
The Big Brain Podcast features conversations with crypto's most influential thinkers, builders, and traders.
Co-hosted by The Block CEO Larry Cermak and MegaETH CSO Namik Muduroglu, these interviews challenge ideas, dig into mental models, and push guests beyond the headlines.
This show isn't about predicting the future of crypto—it’s about spotlighting the big brains shaping it.
Co-hosted by The Block CEO Larry Cermak and MegaETH CSO Namik Muduroglu, these interviews challenge ideas, dig into mental models, and push guests beyond the headlines.
This show isn't about predicting the future of crypto—it’s about spotlighting the big brains shaping it.
11 Episodes
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In episode 10 of The Big Brain Podcast, Larry and Namik are joined by Gauntlet founder and CEO Tarun Chitra. Tarun recounts how an unexpected ADL event on a tiny test position pushed him to research how exchanges handle insolvency when liquidations fail, especially after October 10th. He argues the common ranking approach concentrates losses unfairly and may overshoot during cascading events. The discussion also covers transparency, insurance funds, and why improving these systems matters if perp exchanges want to onboard new users.
OUTLINE
00:00:00 - Introduction
00:00:54 - Tarun’s background
00:10:50 - Tarun's ADL paper
00:15:40 - ADL usage
00:26:25 - Transparency gap
00:31:44 - Critiques of Tarun's paper
00:36:32 - Impact of Tarun's paper
00:41:09 - Potential fixes
00:45:31 - Cult-like communities in crypto
00:52:42 - 10x verticals looking ahead
01:02:29 - Conclusion
Guest links:
Tarun Chitra - x.com/tarunchitra
Gauntlet - x.com/gauntlet_xyz
Show links:
- Apple: apple.co/43F3vmq
- Spotify: spoti.fi/44NT1lZ
- Larry: x.com/lawmaster
- Namik: x.com/NamikMuduroglu
- The Block Podcasts: x.com/TheBlockPods
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In episode 9 of The Big Brain Podcast, Larry and Namik are joined by Infinex founder Kain Warwick. The trio discuss how crypto's complex user experience remains a roadblock for projects to gain broader adoption and find new users, and how Infinex aims to tackle this by being the first true "superapp." The conversation also digs into multi-chain routing, gas abstraction, fundraising, “CT mafia” dynamics, and how Infinex aims to compete with MetaMask, Phantom, and Coinbase Wallet.
OUTLINE
0:00 – Introduction
2:51 – Evolution of Infinex Vision
5:30 – Decentralization vs User Experience
8:29 – Infinex in a Multi-Chain Future
12:30 – User Experience in Super Apps
15:10 – How Infinex Works Behind Scenes
19:25 – Funding Challenges for Super Apps
25:40 – YAP Run Drama Reflections
27:44 – Social Media’s Impact on Founders
29:56 – Navigating Crypto Regulations
31:25 – Token Distribution Strategies
34:09 – Token Launch & Listing Challenges
36:46 – On-Chain Liquidity & Multi-Chain
38:50 – Re-Engaging Users Online
41:28 – TGE Strategy Breakdown
44:40 – Token Utility & Revenue Models
51:53 – Competing in a Crowded Market
Guest links:
Kain Warwick - https://x.com/kaiynne
Infinex on X - https://x.com/infinexInfinex - https://infinex.xyz/
Show links:
Larry - https://x.com/lawmaster
Namik - https://x.com/NamikMuduroglu
In episode 8 of The Big Brain Podcast, Lighter founder Vladimir Novakovski explains why he built a zero-fee, ZK-powered perp DEX as an Ethereum L2, how it stacks up against CEXs and rival perp chains, and what they learned from recent market stress ahead of their token launch.
OUTLINE
00:00 – Introduction
04:50 – What Lighter is
06:15 – Why Ethereum L2 and ZK
11:03 – Zero-fee retail model
18:11 – Robinhood relationship & RH Chain
20:30 – L1 vs L2 value capture
27:08 – TGE timing and token value
30:29 – DYDX, Hyperliquid and CEX vs DeFi
35:52 – 10/10 crash and LLP risk
39:50 – Infra upgrades and closing
Guest links:
Vladimir Novakovski - https://x.com/vnovakovski
Lighter - https://x.com/Lighter_xyz
Show links:
Larry - https://x.com/lawmaster
Namik - https://x.com/NamikMuduroglu
In this episode of The Big Brain Podcast, Eli Ben-Sasson – co-founder of Zcash and Starknet – joins The Block President Larry Cermak and MegaETH CSO Namik Muduroglu.
The conversation delves into the challenges of ensuring integrity in privacy payments on decentralized public blockchains, highlighting the role of ZK proofs in validating computations without compromising sensitive information.
OUTLINE
00:00 Introduction
03:48 From Academia to Crypto
08:52 Zcash Privacy Overview
13:06 Monero vs. Zcash
15:05 The Future of Privacy
16:50 Quantum Threats
24:13 Zcash's Evolution
28:23 Starknet & BTCFi
33:13 Bitcoin's Future
41:08 Why Privacy Matters
43:14 The Future of Starknet
Guest links:
Eli Ben-Sasson - https://x.com/EliBenSasson
Starknet BTCFi - https://www.starknet.io/blog/starknet-x-bitcoin-the-next-step-btcfi-on-starknet/
Show links:
Larry - https://x.com/lawmaster
Namik - https://x.com/NamikMuduroglu
In this episode of the Big Brain Podcast, Larry and Namik are joined by Wintermute Founder and CEO Evgeny Gaevoy to discuss the recent historic crypto crash, explaining how extreme leverage, exchange failures, and forced ADL liquidations led to market chaos and liquidity breakdowns across the ecosystem.
OUTLINE
00:00 Introduction
00:45 What Happened?
04:46 Understanding ADL
12:25 Transparency and Privacy on Hyperliquid
16:35 Circuit Breakers
19:16 Occam’s Razor
21:25 Assessing the Damage
25:24 Lessons learned
28:39 Looking Ahead
30:21 A Maturing Market
32:13 Dealing with Extreme Volatility
35:19 Impact on DeFi
37:28 Wintermute as the Crypto Villain
41:47 What else does Wintermute do?
44:11 Conclusion
GUEST LINKS
https://x.com/evgenygaevoy
https://x.com/wintermute_t
This episode of the Big Brain Podcast is brought to you by our sponsor, Canton Network.
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In this episode of the Big Brain Podcast, Larry and Namik are joined by Dragonfly's Tom Schmidt Alok Vasudev of Standard Crypto. They dive into current trends in venture capital within the crypto space, touching on how market conditions have evolved since 2021, the role of treasury companies, and the evolving regulatory landscape.
OUTLINE
00:00 Introduction 01:06 Alok's Background 04:45 Tom's Background 06:21 Cap Table Competition 07:53 Crypto 'Metas' 13:09 Copycat Crypto Projects 15:26 Brand Positioning 17:45 Web3 Moats 19:29 Crypto Treasury Companies 27:28 Regulatory Tailwinds 30:38 Consumer Adoption
GUEST LINKS
https://x.com/tomhschmidt
https://x.com/AlokVasudev
Are you hiring in crypto?
Use Campus to quickly find your best candidates with our challenging Crypto Assessment Test.Faster hiring, stronger teams.
Sign up for a trial today: theblock.co/campus
Jack Mallers recounts his bitcoin journey, and explains how the US government could expunge its debt by dumping USD into gold and bitcoin.
OUTLINE:
00:00 Introduction
06:55 Mallers Family Office
09:50 Founding Strike
14:53 Orange-Pilling El Salvador
22:23 Bitcoin & Tether
26:18 International Bitcoin Policies
32:39 US Bitcoin Policy
53:30 Twenty One
In this episode, Paolo Ardoino delves into the factors that contributed to Tether’s USDT becoming the world’s largest stablecoin. Additionally, Ardoino discusses Tether’s strategic investment in AI, energy, biotech, and other industries, showcasing their long-term vision.
OUTLINE:
00:00 Introduction
00:30 Paolo's Background
1:21 Tether's Path to Success
04:04 Stablecoin Policy
07:23 USDT Adoption in Emerging Markets
12:15 Tether Gold
16:30 Tether & US Hegemony
21:25 Responsible Crypto Education
22:54 Tether Wallet Development Kit
25:00 Chain Preferences
28:52 Tether's Investment Strategy
45:13 Infinite Money Glitch
SHOW LINKS:
Apple: https://apple.co/43F3vmq
Spotify: https://spoti.fi/44NT1lZ
Larry: https://x.com/lawmaster
Namik: https://x.com/NamikMuduroglu
The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
Paolo: https://x.com/paoloardoino
Tether: https://tether.io/
Tether USDT: https://tether.to/
Tether Gold: https://gold.tether.to/
Holepunch: https://holepunch.to/
Keet: https://keet.io/
Wallet Development Kit: https://wallet.tether.io/
In this episode, Guy Young & Rune Christensen discuss the evolution of DeFi, noting how it has become more grounded in reality and sustainable business models, moving away from the early hype and ideological claims.
OUTLINE:
00:00 Introduction
01:23 DeFi Ain't What it Used To Be
08:27 Ethena's Success
13:01 Get $HYPE(D)
15:08 HL L1
16:38 'Ecosystem Protocols'
19:32 DeFi User Capture
21:42 DeFi Endgame
22:05 Hyper-rational Users Onchain
24:53 Compressing DeFi Rates
27:16 Stealing from the Rich
28:43Onchain KYC
30:57 Forking DeFi
33:57 The Future of Finance
37:50 'MicroStrategy Playbook" for Alts
42:19 Bitcoin DeFi?
43:57 F.A.F.O. Onchain
SHOW LINKS:
- Apple: https://apple.co/43F3vmq
- Spotify: https://spoti.fi/44NT1lZ
- Larry: https://x.com/lawmaster
- Namik: https://x.com/NamikMuduroglu
- The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
- Rune: @RuneKek
- Guy: @gdog97_
- Sky: https://sky.money/
- Ethena: https://ethena.fi/
The Big Brain Podcast is co-hosted by The Block CEO Larry Cermak and MegaETH CSO Namik Muduroglu.
In this episode, Haseeb Qureshi & Jordi Alexander discuss the similarities between poker and crypto, the economics of bitcoin's endgame, the intersection of AI and crypto, and more.
OUTLINE:
00:00 Introduction
02:25 Similarities between Poker & Crypto
06:33 Maintaining Crypto Conviction
12:40 Surviving the FTX Fallout
17:55 FTX Marketing Spend
24:05 The Trump Era of Crypto
26:34 Bitcoin Endgame Economics
34:32 Crypto & AGI
43:07 Analysts vs. LLMs
47:47 Market Making & AI
51:52 F.A.F.O. Onchain
SHOW LINKS:
- Apple: https://apple.co/43F3vmq
- Spotify: https://spoti.fi/44NT1lZ
- Larry: https://x.com/lawmaster
- Namik: https://x.com/NamikMuduroglu
- The Block Podcasts: https://x.com/TheBlockPods
GUEST LINKS:
- Haseeb: https://x.com/hosseeb
- Jordi: https://x.com/gametheorizing
EPISODE LINKS:
- AI 2027: https://ai-2027.com/
- Noise: https://www.noise.xyz/
- Dave White Thread: https://x.com/_Dave__White_/status/1866497496773804434
It's gonna be a big show.










