The Pain Beat

Editor's note: Welcome to the 23rd episode of The Pain Beat, PRF's podcast series!  The Pain Beat brings together the world's leading pain investigators in order to spark dialogue and debate around important ideas in pain research.  The Pain Beat podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here. This episode of the Pain Beat covers ion channel disorders known as channelopathies that underlie painful conditions.  The conversation covers from human genetics, structural analyses, electrophysiological functional characterizations to personalized medicine and new therapeutic strategies. Participants include: Dr. Angelika Lampert, PhD, Aachen University, Germany Dr. Candice Paulsen, PhD, Yale University, US Dr. See Wan Tham, MD, Seattle Children's Hospital, US Moderated and organized by  Dr. John Del Rosario, PhD, Washington University in St. Louis, US.  This episode was produced by Lite Yang, Washington University in St. Louis, US and edited by Dieu Ni Doan, MD, PhD., Harvard Medical School Music was provide by Kevin Seal of Seal Party. Other episodes of the Pain Beat can be found on Apple Podcast, Spotify and the Pain Research Forum. 

Editor's note: Welcome to the 22nd episode of The Pain Beat, PRF's podcast series!  The Pain Beat brings together the world's leading pain investigators in order to spark dialogue and debate around important ideas in pain research.  The Pain Beat podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here. On this episode, experts in pain research discuss the modification of pain by homeostatic drives and survival threats.   How for example, do hunger and sleep modify the pain experience and how are they themselves modified by pain. What are the circuits and mechanisms underlying these interactions?   Participants on the podcast: Loren Martin, PhD, University of Toronto Nitsan Goldstein, PhD, MIT J. Nicholas Betley, PhD, University of Pennsylvania Alban Latremolier, PhD, Johns Hopkins University. Al Nie, Johns Hopkins University (Organizer and Moderator)   Music provided by Kevin Seal.  Other episodes of the Pain Beat can be found on Apple Podcast, Spotify and the Pain Research Forum.   

The first interview in the PRF Spotlight Series: Voices Shaping Pain Science features Dr. Michael Gold, PhD delving deep in to discussion of the history and future of sodium channels. From the identification of sodium channels as drivers of nociceptor excitability to the emergence of NaVs as therapeutic targets, this conversation bridges the history of pain research with the future of mechanism-based analgesia. Part 1 of our interviews on Sodium Channels and the Making of a Field.   Michael Gold, PhD University of Pittsburgh   Francisco Isaac  Gomes-Aragão, DDS, MSC, PhD University of São Paulo, BR   Beatriz Lima Adjafre, PhD University of São Paulo, Br   Music by Seal Party.   

Manager's note: The Pain Beat, launched and supported by a generous grant from the MAYDAY Fund, with additional funding from the Rita Allen Foundation, brings together the world's leading pain investigators with the purpose of sparking dialogue and debate around important ideas in pain research. Guided by Lite Yang, Scientific Director and co-producer, and Rebecca Seal, Chair Editorial Board of PRF, the podcasts feature open and spirited discussions about the hottest topics in pain and how the field moves forward. Here we dive into a topic that's both surprisingly complex and often overlooked—eye pain. Our eyes are among the most sensitive structures in the human body, yet the mechanisms behind ocular pain remain poorly understood. In this episode, we have the pleasure hosting clinicians who are treating patients with eye pain every day speak with their colleagues and collaborators, who are preclinical pain researchers working to unravel the underlying biology. What emerged was a fascinating conversation about the different types and distinct mechanisms driving eye pain. Our guests explored the organ's intricate structures and their relationships to sensation as well as the role of different brain regions in shaping how we ultimately perceive and experience ocular discomfort. Dr. Sue Aicher, Ph.D., Oregon Health and Science University, Dr. Anna Matynia, Ph.D. University of Houston college of Optometry, Dr. Brooke Harkness, O.D., M.S., FAAO, Casey Eye Institute, Oregon Health and Science University, Dr. Lindsey Delott, M.D., University of Michigan Kellogg Eye Center Dr. Anat Galor, M.D., M.S.P.H., Bascom Palmer Eye Institute at University of Miami, Moderator was Dr. Sejiro Littleton, Ph.D., Duke University This episode was produced by Lite Yang, and edited by Dieu Ni Daon.  Music by Kevin Seal of Seal Party.

Manager's note: The Pain Beat, launched and supported by a generous grant from the MAYDAY Fund, with additional funding from the Rita Allen Foundation, brings together the world's leading pain investigators with the purpose of sparking dialogue and debate around important ideas in pain research. Guided by Rebecca Seal, scientific director of The Pain Beat and Editor-in-Chief of Pain Research Forum, the podcasts feature open and spirited discussions about the hottest topics in pain and how the field moves forward. For this episode, Adam Dourson and Lite Yang served as both creators and producers. Lite Yang moderates an important discussion with leaders in the pain field, which provides insights into current work to use human donor tissues to guide basic research findings to increase the success of clinical outcomes. This is update on Episode 4 recorded in 2021, which featured another group of leading pain researchers. Podcast participants include: Robert Gereau, PhD, Washington University in Saint Louis, US Wenqin Luo, PhD, University of Pennsylvania, US Theodore Price, PhD, UT Dallas, US William Renthal, MD, PhD, Harvard University, US Lite Yang, Washington University in Saint Louis, US PRF thanks Kevin Seal for creating the music.