The Human Upgrade: Biohacking for Longevity & Performance

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if your brain is electrically "awake," you will stay "tired but wired."The "switch" I use to fix this is an amino acid called L-theanine. It crosses the blood-brain barrier to increase Alpha waves, which quiet the prefrontal cortex and stop overthinking. By boosting GABA and lowering glutamate, it prepares the brain for rest without the groggy "hangover" of traditional sedatives.To make this work, I follow a strict protocol: taking 400mg–1000mg about 45 minutes before bed on an empty stomach. I also protect my "Alpha state" by blocking blue and green "junk light" with TrueDark glasses, which prevents cortisol spikes that ruin sleep architecture. When you combine the right compounds with a dark, low-stimulation environment and consistent timing, sleep stops being something you chase and becomes something your body does automatically.Timestamps:00:00 – Introduction00:23 – How the Brain Enters Sleep01:00 – Why Most Supplements Fail02:15 – Beta Waves: The Sleep Blocker03:29 – Alpha Waves: The Sleep Gateway04:51 – The Amino Acid That Shifts Your Brain06:11 – Introducing L-Theanine06:48 – Common L-Theanine Mistakes08:02 – The Right Protocol09:34 – Light & Your Sleep Environment11:13 – Fixing Your Light Environment12:14 – The Full Sleep System13:59 – Putting It All TogetherThank you to our sponsors!AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision.  - Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. You'll Learn: How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot Why cell viability and placement matter more than raw cell count, and how RMI measures both 10 minutes before every injection How orthopedic stem cell protocols achieve 82.5 percent improvement in joint function across 8,000 treated joints Why Dave calls RMI the best hardware upgrade available and 40 Years of Zen the best software upgrade, and how the two work together What the difference feels like between going from standard resolution to 4K inside your own brain Thank you to our sponsors!     - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Victor Urzola, RMI Clinic Costa Rica, stem cell therapy, brain optimization, neurocognitive protocol, focused ultrasound, transcranial magnetic stimulation, neuroinflammation, plasmapheresis, orthopedic stem cells, mesenchymal stem cells, blood brain barrier, regenerative medicine, anti-aging, longevity, biohacking, Dave Asprey, erectile dysfunction treatment, stem cell facelift, human performance Resources:   • Learn More About All Of The Treatments at RMI by visiting: https://daveasprey.com/rmi/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Trailer 01:02 – Introduction and RMI Overview 03:02 – Cognitive Protocol Explained 05:39 – Dave's Brain Treatment Experience 13:08 – RMI Results & Patient Outcomes 15:32 – Plasmapheresis (Blood Cleanse) 17:10 – Orthopedic Stem Cell Treatments 23:49 – Enhanced Protocol (Sexual Health – Men) 25:29 – Sexual Health – Women 27:40 – Facial Stem Cell Treatment 30:05 – Closing & Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness. Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere. This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for. You'll Learn: Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety The six scientifically backed ways to open your right brain and unlock experiences of real meaning Why self-improvement fails without first understanding the neuroscience of how ideas install in the brain How suffering, handled correctly, is the single most powerful path to consciousness and purpose Why romantic love, beauty, and deep conversation are forms of neurological medicine What Dave's $2.5 million biohacking journey taught him about the limits of optimization The Buddhist physics of suffering: pain times resistance, and how to lower the resistance instead of the pain  Thank you to our sponsors!     - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - Join My Low-Oxalate 30-Day Challenge: daveasprey.com/2026-low-ox-reset - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Arthur Brooks, Harvard happiness research, meaning of life, hemispheric lateralization, right brain left brain, brain optimization, neuroplasticity, consciousness neuroscience, mental health crisis, depression anxiety solutions, human performance, self-improvement science, longevity mindset, biohacking happiness, Dave Asprey, functional medicine, suffering and purpose, AI limits, meaning and purpose, How to Build a Life Resources:   • Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Trailer 00:49 – Introduction 02:09 – Teaching & Learning Science 07:05 – Consciousness & Brain Hemispheres 18:51 – Mental Health & Meaning Crisis 20:08 – 6 Ways to Open the Right Brain 21:44 – Deep Questions & Life's Purpose 27:16 – Romantic Love & Relationships 34:37 – Transcendence & Self 41:18 – Finding Your Calling 49:33 – Beauty 53:41 – Suffering & Meaning 57:20 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. You'll Learn: Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine Thank you to our sponsors!    Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayPre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVEBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health Resources:   • Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 00:00 - Trailer 01:10 - Intro03:12 - Kids & Gas: Gut Imbalance in Children 06:42 - Pills vs. Powder Probiotics 07:28 - Omnibiotic Overview & Dave's Story 10:44 - Probiotics & Heart Rate Variability14:14 - GLP-1 Drugs & the Microbiome 17:24 - Gut & Sleep Quality 19:13 - Probiotics & SIBO 27:47 - Gut Bacteria & ADHD 29:55 - Gut, Libido & Fertility 36:04 - Gut & Unusual Microbiome Facts 43:22 - Histamine Intolerance & Probiotics 51:58 - Kids' Microbiome vs. Adults' 56:10 - Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBEI transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.To reverse this, I use 7 specific daily habits to flip the self-healing switch:- Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.- Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.- Mechanical Rest: I practice "Eye Fasting"—looking at true distance—to release the mechanical tension of constant near-focus.- Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.- Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.- Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.- Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.Timestamps:00:00 – Intro01:05 – The Problem with Traditional Vision Care02:48 – How Your Eyes Repair Themselves at Night05:03 – How Modern Life Breaks the Repair Cycle05:53 – The 7 Habits to Activate Your Eye's Self-Healing Switch06:07 – Habit 1: Red Light Therapy07:18 – Habit 2: Blueberries and Rhodopsin09:22 – Habit 3: Cold Exposure for Blood Flow11:10 – Habit 4: Grounding to Reduce Oxidative Stress13:38 – Habit 5: Eye Fasting (Distance Viewing)15:45 – Habit 6: Deliberate Blinking17:53 – Habit 7: Sunset Light and Circadian RepairThank you to our sponsors!Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources:  -https://www.nbc.com/saturday-night-live  -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources:  -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/  *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources:  -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/  *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. Sources: -https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html -https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html  *Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. Sources:  -https://pubmed.ncbi.nlm.nih.gov/41754195/  -https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/  *Measles Is Back — and the Math Is Unambiguous Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. Sources:  -https://www.cdc.gov/measles/cases-outbreaks.html  -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/  This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026  Thank you to our sponsors!  -  Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap-  The One Device | Use code DAVE for $10 off at theonedevice.com/dave Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Trailer 00:41 – SNL Roasts the MAHA Movement 03:20 – Pistachios and Longevity 04:37 – AI as Your Health Advisor 06:12 – Gut Biofilms and Microbiome Architecture 07:44 – Colon Cancer in Young People 09:23 – The Measles Comeback See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care. Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino. This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology. You'll Learn: Why testing TSH alone misses thyroid dysfunction in the vast majority of people What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3 Why T4-only medications like Synthroid fail and what works better How low thyroid directly tanks testosterone and libido in both men and women The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods How Hashimoto's connects to broader autoimmune risk and what drives it into remission Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off  Thank you to our sponsors!    TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off. BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid  Resources:   • Learn More About McCall’s Work At: https://www.modernthyroidclinic.com/ • Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Trailer 01:05 – Intro & Guest Background 02:26 – Dave & McCall's Thyroid Stories 05:26 – How Thyroid Hormones Work 12:51 – Why T4-Only Meds Fall Short 23:05 – Why Thyroid Dysfunction Is So Common 23:59 – Fluoride, Bromine & Environmental Triggers 26:39 – Thyroid & Low Testosterone 27:31 – Optimal Lab Ranges for TSH, T4 & T3 36:58 – Mold, Hashimoto's & Autoimmunity 44:44 – Thyroid, ADHD & Mental Performance 49:38 – Supplements for Thyroid Support 51:52 – Vitamin D & Circadian Rhythms 56:30 – T3 Safety Myths & Medical Misinformation 1:00:16 – Key Takeaways & Where to Get Help See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ -Find a UNIFYD Healing Center near you: https://www.unifydhealing.com/locationsJason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies. Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing. You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness. You will Learn: Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System How encoded light affirmations restructure the molecular formation of water in your body without conscious effort What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them How full spectrum visible light maps directly onto the body's energy centers and organ systems Why the metamatrix font used in The Light System produces stronger biological effects than standard text How this technology was invented by a programmer combining transcendental meditation with software development What happens to your brain state when you stare at encoded light and why it resembles deep meditation without the effort How geometry, specifically the pyramid shape, amplifies photonic output and room coverage Why altered states accessed through light may be one of the most underexplored frontiers in brain optimization and neuroplasticity How to use The Light System for sleep optimization, pain relief, and cellular recovery Thank you to our sponsors!    Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Go to timeline.com/dave and save 20% with code DAVE20 STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: The Light System, Jason Shurka, Unified Healing, Robert Religa, biophotons, metamatrix font, encoded affirmations, water structuring, electrical impedance spectroscopy, cellular conductivity, full spectrum visible light, pyramid geometry, transcendental meditation, Masaru Emoto, water crystals, morphogenic field, quantum biology, Gaia Network, Dr. Glenn Ryan, biofield, meditation technology, hair regrowth, autism light therapy, Dave Asprey, biohacking, mitochondria, smarter not harder Resources:   • Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ • Find a UNIFYD Healing Center near you: https://www.unifydhealing.com/locations• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 00:00 – Trailer 01:20 – Intro 03:50 – What Is The Light System? 05:39 – Encoded Affirmations & Metamatrix Font 08:10 – Dr. Emoto's Water Experiment 10:13 – Light Restructures Body Water 13:09 – Skeptics & Quantum Science 18:43 – 80% Conductivity Study 20:45 – The Body Heals Itself 23:40 – Ego & Certainty 26:37 – Real-World Testimonials 36:43 – Reversing Asperger's 38:24 – Light System & Autism 41:14 – Why Not a Phone? 43:39 – Biophotons Are Real 56:37 – Color Settings & Programs 58:35 – Wrap-Up & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/Timestamps:00:00 - The Anti-Aging Switch01:30 - Chronological vs. Biological Age02:32 - How Aging Works at the Cellular Level04:58 - 43 Ways to Upgrade Your Mitochondria07:37 - What Is Autophagy09:17 - The Stages of Fasting10:46 - What Happens During a 3-Day Fast13:04 - How to Fast Correctly14:42 - Breaking the Fast15:58 - The Power of SubtractionThank you to our sponsors!-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. Sources: https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance  Bats Are Breaking the Telomere Model A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing. Sources: https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 https://www.nature.com/articles/telomere-bat-aging-2026 The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial The First Longevity Supplement to Move Vascular Age Like Exercise A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second — equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons. Sources: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278 https://clinicaltrials.gov/study/NCT06145087 https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi Carbon Monoxide Exposure Is Up 50% in 2026 — And Most People Won't Know Until It's Too Late Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 — a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year — and most of them never saw it coming. Sources: https://kffhealthnews.org/morning-briefing/friday-march-6-2026 https://www.cdc.gov/niosh/topics/co/default.html https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026   Fat Plus Carbs Around Training May Actually Be the Metabolic Move A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase — directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026 https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training  All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sleep medication daytime performance, suvorexant alertness, sleep score vs performance, telomere aging myth, bat longevity telomeres, DNA repair aging, fenugreek blood glucose, fenugreek insulin sensitivity, CGM glucose hack, longevity supplement clinical trial, vascular aging markers, arterial stiffness reversal, pulse wave velocity supplement, carbon monoxide poisoning 2026, CO detector home safety, environmental toxin biohacking, fat and carbs exercise, macronutrient timing training, insulin sensitivity workout, metabolic flexibility training, biohacking news, longevity research 2026 Thank you to our sponsors!  - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Intro 00:20 – Trailer 00:57 - Story #1: Sleep Meds & Morning Performance 02:42 - Story #2: Bats & the Telomere Model 04:33 - Story #3: Fenugreek & Glucose Spikes 06:00 - Story #4: Multi-Ingredient Longevity Stack Trial 07:51 - Story #5: Carbon Monoxide: The Silent Threat 09:45 - Story #6: Fat + Carbs Around Exercise 11:25 - Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors!    Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources:   • Learn More About Dr. Houman’s Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 00:00 – Introduction 01:15 – Low Testosterone Epidemic 04:23 – Ejaculation & Testosterone 07:30 – Refractory Period & Aging 09:58 – Porn-Induced ED 11:09 – Cabergoline & Prolactin Management 12:42 – Oral Testosterone 13:24 – Testosterone Target Levels 16:46 – Supplements for Testosterone 18:46 – Anxiety-Based ED 26:23 – Penis Enhancement Options 27:37 – Shockwave Therapy 28:57 – Cialis for Longevity 29:56 – Fat & Filler Injections 34:50 – Pre-Sex Optimization 40:13 – Red Light Therapy 42:18 – Heat & Cold for Testosterone 43:35 – Underwear & Microplastics 44:58 – Testosterone & Fertility 49:15 – HCG & Preserving Fertility 52:00 – Testosterone Dosing Timing 53:22 – Creatine & Mitochondrial Health 55:20 – Overtraining Effects 56:24 – Peptides (PT-141) 59:08 – Optimal Diet for Fertility See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences. Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity. You'll Learn: Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit How your mitochondria pre-process sensory reality before your auditory cortex even fires Why emotions like anger, love, and remorse are computational tools evolution built into your reward function How low energy and blood sugar directly degrade your decision-making at a hardware level What "resource rationality" means and how to use it to make better decisions under constraint Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head How neuroplasticity can eliminate the inner critic and reshape your mental operating system Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence  Thank you to our sponsors!  -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.-Quantum Upgrade | Try it free for 15 days — no credit card required — at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data.-Go to timeline.com/dave and save 20% with code DAVE20  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By Resources:   • Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353 • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Intro00:50 - Tom's Background & Chronic Fatigue 10:22 – Mathematics of Mind 12:43 – Memory and Emotion 15:29 – Decision Making Under Constraints 21:10 – Computational Problems of Consciousness 24:18 – Reality Pre-Processing 26:14 – Meat Robots vs Stochastic Parrots 29:21 – Emotions: Game Theory 35:39 – Dual Systems: Model-Based vs Model-Free 39:22 – Mitochondria and Consciousness 50:00 – Testing AI Like Humans 52:11 – Choosing AI Models 57:14 – AI Research Questions See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBEThink 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it.Thank you to our sponsors! -Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com  Chapters:0:00 – Introduction0:38 – The Real Reason You're Still Tired0:59 – How Light Controls Your Sleep Quality1:36 – Circadian Rhythm Explained (NASA-Approved)2:51 – The Secret Sleep Trigger5:29 – Blue Light: The Silent Sleep Killer6:12 – How to Hack Your Evening Light7:52 – Screen Time vs. Sleep Time8:12 – Social Jet Lag: The Weekend MistakeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: Healthy Diets That Offset "Bad Genes" A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol. • Sources: -https://www.science.org/doi/10.1126/sciadv.ads7559 -https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179 -https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity Micro-Habits in Sleep, Activity, and Diet That Extend Life Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation. • Sources: -https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424 -https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502 -https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too • Sources: -https://elifesciences.org/reviewed-preprints/108825v2 -https://www.nature.com/articles/s42255-025-01297-8 -https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review Tyrosine and Lifespan: What the Data Says for Men A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically  • Sources: -https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx -https://www.eurekalert.org/news-releases/1105915 -https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking. • Sources: -https://www.sciencedaily.com/releases/2024/07/240718124709.htm -https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds -https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers -https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387 All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026 Thank you to our sponsors!  -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.comResources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 0:00 - Introduction 0:18 - Story #1: Diet vs. Genetics 2:14 - Story #2: 1% Better Every Day 4:26 - Story #3: Sulfur Amino Acids & Fat Loss 5:55 - Story #4: Tyrosine & Longevity 7:58 - Story #5: Doomscrolling & Aging 10:00 - Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging. Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization. This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.  You'll Learn: Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine Thank you to our sponsors!   The One Device | Use code DAVE for $10 off at http://theonedevice.com/daveHeartMath | Go to https://www.heartmath.com/dave to save 15% off.Igniton | Go to Igniton.com and use code DAVE to save 15% off.Puori | Go to http://Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding Resources:   • Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 00:00 – Introduction 03:00 – Microplastics in the Brain 08:40 – Olyxir Tea Strip Solution 10:10 – Health Impacts & Weight Gain 11:05 – Environmental Solutions 14:29 – The Teabag Problem 18:57 – How to Remove Microplastics 22:04 – Olive Leaf Benefits 28:26 – Josephine's Scientific Background 33:00 – Guarana & Lymphatic Support 34:22 – Skincare & Microplastics 36:38 – Sauna Protocol 44:19 – Household Exposure Sources 47:18 – Workout Clothing Risk 48:59 – Leather vs Synthetic Fashion 50:54 – Pregnancy & Fertility 54:20 – Closing & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.  You'll Learn: Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time Thank you to our sponsors!   • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs Resources:   • Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Trailer 00:53 – Intro to Precision Medicine 01:58 – Dr. Bajnath's Holistic Health Journey 05:03 – Pharmaceuticals vs. Supplements 07:58 – Peptides and Longevity Molecules 10:34 – Sexual Health and Vitality 13:56 – Vascular Health and Blood Flow 15:14 – Multi-Omics Approach 19:03 – DNA and Genomics 22:17 – Transcriptomics and RNA 24:24 – Proteomics and Inflammation Markers 32:00 – The Human Exposome 34:55 – Key Health Biomarkers 36:58 – Cell Membrane Dynamics 40:28 – Biological Investment Strategy 41:53 – Life Extension Possibilities 48:52 – Bioenergetics and Mitochondria 49:47 – Quantum Medicine and the Future 51:33 – Vagal Nerve Stimulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.The twist? You can activate it in just 10 minutes a day, no prescription required.Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...Thank you to our sponsors! -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/daveResources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com  0:00 – Introduction0:46 – Lobsters and Human Longevity Connection1:14 – Understanding Telomeres and Aging2:26 – How Lobsters Defy Aging3:32 – Rethinking Aging Biology4:53 – The Telomerase Challenge6:43 – Natural Ways to Protect Telomeres9:33 – Meditation's Role in Anti-Aging11:04 – Different Meditation Techniques13:19 – Benefits and Long-Term EffectsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: Sinclair’s This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.   • Sources: – World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026   – NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair    AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.   • Sources: – Nature: https://www.nature.com/articles/d41586-026-00365-7   – Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier   Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.   • Sources: – New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/   – Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954   – Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM    The disease we thought was dead: measles comes roaring back Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.   • Sources: – AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026   – ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078   – CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections    DC vs your health: Trump’s State of the Union health reset President Donald Trump’s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.   • Sources: – Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup   – Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/   – This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/  All source links are provided for direct access to the original reporting and research.  This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update  Thank you to our sponsors!  -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 0:00 - Introduction 0:30 - Story #1: David Sinclair 2026 2:13 - Story #2: Google Drug Discovery 3:48 - Story #3: El Mencho Biohacking5:30 - Story #4: Measles Outbreak 6:51 - Story #5: Trump State of the Union 8:00 - Weekly Roundup 9:10 - Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You’ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what’s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You’ll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors!   • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources:   • Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com    Timestamps: 0:00 – Trailer 1:22 – Introduction to Peptides 7:52 – Peptide Delivery Systems & Pens 14:22 – Safety & Regulation of Peptides 19:22 – SS-31 & Mitochondrial Health 26:22 – Blending Peptides & Cross-Linking 38:22 – Growth Hormone Peptides 44:22 – FLGR-242: The New Myostatin Inhibitor 54:22 – Melanin & Consciousness 57:22 – Klotho: The Longevity Peptide 59:25 – Regulatory Landscape & Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from LYMA by using code ‘DAVE10’ at: https://lyma.life/  -Offer not valid on LYMA Laser PRO or LYMA Youth SystemIn this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy and her scientific team engineered a rare kind of at-home cold laser that delivers precise 808nm light with deep penetration, without burning, cutting, or “damaging to rebuild.” Their work is backed by published research in the Aesthetic Surgery Journal, and they’ve tested gene expression in human dermis, including a reported sixfold increase in SIRT1, a major longevity pathway. This is why you can trust this conversation. It’s not vibes, it’s engineering, biology, and data. Most “red light” products are basically glorified LEDs. They can be fine for the surface, but they do not deliver the kind of coherent, polarized, monochromatic light that your cells actually respond to in deep tissue. That matters because your mitochondria run the whole show. When mitochondria get a clean signal and more usable energy, your body suddenly has budget for repair, collagen, circulation, and recovery. That is the real mechanism behind anti-aging that does not rely on controlled injury. We get into how this kind of light hacking can change skin quality, muscle support under the skin, and even scars and fascia. We talk cartilage, knees, jowls, pigmentation, and the weird reality that you might not feel anything while it’s working. Dave also shares his early biohacking experiments using light for brain optimization, including the time he overdid it and temporarily scrambled his speech. That story will make you respect the power of light as a biological tool. We also talk human performance and travel. Dave breaks down how he uses light management for sleep optimization and jet lag, and why controlling light is as important as controlling food, fasting, ketosis, and metabolism. There’s also a practical angle here that most people miss: with AI, you can now take dense PubMed research and translate it into usable decisions without needing a PhD, which changes how fast you can learn, test, and personalize. If you care about longevity, neuroplasticity, recovery, and looking younger without trashing your tissue, this episode gives you a smarter way to think about lasers, supplements, nootropics, and the whole functional medicine stack. This is Smarter Not Harder biohacking, with a laser. You’ll Learn: • Why LED “red light therapy” is not the same as laser-based mitochondrial activation • How coherent light influences mitochondria, collagen quality, and anti-aging repair • What gene expression changes like SIRT1 suggest about longevity signaling • How light may support brain optimization, circulation, and neuroplasticity • Why scars and fascia can disrupt performance, and how light can support remodeling • How Dave uses light and lifestyle hacking for sleep optimization, travel, and metabolism • How AI makes research-driven biohacking more accessible and more personal Thank you to our sponsors!  • KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.• EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cold laser therapy, 808nm laser, LYMA laser, infrared light therapy, red light vs laser, mitochondrial activation, SIRT1 gene expression, longevity biohacking, anti aging skin tech, collagen regeneration, fascia repair, scar healing laser, pigmentation removal light, brain optimization light therapy, neuroplasticity support, circulation enhancement, human performance recovery, functional medicine tools, Dave Asprey biohacking Resources:   • LYMA Website (Use Code ‘DAVE10’ For A Discount: https://lyma.life/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: • 0:00 — LYMA Laser Origin • 1:20 — Dave’s Early Light Experiments • 5:15 — Laser vs LED • 10:54 — Safety and Diffusion Lens • 16:37 — 808nm and the Brain • 19:36 — Intimate Performance Effects • 26:03 — Knee Before and After • 29:25 — Vampire Bat and Veins • 37:36 — 6x SIRT1 Activation • 42:42 — Mitochondrial Signaling • 45:04 — Veins and Pigmentation • 52:14 — Scar Recovery See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.