Alternatively Speaking

Welcome to Alternatively Speaking, a new podcast series by KCSA Podcast Labs, the team behind the Green Rush Podcast. Join us on a captivating journey through the complex and fascinating world of longevity in our single-season, 10-episode series. Each week, we dive deep into the advancements and challenges surrounding the pursuit of longer, healthier lives. From exploring the scientific foundations of aging and the latest technologies aimed at combating it to examining the economic implications and who stands to benefit financially, our conversations provide a comprehensive look at this rapidly evolving field. For the first episode, our hosts Lewis Goldberg, Anne Donohoe, and Phil Carlson discuss what led them to start Alternatively Speaking, why the first series will focus on longevity, and the key experts lined up to enlighten us on this new quest for information. Our social channels can be found @KCSAPodcastLabs - or drop us an email at [email protected]. Who else should we be speaking with? What other topics would you like us to explore? We want to hear from you!  Here’s to a long, healthy, productive life! Show Credits: This episode was hosted by Anne Donohoe of KCSA Strategic Communications. Special thanks to our Program Director, Shea Gunther, and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing [email protected]. You can also connect with us via our social channels: X: @KCSAPodcastLabs Instagram: @KCSAPodcastLabs LinkedIn: https://www.linkedin.com/company/kcsapodcastlabs/

Welcome to Alternatively Speaking, a KCSA Podcast Labs production. In our debut season, we're diving into a revolutionary concept in health span, longevity, and healthcare. Today, we welcome our first-ever guest, Jamie Justice, Executive Vice President of the Health Domain at XPRIZE Foundation and Adjunct Professor in Internal Medicine Section on Gerontology and Geriatric Medicine, and Sticht Center on Healthy Aging and Alzheimer’s Prevention at Wake Forest University School of Medicine (WFUSM). Jamie is dedicated to Geroscience research that advances the hypothesis that by targeting the basic biology of aging the incidence of multiple age-related diseases can be delayed or prevented. Her training background at University of Colorado Boulder and WFUSM allowed her to lead translational research and clinical trials networks to test the Geroscience hypothesis in humans. At WFUSM, Jamie was director of the Biogerontology Lab, and co-leader of the Integrative Biology Core (IBC) of the WF Claude D. Pepper Older Americans Independence Center (OAIC) and was a Principal Investigator of the National Institute of Aging-supported Geroscience Education and Training Network, an engaged member of the Translational Geroscience Network, Gerontological Society of America’s ESPO scientific section officer and executive committee member from 2018-2021. Jamie is the recipient of the Jarrahi Research Scholars Fund in Geroscience Innovation, the 2022 Vincent Cristofalo Rising Star in Aging Research, and the 2022 NIA Nathan W Shock Awardee. In her new role as EVP of Health Domain she will lead international networks to drive innovative solutions to improve human health and aging that is affordable and accessible to all. Podcast Highlights: Introduction & XPRIZE Foundation Origins (00:00 - 02:29): Overview of the longevity industry, the impact of the Ansari XPRIZE on private space travel, and XPRIZE’s influence on companies like SpaceX. Jamie Justice’s Background & Passion for Research (02:30 - 06:14): Jamie’s journey into gerontology, early research experiences with older adults, and her focus on empathy and the human aspect of aging. Exploring Aging & Longevity (06:15 - 10:21): Discussion on the fundamental questions of aging, how different interventions (lifestyle, supplements, drugs) impact human health and longevity. Translating Aging Research into Practice (10:22 - 13:10): Jamie’s work at Wake Forest, ongoing efforts to apply aging research in real-world settings, and the philosophical aspects of aging—living fully versus focusing on death. Healthspan vs. Lifespan & Longevity Goals (13:11 - 20:43): Exploring the concept of the ‘longevity dividend,’ aligning biological health with extended life, and the strategies to improve healthspan by optimizing current biology. XPRIZE HealthSPAN Award & Future of Aging Research (20:44 - 28:28): Introduction to the XPRIZE HealthSPAN Award program, the bold scientific goals it supports, challenges in aging research, and the collaborative efforts to advance the field. Social Media: X: @j_n_justice LinkedIn: https://www.linkedin.com/in/jamie-justice-ph-d-6b933146/ Other Links/Mentions: https://www.xprize.org/ https://www.xprize.org/prizes/healthspan Show Credits: This episode was hosted by Anne Donohoe of KCSA Strategic Communications. Special thanks to our Program Director, Shea Gunther and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing [email protected]. You can also connect with us via our social channels: X: @KCSAPodcastLabs Instagram: @KCSAPodcastLabs LinkedIn: https://www.linkedin.com/company/kcsapodcastlabs/

Welcome to Alternatively Speaking, a KCSA Podcast Labs production. In our debut season, we're diving into a revolutionary concept in health span, longevity, and healthcare.  Today, we sat down with Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.  Dr. Barzilai discovered the first “longevity gene” in humans. His research established that the gene variant that leads to high HDL, or “good cholesterol,” is linked to healthy aging and extreme longevity. Dr. Barzilai has been profiled by major outlets, including The New York Times, PBS’ “NOVA scienceNow” and National Geographic. Treatments for age-related diseases like type 2 diabetes are being developed based on Dr. Barzilai’s work and are currently in clinical trials. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. Dr. Barzilai is a professor of medicine (endocrinology) and of genetics, a member of the Diabetes Research Center, and director of the Diabetes Research and Training Center’s Animal Physiology core. Podcast Highlights: Introduction & Dr. Nir Barzilai’s Groundbreaking Discovery (00:00 - 03:15): Overview of Dr. Nir Barzilai’s discovery of the first “longevity gene” in humans and its link to healthy aging. Discussion on the significance of high HDL cholesterol and how it relates to extreme longevity. The Science Behind Longevity Genes (03:16 - 08:32): Dive into the specific genetic markers that contribute to longevity. Dr. Barzilai shares insights on the mechanisms of aging and the potential to delay or reverse age-related diseases. Current Clinical Trials on Age-Related Diseases (08:33 - 12:10): An exploration of the treatments for type 2 diabetes and other age-related conditions that are being developed from Dr. Barzilai’s research, with an update on the progress of these clinical trials. Nutritional and Genetic Influence on Lifespan (12:11 - 17:48): How both genetics and nutrition shape our healthspan and longevity. Dr. Barzilai explains the latest findings on how diet can influence aging and the role of genetics in extending life. Mental and Physical Decline in Aging (17:49 - 21:22): Discussion on the common declines in physical and mental health with aging, and how they impact longevity. Dr. Barzilai talks about ongoing research into mitigating these declines. Future of Longevity Research (21:23 - 26:55): Dr. Barzilai shares his vision for the future of aging research, focusing on potential br Social Media: @NirBarzilaiMD: https://x.com/nirbarzilaimd?lang=en  https://www.linkedin.com/in/nir-barzilai-7a86a7212/  Other Links/Mentions/Resources: Age Later by Nir Barzilai, M.D. https://us.macmillan.com/books/9781250230867/agelater  Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai  American Federation for Aging Research (AFAR) https://www.afar.org/ Aging is a Treatable Condition - Worth.com The 4 most promising anti-aging drugs investors are sleeping on, according to a leading longevity researcher - Business Insider What is your Biological Age? - The New York Times Show Credits: This episode was hosted by Anne Donohoe and Phil Carlson of KCSA Strategic Communications.  Special thanks to our Program Director, Shea Gunther, and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing [email protected]. You can also connect with us via our social channels:

Welcome to Alternatively Speaking, a KCSA Podcast Labs production. In our debut season, we're diving into a revolutionary concept in health span, longevity, and healthcare.  Today, we sat down with Dr. Moshe Szyf, a pioneering figure in the field of epigenetics with a career spanning over three and a half decades. A founding figure in behavioral and psychiatric epigenetics, Dr. Szyf has authored over 300 influential papers that have significantly contributed to our understanding of how environmental factors and behaviors can influence gene expression without altering the DNA sequence itself.  Dr. Szyf serves as Chairman, CEO, and Chief Scientific Officer of HKG Epitherapeutics, focusing on developing epigenetic tools for clinical medicine, early disease detection, and personalized healthcare. He also currently holds the prestigious position of James McGill Professor of Pharmacology and Therapeutics at McGill University in Montreal, where he also holds the GlaxoSmithKline Chair in Pharmacology.  Dr. Szyf is a sought-after speaker, having presented at the Nobel Forum and delivered a TED talk on DNA and early life experiences. His work bridges academic research and practical applications, aiming to translate epigenetic insights into tangible health benefits for society. Podcast Highlights: Introduction to Epigenetics (00:11 - 02:37): Dr. Moshe Szyf is introduced as a pioneer in epigenetics. The concept of epigenetics is explained as the "software" that programs DNA, influencing how genes function without changing the DNA sequence itself. HKG Epitherapeutics and Epigenetic Testing (02:38 - 06:05): Discussion of Dr. Szyf's company, HKG Epitherapeutics, which develops epigenetic tests for early disease detection, aging assessment, and health monitoring. Epigenetics vs. Traditional Testing (06:06 - 09:44): Explanation of how epigenetic testing differs from traditional blood tests and genetic testing, offering insights into the dynamic changes happening at the DNA level. Consumer Impact and Health Empowerment (09:45 - 14:42): Examples of how consumers have used epigenetic tests to gain insights into their biological age and health status, leading to lifestyle changes. COVID-19's Impact on Healthcare Autonomy (29:38 - 33:40): Discussion on how the pandemic has led to increased public interest in personal health management and a shift towards more patient autonomy in healthcare decisions. Future of Precision Medicine (39:12 - 42:06): Dr. Szyf's views on the role of epigenetics in precision medicine, particularly in guiding personalized drug treatments and lifestyle interventions. Ethical Considerations and Balanced Approach to Longevity (34:55 - 39:11): Dr. Szyf's perspective on extreme anti-aging approaches, emphasizing the importance of balance and quality of life over extreme life extension methods. Future Developments in Epigenetics (43:25 - 45:37): Discussion of anticipated breakthroughs in epigenetic technology, including improved accuracy in testing and applications for early detection of various chronic diseases. Social Media: LinkedIn https://www.linkedin.com/in/moshe-szyf-99ab283/?originalSubdomain=ca  @epimedtech https://twitter.com/epimedtech  Other Links/Mentions/Resources: EpiMedTechGlobal https://epimedtech.com/  Dr. Szyf’s Ted Talk https://www.ted.com/talks/moshe_szyf_how_early_life_experience_is_written_into_dna?subtitle=en  CDC Resources for Epigenetics https://www.cdc.gov/genomics-and-health/about/epigenetic-impacts-on-health.html  Show Credits: This episode was hosted by Anne Donohoe and Phil Carlson of KCSA Strategic Communications.  Special thanks to our Program Director, Shea Gunther, and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing [email protected]. You can also connect with us via our social channels:

Welcome to Alternatively Speaking, a KCSA Podcast Labs production. In our debut season, we're diving into a revolutionary concept in health span, longevity, and healthcare.  We sat down with Dr. Bob Hariri, a renowned biomedical scientist, surgeon, and entrepreneur. He is the Founder, Chairman, and CEO of Celularity, a biotechnology company leading the next evolution in cellular medicine. Dr. Hariri pioneered the use of stem cells to treat a range of life-threatening human diseases and continues today to make transformative contributions in the fields of immuno-oncology and cell therapeutics along with tissue engineering and functional regeneration.  Dr. Hariri is widely acknowledged for his discovery of pluripotent stem cells derived from the human placenta, and as a member of the team that discovered the physiological activities of tumor necrosis factor (TNF). He holds over 150 issued and pending patents for discoveries including placenta-derived stem cells, which Nature recognized as one of the ten most important patent estates in the field. Dr. Hariri was the founder and CEO of Anthrogenesis Corporation, and after its acquisition by Celgene Corporation, served as CEO of Celgene Cellular Therapeutics. Dr. Hariri also co-founded the genomic-based health intelligence company, Human Longevity, Inc. Podcast Highlights: Introduction & Dr. Bob Hariri’s Research (1:00): Dr. Hariri's background and journey to longevity science. Placental Stem Cells (04:30): Advantages of using placental-derived stem cells and their ethical considerations. Universal Donor Tissue (10:05): Concept of the placenta as a universal donor tissue is explored, highlighting its potential in cellular therapies. Genetic Modification (12:40): Process of gene modification in stem cells and their natural intelligence. Chimerism (20:35): Potential therapeutic benefits of chimerism in cellular medicine. Adult Stem Cell Banking (24:18): Cellularity's adult stem cell banking program and its value for future treatments. Future of Stem Cell Medicine (36:40): A vision of stem cell medicine in 10 years, including potential treatments for cancer, autoimmune diseases, and aging-related conditions. Other Links/Mentions/Resources: Cellularity's official website: https://www.cellularity.com/  National Institutes of Health (NIH) information on stem cells: https://stemcells.nih.gov/  FDA resources: https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products  Nature article on chimerism: https://www.nature.com/articles/d41586-021-01001-2  The American Society for Gene and Cell Therapy's patient education page: https://asgct.org/education  Social Media: Dr. Hariri's Instagram: https://www.instagram.com/drbobhariri/?hl=en Dr. Hariri's LinkedIn: https://www.linkedin.com/in/bob-hariri-md-phd-3654b239/ Show Credits: This episode was hosted by Lewis Goldberg of KCSA Strategic Communications.  Special thanks to our Program Director, Shea Gunther, and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing [email protected]. You can also connect with us via our social channels: X: @KCSAPodcastLabs Instagram: @KCSAPodcastLabs LinkedIn: https://www.linkedin.com/company/kcsapodcastlabs/