Moderator: James Rathmell, M.D. Participants: Jie Sun, M.D., Ph.D. and Clyde Matava, M.B.Ch.B.., M.Med., M.H.S.C. Articles Discussed: Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial Choice of Anesthetic Maintenance Is Not Merely a Matter of Preference, but One of Safety: Insights from the AmPRAEC Study Transcript
Moderator: BobbieJean Sweitzer, M.D. Participants: Kristin L Schreiber, M.D., Ph.D. and Eric S. Schwenk, M.D. Articles Discussed: A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain Determining Pain Phenotype: A Major Advancement in Providing Individualized Care Transcript
Moderator: BobbieJean Sweitzer, M.D. Participants: Rutger van der Schrier, M.D., Ph.D. and Steven L. Shafer, M.D Articles Discussed: Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic–Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression Toward More Physiologic Models for Predicting the Impact of Opioids on Ventilation Transcript
Moderator: BobbieJean Sweitzer, M.D. Participants: Taiki Kojima, M.D., M.P.H. and Clyde Matava, M.B.Ch.B.., M.Med., M.H.S.C. Articles Discussed: Adverse Events Associated with Airway Management in Pediatric Anesthesia: A Prospective, Multicenter, Observational Japan Pediatric Difficult Airway in Anesthesia (J-PEDIA) Study Airway Management Issues in Japanese Children Are No Different: Insights from the J-PEDIA Study Transcript
Moderator: James Rathmell, M.D. Participants: Osama Abou-Arab, M.D. PH.D. and Matthieu Legrand, M.D., Ph.D. Articles Discussed: Early Use of Norepinephrine in High-risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial Preventing Hypotension during Induction of General Anesthesia: Is Preemptive Norepinephrine the Answer? Transcript
Creator: James P. Rathmell, M.D. November 2025, Volume 143, Issue 5 Overview of November issue original studies.
Creator: James P. Rathmell, M.D. October 2025, Volume 143, Issue 4 Overview of October issue original studies. Transcript
Moderator: James Rathmell, M.D. Participants: Ji-Hyun Lee, M.D., Ph.D. and Andrew J. Davidson, M.D., M.B.B.S. Articles Discussed: Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial The Second Randomized Trial to Suggest You Shouldn't Change Your Anesthetic in Infants to Avoid Neurotoxicty Transcript
Moderator: James Rathmell, M.D. Participants: Shiqian Shen, M.D. and Cyrus David Mintz, M.D., Ph.D. Articles Discussed: Hippocampal Neural Dynamics and Postoperative Delirium-Like Behavior in Aged Mice Neural Network Dynamics of Postoperative Delirium: is it all About Neurons Striking the Right Balance? Transcript
Moderator: BobbieJean Sweitzer, M.D. Participants: Bernd Saugel, M.D. and Michael R. Mathis, M.D. Articles Discussed: The StatistiCal Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement Cardiac Output Measurement and Reporting: More Than Just Going With the Flow Transcript
Creator: James P. Rathmell, M.D. September 2025, Volume 143, Issue 3 Overview of September issue original studies. Transcript
Moderator: James P. Rathmell, M.D. Participants: Nikolay O. Kamenshchikov, M.D. and Lorenzo Berra, M.D. and Kamrouz Ghadimi, M.D. Articles Discussed: Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial): A Randomized Controlled Trial Nitric Oxide and Kidney Injury after Cardiac Surgery: A Solution Looking for a Problem
Moderator: James P. Rathmell, M.D. Participants: Paul Lee-Archer and Clyde Matava, M.B.Ch.B., M.Med., M.H.S.C. Articles Discussed: Development of the Pediatric Scale for Quality of Recovery (PedSQoR) Measuring what Matters - the Pediatric Scale for Quality of Recovery
Creator: James P. Rathmell, M.D. August 2025, Volume 143, Issue 2 Overview of August issue original studies. Transcript
Moderator: James P. Rathmell, M.D. Participants: Albert Garcia-Casanovas, M.H.A. and Douglas Colquhoun, M.B., M.Sc., M.P.H. Articles Discussed: Association Between Adherence to Patient Blood Management Recommendations and Postoperative Complications in Hip and Knee Arthroplasty Patient Blood Management: Moving Beyond Guidelines to Action Transcript
Moderator: BobbieJean Sweitzer, M.D. Participants: Jessica R Ansari, M.D., M.S. and Craig M. Palmer, M.D. Articles Discussed: Uterine Tone Numeric Rating Score as an Early Indicator of Major Postpartum Hemorrhage During Cesarean Delivery: A Prospective Observational Study Predicting the Unpredictable: A New Approach to Predict Postpartum Hemorrhage from Uterine Atony Transcript
Creator: James P. Rathmell, M.D. July 2025, Volume 143, Issue 1 Overview of July issue original studies. Transcript
Moderator: James P. Rathmell, M.D. Participants: Carmen Bozic, M.D. Articles Discussed: Suzetrigine, a Nonopioid NaV1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials Suzetrigine: First in a New Class of Nonopioid Analgesics for Acute Pain Transcript
Moderator: James P. Rathmell, M.D. Participants: Rebecca L. Wu, M.D. and Max B. Kelz, M.D., Ph.D. Articles Discussed: TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males Alluring Potential to Accelerate Emergence and Ameliorate Opioid-induced Respiratory Depression without Antagonizing Analgesia: Danavorexton Enters the Anesthetic Landscape Transcript
Moderator: BobbieJean, M.D. Participants: Douglas Colquhoun, M.B., M.Sc., M.P.H. and Stephan R. Thilen Articles Discussed: Neuromuscular Blockade and Antagonism in Patients with Renal Impairment: A Multicenter Retrospective Cross Sectional Study On and Off Label Use of Sugammadex in Patients with Renal Impairment in the 6 ½ Years Following FDA Approval Transcript