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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe
You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.
1114 Episodes
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Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.
T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains
In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response
This is the first part of a diaeventontological framing of lipid peroxidative mechanisms for CNS neurodegeneration. Dr Guerra describes recent published research (JLR 2018 .59:312pp.) and develops some of the key elements of the ferroptosis programmed cell death mechanism leading to oligodendrocyte and neuronal degeneration that will participate in a grander understanding of injury-induced and idiotypic age-associated disease in the CNS. 25 March 2019.
In this podcast, Dr Daniel Guerra of Authentic Biochemistry and VerEvMed endeavours to examine the bioenergetic and pro-inflammatory prodromal patho-biochemistry of age-onset Alzheimer's Disease using his diaeventontological toolkit.
Dr. Daniel J. Guerra introduces his paradigmatic shift for understanding biochemical phenomena as prolegomena to understanding Alzheimer's Disease.
Dr Daniel Guerra of Authentic Biochemistry in his initial podcast introducing the show and starting off with initial content on current Alzheimer's Disease research
ReferencesBiochemical and Biophysical Research Communications 2025. Volume 790, 19 November 152879Circulation.2020 Dec 15;142(24):2356-2370Oncogene. 2022 Oct 10;41(45):4917–4928.Guerra, 2026. Unpublished Lectures.Jager /Richards 1969. Gimme Shelter. Rolling Stoneshttps://music.youtube.com/watch?v=EJRdDhnTRoo&si=A6nBqe3Nlcag5h_qTchaikovsky PI. 1878. Violin Concerto in D Major. Op 35https://music.youtube.com/watch?v=2Q_DzWUvcL8&si=MztYJD0Cy8dO8DX9
ReferencesInt J Biol Sci. 2015; 11(11):1272–1280Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023J Neuroinflammation. 2019; 16: 34.Front Immunol. 2019; 10: 345.Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55.Miller, S. 1977 Wintertimehttps://open.spotify.com/track/4yQCgQVUIRBUnLdmXtZ0bo?si=7bff609684b6471a
ReferencesSci Signal. 2017 Jan 31; 10(464):eaaf7478.Cell Metab. 2017 Jun 6;25(6):1374–1389.e6Int J Biol Sci. 2024 Jan 1;20(2):585-605.Telemann, GP. 1716.Viola Concerto in G Major51:G9https://music.youtube.com/playlist?list=OLAK5uy_nvXWQr9OaAGFbnxWPqDXVDeDxwU4RxNkc&si=rVf9NxsYaQoefkyF
ReferencesNat Commun. 2019 Dec 20;10:5808.Biomolecules. 2025 Mar 18;15(3):433Cell Death Discovery volume 10, Article number: 180 (2024)International Journal of Biological Macromolecules 2026 Volume 337, Part 1, January 149292Guerra, DJ. 2026. Unpublished Lectures Hayward/Pinder/Lodge/Thomas 1971 Every Good Boy Deserves Favor, Moody Blues https://music.youtube.com/playlist?list=OLAK5uy_mF0jEup6X729SMl4CGLIPjd_U6jTf0DX8&si=grMMpMhe4AuDWz_9Bruch, M 1866 Violin Concerto 1 in G Minor Op26https://music.youtube.com/channel/UC0i1Q650ld0ZfsODrQG8vxQ?si=kmcMRpZlPiV1F0d6
ReferencesSci Signal. 2017 Jan 31; 10(464):eaaf7478Nature. 2009 Apr 23;458(7241):1056–1060.Signal Transduct Target Ther. 2022 Mar 4;7(1):66Guerra, DJ. 2026.Unpublished LecturesBeethoven, LV. 1822. Symphony 9 in D Minor op 125.https://music.youtube.com/watch?v=FwDo7MdaxhA&si=ZDCuHWAHPN-mPpqp
ReferencesFASEB J. 2019 Aug;33(8):9656-9671. Nat Med. 2018 Aug;24(8):1246-1256Nat Med. 2022 Aug;28(8):1556-1568EBioMedicine. 2019 Sep;47:446-456Guerra,DJ. 2026Unpublished LecturesDixon, W. 1968 Spoonful. Creamhttps://music.youtube.com/watch?v=YkK347-sxg0&si=IhuzPF0HDGd29ZWYPage/Jones/Bonham. 1969. Communication Breakdown LZIhttps://music.youtube.com/watch?v=3EH7QMVnSRI&si=1UT5DlaU_ZKonXqJLamm, R. 1969South California Purples, CTAhttps://music.youtube.com/watch?v=CM_3KrNOZxM&si=bR9a1aq13Ep4hzEX
ReferencesAging Cell. 2023 Jul 9;23(1):e13920 bioRxiv [Preprint]. 2025 Mar 25:2025.03.22.644753Austin, G. 1926. Five foot Two Eyes of Bluehttps://open.spotify.com/track/2dloA2Xw41XN4kRrOgnx81?si=f6bd077287c54742Morton, GS 1965. Sophisticated Boom Boom . The Shangri-lashttps://open.spotify.com/track/29bV7N2KQ06j7sJQPrmrBv?si=62be726ab11545c6Garber, J. 1926 Baby Facehttps://open.spotify.com/track/2evkH9IeWX1VDZ9WPHoUvE?si=0267887ab15e4ce9Weatherly, F. 1910. Danny Boy. https://open.spotify.com/track/1VLTwDHRsJ9jYXGMktz3zk?si=83c148acbdcd4fb2
references FEBS J. 2008 Mar;275(5):1025-38Mol Med Rep. 2018 Sep 27;18(6):4793–4801Eur J Immunol. 2020 Oct 25;50(11):1643–1652Dawson, J. 1971 Last Lonely Eagle NRPShttps://music.youtube.com/watch?v=KU8kalZM4KE&si=kti7elgiZflGW3tjDylan, B. 1963 Don't Think Twicehttps://music.youtube.com/watch?v=Kv7K9ghgcgA&si=Qp33XJQDNvxK0k-BSchmelzer, JM 1664 Violin Sonatas Romanescahttps://music.youtube.com/playlist?list=OLAK5uy_k8TeNzQczMKnGy8h8DZ5Wgl_JEHxlc-m4&si=wplciKfIq96hReu2
ReferencesNature Communications 2013. 4(1685):1685PNAS 1996. Nov. 26, 199693 (24) 14002-14007 J Exp Med. 1995 May 1;181(5):1755–1762 Eur J Immunol. 1997 Jan;27(1):147-54. Blood. 2021 Jan 28;137(4):500-512 Hematol Oncol. 2024 Jan 17;17(1):5.Hunter/Garcia. 1975. Cruel White Waterhttps://music.youtube.com/watch?v=T-oBD3F74Nk&si=EsT_UjmZqCNrOpedSeger, B. 1978. We've Got Tonighthttps://music.youtube.com/watch?v=uZQR3KqvYPc&si=2ny38UCF1hTC5CIWLightfoot, G. 1970. If you Could Read my Mind Love https://music.youtube.com/watch?v=fT_J-LNqVvw&si=mX4RjNzLQhlYOuisChopin, F. 1839 Sonata in E Minor OP 28. https://music.youtube.com/watch?v=2bFo65szAP0&si=glSyZ1rVuazz_vOo
ReferencesRedox Biology 2021. volume 47, November102165Front. Immunol., 2016. 30 March Sec. T Cell Biology Volume 7 -Trends in Molecular Medicine.2025. Volume 31, Issue 3p224-239. March Guerra, DJ.2026. Unpublished LecturesLennon/McCartney1968. Hello/Goodbyehttps://open.spotify.com/track/0vZ97gHhemKm6c64hTfJNA?si=4855145eb2ac4a6dLennon/McCartney.1968. Penny Lanehttps://open.spotify.com/track/1h04XMpzGzmAudoI6VHBgA?si=c6668f09fc9948ef
ReferencesImmunology 2025. Volume176, Issue1.September: Pages 74-86.J Cell Sci. 2021 Sep 24;134(18):jcs258965J Neurosci. 2023 Feb 8;43(6):885–901Schubert, F. 1822 Unfinished Symphony *8 (7) in B Minor D759https://music.youtube.com/watch?v=3tisvEpblig&si=NORH_pA8-vc5mCcm
ReferencesGuerra, DJ. 2026. Unpublished LecturesClapton/Allman et al. 1970 Layal and Other Love Songs. Derek and the Dominoes.https://music.youtube.com/playlist?list=OLAK5uy_n4ffCOm4RQ1UqnxRkE-JSgQIOl9DbO7Yo&si=H-F9QqRgDp8KRzxT
ReferencesSci Signal. 2017 Jan 31; 10(464):eaaf7478.Guerra, DJ. 2026. Unpublished LecturesLennon/McCartney. 1966. She Said She Said Beatles Revolverhttps://youtu.be/rLzfo59AdEc?si=2J-sKlX4r4JstzKkLennon/McCartney. 1969. She's So Heavy Beatles Abbey Roadhttps://music.youtube.com/watch?v=tAe2Q_LhY8g&si=LHuEwWvRmUKGQ0dyBach, JS . 1717. Chaconne No.2 BMW 1004. https://music.youtube.com/watch?v=ngjEVKxQCWs&si=1kPb-z0TEfPL5Dvl
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I engage with your episodes with considerable interest and a strong sense of curiosity. Discovering your lectures on Castbox was particularly gratifying. Thank you, Doctor.
listening to episode one from 2019 in which Doctor Guerra was talking about insulin and Alzheimer's disease. I googled it. now 12/12/2025 some are starting to call AD type 3 diabetes. BRAVO DR. DANIEL J. GUERRA!!!! . It seems to me that diabetes screws with everything in the body. . Robert Bristow LVN.