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Broken Brain with Dhru Purohit
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Broken Brain with Dhru Purohit

Author: Dhru Purohit, Dr. Mark Hyman

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The Broken Brain podcast will help you take your brain health to the next level and teach you how to live your best life! Listen as host and serial entrepreneur Dhru Purohit interviews the top experts in the field of neuroplasticity, epigenetics, biohacking, mindfulness and functional medicine.
79 Episodes
When you look into just about every health problem that we face in the world today—anxiety, depression, fatigue, digestive problems, hormone imbalances, diabetes, heart disease, or autoimmune conditions—they are all inflammatory in nature or have an inflammatory component. But inflammation starts brewing in the body long before these diseases become noticeable, not to mention diagnosable. By the time a health problem is advanced enough to be officially diagnosed, inflammation has typically already caused significant damage to the body.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Will Cole, a leading Functional Medicine expert who consults people around the world via webcam and locally in Pittsburgh, Pennsylvania. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems. Dr. Cole was named one of the top fifty Functional Medicine and integrative doctors in the nation and is a health expert for mindbodygreen and goop. Dr. Cole is the author of the book, Ketotarian in which he melds the powerful benefits of a ketogenic diet with a plant-based one. His new book, The Inflammation Spectrum, was just released.  In this episode, Dhru and Dr. Will Cole talk about why inflammation plagues so many people and how to create awareness to address this issue. They discuss how inflammation tends to develop in eight primary systems in the body, and how someone can identify where inflammation is rooted in their body and where they are on the inflammation spectrum. They also talk about how to design a personalized food and lifestyle plan to alleviate the effects of inflammation and optimize your health. For more on Dr. Will Cole, be sure to follow him on Instagram @drwillcole, on Facebook @doctorwillcole, on Twitter @drwillcole, and on YouTube @drwillcole. Check out his podcast, The goopFellas, here, and check out his website You can order his new book, The Inflammation Spectrum, right here. Also, below are links to some of Dr. Cole’s favorite interviews from his own podcast The goop Fellas:Being Rob LoweWhy Relationships Fail with Terry RealWhen We Stop Filling The Void with Melissa Hartwig Urban
We are living in the middle of a stress epidemic. The World Health Organization calls stress “the health epidemic of the twenty-first century.” Common complaints such as low libido, anxiety, poor memory, the inability to concentrate, and many gut problems seem completely unrelated, but often have stress as a root cause. The way we’re living our modern lifestyle is causing us a lot of problems. We think we can get away with burning the candle at both ends forever, but the reality is very different.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Rangan Chatterjee, one of the most influential doctors in the UK who wants to change how medicine will be practiced for years to come. He hosts the biggest health podcast in Europe, Feel Better, Live More, which Apple has announced as one of the most downloaded new podcasts of the past year. He is known for finding the root cause of people's health problems, and he has highlighted his methods in the groundbreaking BBC television show, Doctor in the House, which has been shown in over 70 countries around the world. His first book, How to Make Disease Disappear, is an international bestseller, his most recent book, the #1 bestseller, The Stress Solution, tackles what the WHO calls the health epidemic of our time—stress. Dr. Chatterjee’s mission is to help 100 million people feel fantastic by restoring them to optimal health.In this episode, Dhru and Dr. Chatterjee talk about practical solutions and simple interventions to help you destress and reset your life, and how implementing small changes to your routine can reduce or completely eradicate stress. They discuss the importance of prioritizing regular breaks and setting boundaries around personal time. They also talk about the power of human touch and why scheduling regular time with your family and friends is essential to our health. In this episode, we dive into:-The importance of a morning routine (3:06) -The 3M’s: Mindfulness, Movement, and Mindset (4:40)-Micro and macro stress doses and your personal stress threshold (19:07)-How stress is a key driver in overall blood sugar levels (25:10)-How your environment impacts your health (40:11)-The power of human touch on our health and stress levels (44:37)-The 3D greeting to create meaningful connection (58:52)-The importance of regular downtime (1:08:50)-The framework for finding meaning and purpose in your life (1:14:40)-Learn more about Dr. Rangan Chatterjee and his work (1:42:44)For more on Dr. Rangan Chatterjee, be sure to follow him on Instagram @drchatterjee, on Facebook @drchatterjee, on Twitter @drchatterjeeuk, and on YouTube @drchatterjee. Check out his podcast, Feel Better, Live More, here, and check out his website You can order his new book, The Stress Solution, right here.Also, below are links to the podcast interviews Dr. Chatterjee mentioned in the interview from his own podcast Feel Better, Live More:-How Our Childhood Shapes Every Aspect of Our Health with Dr. Gabor Mate-Stress - The Health Epidemic of the 21st Century with Dr. Rangan Chatterjee-Uncovering the Real Causes of Depression with Johann Hari Part 1-Uncovering the Real Causes of Depression with Johann Hari Part 2
When you think of aging, what comes to mind? Do you view it as a positive rite of passage or a negative phenomenon that must simply be endured? You might assume that you’re destined for the latter. But, it doesn’t have to be that way. You can be an active participant in your own aging process. Your habits and your environment have a lot of influence on your longevity, and how you’ll feel in your later years.On today’s Broken Brain Podcast, our host, Dhru, talks to Dave Asprey, founder and CEO of Bulletproof 360, creator of the global phenomenon Bulletproof Coffee, a two-time New York Times bestselling author, the host of the Webby award-winning podcast Bulletproof Radio, serial entrepreneur, and global change agent. Dave has dedicated over two decades of his life identifying and working with world-renowned doctors, scientists, luminaries of human existence, and innovators to uncover the most advanced methods for enhancing mental and physical performance. Dave’s discoveries and the companies he has founded offer tools that enable people the opportunity to take control of body, mind and biology—elevating human performance far beyond what we ever dreamed possible. In this episode, Dhru and Dave talk about how he is on a mission to prove that humans can live to 180 in this lifetime, and not just live, but really thrive, by avoiding disease, having better sex, and supercharging our brain-power. They also talk about the Seven Pillars of Aging that contribute to degeneration and diseases, and how simple interventions like diet, sleep, exercise, and little-known but powerful hacks from ozone therapy to light therapy, can decelerate cellular aging and help your body’s ability to heal and rejuvenate.In this episode, we dive into:-Why Dave’s goal is to live to 180 (2:33)-The real cause of balding and hair loss (5:46)-The biggest fear around aging (10:47)-The four things that will most likely kill us as we age (30:37)-The benefits of ozone therapy (34:42)-Dave’s story and the key pillars that were aging him and making him sick (39:23)-The 7 Pillars of Aging (48:50)-How our environment affects how we age (53:07)-The anti-aging benefits of light therapy (59:27)-The most important investment you should make when it comes to your health (1:03:13)-Learn more about Dave and his work (1:15:40) For more on Dave Asprey, be sure to follow him on Instagram @dave.asprey, on Facebook @bulletproofexecutive, on Twitter @bulletproofexec, and on YouTube @bulletproof. Check out his podcast, Bulletproof Radio, here, and check out his website You can order his new book, Super Human, right here. 
Is there something that you’re dreaming about—that you would love to share with the world, but maybe you’re afraid to give a voice to it because you’re not sure how it will turn out, what others will think, or how you can make money doing something that you truly love? On today’s Broken Brain Podcast, our host, Dhru, talks to Max Lugavere, a filmmaker, health and science journalist, and the author of the New York Times best-selling book Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life. He is also the host of the #1 iTunes health podcast The Genius Life. Lugavere appears regularly on the Dr. Oz Show, The Rachael Ray Show, and The Doctors. He has contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast, has been featured on NBC Nightly News, The Today Show, and in The Wall Street Journal. He is a sought-after speaker and has given talks at South by Southwest, TEDx, the New York Academy of Sciences, the Biohacker Summit in Stockholm, Sweden, and many others.In this episode, Dhru and Max talk about the steps it takes to build your career in the wellness space, and how to put out content that is true to you. They also talk about the lessons he learned from putting out award winning documentaries, New York Times best-selling books, and a #1 ranked health podcast.In this episode, we dive into:-Max’s background story (4:30) -What inspired Max to create a documentary on the prevention of neurodegenerative diseases (14:10)-How to move through imposter syndrome (27:34)-How to find your voice (34:08)-How Max funded his first documentary (41:43)-How to financially support yourself when you are first starting out on your entrepreneurship journey (52:40) -How Max’s documentary ended up on the Dr. Oz show (1:09:02)-How to write a book proposal (1:26:04)-The process of writing a book (1:29:38)-How to pitch a podcast (1:37:45)-How to make a living in the field you are passionate about (1:46:10)For more on Max Lugavere, be sure to follow him on Instagram @maxlugavere, on Facebook @maxlugavere, on Twitter @maxlugavere, and on YouTube @maxlugavere. Check out his podcast, The Genius Life, here, and check out his website You can order his book, Genius Foods, right here. His new book, The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary, will be released March 2020.
Each of us is born with a unique set of gifts, talents, and strengths that we’re put on earth to express and contribute. When you hold back from sharing yourself and your gifts, you’re stealing from those who need you most. On today’s Broken Brain Podcast, our host, Dhru, talks to Marie Forleo, a born-and-raised Jersey girl with nothing more than passion, a laptop, and a dream. Marie Forleo has created a socially conscious digital empire that inspires millions across the globe. Named by Oprah as a thought leader for the next generation, she’s the star of the award-winning show MarieTV, with over 50 million views, and host of The Marie Forleo Podcast, with more than ten million downloads. Marie runs the acclaimed business training program, B-School, and has taught entrepreneurs, artists, and multipassionate go-getters from all walks of life how to dream big and back it up with daily action to create results.  In this episode, Dhru and Marie talk about how if you're having trouble solving a problem or making a dream happen, the problem isn't you, it's not that you're not hardworking, intelligent or deserving, but that you haven't yet installed the one key belief that will change everything — everything is figureoutable. They discuss the three most common excuses that derail us and how to reframe our thinking around it. They also talk about the importance of starting before you are ready, and how to turn fear into productive, creative fuel. In this episode, we dive into:-Where the phrase Everything is Figureoutable came from (6:49)-How to change the beliefs that hold you back (15:21)-The three rules of the Everything is Figureoutable philosophy (17:56)-The two destructive thoughts that will derail you from new opportunities (23:14)-How to shift your mindset around failure (39:17)-Why you should start before you’re ready (44:31)-How to create a support system when you don’t have one (47:15)-How to reframe your thinking around excuses (57:10)-Why it is your responsibility to share your gift with the world (1:08:40)-Learn more about Marie and her work (1:14:48) For more on Marie Forleo, be sure to follow her on Instagram @marieforleo, on Facebook @marieforleo, and on Twitter @marieforleo. Check out her website You can order her book, Everything is Figureoutable, right here. When you order the book you will receive a FREE 5-day, live online program (valued at $499). Learn more at 
Creativity is a force inside every person that, when unleashed, transforms our lives and delivers vitality to everything we do. Left unexpressed, it can be a poison, leading to unhappiness, unfulfillment, and that feeling there is something missing.On today’s Broken Brain Podcast, our host, Dhru, talks to Chase Jarvis, an award-winning artist, entrepreneur, and one of the most influential photographers of the past decade. He has created campaigns for Apple, Nike, Red Bull and others, was a contributor to the Pulitzer-winning New York Times story Snowfall, and earned an Emmy nomination for his documentary Portrait of a City. He also created Best Camera–the first photo app to share images to social networks, and is the Founder of CreativeLive, where more than 10 million students learn photography, video, design, music, and business from the world’s top creators and entrepreneurs. In this episode, Dhru and Chase talk about why establishing a creative practice is as important to our well-being as exercise or nutrition. They discuss Chase’s road map for unlocking your creative potential, pursuing your dreams and succeeding in the process. They also talk about the importance of cultivating meaningful relationships, and building your core community when working to accomplish a goal. In this episode, we dive into:-How to design the life you truly desire (1:46)-What creativity really means (18:42)-Why success is an inside job (19:56)-How to take the first step to pursue your dreams (24:05)-The four steps to unlock your creative potential (28:07)-How to design a daily practice to pursue your dreams (35:25) -The three challenges that can derail you from your creative pursuit (52:12)-Why the company we keep is so vital to our success (1:05:25)-Chase’s principles for goal setting (1:17:18)-Learn more about Chase and his work (1:29:36) For more on Chase Jarvis, be sure to follow him on Instagram @chasejarvis, on Facebook @chasejarvis and on Twitter @chasejarvis. Check out his website and You can pre-order his book, Creative Calling: Establish a Daily Practice, Infuse Your World with Meaning, and Succeed in Work + Life, right here. If you pre-order the book you will get access to a FREE 4-hour live workshop - learn more at 
What do women’s health, dirt, and household pets have in common? More than you might think. When it comes to all living things, bacteria play a major role. Now, with emerging research in the microbiome contained within the soil, animals, and our bodies, we are able to find fascinating and helpful links for keeping good bacteria alive and well to support a wide variety of health functions. On today’s Broken Brain Podcast, our host, Dhru, talks to Kiran Krishnan, a research microbiologist that has been involved in the dietary supplement and nutrition market for the past 18 years. He comes from a university research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. Kiran established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition. Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development and research company. He is a co-founder and Chief Scientific Officer at Microbiome Labs. He is a frequent lecturer on the human microbiome at medical and nutrition conferences. He is an expert guest on national and satellite radio, has appeared in several international documentaries, and has been a guest speaker on several International health summits as a microbiome expert. He is currently involved in 16 novel human clinical trials on probiotics and the human microbiome.In this episode, Dhru and Kiran talk about a fascinating new study on dogs and leaky gut, and how it’s a major driver of chronic illness in dogs. They discuss how the vaginal microbiome is being destroyed, especially at OBGYN offices, and what dysbiosis in the vaginal microbiome can lead to. They also talk about another study on acne and the gut-skin axis and how Kiran discovered a method to modulate the gut microbiome to achieve healthier skin in 30 days. In this episode, we dive into:-Leaky gut and dogs (9:33)-Why you shouldn’t feed your dog coconut oil (15:46)-Is coconut oil really bad for us? (17:08)-Why diversity in our diet is so important (27:20) -How the vaginal microbiome is being destroyed (28:34) -Why you shouldn’t use coconut oil as a personal lubricant and what to use instead (34:21)-How spore-based probiotics can prevent the growth of acne (42:50) -Keystone stains and how they play a key role in keeping us healthy (48:59)-The challenge with probiotics on the market (1:08:31)-Probiotic companies that are doing it right (1:14:26)-What Kiran does in his daily life to support his overall health (1:16:07)-Why having a dog in your home lowers rates of allergies and asthma, especially in kids (1:24:21)-Learn more about Kiran and his work (1:26:08) For more on Kiran Krishnan, be sure to follow him on Instagram @kkiran_00 and on Facebook @kirankrishnan. Check out his website To learn more about the Microbiome Keynotes Symposium visit: Below are a few published studies by Kiran Krishnan on spore-based probiotics and the impact on the gut microbiome:IBS study: gut study: study: studies Kiran mentioned during the interview are currently going through a peer-review process. Once they are published we will update the show notes with links to the studies.
We all know there are universal rules to follow when it comes to eating a healthy diet, but personalization should be at the top of the list. While we have a lot in common as human beings and there are certain nutritional guidelines applicable to all of us, we’re different in important ways too. We have different genetics, constitutions, health status, activity levels, lifestyles, and goals, and all of these factors determine what an optimal diet is for each of us. On today’s Broken Brain Podcast, our host, Dhru, talks to Chris Kresser, the CEO of Kresser Institute for Functional & Evolutionary Medicine, the co-director of the California Center for Functional Medicine, the creator of, and the New York Times bestselling author of The Paleo Cure. He is known for his in-depth research uncovering myths and misconceptions in modern medicine and providing natural health solutions with proven results. Chris was named one of the 100 most influential people in health and fitness by, and his blog is one of the top-ranked natural health websites in the world. He recently launched Kresser Institute, an organization dedicated to reinventing healthcare and reversing chronic disease by training healthcare practitioners in Functional and evolutionary medicine. In this episode, Dhru and Chris talk about an ancestral diet and lifestyle and the potential for preventing chronic disease. They discuss how to personalize your diet to fit your lifestyle, body type, genetic blueprint, individual needs, and specific health conditions. They also talk about the benefits of intermittent fasting and how you can determine the right approach for you, as well as when it is not recommended. In this episode, we dive into:-Why one specific diet is not right for everyone (3:08) -How to personalize your diet (6:12) -A current diet trend that might not actually be healthy (9:26)-The truth about the bioavailability of nutrients from plant-based foods (18:03) -What we can learn from the ancestral diet (34:35)-The biggest mistake in nutritional science (38:21)-A good starting place to determine your ideal macronutrient ratio (40:47)  -The most effective approach to intermittent fasting (45:03) -Who shouldn’t do intermittent fasting (50:38)-When lab testing is necessary (54:18)-Chris’s take on the latest health trends (1:07:17)-Learn more about Chris and his work (1:13:30) For more on Chris Kresser, be sure to follow him on Instagram @chriskresser, on Facebook @chriskresserlac, on Twitter @chriskresser, and on YouTube @chriskresser. Check out his website To learn more about his ADAPT Health Coach Training Program and his ADAPT Practitioner Training Program visit: You can also find his book, The Paleo Cure, right here. 
Jennifer is one of the nation’s leading parenting experts and the founder of Connected Parenting. She is the author of Connected Parenting: How To Raise A Great kid and You’re Ruining My Life! (But Not Really) Surviving the Teenage Years with Connected Parenting.Jennifer was the Parenting expert on CBC’s Steven and Chris show for eight seasons and has appeared frequently on Canada AM and Breakfast Television. Her advice can be found in many Canadian and U.S. magazines, such as Today’s Parent, Redbook, Parent Magazine and Canadian Family. Jennifer has been helping children, teens and families get connected for over twenty years.Here are more of the details from this episode:- How Jennifer discovered compassionate parenting and family therapy as her calling (4:50)- The power of limbic bonding for you and your child (7:27)- What traditional parenting got wrong about “You should know better!” (15:50)- What are mirror neurons and how they can help (19:13)- How yelling impacts the fight or flight response and stress hormones (24:40)- Breaking down the CALM technique (27:00)- Practicing active listening with the CALM technique in real situations (44:40)- Approaching disagreements with teenagers more mindfully (52:20)- Dealing with full-on tantrums and what happens when you give them permission to meltdown (57:10)- Advice for couples and how to use mirroring for intimate relationships (1:15:50)- Taking a modern approach to the modern problems kids are dealing with (1:30:05)- Why too much power leads kids to feel anxious (1:50:30)- Learn more about Jennifer’s work (1:54:20)
Every time we eat, we have a chance to boost our brain function! That's why what we choose to put on our plate is one of the most critical health interventions er can make.Food not only affects our likelihood of disease, but it can lengthen our lives, change our mood, and even affect the expression of our DNA. By approaching disease with a holistic perspective, of which food is a vital part, we can tackle the root causes of illness and truly live well. We can change our destiny by making better choices today.In this special mini-episode, I speak with Dr. Rupy Aujla, Max Lugavere, Dr. Rangan Chatterjee, and Dr. David Perlmutter about an empowered approach to supporting the brain, starting with food first.Follow today's guests in this mini-episode here: For the Night by Chill Study
Comments (9)

Niclas Daniels

48:40 #supplements for #neuropathy.

Jul 5th

Sanja Lovrečič

Love it!

May 22nd

Randall Wilkinson

had to listen to this one twice

May 20th


Thank you so much for most insightful podcast,first time listener to your podcast which was forwarded by a friend. Presentation on science behind the yoga beautiful connections on how The Practice can change your body on a cellular level. As a Yoga teacher and a Family medicine provider i most definitely interweave both. I did my research and I studied ( and continue to study)along with taking a 200hour class. We all start from somewhere the key is to continue to grow while learning. "I can only bring someone as far as I have gone," Love it! Ericajane

Mar 16th

Jennifer Marie Hancock

I recently asked my Dr to check my hormone levels and, sure enough, everything came back "normal." how does this explain the crazy fatigue I've been experiencing the past year? how do we find drs that specialize in holistic medicine and would health insurance even cover something like that? I have no idea to whom I'm asking these questions, lol, just thinking out loud I suppose.

Jan 16th

Felipe Arenas Ortiz

Great podcast. I love the production, the quality of the questions within the interview and the information it gives us. Thanks!

Dec 3rd

Megan Rose Ryan

First episode I'm listening to from this podcast. Diggin' it! But what's up with the interviewer's mic? The echo makes it a bit hard to understand.

Nov 27th

Tom Bradley

Just ordered the doctors book after listening to this. great episode

Oct 8th


What an exceptional episode. I don't use that term lightly. I work as a personal trainer and am looking at going into medicine. Medicine as I know it has always been traditional, and that made me hesitate pursuing it as a career. As of late, I have come across functional medicine which touches on a lot of what I try to emphasize to my clients: the importance of sleep, stress relief, eating, etc...and how it affects your life. To be able to explain to someone the true science behind why their body responds the way it does is life-changing. Thank you for making this information available. I have now discovered the way to combine two fields I love. Keep the knowledge flowing!

Jun 15th
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