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Broken Brain with Dhru Purohit
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Broken Brain with Dhru Purohit

Author: Dhru Purohit, Dr. Mark Hyman

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The Broken Brain podcast will help you take your brain health to the next level and teach you how to live your best life! Listen as host and serial entrepreneur Dhru Purohit interviews the top experts in the field of neuroplasticity, epigenetics, biohacking, mindfulness and functional medicine.
61 Episodes
Big feelings are part of life. In fact, there are times when everyone will feel sad, angry, hurt, and disappointed. When it comes to helping our children process big feelings, we want to help them discover their natural strengths and build new tools for looking inside, making sense of what they are experiencing, and internalizing new ways to approach challenges and stress.On today’s Broken Brain Podcast, our host, Dhru, talks to Deena Margolin, a marriage and family therapist and mindfulness teacher in Los Angeles who works primarily with children and families. Trained in the field of Interpersonal Neurobiology, Deena explores how the mind, brain, and our relationships come together to shape who we become—and how we can harness the potential of neuroplasticity, the mind’s incredible ability to change throughout the lifespan, to grow healthier and happier.In this episode, Dhru and Deena talk about how trauma impacts the development of a child and their future stress response. They discuss how stress impacts our survival system, how to help your child regulate their nervous systems in a hard moment, and understanding what’s really driving our child’s behavior. They also talk about how parenting is about being present, not perfect, and how to raise resilient and mindful kids.In this episode, we dive into:-How Adverse Childhood Experiences (ACEs) impact the development of a child (2:50)-The connection between a high ACEs score and the likelihood of developing a chronic disease (4:32)-How trauma impacts the brain (6:11)-The four F’s of survival (8:39)-What can happen when trauma gets stored in the body (9:50)-The three pillars to help kids build resilient qualities (19:48)-How nonverbal communication can trigger your child’s own threat state (26:08)-Time out vs. time in and creating a safe space for big feelings (41:15)-The power of pause when your feeling angry, confused, or overwhelmed (1:00:47)-Modern day parenting (1:07:09)-Learn more about Deena and her work (1:10:21)-Deena’s book recommendations (1:11:10)For more on Deena, be sure to follow her on Instagram @deenamargolin and check out her website
Psychedelics were the subject of serious medical research in the 1940s to the 1960s, when many scientists believed some of the mind-bending compounds held tremendous therapeutic promise for treating a number of conditions including severe mental health problems and alcohol addiction. By the mid-60s, research into psychedelics was shut down for decades.After the blackout ended, the doctor we have on the podcast today was among the first to initiate a new series of studies on psilocybin—the psychoactive compound in “magic” mushrooms.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Roland Griffiths, a Professor in the Departments of Psychiatry and Neurosciences at Johns Hopkins University School of Medicine. He has conducted extensive research with sedative-hypnotics, caffeine, and novel mood-altering drugs. In 1999, he initiated a research program at Johns Hopkins investigating the effects of the classic hallucinogen psilocybin that includes studies of psilocybin-occasioned mystical-type experiences in healthy volunteers, psilocybin-facilitated treatment of psychological distress in cancer patients, psilocybin-facilitated treatment of cigarette smoking cessation, psilocybin effects in beginning and long-term meditators, and psilocybin effects in religious leaders.In this episode, Dhru and Dr. Griffiths talk about his extensive research with psilocybin in the treatment of psychological distress in cancer patients and cigarette smoking cessation. They discuss the connection between psilocybin, spirituality, and consciousness. They also talk about psychedelics and their potential for treating conditions ranging from drug and alcohol dependence to depression and post-traumatic stress disorder.In this episode, we dive into:-The connection between psychedelics, spirituality, and consciousness (7:48)-The history of psychedelic research (8:28)-The reintroduction of psychedelic research by Dr. Roland Griffiths and others (12:27)-Why research participants rated their psychedelic experience as one of their most meaningful (16:36)-What is happening in the brain when using psychedelics (23:39)-How psychedelics can help us understand altered states of consciousness (29:09)-The therapeutic benefits of psilocybin for the treatment of addiction (40:16)-How a single dose of psilocybin substantially diminished depression and anxiety in cancer patients (44:52)-The future of psychedelics (48:07)-The downside and risks of psychedelics (56:14)-Learn more about Dr. Roland Griffiths and his work (1:00:24)For more on Dr. Roland Griffiths and his research on psychedelics check out his website
What you choose to put on your plate is one of the most important health interventions you can make. Food not only affects our likelihood of disease, but it can lengthen our lives, change our mood, and even affect the expression of our DNA. By approaching disease with a holistic perspective, of which food is a vital part, we can tackle the root causes of disease and truly live well.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Rupy Aujla, an NHS medical doctor and founder of The Doctor's Kitchen, a project to inspire patients about the beauty of food and medicinal effects of eating well. Dr. Rupy is the founder of Culinary Medicine, a nonprofit organization which aims to teach doctors and medical students the foundations of nutrition as well as teaching them how to cook. He is also the author of two bestselling cookbooks The Doctor’s Kitchen and his latest book, Eat to Beat Illness.In this episode, Dhru and Dr. Rupy talk about how our bodies can better fight off illness through eating well. They discuss how we can eat to reduce the risk of brain disease, cardiovascular problems, inflammation imbalance, poor immunity, and even reduce the chances of cancer. They also talk about how we can heal our bodies through simple lifestyle changes including exercise, stress reduction, sleeping well, and finding purpose in our lives.-Dr. Rupy shares how he healed his own heart condition through food and lifestyle intervention (1:45)-The connection between lifestyle and heart disease (5:01)-The impact our diet can have on the function of our brain (11:12)-Foods to support brain health (18:07)-Quality fats for brain health (21:15)-Lifestyle factors and tips for sleep (28:35)-The power of gratitude (33:41)-Exercise and why inflammation in small amounts might be a good thing (36:48)-Mitochondrial support, improving immune function, and boosting immunity (45:05)-The connection between the immune system and gut health (46:58)-Food additives in seemingly healthy foods and how they impact the body (55:12)-Skin health and acne (57:14)-Culinary Medicine (1:00:59)-Eat to beat cancer (1:11:59)-Dr. Rupy’s online course to learn the key aspects of healthy eating that have the biggest impact on your wellbeing (1:14:02)-Learn more about Dr. Rupy and his work (1:16:56)For more on Dr. Rupy, be sure to follow him on Instagram @doctors_kitchen, on Facebook @thedoctorskitchen, on Twitter @doctors_kitchen, and on YouTube @thedoctorskitchen. Check out his website and his podcast, The Doctor’s Kitchen, here. You can learn more about his online course, here, and you can find his books, The Doctor’s Kitchen and Eat to Beat Illness, right here.
Do you often walk away from people wondering if you said the right thing? Or maybe you find yourself constantly feeling like you’re not good enough. And then there are those who don’t feel like it’s okay to be themselves for one reason or another, which holds them back from sharing their real gifts with the world. Most people are concerned about what others think about them, and often say and do things just to get the approval of others. These thoughts and behaviors seem to be so much a part of who we are that we assume it’s just part of being human. But you can actually eradicate these thoughts and behaviors by eliminating the deep-seated limiting beliefs that cause them.On today’s Broken Brain Podcast, our host, Dhru, talks to Shelly Lefkoe, co-founder and Vice President of Lefkoe Institute, a San Francisco Bay Area firm whose mission is “To significantly improve the quality of life on the planet by having people recreate their lives and live as the unlimited possibilities they are.” Shelly has had the privilege of helping thousands of clients worldwide rid themselves of a wide variety of problems including phobias, relationships that never seem to work, violence, procrastination, unwillingness to confront people, health and wellness issues, and sexual dysfunction. Her clients have been able to eliminate emotional patterns such as fear, hostility, shyness, anxiety, depression, worry about what people think of them, and a negative sense of themselves.  In this episode, Dhru and Shelly talk about limiting beliefs and how they are formed. They discuss how most behavior is driven by our deeply ingrained and typically unconscious beliefs, and how we can reframe the negative meaning we have given to a particular situation to break through limiting beliefs. They also talk about parenting and how by being conscious in the way we raise our children we can create more confident, kind generations.In this episode, we dive into:-What underlies every problem that people have (2:13)-What are beliefs and when do they stop serving us (3:41)-Why you should stop worrying about what other people think of you (9:22)-Where our beliefs get formed (10:41)-Why our beliefs stay with us for so long (20:55)-The belief that ruins people's lives (32:38)-What couples fight about the most (47:27)-How meaning is related to beliefs (48:18)-Why what you do is not who you are (59:26)-Learn more about Shelly and her work (1:02:06)For more on Shelly Lefkoe, be sure to follow her on Facebook @LefkoeInstitute and check her website and You also can learn more about her program Parenting the Lefkoe Way, right here.
1.7 million people suffer some type of traumatic brain injury each year in the US—from a mild concussion to coma to death. It is estimated that 5.3 million Americans suffer from a long-term disability from a traumatic brain injury.On today’s Broken Brain Podcast, our host, Dhru, talks to JJ Virgin, a celebrity nutrition expert and Fitness Hall of Famer. JJ is the author of four New York Times best sellers: The Virgin Diet, The Virgin Diet Cookbook, JJ Virgin’s Sugar Impact Diet, and JJ Virgin’s Sugar Impact Diet Cookbook. Her latest book, Warrior Mom: 7 Secrets to Bold, Brave Resilience, shows mothers everywhere how to be strong, positive leaders for their families, while exploring the inspirational lessons she learned as she fought for her own son’s life.In this episode, Dhru and JJ talk about how she helped her son heal from a traumatic brain injury. They discuss some of the therapies that helped her son recover, like hyperbaric oxygen therapy, neurofeedback, and stem cell therapy. They talk about why fish oil is critical for mental health and traumatic brain injury recovery, as well as the benefits of a ketogenic diet. They also talk about the lessons she learned from this journey that are crucial to building a healthy, resilient mindset. In this episode, we dive into:-JJ’s personal story of her son’s traumatic brain injury (2:22)-How do you know if you’ve had a traumatic brain injury (7:19)-Traumatic brain injuries and depression (8:18)-Why fish oil is critical for mental health and traumatic brain injury recovery (9:27)-The benefits of a ketogenic diet for brain injuries (25:12)-Connecting the dots between what you eat and how you feel (27:41)-Hyperbaric oxygen therapy to help with brain healing (30:39)-Stem cell therapy (31:26)-Why putting your health first is not selfish (46:56)-The importance of asking the right questions to reframe a situation (50:05)-An important lesson for caregivers (56:38)-Traumatic brain injuries and the lack of support and community (57:25)-The single most important thing you can do to be healthy (59:59)-The importance of quality relationships with friends and family (1:03:46)-Mindshare Summit for health and wellness entrepreneurs (1:07:25)-Learn more about JJ and her work (1:13:22)For more on JJ Virgin, be sure to follow her on Instagram, on Facebook @JJVirginOfficial, and on YouTube @JJVirgin. Check out her podcast The JJ Virgin Lifestyle Show, and check her website You also can find her books right here.
Who would you be if you weren't defined by the limiting dialogue of your own mind? We exist within mental constructs that dictate our thoughts, feelings, and actions. Suffering is a byproduct of these mental constraints. To create an extraordinary life we have to reveal the limiting framework of our perceived reality and shift the perception we have of ourselves in order to become limitless.On today’s Broken Brain Podcast, our host, Dhru, talks to The Mind Architect Peter Crone, a writer, speaker and thought leader in human potential who works with entertainers, professional athletes, and global organizations.In this episode, Dhru and Peter discuss how our own perceptions and self-limiting beliefs shape our reality, and how to find freedom from a self-imposed mental jail cell. They talk about how to redesign the subconscious mind that drives behavior to inspire a new way of living, from limitation and stress to freedom and joy. They also talk about how the challenges that we experience in our lives are an opportunity to grow, and to be patient, trusting, loving, accepting, and understand that it all works out. We are beneficiaries of life, not victims of it.In this episode, we dive into:-What blocks us from having freedom in our life (2:21)-What is true happiness? (8:59)-Why the first step in healing is acceptance (9:45)-The impact of stress on our digestion (16:23)-Peter’s personal story of losing both parents at a young age (20:28)-How past hurt informs future fear (23:16)-Finding freedom in uncertainty (26:39)-How to break free from judgment (29:37)-Constraints of the subconscious (45:38)-The power of imagination (52:04)-How to be more mindful of language (1:05:29)-Perfectionism and the stories we make up about ourselves (1:20:22)-The Healed documentary (1:22:18)-Learn more about Peter and his work (1:31:38)For more on Peter Crone, be sure to follow him on Instagram @petercroneofficial and check out his website 
Autism affects 1 in every 59 children in the US. This includes 1 in 37 boys and 1 in 151 girls, according to the CDC. The diagnosis of autism can be shocking and difficult for parents and families which may leave them feeling isolated, alone, helpless, and hopeless, but it doesn’t have to be that way.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Theresa Lyons, an International Autism Educator, Ivy League Scientist, and parent of an autistic child. Dr. Lyons is the premiere voice of scientific reason in the world of autism and has become known as “The Professor of Healing Autism.” Dr. Lyons works with hospital systems, private and non-governmental organizations, and parents to drastically diminish the knowledge gap between the cutting edge science of healing autism and current patient care, so that medical expenses are decreased, burdens on governmental programs, including education, are lessened, and the child flourishes.In this episode, Dhru and Dr. Lyons talk about the science of treating autism spectrum disorder and why the life expectancy of someone on the spectrum is so low. They discuss Dr. Lyon’s Autism Healing Matrix and the necessary steps to take to begin to treat autism. They also talk about how to support parents who have kids on the spectrum, the importance of celebrating success, and how to bring more joy into the parent/child relationship.In this episode, we dive into:-The science of the autism spectrum (5:32)-Why the life expectancy of someone on the autism spectrum is so low (8:12)-Why autism is on the rise (10:25)-Dr. Lyon’s personal story of her daughter being diagnosed with severe autism (14:48)-The first steps of treating autism (20:27)-The Autism Healing Matrix (27:51)-How diet plays a role when it comes to autism (35:42)-The importance of building a healthcare team (42:47)-Supplements for autism (48:26)-Melatonin for sleep disorders in autism (54:24)-Gut dysbiosis and autism (58:10)-Educational approaches for the developmental catch-up phase (1:04:11)-The importance of celebrating successes (1:10:25)-How to support parents who have kids on the autism spectrum (1:21:16)-Learn more about Theresa and her work (1:30:04)For more on Dr. Theresa Lyons, be sure to follow her on Instagram @navigating_awetism, on Facebook @NavigatingAWEtism, on YouTube @NavigatingAwetism, and at her website Check out her online courses: Probiotics to Heal Awetism and Eat to Heal Awetism. Also, be sure to check out Dr. Mark Hyman’s exclusive interview with Dr. Suzanne Goh, a board-certified pediatric neurologist and leader in the treatment of autism spectrum disorder, right here.
We are a society that praises being busy. The more you cram into a day and the fewer hours you need to sleep the more productive and successful you seem, but are you? And at what cost?On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Saundra Dalton-Smith, an author, speaker, and board-certified internal medicine physician. Dr. Dalton-Smith is an international media resource on the mind-body-spirit connection and one of the top 100 medical experts in Good Housekeeping Doctors’ Secrets. She has been featured in many media outlets including Women’s Day, Redbook, First For Women, MSNBC, and Prevention. She is the author of Set Free to Live Free and Come Empty. Her newest release is Sacred Rest: Recover Your Life, Renew Your Energy, Restore Your Sanity.In this episode, Dhru and Dr. Saundra talk about the seven types of rest and why a deficiency in any one of these areas can have unfavorable effects on your health, happiness, relationships, creativity, and productivity. They discuss why so many people struggle with fatigue and insomnia, and the importance of giving yourself permission to embrace rest. They also talk about setting boundaries, and how to increase your overall happiness to live your best life.In this episode, we dive into:-Dr. Saundra’s personal story and what inspired her work (2:21)-Why so many people struggle with insomnia and fatigue (5:21)-The difference between sleep and rest (7:57)-The 7 types of rest (9:46)-How to prioritize rest using the R-E-S-T method (12:56)-The importance of rest when it comes to our overall health (15:14)-How to create boundaries when it comes to rest (23:22)-How a lack of rest negatively impacts brain function (24:20)-The Gifts of Rest (27:26)-Dr. Saundra’s tips for parents on rest (33:16)-The importance of community and intentional friendships (39:55)-Learn more about Dr. Saundra and her work (47:43)For more on Dr. Saundra Dalton-Smith, be sure to follow her on Instagram @DrDaltonSmith, on Facebook @DrSaundraDaltonSmith, on Twitter @DrDaltonSmith, and on Pinterest @DrDaltonSmith. Check out her website and her book, Sacred Rest: Recover Your Life, Renew Your Energy, Restore Your Sanity, right here. You can also take her free Rest Quiz to find out what type of rest you need to live your best life.
We all know the importance of getting enough sleep, though most of us scrape by with as little as possible. It turns out that sleep can make or break your ability to lose weight, age slowly, prevent cancer, and perform at a high level. When your sleep suffers, you suffer major consequences far beyond the dark circles under your eyes. Sleep is an incredible foundation for your overall health—and it’s one that you must lay the groundwork for on a daily basis. Making small changes to your habits can pay off tremendously when it comes to getting better sleep and transforming your overall health.On today’s Broken Brain Podcast, our host, Dhru, talks to Shawn Stevenson, author of the international bestselling book, Sleep Smarter and creator of The Model Health Show, featured as the #1 health podcast on iTunes. He is the founder of the Advanced Integrative Health Alliance, a company that provides wellness services for individuals and organizations worldwide. Shawn has been featured in Entrepreneur magazine, Fast Company, Forbes, Men's Health magazine, The Dr. Oz Show, ESPN, CNN, and many other major media outlets.In this episode, Dhru and Shawn talk about how sleep is the foundation of health and how it impacts your body, brain, and performance. They discuss how to create the ideal sleep sanctuary, how to regulate your circadian rhythm, the most important sleep nutrients, and stress-reduction exercises and fitness tips to keep you mentally and physically sharp. They also talk about how hitting rock bottom is a catalyst for change, the power of mindset, and the importance of finding your why.In this episode, we dive into:-How Shawn overcame degenerative disc disease (1:32)-Placebos and the power of the mind (4:08)-The importance of movement for nutrient assimilation (16:48)-What happens in our brain when we sleep (33:25)-Quantity vs. quality when it comes to sleep and getting efficient sleep cycles (35:21)-How your brain size actually shrinks when you’re sleeping (37:22)-The glymphatic system and brain detoxification (38:14)-How caffeine impacts your sleep (40:01)-How to counterbalance late night caffeine consumption (44:49)-Key nutrients for sleep (47:18)-The gut microbiome and sleep connection (52:05)-Sleep and fat loss (56:37)-How technology impacts our sleep (58:23)-The impact of temperature on sleep (1:07:14)-Mindset, hitting rock bottom, and finding your why (1:11:48)-Learn more about Shawn and his work (1:24:31)For more on Shawn Stevenson, be sure to follow him on Instagram @ShawnModel, and on Facebook @TheModelHealthShow. Check out his podcast The Model Health Show, and check his website You also can find his book, Sleep Smarter, right here.
The human body is one of the most complex systems on the planet, and not all bodies are the same. Anyone who has struggled on a diet knows that what works for someone else may not work for you. We all have a unique body chemistry that needs to be addressed differently, and, without considering the hidden factors that may be affecting our ability to lose weight, we will continue to struggle. This is what Functional Medicine is all about: looking beyond the basics to determine what is right for each individual. On today’s Broken Brain Podcast, our host, Dhru, talks to Dana James, a triple certified nutritionist, Functional Medicine practitioner, and cognitive behavioral therapist. She takes a rare approach to women’s weight loss by putting self-worth at the center of the conversation. She is the author of the best selling book, The Archetype Diet, which has helped thousands of women improve their self-worth, release childhood shame and find equilibrium in their physical body. She has been featured in The New York Times, Time Magazine, Forbes, Vogue, Elle and Goop and offers a unique perspective on physical body and mind integration. In this episode, Dhru and Dana talk about how you can alter your diet to help feed your unique body chemistry while simultaneously examining how your sense of self-worth shapes your behaviors—including what you eat—in ways that may be working against your goals. They also talk about how the weight loss equation of “calories in, calories out” is inadequate, and how other factors, such as hormones, sleep, inflammation, the gut microbiome, unexpressed emotions, and genes all influence your ability to lose weight and keep it off. In this episode, we dive into:-The connection between unexpressed emotions and weight loss (2:43)-How subconscious beliefs inform our eating and our weight (7:53)-The social stigma around weight gain and obesity (11:47)-The Nurturer Archetype (18:26)-The Wonder Woman Archetype (22:56)-The Femme Fatale Archetype (34:51)-The 3-R reprogramming process (41:51) -The Ethereal Archetype (42:24)-The importance of personalization when it comes to diet (50:17) -Body acceptance (54:45)-Stress reduction techniques (56:18)-Emotional Freedom Technique (EFT) (1:01:48)-Societal pressure around weight loss and body image (1:05:12)-Visceral fat and chronic disease (1:11:40)-Learn more about Dana and her work (1:13:20)For more on Dana James, be sure to follow her on Instagram @danajames and check out her website and You also can find her book, The Archetype Diet, right here.
Comments (8)

Sanja Lovrečič

Love it!

May 22nd

Randall Wilkinson

had to listen to this one twice

May 20th


Thank you so much for most insightful podcast,first time listener to your podcast which was forwarded by a friend. Presentation on science behind the yoga beautiful connections on how The Practice can change your body on a cellular level. As a Yoga teacher and a Family medicine provider i most definitely interweave both. I did my research and I studied ( and continue to study)along with taking a 200hour class. We all start from somewhere the key is to continue to grow while learning. "I can only bring someone as far as I have gone," Love it! Ericajane

Mar 16th

Jennifer Marie Hancock

I recently asked my Dr to check my hormone levels and, sure enough, everything came back "normal." how does this explain the crazy fatigue I've been experiencing the past year? how do we find drs that specialize in holistic medicine and would health insurance even cover something like that? I have no idea to whom I'm asking these questions, lol, just thinking out loud I suppose.

Jan 16th

Felipe Arenas Ortiz

Great podcast. I love the production, the quality of the questions within the interview and the information it gives us. Thanks!

Dec 3rd

Megan Rose Ryan

First episode I'm listening to from this podcast. Diggin' it! But what's up with the interviewer's mic? The echo makes it a bit hard to understand.

Nov 27th

Tom Bradley

Just ordered the doctors book after listening to this. great episode

Oct 8th


What an exceptional episode. I don't use that term lightly. I work as a personal trainer and am looking at going into medicine. Medicine as I know it has always been traditional, and that made me hesitate pursuing it as a career. As of late, I have come across functional medicine which touches on a lot of what I try to emphasize to my clients: the importance of sleep, stress relief, eating, etc...and how it affects your life. To be able to explain to someone the true science behind why their body responds the way it does is life-changing. Thank you for making this information available. I have now discovered the way to combine two fields I love. Keep the knowledge flowing!

Jun 15th
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