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Broken Brain with Dhru Purohit
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Broken Brain with Dhru Purohit

Author: Dhru Purohit, Dr. Mark Hyman

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The Broken Brain podcast will help you take your brain health to the next level and teach you how to live your best life! Listen as host and serial entrepreneur Dhru Purohit interviews the top experts in the field of neuroplasticity, epigenetics, biohacking, mindfulness and functional medicine.
74 Episodes
Creativity is a force inside every person that, when unleashed, transforms our lives and delivers vitality to everything we do. Left unexpressed, it can be a poison, leading to unhappiness, unfulfillment, and that feeling there is something missing.On today’s Broken Brain Podcast, our host, Dhru, talks to Chase Jarvis, an award-winning artist, entrepreneur, and one of the most influential photographers of the past decade. He has created campaigns for Apple, Nike, Red Bull and others, was a contributor to the Pulitzer-winning New York Times story Snowfall, and earned an Emmy nomination for his documentary Portrait of a City. He also created Best Camera–the first photo app to share images to social networks, and is the Founder of CreativeLive, where more than 10 million students learn photography, video, design, music, and business from the world’s top creators and entrepreneurs. In this episode, Dhru and Chase talk about why establishing a creative practice is as important to our well-being as exercise or nutrition. They discuss Chase’s road map for unlocking your creative potential, pursuing your dreams and succeeding in the process. They also talk about the importance of cultivating meaningful relationships, and building your core community when working to accomplish a goal. In this episode, we dive into:-How to design the life you truly desire (1:46)-What creativity really means (18:42)-Why success is an inside job (19:56)-How to take the first step to pursue your dreams (24:05)-The four steps to unlock your creative potential (28:07)-How to design a daily practice to pursue your dreams (35:25) -The three challenges that can derail you from your creative pursuit (52:12)-Why the company we keep is so vital to our success (1:05:25)-Chase’s principles for goal setting (1:17:18)-Learn more about Chase and his work (1:29:36) For more on Chase Jarvis, be sure to follow him on Instagram @chasejarvis, on Facebook @chasejarvis and on Twitter @chasejarvis. Check out his website and You can pre-order his book, Creative Calling: Establish a Daily Practice, Infuse Your World with Meaning, and Succeed in Work + Life, right here. If you pre-order the book you will get access to a FREE 4-hour live workshop - learn more at 
What do women’s health, dirt, and household pets have in common? More than you might think. When it comes to all living things, bacteria play a major role. Now, with emerging research in the microbiome contained within the soil, animals, and our bodies, we are able to find fascinating and helpful links for keeping good bacteria alive and well to support a wide variety of health functions. On today’s Broken Brain Podcast, our host, Dhru, talks to Kiran Krishnan, a research microbiologist that has been involved in the dietary supplement and nutrition market for the past 18 years. He comes from a university research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. Kiran established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition. Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development and research company. He is a co-founder and Chief Scientific Officer at Microbiome Labs. He is a frequent lecturer on the human microbiome at medical and nutrition conferences. He is an expert guest on national and satellite radio, has appeared in several international documentaries, and has been a guest speaker on several International health summits as a microbiome expert. He is currently involved in 16 novel human clinical trials on probiotics and the human microbiome.In this episode, Dhru and Kiran talk about a fascinating new study on dogs and leaky gut, and how it’s a major driver of chronic illness in dogs. They discuss how the vaginal microbiome is being destroyed, especially at OBGYN offices, and what dysbiosis in the vaginal microbiome can lead to. They also talk about another study on acne and the gut-skin axis and how Kiran discovered a method to modulate the gut microbiome to achieve healthier skin in 30 days. In this episode, we dive into:-Leaky gut and dogs (9:33)-Why you shouldn’t feed your dog coconut oil (15:46)-Is coconut oil really bad for us? (17:08)-Why diversity in our diet is so important (27:20) -How the vaginal microbiome is being destroyed (28:34) -Why you shouldn’t use coconut oil as a personal lubricant and what to use instead (34:21)-How spore-based probiotics can prevent the growth of acne (42:50) -Keystone stains and how they play a key role in keeping us healthy (48:59)-The challenge with probiotics on the market (1:08:31)-Probiotic companies that are doing it right (1:14:26)-What Kiran does in his daily life to support his overall health (1:16:07)-Why having a dog in your home lowers rates of allergies and asthma, especially in kids (1:24:21)-Learn more about Kiran and his work (1:26:08) For more on Kiran Krishnan, be sure to follow him on Instagram @kkiran_00 and on Facebook @kirankrishnan. Check out his website To learn more about the Microbiome Keynotes Symposium visit: Below are a few published studies by Kiran Krishnan on spore-based probiotics and the impact on the gut microbiome:IBS study: gut study: study: studies Kiran mentioned during the interview are currently going through a peer-review process. Once they are published we will update the show notes with links to the studies.
We all know there are universal rules to follow when it comes to eating a healthy diet, but personalization should be at the top of the list. While we have a lot in common as human beings and there are certain nutritional guidelines applicable to all of us, we’re different in important ways too. We have different genetics, constitutions, health status, activity levels, lifestyles, and goals, and all of these factors determine what an optimal diet is for each of us. On today’s Broken Brain Podcast, our host, Dhru, talks to Chris Kresser, the CEO of Kresser Institute for Functional & Evolutionary Medicine, the co-director of the California Center for Functional Medicine, the creator of, and the New York Times bestselling author of The Paleo Cure. He is known for his in-depth research uncovering myths and misconceptions in modern medicine and providing natural health solutions with proven results. Chris was named one of the 100 most influential people in health and fitness by, and his blog is one of the top-ranked natural health websites in the world. He recently launched Kresser Institute, an organization dedicated to reinventing healthcare and reversing chronic disease by training healthcare practitioners in Functional and evolutionary medicine. In this episode, Dhru and Chris talk about an ancestral diet and lifestyle and the potential for preventing chronic disease. They discuss how to personalize your diet to fit your lifestyle, body type, genetic blueprint, individual needs, and specific health conditions. They also talk about the benefits of intermittent fasting and how you can determine the right approach for you, as well as when it is not recommended. In this episode, we dive into:-Why one specific diet is not right for everyone (3:08) -How to personalize your diet (6:12) -A current diet trend that might not actually be healthy (9:26)-The truth about the bioavailability of nutrients from plant-based foods (18:03) -What we can learn from the ancestral diet (34:35)-The biggest mistake in nutritional science (38:21)-A good starting place to determine your ideal macronutrient ratio (40:47)  -The most effective approach to intermittent fasting (45:03) -Who shouldn’t do intermittent fasting (50:38)-When lab testing is necessary (54:18)-Chris’s take on the latest health trends (1:07:17)-Learn more about Chris and his work (1:13:30) For more on Chris Kresser, be sure to follow him on Instagram @chriskresser, on Facebook @chriskresserlac, on Twitter @chriskresser, and on YouTube @chriskresser. Check out his website To learn more about his ADAPT Health Coach Training Program and his ADAPT Practitioner Training Program visit: You can also find his book, The Paleo Cure, right here. 
Jennifer is one of the nation’s leading parenting experts and the founder of Connected Parenting. She is the author of Connected Parenting: How To Raise A Great kid and You’re Ruining My Life! (But Not Really) Surviving the Teenage Years with Connected Parenting.Jennifer was the Parenting expert on CBC’s Steven and Chris show for eight seasons and has appeared frequently on Canada AM and Breakfast Television. Her advice can be found in many Canadian and U.S. magazines, such as Today’s Parent, Redbook, Parent Magazine and Canadian Family. Jennifer has been helping children, teens and families get connected for over twenty years.Here are more of the details from this episode:- How Jennifer discovered compassionate parenting and family therapy as her calling (4:50)- The power of limbic bonding for you and your child (7:27)- What traditional parenting got wrong about “You should know better!” (15:50)- What are mirror neurons and how they can help (19:13)- How yelling impacts the fight or flight response and stress hormones (24:40)- Breaking down the CALM technique (27:00)- Practicing active listening with the CALM technique in real situations (44:40)- Approaching disagreements with teenagers more mindfully (52:20)- Dealing with full-on tantrums and what happens when you give them permission to meltdown (57:10)- Advice for couples and how to use mirroring for intimate relationships (1:15:50)- Taking a modern approach to the modern problems kids are dealing with (1:30:05)- Why too much power leads kids to feel anxious (1:50:30)- Learn more about Jennifer’s work (1:54:20)
Every time we eat, we have a chance to boost our brain function! That's why what we choose to put on our plate is one of the most critical health interventions er can make.Food not only affects our likelihood of disease, but it can lengthen our lives, change our mood, and even affect the expression of our DNA. By approaching disease with a holistic perspective, of which food is a vital part, we can tackle the root causes of illness and truly live well. We can change our destiny by making better choices today.In this special mini-episode, I speak with Dr. Rupy Aujla, Max Lugavere, Dr. Rangan Chatterjee, and Dr. David Perlmutter about an empowered approach to supporting the brain, starting with food first.Follow today's guests in this mini-episode here: For the Night by Chill Study
Nutrition experts have long debated whether there is an optimal diet that humans evolved to eat. Studies show that modern hunter-gatherer groups across the globe generally have phenomenal heart and metabolic health, yet they eat a variety of diets, and tend to avoid the chronic diseases that kill most Americans. On today’s Broken Brain Podcast, our host, Dhru, talks to Anahad O’Connor, a bestselling author and reporter for The New York Times. He joined the paper in 2003 and writes for Science Times – the paper’s weekly science and health section – and the Well blog. Anahad covers nutrition, medicine and chronic disease. He has published a number of groundbreaking investigative stories for the Times, including a series in 2015 that exposed Coca-Cola’s funding of scientific research that sought to downplay the role of sugar-sweetened beverages in the obesity epidemic. In 2018, he and his colleagues won an award from the Association of HealthCare Journalists for Planet Fat, a series that examined the food industry’s role in the spread of global obesity. Anahad is a graduate of Yale University and is a frequent guest on national news programs, such as PBS NewsHour, Good Morning America, and NPR’s All Things Considered. He is also the author of four books.In this episode, Dhru and Anahad talk about what life is like in hunter-gatherer societies, what a typical hunter-gatherer diet looks like, the challenges that are faced in these societies, and if there really is an optimal diet for humans. They talk about time-restricted eating and how when you eat could be more important than what you eat, how food variety causes you to eat more, something known as sensory-specific satiety, and why this is one of the reasons people in hunter-gatherer socieites don’t overeat and become obese. They also discuss another article Anahad wrote in the New York Times, How to Get Strong, and how everyone knows that exercise is one of the best things you can do for your health, but most people ignore one crucial component of it: resistance training and how it can reverse the age-related cellular damage that contributes to sarcopenia and functional impairment. In this episode, we dive into:-Modern hunter-gatherer societies and why they tend to avoid chronic diseases (3:09)-The importance of eating local and seasonal foods (14:56)-Time-restricted eating (17:47)-Why food variety causes your to eat more (24:08) -Nature’s perfect food (31:04)-Anahad’s groundbreaking investigative report that exposed Coca-Cola’s funding of scientific research that sought to downplay the role of sugar-sweetened beverages in the obesity epidemic (41:23)-The impact of lifestyle and social connections on overall health (53:22)-Longevity and resistance training (1:02:07) -How to make resistance training practical (1:11:13)-Learn more about Anahad and his work (1:19:06)For more on Anahad O’Connor, be sure to follow him on Twitter @anahadoconnor, and check out his articles for the New York Times, right here.
The hardest part about achieving a dream often isn’t actually achieving it, it’s stepping through your fear of the unknown when you don’t have a clear plan. Having a teacher or boss tell you what to do makes life a lot easier. But nobody achieves a dream from the comfort of certainty. On today’s Broken Brain Podcast, our host, Dhru, talks to Alex Banayan, the only national bestselling business author under 30 in America. His book, The Third Door: The Wild Quest to Uncover How the World’s Most Successful People Launched Their Careers, has been translated into more than a dozen languages. Over the course of his unprecedented seven-year journey, Alex interviewed the most innovative leaders of the past half-century, including Bill Gates, Lady Gaga, Larry King, Maya Angelou, Steve Wozniak, Jane Goodall, Jessica Alba, Quincy Jones, and more.Alex has been named on Forbes’ 30 Under 30 list, Business Insider’s Most Powerful People Under 30, and has been featured in major media, including The Washington Post, Fortune, CNBC, MSNBC, Fox News, and NBC News. Alex is an acclaimed keynote speaker, and has presented the Third Door framework to business conferences and corporate leadership teams around the world, including Apple, Google, Nike, IBM, Snapchat, Salesforce, and Disney.In this episode, Dhru and Alex talk about the seven year mission he undertook to unlock the secret to immense success from some of the most successful people in the world. They discuss the importance of mindset and that when you change what you believe is possible, you change what becomes possible. They talk about how to stay resilient in the face of rejection, and how our growth comes from our mistakes. They also talk about the importance of cultivating meaningful relationships, and the impact it has on our health and mindset when working to accomplish a goal.In this episode, we dive into:-The analogy of what the Third Door is (4:28)-Alex’s personal journey (7:01)-The difference between fearlessness and courage (33:30)-How to figure out what you want to do in life (41:11)-Alex’s 30-Day Challenge to uncover your path (42:37)-The importance of having an inside man to support you on your journey (54:11)-How to cultivate meaningful friendships (1:10:42)-Alex’s advice for difficult conversations (1:15:08)-How to overcome failure (1:24:52)-Learn more about Alex and his work (1:34:09)For more on Alex, be sure to follow him on Instagram @alexbanayan, on Facebook @alexbanayan, and on Twitter @alexbanayan. Check out his website You can find his book, The Third Door: The Wild Quest to Uncover How the World's Most Successful People Launched Their Careers, right here.
What often blocks most people from success and feeling capable in life is the ability to experience, move through, and handle unpleasant feelings, such as sadness, shame, helplessness, anger, embarrassment, disappointment, frustration, and vulnerability. Knowing how to deal with intense, overwhelming, or uncomfortable feelings is essential to building confidence, emotional strength, and resilience. Yet when we distract or disconnect from these feelings, we move away from confidence, health, and our desired pursuits, ultimately undermining our ability to fully realize our ambitions.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Joan Rosenberg, a psychologist who is known as an innovative thinker, acclaimed speaker, and trainer. She is a professor of graduate psychology at Pepperdine University in Los Angeles, CA, and is a two-time TEDx speaker and member of the Association of Transformational Leaders. Dr. Rosenberg has been featured in the documentary I Am, The Miracle Mindset, Pursuing Happiness, and The Hidden Epidemic. She’s been seen on CNN’s American Morning, the OWN network, and PBS, as well as appearances and radio interviews in all of the major metropolitan markets. Her latest book, 90 Seconds to a Life You Love: How to Master Your Difficult Feelings to Cultivate Lasting Confidence, Resilience and Authenticity, was released this past February. In this episode, Dhru and Dr. Rosenberg talk about how to work through unpleasant feelings, and how to build emotional strength to create the life of your dreams. They discuss why worrying about what other people think of you is really just a distraction from feeling vulnerable, and why harsh self-criticism is one of the most destructive things we can do to ourselves. They also talk about why speaking your truth is the most important action to take to cultivate confidence, authenticity, and resilience. In this episode, we dive into:-How our emotions are tied to our success (1:59)-Why it’s so difficult for us to experience unpleasant feelings (11:59)-Why labeling our feelings is so important (16:54)-How to build confidence (25:25)-How to stay present to your feelings through The Rosenberg Reset Formula (31:28)-What is really underneath fear and anxiety (38:08)-How to release painful memories and old stories (44:22)-The importance of speaking your truth to build confidence (52:32)-Why compliments are so difficult to receive (1:04:50)-Finding your purpose (1:08:03)-How to be resilient in the face of change (1:12:23)-Learn more about Dr. Rosenberg and her work (1:16:22)For more on Dr. Joan Rosenberg, be sure to follow her on Instagram @drjoanrosenberg, on Facebook @drjrosenberg, and on Twitter @drjoanrosenberg. Check out her website You can find her book, 90 Seconds to a Life You Love: How to Master Your Difficult Feelings to Cultivate Lasting Confidence, Resilience and Authenticity, right here. Lastly, here is a bonus gift from Dr. Rosenberg:
In Functional Medicine, we put a heavy emphasis on gut health. We know that a strong gut is not just essential for digesting food and absorbing nutrients, but that it plays a vital role in the immune system and affects the health of the entire body. On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Marvin Singh, an integrative gastroenterologist. Dr. Singh graduated from the Virginia Commonwealth University School of Medicine, and completed his residency training in internal medicine at the University of Michigan Health System, followed by a fellowship training in Gastroenterology at Scripps Clinic and Green Hospital. Dr. Singh was also trained by Dr. Andrew Weil, a pioneer in the field of integrative medicine, at the University of Arizona Center for Integrative Medicine. Dr. Singh uses cutting-edge tests and personally designed protocols to develop a truly individualized plan for his patients based on their genetics, microbiome, metabolism, and lifestyle.In this episode, Dhru and Dr. Singh talk about the cutting edge research of DNA methylation PhenoAge, which can predict things like aging, inflammation, and heart disease. They discuss how changes in the gut microbiome can impact gene expression, how our microbiome influences the dietary choices we make, and how our gut health can have a significant effect on healthy aging. They also talk about the implications of diet and the gut microbiome in neuroinflammatory and neurodegenerative disease. In this episode, we dive into:-How DNA methylation can predict age and age-related outcomes (2:24)-How our gut microbiome influences our food choices (9:35)-The gut-brain connection (13:22)-The gut microbiome and neurodegenerative diseases (17:35)-Dr. Singh’s personal health journey (21:51)-Why personalization is so important when it comes to our gut health (43:29)-Food sensitivity testing (46:56)-Gut microbiome testing (54:05)-Probiotics (59:49)-How exercise impacts our gut health (1:07:12)-Prebiotics (1:09:59)-Digestive enzymes (1:13:05)-Fecal transplants (1:20:33)-Colon hydrotherapy (1:26:39)-How social connections impact our health (1:32:19)-Learn more about Dr. Singh and his work (1:38:16)For more on Dr. Marvin Singh, be sure to follow him on Instagram @DrMarvinSingh, on Facebook @DrMarvinSingh, and on Twitter @DrMarvinSingh. Check out his website, and download his FREE 4 Week Gut Reset e-book, right here. Dr. Singh was also featured in the Interconnected Docu-series which you can watch here. If you’re looking to work with an integrative practitioner you can search for one here:-The Institute for Functional Medicine: -The Andrew Weil Center for Integrative Medicine:, check out the article Dhru referenced during the interview from Anahad O’Connor: Is There an Optimal Diet for Humans?
When it comes to addiction, Functional Medicine can offer a comprehensive approach to treating the whole person. Mind, body, and spirit need to be taken into account, as well as diet and lifestyle interventions and the ever-so-essential aspect of a supportive and uplifting community. With a systems-based approach, we can cover all of these areas and more, to create long-term recovery.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. David Haase, a leading educator and innovator in the emerging field of personalized systems medicine. He graduated from Vanderbilt University School of Medicine and completed his medical residency at the Mayo Clinic where, despite the undeniable brilliance and dedication of the doctors around him, he saw countless instances of patients getting better not because of medical advances, but in spite of them.After years of turbulent reflection, Dr. Haase founded the MaxWell Clinic in Tennessee with the expressed goal to better understand and enable the human body’s miraculous ability to create health. He treats a wide range of conditions and has a special expertise in neurodegenerative and other brain-related challenges, fatigue, and other conditions caused by mitochondrial, inflammatory, and immune dysregulation. Dr. Haase also teaches internationally, including for the Institute for Functional Medicine.In this episode, Dhru and Dr. Haase talk about how Functional Medicine is a great way to address complex chronic conditions like substance use disorders. They discuss how early life trauma impacts brain development and increases the likelihood of stress, pain and addiction. They also talk about how we can use Functional Medicine to transition from acute care to long-term sustainable recovery.In this episode, we dive into:-The connection between stress, pain, and addiction (13:15)-How opioids affects the gut-brain interaction (19:07)-Addiction as a chronic disease (22:44)-How early life trauma impacts brain development (28:19)-How nutritional deficiencies impact stress, pain, and addiction (35:18)-Environmental toxins and the susceptibility to stress, pain, and addiction (42:02)-The importance of community when it comes to our health (51:46)-Dr. David Haase’s story of how he got into systems-based medicine (57:26)-How a Functional Medicine doctor can play an important role to support someone in their recovery (1:08:08)-Learn more about Dr. Haase and his work (1:13:49)For more on Dr. David Haase, be sure to follow him on Instagram @davidhaasemd, on Facebook @davidhaasemd, and on Twitter @davidhaasemd. Check out his website You can find his book, Curiosity Heals the Human: How to Solve “Unsolvable” Medical Challenges with Better Questions and Advanced Technologies, right here.
Comments (9)

Niclas Daniels

48:40 #supplements for #neuropathy.

Jul 5th

Sanja Lovrečič

Love it!

May 22nd

Randall Wilkinson

had to listen to this one twice

May 20th


Thank you so much for most insightful podcast,first time listener to your podcast which was forwarded by a friend. Presentation on science behind the yoga beautiful connections on how The Practice can change your body on a cellular level. As a Yoga teacher and a Family medicine provider i most definitely interweave both. I did my research and I studied ( and continue to study)along with taking a 200hour class. We all start from somewhere the key is to continue to grow while learning. "I can only bring someone as far as I have gone," Love it! Ericajane

Mar 16th

Jennifer Marie Hancock

I recently asked my Dr to check my hormone levels and, sure enough, everything came back "normal." how does this explain the crazy fatigue I've been experiencing the past year? how do we find drs that specialize in holistic medicine and would health insurance even cover something like that? I have no idea to whom I'm asking these questions, lol, just thinking out loud I suppose.

Jan 16th

Felipe Arenas Ortiz

Great podcast. I love the production, the quality of the questions within the interview and the information it gives us. Thanks!

Dec 3rd

Megan Rose Ryan

First episode I'm listening to from this podcast. Diggin' it! But what's up with the interviewer's mic? The echo makes it a bit hard to understand.

Nov 27th

Tom Bradley

Just ordered the doctors book after listening to this. great episode

Oct 8th


What an exceptional episode. I don't use that term lightly. I work as a personal trainer and am looking at going into medicine. Medicine as I know it has always been traditional, and that made me hesitate pursuing it as a career. As of late, I have come across functional medicine which touches on a lot of what I try to emphasize to my clients: the importance of sleep, stress relief, eating, etc...and how it affects your life. To be able to explain to someone the true science behind why their body responds the way it does is life-changing. Thank you for making this information available. I have now discovered the way to combine two fields I love. Keep the knowledge flowing!

Jun 15th
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