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Broken Brain with Dhru Purohit
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Broken Brain with Dhru Purohit

Author: Dhru Purohit, Dr. Mark Hyman

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The Broken Brain podcast will help you take your brain health to the next level and teach you how to live your best life! Listen as host and serial entrepreneur Dhru Purohit interviews the top experts in the field of neuroplasticity, epigenetics, biohacking, mindfulness and functional medicine.
97 Episodes
The most common explanation for why exercise makes us happy is far too simplistic. The psychological effects of movement cannot be reduced to an endorphin rush. Physical activity influences many other brain chemicals, including those that give you energy, alleviate worry, and help you bond with others. It reduces inflammation in the brain, which over time can protect against depression, anxiety, and loneliness. Regular exercise also remodels thephysical structure of your brain to make you more receptive to joy and social connection. These neurological changes rival those observed in the most cutting-edge treatments for both depression and addiction. On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Kelly McGonigal, a health psychologist who specializes in understanding the mind-body connection. She is the bestselling author of The Willpower Instinct and The Upside of Stress. Her latest book, The Joy of Movement, explores why physical exercise is a powerful antidote to the modern epidemics of depression, anxiety, and loneliness.In this episode, Dhru and Kelly talk about how exercise can improve the treatment outcomes for depression, anxiety, and addiction. They discuss the science of why people who are regularly active have a stronger sense of purpose, experience more gratitude, love and hope, feel more connected to their communities, and are less likely to suffer from loneliness or become depressed. They also talk about how during physical activity, muscles secrete hormones into our bloodstream that make our brain more resilient to stress, which scientists call “hope molecules.” In this episode, we dive into:-The moment that changed Kelly’s life (1:58)-The connection between joy and movement (8:13)-How exercise can help with mental health (19:25)-How to get past the mental barriers when it comes to movement and exercise (28:24)-The role movement plays when it comes to loneliness (38:30)-Why the so-called “Runner’s High” is more than just an endorphin rush, and how it helps to reduce inflammation in the brain (50:22)-How exercise teaches us to be better at stress (56:27)-Why you should set a goal that involves movement, not just weight loss (1:00:59)-How exercise enhances healing (1:13:39)-Where to learn more about Dr. Kelly McGonigal (1:22:40)For more on Dr. Kelly McGonigal, be sure to follow her on Instagram @kellymariemcgonigal, and on Facebook @kellymcgonigalauthor. You can find her music playlists on Spotify by searching her name: Kelly McGonigal. Check out her website You can find her book, The Joy of Movement, right here.
Jerry Colonna, an executive coach for CEO’s and leaders, asks us to reflect on an important question when it comes to taking responsibility for our lives, “How have I been complicit in creating the conditions I say I don't want?”.On today’s Broken Brain Podcast, our host, Dhru Purohit talks to us about this question and how to catch and stop self-sabotage, and the two big ideas that will help you in the process. In this episode, we dive into:-Big idea #1: we don’t speak up (4:48)-How to stop people pleasing (7:05)-Big idea #2: being honest with yourself (12:08)For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 335-6565. You can find Jerry Colonna’s book, Reboot: Leadership and the Art of Growing Up, right here. 
Our modern day life provides us with infinite opportunities, along with endless temptations. We can eat whatever we want, whenever we want. We can immerse ourselves in the vast, enticing world of digital media. We can buy goods and services for rapid delivery with our fingertips or voice commands. But living in this 24/7 hyper-reality poses serious risks to our physical and mental states, our connections to others, and even to the world at large.On today’s Broken Brain Podcast, our host, Dhru, talks to Drs. David and Austin Perlmutter. Dr. David Perlmutter is a Board-Certified Neurologist and four-time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, andThe Journal of Applied Nutrition. His books have been published in 34 languages and include the #1 New York Times bestseller Grain Brain, The Surprising Truth About Wheat, Carbs and Sugar, with over 1 million copies in print. Dr. Austin Perlmutter is a board-certified internal medicine physician. He received his medical degree from the University of Miami and completed his internal medicine residency at Oregon Health and Science University in Portland Oregon. His academic focus is in understanding the decision-making process, how it is influenced by internal and external factors, and how it changes our health and illness outcomes. Austin, along with David Perlmutter, M.D., is the co-author of the newly released book, Brain Wash. In this episode, Dhru and Drs. David and Austin Perlmutter talk about how our health, our relationships, and even our thinking has been damaged by our modern culture. They discuss how the modern world creates structural and functional alterations to our brains, and how this increases our poor choices. They also talk about how exercise rewires and restructures the brain for better functioning, the health benefits of nature, and how to start to incorporate more nature into our lives.In this episode, we dive into:-What it was like working on a book together (1:49)-What is hijacking our brain and making it difficult to implement change (5:27)-The new reality that we find ourselves in (11:47)-How chronic inflammation impacts our ability to make healthy choices (16:44)-The connection between poor sleep and increased hunger (18:50)-Disconnection syndrome and how it impacts us (27:27)-How technology changes our brain (31:00)-The relationship between exercise and our decision making process (46:57)-The Ten-Day Brain Wash reset for your brain and body (54:21) -Where to learn more about Drs. David and Austin Perlmutter (1:02:31)For more on Drs. David and Austin Perlmutter, be sure to follow them on Instagram @davidperlmutter and @austinperlmutter, on Facebook @davidperlmuttermd, and on Twitter @austinperlmuttermd. Check out their websites: and You can find their book, Brain Wash, right here.
New! Every Tuesday we'll be releasing a bonus episode with host Dhru Purohit.Have a suggestion for a topic for a bonus episode? Text Dhru at 302-335-6565Today's Episode: 4 Ways to Break Free of the Cycle of Comparison1) Understand the Pendulum Concept2) How to catch yourself early using the Falling Still method3) Create Clarity and unplugging from the matrix4) Focusing on momentum, not just goalsFollow Dhru on Social Media:
We currently live in a society where chronic illness, obesity, drug dependence, anxiety, and depression are rapidly becoming the prevailing norms. According to the CDC, more than half of U.S. adults have been diagnosed with a chronic disease. 68% are overweight or obese, 70% are taking at least one prescription drug, and 97% are not managing to maintain four of the most basic habits required for long-term health: decent nutrition, adequate exercise, not smoking, and maintaining a healthy body composition.On today’s Broken Brain Podcast, our host, Dhru, talks to Pilar Gerasimo, an award-winning health journalist, pioneering social explorer, and author of, The Healthy Deviant: A Rule-Breaker’s Guide to Being Healthy in an Unhealthy World. Pilar is best known for her work as founding editor of Experience Life magazine, which today reaches more than 3 million people nationwide, Pilar has also served as chief creative officer for the Institute for Integrative Nutrition, and as top health editor for The Huffington Post.Today, Pilar co-hosts a five-star rated podcast called The Living Experiment with Whole30 co-founder Dallas Hartwig. She speaks at universities and leads workshops at retreat centers like Kripalu, Sundance, and 1440 Multiversity. She also consults for organizations committing to transforming health and happiness around the globe. When she’s not travelling, Pilar hangs out on her family’s organic, communal farm in Wisconsin with a bunch of cows, chickens, and her goofy pit bull pal, Calvin.In this episode, Dhru and Pilar talk about how to break out of the unhealthy matrix that society has us living in when it comes to believing we’re not enough, not good enough, or that we’re never going to be enough. They discuss why we value other people’s opinions more than our own, and why we try to fit in at the expense of our own health. They also talk about the Healthy Deviant approach to living, how to develop the skills of a healthy person, and the first thing you can do to start making healthy changes in your life. In this episode, we dive into:-The current societal standards we’re living in today (1:35)-Pilar’s health journey and what led to her breaking point (6:55)-The unhealthy default reality (17:38)-Why your health is heavily influenced by your peers (26:26)-The most important thing to focus on in your life right now (34:29)-The three nonconformist competencies of Healthy Deviance and how they support healthy self-regulation (46:10)-Challenging the vicious cycle of helplessness (57:09)-How you can inspire others to live a healthy lifestyle (1:03:14)-Where to learn more about Pilar Gerasimo (1:13:51)For more on Pilar Gerasimo, be sure to follow her on Instagram @pgerasimo, on Facebook @pgerasimo, and on Twitter @pgerasimo. Check out her website and Check out her podcast, The Living Experiment. Take the Healthy Deviant quiz here. You can find Pilar’s book, The Healthy Deviant: A Rule Breaker’s Guide to Being Healthy in an Unhealthy World, right here. 
Happy New year! Text me today at (302) 335-6565In this episode host Dhru Purohit goes solo with the microphone to talk about 9 things he commonly sees people doing (whether they realize it or not) that hold them back from their goals and dreams.Are you doing one of these 9 things?See the instagram post that inspired this podcast:’s dive into this episode:* (1) We obsess over what others think of us! (5:42)* (2) Waste time on social media. (13:30)* (3) We don’t ask for help or support from friends. (18:15)* (4) We blame everyone instead of looking within. (23:20)* (5) We avoid setting an invention for the day! (27:10)* (6) We spend time with the wrong people. (31:10)* (7) We don’t read books that help us level up. (34:29)* (8) We live the life that others expect of us, instead of a life true to you! (39:10)* (9) We are hard on ourselves all day, everyday! (46:15)For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruXpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit.By the way! Text Me: (302) 335-6565
One of the very best scientific predictors for how any child turns out in terms of happiness, academic success, leadership skills, and meaningful relationships is whether at least one adult in their life has consistently shown up for them.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Tina Bryson, the founder and executive director of The Center for Connection, a multidisciplinary clinical practice, and The Play Strong Institute, a center devoted to the study, research, and practice of play therapy through a neurodevelopmental lens.She is a licensed clinical social worker, providing pediatric and adolescent psychotherapy and parenting consultations. Dr. Bryson keynotes conferences and conducts workshops for parents, educators, clinicians, and industry leaders around the world. She is the co-author, with Dan Siegel, of The Yes Brain and the New York Times bestsellers The Whole-Brain Child and No-Drama Discipline, as well as the upcoming Bottom Line for Baby. She earned her Ph.D. from the University of Southern California and lives in Los Angeles with her husband and three children.In this episode, Dhru and Dr. Bryson talk about what it means to be present and really show up for our kids, even if our own caregiver wasn’t really present. They discuss how to develop secure attachment in your kids and how providing a calm, safe presence can radically change how a child’s brain develops. They also talk about how every child needs to feel what Tina calls the Four S’s: safe, seen, soothed, and secure, and strategies for implementing them into your child’s daily life.  In this episode, we dive into:-The best predictor for how well our kids turn out is how we show up as parents (1:50)-How the attachment between a parent and child impacts the development of a child’s brain (5:20) -The Strange Situation Study (7:47)-The four attachment patterns (15:36)-Why secure attachment is the ultimate goal in parenting (23:44) -A parents two primary jobs when it comes to making their kids feel safe (26:58) -Why traditional forms of disciple are counterproductive (32:10)-Understanding what's really underneath your child's behavior and helping them feel seen (35:50) -The most powerful way to help your child in a state of distress (47:21)-Behaviors that can manifest as adults when not feeling safe, seen, soothed and secure as a child (1:10:05)-Where to learn more about Dr. Tina Bryson (1:25:06)For more on Dr. Tina Bryson, be sure to follow her on Instagram @tinapaynebryson, and on Facebook @tinapaynebrysonphd. Check out her website You can find Tina’s book, The Power of Showing Up: How Parental Presence Shapes Who Our Kids Become and How Their Brains Get Wired, right here. 
Most people understand the importance of a healthy gut microbiome for overall health, but have you heard of the mycobiome—the fungi that live inside our bodies, and how it impacts our health?On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Mahmoud Ghannoum and Afif Ghannoum. Dr. Mahmoud Ghannoum is a tenured professor and director of the Center for Medical Mycology at Case Western Reserve University and University Hospitals Cleveland Medical Center in Cleveland, Ohio. He has spent his entire career studying medically important fungi and publishing extensively about their virulence factors, especially in microbial biofilms. Dr. Ghannoum is the scientist that named the mycobiome, the fungal community in the body, and was dubbed “the scientist who is now known as the leading microbiome researcher in the world” by the Washington Post. He is also the founder of the leading antifungal clinical testing company in the world, Next Trillion Sciences, and has been involved in the development of 95% of the antifungals that have come to market since the 1990’s.Afif Ghannoum is a biotechnology attorney by training. He has turned his biotechnology innovations into consumer products that have sold in over 27,000 retail locations in the United States. He has also licensed a technology to a global pharmaceutical company that is now sold in over 100,000 retail locations. Afif is currently the CEO of BIOHM Health, where he has commercialized consumer probiotics and microbiome testing kits around the dual role that fungi and bacteria play in the digestive tract.In this episode, Dhru, Dr. Ghannoum, and Afif talk about the mycobiome and how it can directly influence our weight, digestion, immune system, and mood. They discuss how fungi work in the human gut, in ways that are beneficial, neutral, or detrimental to our health. They also talk about how it can take months or years to shift your gut bacteria in a significant way, but you can alter your gut fungi profile for better or for worse in just 24 hours by changing your diet. Dr. Ghannoum and Affi also explain how their product, BIOHM, helps to maintain the balance of bacteria and fungi in the gut, all while breaking down digestive plaque.In this episode, we dive into:-The mycobiome and how it impacts our health (3:32)-What happens when our fungi get out of balance (7:25)-The damage antibiotics can cause when it comes to the mycobiome (12:31)-Biofilm and how it impacts the mycobiome (15:36)-How you can alter your gut fungi for better or worse in just 24 hours (25:19)-Foods that traditionally get a bad rap and how might they have a positive impact on our mycobiome (38:38)-What we should be eating to take care of our fungi community (45:13)-How sleep impacts our gut health (49:42)-How environmental factors positively or negatively impact the mycobiome (1:01:04)-How Dr. Ghannoum started his career (1:21:22)-Where to learn more about Dr. Ghannoum and Afif (1:30:11)For more on Dr. Mahmoud Ghannoum and Afif Ghannoum, be sure to follow them on Instagram @biohmhealth, @dr.microbiome, and @afifghannoum, as well as on Facebook @biohmhealth. Check out their website and You can find Dr. Ghannoum’s book, Total Gut Balance: Fix Your Mycobiome Fast for Complete Digestive Wellness, right here:
Our friendships are an integral part of who we are and how we evolve. Even though we don’t need each other to survive anymore, we do need each other to thrive. All of the best things in life come from connection, community, and our relationships. ⁣On today’s Broken Brain Podcast, we are sharing an interview with our host, Dhru Purohit, who was interviewed by our dear friend, Shawn Stevenson, on his podcast The Model Health Show. Dhru Purohit is a serial entrepreneur, investor, and documentary filmmaker. He is also the CEO of Dr. Hyman Enterprises and The UltraWellness Center, a Functional Medicine based clinic that specializes in treating chronic disease through personalized medicine. Dhru is a contributing author to two New York Times bestsellers, Clean Gut and Clean Eats, and helped launch the global “clean eating” revolution by co-founding The Clean Program.  In this episode, Dhru and Shawn talk about how our friendships are the most influential thing on our health, success, and happiness. They discuss how social media has made it easier than ever to connect with others, but the challenge comes when we trade our online friends for our offline friends. Our online connections can deepen our friendships, but they aren’t a replacement for real human connection. They also talk about the foundation of an incredible relationship, and why the bigger your goals and dreams are in life, the more you need community and friends to have your back. In this episode, we dive into:-Why Dhru puts so much intention into friendship (4:23)-The Framingham Study and why you are more likely to become obese when a close friend becomes obese (7:38)-Why connection with other human beings is critical to thriving (11:30) -How selecting your group of friends is the ultimate form of biohacking (14:38)-How to make intentional friends (20:41)-How to create deeper, more meaningful friendships (28:30)-The importance of an opt-out event (33:47)-Why making friends is more difficult for men (37:37) -Why meaningful friendships and connections are about depth, not about quantity (38:53)-Where to learn more about Dhru Purohit (56:23)For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. For more on Shawn Stevenson, be sure to follow him on Instagram @ShawnModel, and on Facebook @TheModelHealthShow. Check out his podcast The Model Health Show, and check his website You also can find his book, Sleep Smarter, right here.
Excess insulin and chronic inflammation are powerful threats to our health and longevity, and the underlying thread that weave together virtually every chronic disease. On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Ronesh Sinha, an internal medicine physician in Silicon Valley who works for the Palo Alto Medical Foundation and serves as director for employer wellness, strategy, and product development. He has designed successful health education and wellness programs for over 20 major Silicon Valley companies, launched a medical mobile clinic providing primary care to busy employees, and developed a dedicated consult practice geared to Asians and Indians with insulin resistance and related conditions.His groundbreaking work in reversing diabetes in culturally diverse populations has received global attention with front cover stories in Fortune Magazine and the LA Times, and earned him the Silicon Valley Business Journal’s Excellence in Healthcare award. Dr. Sinha blogs actively on health at, and hosts a popular Bay Area weekly radio show on health. He is passionate about developing innovative, culturally tailored solutions to help diverse populations lead healthier lives. He is also the author of The South Asian Health Solution. In this episode, Dhru and Dr. Sinha discuss what insulin resistance is, why it matters to your health, what happens when insulin resistance persists, and the impact it has on your brain. They talk about the role of ethnicity on insulin resistance and metabolism, and how a sedentary lifestyle impacts insulin resistance. They also talk about the difference between visceral fat and subcutaneous fat, and the lifestyle changes we can implement to address insulin resistance, metabolic dysregulation, and inflammation. In this episode, we dive into:-How insulin resistance impacts our health (1:41)-The connection between insulin resistance and Alzhiemer’s (6:07)-Adaptive insulin resistance vs. chronic insulin resistance (10:47)-Metabolic syndrome and the role triglycerides play in the body (14:03) -The impact of insulin resistance when is comes to specific cultures (29:33)-The connection between a sedentary lifestyle and insulin resistance (35:48)-The hidden danger of being “skinny fat” (39:29) -Statins vs. lifestyle interventions for treating insulin resistance (49:41)-How sleep impacts insulin resistance (59:34)-Fasting and insulin resistance (1:02:02) -Where to learn more about Dr. Ronesh Sinha (1:24:35)For more on Dr. Ronesh Sinha, be sure to follow him on Instagram @roneshsinhamd. Check out his website, and his innovative education and wellness programs at You can find his book, The South Asian Health Solution: A Culturally Tailored Guide to Lose Fat, Increase Energy and Avoid Disease, right here. Lastly, you can learn more about Dr. Sinha’s 8-week online Whole Family Health program that focuses on individuals and families who want to prevent or reverse conditions involving insulin resistance and/or inflammation here:
If you struggle with feeling hopeless, sad, or otherwise mentally fragile, you’re not alone. Depression is officially at epidemic levels, dramatically impacting hundreds of millions of lives. With its symptom-based medicine approach, conventional medicine tackles depression completely wrong. Rather than determine what actually creates that depression, many doctors immediately reach for their prescription pad. But what if there way another way to treat this epidemic?On today’s Broken Brain Podcast, our host, Dhru, talks to Mia Lux, a stand-up comedian, personal growth junkie, former high-school teacher, and recovering lawyer. Mia originally got into stand-up comedy as a way to learn how to fail—a sincere effort to overcome the perfectionist practices that kept her in perpetual burnout as a lawyer and high school teacher. In the process, she wound up working in the personal development space, originally as Director of Content for global transformational education company Mindvalley, and eventually stepping into her role over the past 5 years as host and facilitator, specializing in top wellness/personal development events around the world.Mia always kept a toe in comedy, and found that laughing is just more effective than lecturing. Her newest project, The Conscious-ish Show, is the baby of both worlds: a Late Night style talk-show that takes on topics that really count—health, self-love, depression, sex, spirituality, and more. It is Mia’s mission to make the world's most powerful ideas more accessible by making them truly enjoyable; if you're laughing, you're learning!In this episode, Dhru and Mia take a deep dive into the topic of depression. Mia openly shares her own personal struggle with depression, and the importance of understanding the emotional, psychological and physical causes of it. They discuss the best ways to support someone who is depressed, and some of the key ways to begin to heal. They also talk about understanding what’s really underneath perfectionism, how to get out of your own way, and how to stop people pleasing. Mia also explains how healing laughter and comedy can be.In this episode, we dive into:-Mia’s personal story of depression and being suicidal (2:31)-What can be done about depression (9:31)-What to do or not do if someone in your life is depressed (12:14)-Fear of failure (20:01)-What’s underneath perfectionism (20:42)-How to stop people pleasing (27:34)-The top regret of the dying (31:50)-How to get out of your own way (33:37)-The healing power of laughter and comedy (37:25)-How to intentionally and mindfully create an extraordinary life (46:31)-Self-love and understanding the language you use with yourself (47:36)-Lucid dreaming (49:01)-Where to learn more about Mia (59:55)For more on Mia Lux, be sure to follow her on Instagram @consciousish and @mymialux, and on Facebook @consciousish and @mymialux. Check out her website and, check out this article from the New York Times Magazine, about an Army veteran who was thought to have depression and PTSD by leading military doctors and commanders; turns out his symptoms were really caused by chronic lead poisoning.
We spend countless hours training our dogs, but how often do we consider what they have to teach us? Dogs teach us so many important life lessons. They teach us about gratitude, love and compassion, being present, and so much more. When humans bring a dog into their lives, they are most often looking for a companion; what they may not realize is that they are getting a teacher as well. On today’s Broken Brain Podcast, our host, Dhru, talks to Tamar Geller, a celebrity dog trainer, a New York Times bestselling author, and as Oprah says “A Life Coach for Dogs and their People.” Tamar has revolutionized the way dog training is done. The Loved Dog method that Tamar created over 30 years ago is based on the knowledge she acquired as an Intelligence Officer with the Israeli Elite Special Forces, from the respect she gained for the wisdom of nature while observing wolves in the wild, and her devotion to personal growth.Tamar helps dogs and their people develop a relationship that is based on mutual devotion, as she helps the dog become the best version of himself. Instead of commands, she teaches dogs the life skills that allow them to self-regulate, think before acting, and make better decisions. She also teaches the “pawrents” how to understand their dog’s behavior and become great communicators. Tamar has helped celebrities like Tony Robbins, Ellen DeGeneres, Ben Affleck, Charlize Theron, Reese Witherspoon, Courteney Cox, and of course Oprah, and many other non-famous dog lovers, to have the most awesome dogs.In this episode, Dhru and Tamar talk about how conventional methods of dog training break the bond we are trying to build, and how we are ruining our dogs without even knowing it. They discuss Tamar’s philosophy of dog training, which is about improving the relationship between you and your dog, so your dog is not obedient to you; your dog is devoted to you. Tamar also explains the makeup of dogs’ brains and the core needs that dogs and humans share, as well as how dogs give us the most insight into how we actually show up in all of our relationships.In this episode, we dive into:-Tamar’s approach to dog training and what makes it different and so unique (4:59)-Why traditional dog training environments are not conducive for learning (10:37)-Tamar’s story and how she ended up working with dogs (26:16)-What dogs teach us about being present in our relationships (47:37)-The 6 core needs of dogs and humans (53:20)-Why the need for certainty is vital for your dogs sense of safety (1:09:05) -Misunderstanding your dog’s aggression for fear (1:28:14)-The misconception of unconditional love when it comes to dogs (1:30:03) -Two tips for raising a happy dog (1:33:31)-Where to learn more about Tamar (2:06:23)For more on Tamar Geller, be sure to follow her on Instagram @theloveddog, and check out her website You can order her books, The Loved Dog: The Playful, Non-aggressive Way To Teach Your Dog Good Behavior, and 30 Days To A Well Mannered Dog: The Loved Dog Method, right here.
Despite the ever-increasing number of probiotic supplements, foods, and beverages out there, there’s still a lot of confusion about what probiotics are, how they work, and why we should take them. On today’s Broken Brain Podcast, our host, Dhru, talks to Ara Katz, the Co-Founder and Co-CEO of Seed Health, a microbial sciences company pioneering the application of bacteria to impact human and planetary health. A serial entrepreneur, she’s worked at the intersection of tech, media, and consumer brands. She co-founded the mobile commerce company, Spring, and advises and invests in companies like mindbodygreen and the healthcare startup, Mahmee. She was a fellow at the MIT Media Lab and named in Marie Claire’s The New Guard: The 50 Most Influential Women in the US.In this episode, Dhru and Ara discuss the greatest lessons she has learned in her experience as an entrepreneur and co-founder, as well as the importance of finding the right business partner and nurturing that relationship. They talk about what Ara’s experience as an entrepreneur has taught her about self-care and how her own journey of having a miscarriage helped her to realign her focus to do something that had great meaning and purpose. They also talk about what steps you need to take if you are looking to conduct your own study or clinical research, as well as the importance of integrity when it comes to marketing your business or product. They dive deep into the topic of probiotics and how not all probiotics are created equal, as well as the common misconception that probiotics have to colonize your gut and alter the composition of your microbiome to be effective, which Ara says is actually not true.In this episode, we dive into:-Ara’s current venture, Seed (1:35)-What Ara was doing prior to Seed (6:46)-Ara’s journey into health and wellness and what she learned from her mother’s pancreatic cancer diagnosis and death (9:46) -The impact Ara’s miscarriage had on her and what shifted in her career (12:33)-How Ara’s challenge breastfeeding was the driving force and inspiration for her company, Seed (21:09)-What you should think about when choosing a business partner (34:16)-The difference between a probiotic strain and a probiotic species (40:05)-Why kombucha is not a probiotic (45:58)-A common misconception about probiotics (47:58)-Seed’s Daily Synbiotic (prebiotic + probiotic) and what makes it different from other probiotics (50:54) -What you need to know if you want to do your own clinical study (56:58)-LUCA Biologics, the future of medicine for UTIs and the vaginal microbiome (01:02:15)-SeedLabs probiotic for honey bees (01:10:10)-Where to learn more about Ara and Seed (01:20:44)For more on Ara Katz, be sure to follow her on Instagram @arakatz and @seed, and on Facebook @seedmicrobiome. Check out her website To learn more about Seed University and to become an affiliate visit If you are are a beekeeper and interested in SeedLabs probiotics for bees email Learn more about LUCA Biologics and the development of living medicines targeting the vaginal microbiome at, use code BROKENBRAIN at for 15% off the first month of your Daily Synbiotic subscription. 
There are no guarantees when it comes to successfully conceiving a healthy baby, but there are steps you can take to make sure the very basis of your baby’s life, your genetic raw material, is as healthy as possible even before you conceive. It’s during the preconception period that your baby’s raw genetic material is being formed and influenced.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Afrouz Demeri, a licensed board-certified Naturopathic Medical Doctor specializing in integrative, Functional Medicine for women. Dr. Afrouz finds the root cause for hormonal imbalances, thyroid disorders, stress, weight or digestive issues, fatigue, depression, and anxiety. As faculty of the University of California Irvine, she sees patients at the Susan Samueli Integrative Health Institute or in her Ladera Ranch office in California.Dr. Afrouz has been featured in publications such as Women’s Health, Now Magazine, Weight Wise Expo, and Vitality. When she’s not helping patients find their own lifelong wellness, you can find her studying yoga, cooking for her family of four, or teaching—and dancing—at the local Zumba studio.In this episode, Dhru and Dr. Afrouz talk about all things fertility and how the 90-day period prior to conceiving a baby has the potential to change the genetic code of your baby. They discuss the toxins that can negatively affect your fertility and the overall health of your baby, as well as the importance of detoxing prior to conception. They also talk about how food is the most powerful form of medicine we can use to shift our epigenetics and how what we eat impacts overall egg and sperm quality, and the difference between a healthy diet and a fertility diet. In this episode, we dive into:-Dr. Afrouz’s personal fertility story and journey into medicine (1:41)-How Western medicine looks at miscarriages and what Dr. Afrouz learned in her naturopathic training (18:59)-The importance of looking at both egg quality and sperm quality (24:32)-How mold impacts your fertility and baby’s health (26:16) -Why a vegan diet is not optimal for fertility (43:23)-What Dr. Afrouz did differently during her second pregnancy (54:55)-What couples need to know about the health of sperm (1:00:30)-Dr. Afrouz’s new online course: Trimester Zero (1:27:58)-Why timeline matters when it comes to preparing your body for pregnancy (1:48:38)-Lab testing for fertility (1:49:52)-Eating for fertility (1:56:08)-What you can do today when it comes to air, water, and toxins for optimal health (2:02:19)For more on Dr. Afrouz Demeri, be sure to follow her on Instagram @drdemeri, and on Facebook @aimforwomen. Check out her website To learn more and register for her new course Trimester Zero visit, and her Spring Whole Body Detox at 1440 visit are the air and water filtration systems that Dr. Afrouz recommends: -IQAir - -
Red light therapy has been studied and tested across hundreds of peer-reviewed clinical trials, with overwhelmingly positive results for skin health, collagen production, physical performance and muscle recovery, sleep, joint pain, inflammation, and more. On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Scott Nelson, a co-founder of Joovv, the first company to develop a modular, full-body light therapy device. Prior to starting Joovv, he spent his entire professional career in leadership positions with some of the largest medical device companies in the world, including Medtronic, Covidien, and Boston Scientific. In his spare time, Scott is also the host of Medsider Radio, a top-ranked medical device podcast.In this episode, Dhru and Scott talk about red light therapy, how it interacts with our body and the wide range of benefits to our overall health. They discuss how red light therapy improves brain health and cognitive function, and the emerging research that has shown red light therapy’s potential as a non-invasive treatment for Alzheimer’s, Parkinson’s, and traumatic brain injuries. They also talk about how it can be used as a tool to treat depression and other mental health challenges, as well as how it supports hormone production in both men and women.In this episode, we dive into:-What is red light therapy and how it can positively impact our health (2:16)-How light affects our mitochondria (6:23)-How Joovv got started (9:22)-How red light therapy can improve cognitive function (22:34)-The research on Alzheimer’s and red light therapy (30:19)-The benefits of red light therapy for Seasonal Affective Disorder (SAD) and other mental health conditions (35:39) -How red light therapy increases testosterone (42:13)-The importance of daily natural light exposure (47:06)-The benefits of blue light blocking glasses (57:36)-Where to learn more about Scott and Joovv (1:04:23)For more on Scott Nelson and Joovv, be sure to follow him on Instagram @joovvsocial, on Facebook @joovvsocial, and on YouTube @joovv. Check out his website and learn more about the clinical research on red light therapy here.
More than eight million Americans live with some of the devastating symptoms of PTSD, like Night terrors, flashbacks, and evenings spent in isolation—and it is estimated at least 600,000 post-9/11 veterans are part of that population.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Erik Won, the President of Wave Neuroscience, Inc; a biotechnology company that has innovated a breakthrough technology called Magnetic e-Resonance Therapy (MeRT). This technology utilizes computational neuroanalytics and brain imaging to customize treatment protocols with the aim of restoring optimal neurological function. Dr. Won joined Wave Neuroscience after serving as the Chief Physician and Chief Technology Officer for a Fortune 50 Aerospace company. He also served as a US Navy Flight Surgeon for Marine Medium Helicopter Squadron 268, and received the distinction of serving as the ACE (Aviation Combat Element) Flight Surgeon for the 11th Marine Expeditionary Unit (Special Operations Capable). Dr. Won has been published in numerous peer-reviewed journals and textbooks and presented in numerous academic conferences. He completed his residency at the Harvard OEM combined residency program and was appointed Chief Resident. He received an MPH from the Harvard School of Public Health and an MBA from the University of Southern California, Marshall School of Business.In this episode, Dhru and Dr. Won talk about Magnetic e-Resonance Therapy (MeRT) and how it could address mental health disorders and revolutionize brain-based medicine. They discuss why the rate of suicide among veterans is twice that of the general population, the current standard of care for PTSD, and how MeRT can improve PTSD and traumautic brain injury outcomes. They also talk about how one night of poor quality sleep impacts the brain and what we need to know about the brain’s detoxification system.In this episode, we dive into:-Dr. Won’s experience in the Navy and the impact it had on his life (3:14)-What people don’t understand about being an active service member and the transition from military to civilian life (7:10)-The connection between PTSD and suicide (14:44)-What is MeRT therapy (20:33) -How does MeRT therapy works and what takes place during a typical session (24:41)-What conditions MeRT therapy can be used for (38:26)-How the glymphatic system plays a key role in removing brain waste while you sleep (45:19)-The difference between structural damage and functional damage in the brain (54:05)-Learn more about Wave Neuroscience and where you can find clinics offering MeRT therapy (1:02:31) -Dr. Won’s own experience using MeRT (1:06:32)-The risks and side effects of MeRT therapy (1:07:28)For more on Dr. Erik Won, be sure to follow him on Instagram @braintreatmentcenter, and on Facebook @braintreatmentcenter. Check out his website If you are a member of the Special Operations Forces you can access this treatment for free. Learn more here: Patient response varies from individual and is case by case. Some patients may have no response to treatment. Consult with your physician.
For much of human history friendship was about survival. No one, no matter how strong or independent they were, could live life alone.⁣ So we invested in our village, in our community in our tribe and developed friendships because we needed to. It was a part of our existence.⁣⁣Today, most of us aren’t reliant on friends for daily survival. Our basic needs can be met through the efforts of a lot of people who we aren’t directly connected to. We still need people to grow food for us and keep the lights on, but these people aren’t individuals who we have a direct relationship with.⁣ That’s why we’re seeing more isolation in the Western world, because technically, we don’t “need” each other to survive on a daily basis.⁣But just because you might not need a friend to help you fetch water or grow food or build a house doesn’t mean you don’t need friends to thrive! Thriving in life means having deep and meaningful friendships that have your back and help you live a life of purpose, courage, creativity, and resilience.⁣⁣On today’s Broken Brain Podcast, we are sharing an interview with our host, Dhru Purohit, who was interviewed by our dear friend, Dr. Rangan Chatterjee on his podcast, Feel Better, Live More. Dhru Purohit is a serial entrepreneur, investor, and documentary filmmaker. He is also the CEO of Dr. Hyman Enterprises and The UltraWellness Center, a Functional Medicine based clinic that specializes in treating chronic disease through personalized medicine. Dhru is a contributing author to two New York Times Best-Sellers, Clean Gut and Clean Eats, and helped launch the global “clean eating” revolution by co-founding The Clean Program.  In this episode, Dhru and Dr. Rangan Chatterjee talk about how the bigger your goals and dreams are the more you need friendships that have your back and help you thrive in life.⁣ They discuss why making friends is more difficult as an adult and why this is a particular problem for men—a fifth of whom say they don’t have any close friends. They also talk about why having friendships outside of our intimate relationship is essential, and how to create deeper, more meaningful friendships. In this episode, we dive into:-Why Dhru is so passionate about friendship (2:15)-How friendships are connected to every area of our life (5:02)-The epidemic of loneliness (6:33)-The impact of touch (12:32)-The importance of an opt-out event (24:44)-What to do if you don’t have any good close friends (41:28)-The foundation of an incredible relationship (59:25)-Fear of being a burden (1:01:24)-How to make time for friendships when you have a really busy life (1:11:40)-Dhru’s book recommendations (1:36:06)For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. Below are the book recommendations that Dhru made during the interview:-Never Eat Alone: And Other Secrets to Success, One Relationship at a Time, by Keith Ferrazzi and Tahl Raz-Tribes: We Need You to Lead Us, by Seth Godin-The Seven Principles for Making Marriage Work: A Practical Guide from the Country’s Foremost Relationship Expert, by John GottmanLastly, below are links to the interviews Dhru recommends from Dr. Chatterjee’s podcast Feel Better, Live More:-How Our Childhood Shapes Every Aspect of Our Health with Dr. Gabor Mate-Stress - The Health Epidemic of the 21st Century with Dr. Rangan Chatterjee-Uncovering the Real Causes of Depression with Johann Hari Part 1-Uncovering the Real Causes of Depression with Johann Hari Part 2
Our skin is a reflection of what’s going on with our health beneath the surface. Acne and other skin problems are signals that something is off in our body. Conventional medicine deals with symptoms, so their solutions for acne include lathering on potions and lotions, popping and pricking pimples and taking antibiotics or strong liver-damaging medications. There’s got to be another way, right?Fortunately, there is with Functional Medicine, which addresses the problem’s root cause. From this lens, we can understand that numerous factors contribute to acne, including nutrition, stress, toxicity, inflammation and hormonal and gut imbalances. That’s actually good news because it empowers us to make dietary and lifestyle changes that reverse acne and improve our overall health without the adverse side effects of pharmaceuticals and other invasive procedures.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Robin Berzin, the founder and CEO of Parsley Health. A Summa Cum Laude graduate of the University of Pennsylvania, Robin completed medical school at Columbia University’s College of Physicians and Surgeons, and trained in Internal Medicine at Mount Sinai Hospital in New York City. She has also trained in Functional Medicine with the Institute for Functional Medicine. In 2011, she co-founded the physician communication app Cureatr and subsequently has advised numerous startups in the healthcare space. Robin founded Parsley Health in order to make whole-body, transformative medicine accessible to everyone through better services and smart technology. In this episode, Dhru and Dr. Robin Berzin dive deep into the topic of acne. They talk about the gut-skin connection and what role our gut health plays when it comes to acne. They discuss why conventional acne treatments don’t actually work, and often end up doing more harm, and how to treat acne without medication. They also talk about how the cosmetics we use on our skin can increase inflammation which inturn leads to acne, and the best skincare routine and products for someone suffering with acne. In this episode, we dive into:-Dr. Berzin shares her personal struggle with acne (2:09)-The most common underlying causes of acne (5:31)-The connection between gut health and skin issues (15:45) -The problem with topical antibiotics (25:55) -How omega-6 fatty acids may have a direct impact on acne development (27:56)-The connection between hormones and acne (38:55) -How cosmetics and personal care products alter your skin’s microbiota (45:39)-Lab testing for skin issues (58:03)-The problem with food sensitivity testing (1:01:32)-Learn more about Dr. Robin Berzin and her work (1:12:32)For more on Dr. Robin Berzin, be sure to follow her on Instagram @robinberzinmd, on Facebook @robinberzinmd, and on Twitter @robinberzinmd. Learn more about Parsley Health's new LA Flagship at: and their national services at
When you look into just about every health problem that we face in the world today—anxiety, depression, fatigue, digestive problems, hormone imbalances, diabetes, heart disease, or autoimmune conditions—they are all inflammatory in nature or have an inflammatory component. But inflammation starts brewing in the body long before these diseases become noticeable, not to mention diagnosable. By the time a health problem is advanced enough to be officially diagnosed, inflammation has typically already caused significant damage to the body.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Will Cole, a leading Functional Medicine expert who consults people around the world via webcam and locally in Pittsburgh, Pennsylvania. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems. Dr. Cole was named one of the top fifty Functional Medicine and integrative doctors in the nation and is a health expert for mindbodygreen and goop. Dr. Cole is the author of the book, Ketotarian in which he melds the powerful benefits of a ketogenic diet with a plant-based one. His new book, The Inflammation Spectrum, was just released.  In this episode, Dhru and Dr. Will Cole talk about why inflammation plagues so many people and how to create awareness to address this issue. They discuss how inflammation tends to develop in eight primary systems in the body, and how someone can identify where inflammation is rooted in their body and where they are on the inflammation spectrum. They also talk about how to design a personalized food and lifestyle plan to alleviate the effects of inflammation and optimize your health. For more on Dr. Will Cole, be sure to follow him on Instagram @drwillcole, on Facebook @doctorwillcole, on Twitter @drwillcole, and on YouTube @drwillcole. Check out his podcast, The goopFellas, here, and check out his website You can order his new book, The Inflammation Spectrum, right here. Also, below are links to some of Dr. Cole’s favorite interviews from his own podcast The goop Fellas:Being Rob LoweWhy Relationships Fail with Terry RealWhen We Stop Filling The Void with Melissa Hartwig Urban
We are living in the middle of a stress epidemic. The World Health Organization calls stress “the health epidemic of the twenty-first century.” Common complaints such as low libido, anxiety, poor memory, the inability to concentrate, and many gut problems seem completely unrelated, but often have stress as a root cause. The way we’re living our modern lifestyle is causing us a lot of problems. We think we can get away with burning the candle at both ends forever, but the reality is very different.On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Rangan Chatterjee, one of the most influential doctors in the UK who wants to change how medicine will be practiced for years to come. He hosts the biggest health podcast in Europe, Feel Better, Live More, which Apple has announced as one of the most downloaded new podcasts of the past year. He is known for finding the root cause of people's health problems, and he has highlighted his methods in the groundbreaking BBC television show, Doctor in the House, which has been shown in over 70 countries around the world. His first book, How to Make Disease Disappear, is an international bestseller, his most recent book, the #1 bestseller, The Stress Solution, tackles what the WHO calls the health epidemic of our time—stress. Dr. Chatterjee’s mission is to help 100 million people feel fantastic by restoring them to optimal health.In this episode, Dhru and Dr. Chatterjee talk about practical solutions and simple interventions to help you destress and reset your life, and how implementing small changes to your routine can reduce or completely eradicate stress. They discuss the importance of prioritizing regular breaks and setting boundaries around personal time. They also talk about the power of human touch and why scheduling regular time with your family and friends is essential to our health. In this episode, we dive into:-The importance of a morning routine (3:06) -The 3M’s: Mindfulness, Movement, and Mindset (4:40)-Micro and macro stress doses and your personal stress threshold (19:07)-How stress is a key driver in overall blood sugar levels (25:10)-How your environment impacts your health (40:11)-The power of human touch on our health and stress levels (44:37)-The 3D greeting to create meaningful connection (58:52)-The importance of regular downtime (1:08:50)-The framework for finding meaning and purpose in your life (1:14:40)-Learn more about Dr. Rangan Chatterjee and his work (1:42:44)For more on Dr. Rangan Chatterjee, be sure to follow him on Instagram @drchatterjee, on Facebook @drchatterjee, on Twitter @drchatterjeeuk, and on YouTube @drchatterjee. Check out his podcast, Feel Better, Live More, here, and check out his website You can order his new book, The Stress Solution, right here.Also, below are links to the podcast interviews Dr. Chatterjee mentioned in the interview from his own podcast Feel Better, Live More:-How Our Childhood Shapes Every Aspect of Our Health with Dr. Gabor Mate-Stress - The Health Epidemic of the 21st Century with Dr. Rangan Chatterjee-Uncovering the Real Causes of Depression with Johann Hari Part 1-Uncovering the Real Causes of Depression with Johann Hari Part 2
Comments (11)


Didn't want to text you but leaving a comment instead. Enjoyed this content a lot, made a lot of sense, I could relate to it a lot and it helps me look at how I'm doing things, and how I can move myself forward. Being hard on ourselves every day is one area that resonated most, but I can use/work with the other tips also. Thanks!

Jan 7th

Mariam Korea

Absolutely love this podcast series! I learn so much from different professionals in different areas on my drive to school every single day. Dhru is an exceptional host and conversationalist, keeps you interested throughout the entire interview.

Oct 21st

Niclas Daniels

48:40 #supplements for #neuropathy.

Jul 5th

Sanja Lovrečič

Love it!

May 22nd

Randall Wilkinson

had to listen to this one twice

May 20th


Thank you so much for most insightful podcast,first time listener to your podcast which was forwarded by a friend. Presentation on science behind the yoga beautiful connections on how The Practice can change your body on a cellular level. As a Yoga teacher and a Family medicine provider i most definitely interweave both. I did my research and I studied ( and continue to study)along with taking a 200hour class. We all start from somewhere the key is to continue to grow while learning. "I can only bring someone as far as I have gone," Love it! Ericajane

Mar 16th

Jennifer Marie Hancock

I recently asked my Dr to check my hormone levels and, sure enough, everything came back "normal." how does this explain the crazy fatigue I've been experiencing the past year? how do we find drs that specialize in holistic medicine and would health insurance even cover something like that? I have no idea to whom I'm asking these questions, lol, just thinking out loud I suppose.

Jan 16th

Felipe Arenas Ortiz

Great podcast. I love the production, the quality of the questions within the interview and the information it gives us. Thanks!

Dec 3rd

Megan Rose Ryan

First episode I'm listening to from this podcast. Diggin' it! But what's up with the interviewer's mic? The echo makes it a bit hard to understand.

Nov 27th

Tom Bradley

Just ordered the doctors book after listening to this. great episode

Oct 8th


What an exceptional episode. I don't use that term lightly. I work as a personal trainer and am looking at going into medicine. Medicine as I know it has always been traditional, and that made me hesitate pursuing it as a career. As of late, I have come across functional medicine which touches on a lot of what I try to emphasize to my clients: the importance of sleep, stress relief, eating, etc...and how it affects your life. To be able to explain to someone the true science behind why their body responds the way it does is life-changing. Thank you for making this information available. I have now discovered the way to combine two fields I love. Keep the knowledge flowing!

Jun 15th
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