It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration!GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music!Reference: Stoffel NU, Cercamondi CI, Brit...
Alzheimer's Disease and Related Dementias are a terrible disease on individuals, caregivers, and communities. There are no cures. However, new data has come out discussing the risk factors, polypharmacy, and a potential early detection opportunity. It's time to de-prescribe and follow the money.Reference: Nicholas LH, Langa KM, Bynum JPW, Hsu JW. Financial Presentation of Alzheimer Disease and Related Dementias. JAMA Intern Med. 2021;181(2):220–227. doi:10.1001/jamainternmed.2020.6432Maust DT...
More and more vaccines are getting authorization in the United States to prevent COVID-19. However, sometimes a vaccine trial is not always effective. But even failure can provide new insights. Learn about the Janssen COVID-19 vaccine and what happened with the recent Hepatitis C vaccine candidate.This podcast was recorded prior to the joint CDC and FDA statement on the Johnson & Johnson/Janssen COVID-19 vaccine on April 13th. On April 13th, 2021, the CDC and FDA issued a joint statement ...
The battle against the COVID-19 pandemic has continued for over a year. The evidence continues to update and change, and more and more people are becoming vaccinated. This episode provides a review of the newest literature including guidance on vaccinated individuals. But, remember, don't stop wearing a mask now!Reference: Interim Public Health Recommendations for Fully Vaccinated People. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vacc...
Recently the American Gastroenterological Society updated their guidelines for treatment for a true medical emergency: gastric and esophageal bleeding. This episode reviews the guidelines and highlights the importance of several changes to management. Today's episode is sponsored by a special CEimpact FREE Law focused webinar:Make sure to save your spot for FREE LIVE LAW CE April 1st. 7PM. https://ceimpact.com/law Reference: Henry Z, Patel K, Patton H, et al. AGA Clinical Practice Update...
Aspirgillosis is a deadly fungal infection that is a major cause of mortality in patients with impaired immune systems. The current standard of care has been voriconazole due to the favorable side effect profile compared to amphotericin. However, posaconazole may not have there adverse effects and be a reasonable course of therapy. Is voriconazole just just a phase?Today's episode is sponsored by a special CEimpact FREE Law focused webinar: Save your spot - FREE LIVE LAW CEwebinar o...
The recently published STEP trial showed a dramatic effect on weight loss with the weekly injectable semaglutide versus placebo. Lay media picked up the headlines from this potential "GameChanger" medication for weight loss. With this one shot will patient lose themselves?Reference: Wilding J, Batterham R, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. February 10, 2021. DOI: 10.1056/NEJMoa2032183CPE details for GameChangers Podcast March 2021Lea...
The endocannabinoid system is influenced by compounds found the Cannabis genus of plants and involves two compounds: cannabidiol (CBD) and tetrahydrocannabinol (THC). Federal and state regulation is changing, so the medicinal and recreatoinal use of cannabis-related prodcuts continues to increase. Although not life-threatening, some patients may experience Cannabis Hyperemesis Syndrome. Fortunately, a narrative review outlines the causes and treatment to help get out the weeds of treatment.Re...
The recently published (in a pre-print server) COLCORONA study, sponsored by the Montreal Heart institute and conducted in 6 countries aimed to show if using colchicine would decrease risk of hospitalization and death in outpatients with COVID-19. Will it work? How's the study design? Learn the facts.Reference: Tardif J, Bouabdallaoui N, L'Allier P, et al. Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19. Pre-Print. https://www.medrxiv.org/content/10.1101/2021.01.26.21250494v...
The United States Preventative Services Task Force (USPSTF) recommendations for tobacco cessation have been recently updated. While no major changes to pharmacotherapy recommendations are in the new guidelines, the paper does emphasize that all health care providers can work with patients to help them achieve tobacco freedom. Learn how to support patients in your community.Reference: USPSTF Recommendation: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adul...
The National Asthma Education and Prevention Program released the 2020 Asthma Guideline Update in December 2020. This guideline, published in JAMA, is different from the internal Global Initative for Asthma (GINA) guidelines and represents the first update since 2007. Learn about what makes these guidelines unique and how healthcare providers can maintain breaths.This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!Reference: ...
Irritable bowel syndrome is a common disorder that exacts a significant toll on quality of life. For the first time, the American College of Gastroenterology has published guidelines on the diagnosis and treatment for this disorder.This episode is accredited for CPE. Subscribe at CEimpact( https://www.ceimpact.com/pharmacist ) and claim your CE today!Reference: Lacy, Brian E. PhD, MD, FACG1; Pimentel, Mark MD, FACG2; Brenner, Darren M. MD, FACG3; Chey, William D. MD, FACG4; Keefer, Laurie A. ...
Lyme disease is a complex infection and post infection syndrome can lead to serious outcomes, including death. A new guideline was developed for the diagnosis and treatment of this infection. Spoon!This episode is accredited for CPE. Subscribe at CEimpact( https://www.ceimpact.com/pharmacist ) and claim your CE today!Reference: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 202...
In December 2020, the American College of Cardiology published an Expert Consensus Decision Pathway for Antithrombotic Therapy in Patients undergoing Percutaneous Coronary Intervention. This guideline addresses a timely problem of patients on anticoagulation and antiplatelet therapy.This episode is accredited for CPE. Subscribe at CEimpact ( https://www.ceimpact.com/pharmacist ) and claim your CE today!Reference: 2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Th...
The unbelievable happened in 2020 - a vaccine was developed with high efficacy within 12 months for a novel virus! In December two vaccines for the prevention of the SARS-CoV-2 virus were approved through Emergency Use Authorization in the US. Is it time to get a shot?This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!Reference: Polack F, Thomas S, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. ...
Every December, the American Diabetes Association updates the Standards of Medical Care in Diabetes. The guidelines cover sixteen sections from diabetes advocacy to technology updates. Start 2021 off right - learn what changed and what matters most for individuals with diabetes.This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!Reference: American Diabetes Association. Standards of Medical Care in Diabetes - 2021. Diabetes C...
Myopathy is a common reason for discontinuation of statin medications. The recent SAMSON study examined the nocebo effect and how this may bias patients towards treatment failure. How can clinicians overcome the nocebo effect?This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!Reference: Wood F, Howard J, Finegold J, et al. N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects. N Engl J Med 2020; 383:2182-...
The efficacy of antiretroviral therapy has led to persons with HIV living a near-normal lifespan. But medications only work when used appropriately. The International Antiviral Society-USA Panel published updated recommendations for the treatment and prevention of HIV infections. Treatment of HIV may be distilled into a simple idea - two "nucs" and something else. Learn how to optimize care for your patients.This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/p...
Clostridioides difficile is an important cause of morbidity and mortality in the United States with over 500,000 infections annually. The Infectious Disease Society of America released a clinical quality measure focused on treatment of c diff in March 2020. A review of the diagnosis and treatment will help providers improve quality.This episode is accredited for CPE. Subscribe at CEimpact (https://www.ceimpact.com/pharmacist) and claim your CE today!The CE for this episode is supported by an ...
The question of acetaminophen versus ibuprofen may finally be laid to rest. A recent meta-analysis compared the efficacy and safety of ibuprofen versus acetaminophen for the treatment of fever or pain in children younger than 2 years. Is there a drug of choice?Reference: Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. JAMA Netw Open. ...