CannMed Coffee Talk

Kevelin Barbosa-Xavier is a PhD student in Plant Biotechnology at Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF) where she conducts research under the supervision of Thiago Motta Venancio. She is a computational biologist, investigating the genes and gene networks involved in plant secondary metabolic pathways and fiber production, specifically in the Cannabis sativa species. Kevelin and her team recently published a study titled Cannabis Expression Atlas: a comprehensive resource for integrative analysis of Cannabis sativa L. gene expression, along with a free online tool to help researchers analyze genomic sequence data. We discussed: The team’s main objectives in creating the Cannabis Expression Atlas How our understanding of cannabis genomics compares to other commercial crops How gene expression data can advance plant breeding and genetic engineering Potential applications of the Cannabis Expression Atlas in commercial cannabis cultivation and more Thanks to This Episode's Sponsor: Medicinal Genomics Medicinal Genomics (MGC) uses its unmatched knowledge of the cannabis genome and the microbes affecting cannabis plants to create diverse testing solutions that improve crop yield, accelerate breeding programs, and ensure product safety. Growers and breeders use MGC’s cannabis genome sequencing services to identify novel traits, stabilize genetics, and protect intellectual property. Additionally, Kannapedia.net provides bioinformatics and blockchain certification for cultivar authenticity. Learn more at medicinalgenomics.com Additional Resources Cannabis Expression Atlas: a comprehensive resource for integrative analysis of Cannabis sativa L. gene expression Cannabis Expression Atlas Register for CannMed 25 Meet the CannMed 25 Advisory Board Submit Your Abstract for CannMed 25 Review the Podcast CannMed Archive

Laura Barrett, MBA, BSN, RN, known as “Nurse Laura,” is the Founder and Executive Director of the National Clinical Director Consortium and the Owner and Operator of Ask Nurse Laura. She serves on the boards of several non-profits, including the Connor Sheffield Foundation. Nurse Laura is dedicated to educating individuals and groups about cannabis and psychedelic medicine options, whether in small settings or large conference auditoriums.  Additionally, she is part of the teaching faculty at the University of Maryland's School of Pharmacy and New York University's Business School where she teaches multiple courses - including the collaborative development of a psychedelic elective course for the Masters of Cannabis Science and Therapeutics program. She also conducts training sessions with healthcare provider groups and nursing organizations, delving into state-specific regulations, products, and access for providers. Collaborating closely with pharmacists, providers, and fellow nurses in the cannabis industry, Nurse Laura promotes valuable educational resources for healthcare professionals, patients, and dispensary staff. Her mission is to enhance consistency and reliability in the educational opportunities available, specifically in healthcare. Nurse Laura has hands-on experience in various aspects of the cannabis industry, including cultivation, processing, dispensary operations, sales, marketing, and compliance. She emphasizes the importance of understanding laws and regulations, reviewing scientific research, and gathering patient data to create accessible presentations that support public health. Her balanced approach to cannabis and hemp integrates them into a holistic view of wellness.  Nurse Laura stays informed about current research on the medicinal use of cannabis and psychedelics to help patients and her peers assess the benefits and risks unique to everyone. She crafts tailored care plans incorporating well-established practices that she and her industry peers aim to standardize. Beloved by her patients for their improved health and respected by fellow practitioners for her perseverance and dedication, Nurse Laura is committed to advancing the evolving field of plant medicine therapeutics. Laura is currently working with the Connor Sheffield Foundation on an observational research study about the use of cannabis to treat symptoms of Post Traumatic Stress Disorder (PTSD).  During our conversation we discuss:  How cannabinoids affect trauma responses and support cognitive therapy  Details about the research study, including who should participate and how data will be collected  How patients use different routes of administration, cannabinoid ratios, and dosages to manage certain symptoms  The challenges of doing cannabinoid research and the need for standartization across the US  and more  Thanks to This Episode's Sponsor: McKinney RSA McKinney is made up of regulatory science veterans who apply lessons learned in the nicotine space to help cannabis manufacturers better understand the toxicological and societal implications of their product.  They do that by Identifying base compounds, extracts, flavors and terpenes, understanding how they interact, and ensuring effectiveness for the intended use. They also provide dosing recommendations and establish guidelines for product consistency.  Learn more at mckinneyrsa.com  Additional Resources Connor Sheffield Foundation PTSD Research Study Link AskNurseLuara.com National Clinical Director Consortium Cannabinoid modulation of brain activation during volitional regulation of negative affect in trauma-exposed adults Register for CannMed 25 Meet the CannMed 25 Advisory Board Submit Your Abstract for CannMed 25 Review the Podcast CannMed Archive

With a BSc. in molecular biology and an MSc. in physiology, Liz has studied the human body through many lenses. The focus of her PhD program (Pharmacy) is to explore disorders that have directly impacted her life in the world of professional contact sports, and how cannabinoid products could potentially play a role in these.  As a member of the clinical trial team that was recently awarded funding from the NFL to study cannabinoids in concussion and pain, she is excited to bring new data to the literature exploring cannabinoids and athletics. Liz and her team recently published an extensive literature review titled Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real‑World Cannabinoid Applications In Sport, which establishes a foundation for their future research.   During our conversation, we discussed:  How Liz became interested in the therapeutic potential of cannabinoids Published literature that supports using cannabinoids for neuroinflammation and neurodegenerative disorders Her team’s collaboration with the NFL and ongoing clinical trials focused on neuroinflammation and recovery in athletes, particularly after concussions Current use of cannabis in athletics and how sports organizations are changing their policies  Future directions of research  and more  Thanks to This Episode's Sponsor: The DENT Institute With more than 300,000 patient visits per year, the DENT Neurologic Institute ranks among the largest neuroscience centers in North America. Its 24 subspecialty clinics often treat the most challenging neurologic conditions including but not limited to Migraine, Chronic pain, ALS, MS, Parkinson’s, Dementia, and Neuro-Oncology. With their mission of advancing neuroscience, the Dent Institute established a cannabis clinic in 2016 to aid in the treatment of these chronic conditions seen throughout the institute. Learn more at dentinstitute.com Additional Resources Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real‑World Cannabinoid Applications In Sport trainwithmaryjane.com Train with Mary Jane on Instagram Submit Your Abstract for CannMed 25 Review the Podcast CannMed Archive

Megan Mbengue is the revolutionary force behind Trusted Canna Nurse. With over 10 years of nursing experience in diverse fields like oncology, labor delivery, and hospice care, she brings a unique perspective to her practice. She also holds national certifications in three nursing specialties and a Master of Science degree in Medical Cannabis Therapeutics. Codi Peterson is the Chief Science Officer at The Cannigma and a practicing pharmacist with a passion for cannabis-based medicine. Given his diverse pediatric pharmacy experience and knack for educating, he aims to educate as many as possible about the medicinal potential of cannabis Codi and Megan have launched a new IRB-approved survey through the University of California that aims to better understand the signs, symptoms, and challenges of CHS. They want to understand the key indicators of this condition, hear about any remedies that work, and learn more about navigating healthcare as a CHS patient.  If you or someone you know has suffered from CHS (and are over 18), please take a moment to fill out their survey. Not only will you be helping this vital research, but participants will be entered into a drawing to win one of three $100 gift cards. I’ve put a link in the show description so it’s easy to find.  During our conversation, we discuss:  Overview of CHS symptoms   Early Symptoms and the Prodrome Phase  Clinical experiences treating CHS patients  The Potential Causes   Challenges in diagnosing CHS  Treatment and Abstinence from Cannabis  Thanks to This Episode's Sponsor: Trusted Canna Nurse Trusted Canna Nurse was founded by Megan Mbengue and Ariane Williams, two nurses who are dedicated to bridging the gap between traditional medicine and the world of cannabis and psychedelics. They specialize in creating evidence-based treatment plans for all ages that address chronic illnesses, treatment-resistant conditions, mental health, autism, and more.  Learn more at trustedcannanurse.com  Additional Resources Take the CHS Survey! Cannabinoid Hyperemesis Syndrome What You Need to Know [Video] what-is-chs.com Connect with Megan (Instagram, LinkedIn) Connect with Codi (Instagram, LinkedIn) Submit Your Abstract for CannMed 25 Review the Podcast CannMed Archive

Justin Esquivel is CEO & Geneticist, Green Luster Phenos™ and has been an influencer and leader in the cannabis industry for 15 years. Esquivel was the head grower and geneticist of an indoor commercial-scale cultivation operation back in 2012.  Justin has consulted with over 100 cannabis facilities, 72 of which operate commercial canopies.  Esquivel provides home growers with pest and bacteria-resistant genetics in seed and breeders’ cut form on a global scale!  He brings standard operating procedures to a gold standard.  His one-of-a-kind approach to plasticity breeding has sparked tons of interest across the globe.  Esquivel also specializes in Cannabis Tissue Culture & Selective Homozygous Breeding, enabling his company to bring exotic tailored offspring to growers globally!During our conversation, we discuss:  Justin’s background in traditional ag and how that applies to cannabis  How he uses tissue culture to store genetics and eliminate pathogens  The process for creating stable cannabis varieties How purposely introducing pests into the breeding room helps select for resistance traits  The application of analytical tools, such as PCR, HPLC, and marker-assisted breeding  Thanks to this episode’s Sponsor: Rare Earth Genomics.  Rare Earth Genomics is a dynamic partnership formed with Texas A&M AgriLife, one of the world’s leading research institutions, to accelerate hemp research and create tools for farmers. Their mission is to increase the likelihood of a successful harvest for farmers through genetic analysis and rigorous environmental testing of vigorous cultivars.  Learn more at rareearthgenomics.com  Additional Resources:  greenlusterphenos.com Review the Podcast CannMed Archive

Dr. John Streicher is a Professor in the Department of Pharmacology in the College of Medicine at the University of Arizona. He has built a long-term research program focused on finding improved treatments for pain. This has encompassed multiple approaches over the years, including testing cannabinoid and non-cannabinoid constituents of Cannabis sativa, identifying new ways to target opioid receptor signaling, and identifying new receptor targets in the body for pain relief. His lab works on both the basic science knowledge of how these systems work and also works to create new drugs for human therapy. During our conversation, we discussed: The basics of terpenes. What they are and their role in cannabis The cannabimimetic effects of terpenes and their synergistic effects with cannabinoids What levels of terpenes are needed to get a therapeutic effect A recent study showing terpenes can relieve chronic neuropathic pain Combining terpenes with other drugs, such as opioids, to get better pain relief at lower doses Which terpenes provide the best pain relief Thanks to This Episode's Sponsor: Healer Healer is a trusted, physician-developed medicinal cannabis brand founded to address the challenges of helping people and health providers get the best results with safe, reliably dosable products and education on how to best use them. Healer Hemp products are available nationwide and include a step-by-step usage guide and response tracker. Healer’s distinctive product formulations and education are based on the latest research and work of leading cannabis clinician, Dr. Dustin Sulak, D.O. Visit Healer.com or HealerCbd.com Additional Resources: Terpenes are Cannabimimetic and Enhance Cannabinoid Activity Terpenes Relieve Chronic Pain A Review Article of Terpenes in Pain A Screen of Minor Cannabinoids in Pain The University of Arizona Comprehensive Center for Pain and Addiction Review the Podcast CannMed Archive

Dr. Harold Han is Chief Science Officer and co-founder of Vertosa, and the pioneer in water compatible cannabinoid ingredients for infused products. Harold designed the industrial leading cannabis emulsions that are widely applied in the cannabis beverage brands. Harold holds 16 patents in emulsion applications, and prior to founding Vertosa, he led a team that developed the emulsification oil for Bio Rad’s Digital Droplet PCR system. Harold also publishes a regular series explaining the science of cannabis for product makers under the monicker "The Happy Chemist" — a nickname you'll understand after you watch the interview. One of his recent articles describes the different factors that contribute to cannabis beverage potency loss, which is a challenge for beverage brands. In fact, in regulated markets it’s common to see a 10-15% variation in potency compared to the label claim. In unregulated hemp-derived beverages, it can be even higher. During the conversation we discuss The difference between cannabis beverages and alcoholic beverages What happens when cannabinoids oxidize How to put THC into water-based products using physical and chemical processes How every aspect of the supply chain can lead to potency loss in cannabis beverages Which beverage ingredients hasten potency loss How packaging conditions can affect scalping and oxidation rates Thanks to This Episode's Sponsor: Vertosa Vertosa creates industry-leading active ingredients for infused product makers. Their patent-pending nano- and micro-emulsions are carefully designed for the specific needs of each customer, and their pre-suspended aqueous solutions empower them to create incredibly homogenous and stable products while maximizing bioavailability, clarity, and taste. Learn more at Vertosa.com Additional Resources Happy Chemist Article Series The Cannabis Beverage Manufacturing Handbook Review the Podcast CannMed Archive

Dr. Deb Kimless has been in the medical cannabis field since 2013 where her diverse involvement spans many areas including cannabis cultivation, processing, formulation, testing, patient care, and conducting research. She consults within the industry as an advisor for companies who are interested in novel formulations specific to medical conditions, develops protocols, obtains IRB approval, conducts clinical trials, and helps to publish the results. At CannMed 24, Deb presented a poster that shared data from an open-label clinical trial investigating using a cannabinoid-enhanced topical cream for alleviating Restless Leg Syndrome. RLS is condition that affects up to 10% of the US population, including Deb. She found relief using a CBDA-based topical cream and is working with the product manufacturer to conduct clinical trials that demonstrate its effectiveness.  During our conversation, we discuss:  The symptoms of RLS and possible causes  Deb’s own struggles with RLS  Why many conventional and pharmaceutical treatments of RLS fall short  Why CBDA appears to be effective at alleviating RLS symptoms  Why a transdermal approach is better than ingesting or inhaling cannabinoids  Results from the open label clinical trial including some remarkable success stories  Thanks to This Episode's Sponsor: Trusted Canna Nurse Trusted Canna Nurse was founded by Megan Mbengue and Ariane Williams, two nurses who are dedicated to bridging the gap between traditional medicine and the world of cannabis and psychedelics. They specialize in creating evidence-based treatment plans for all ages that address chronic illnesses, treatment-resistant conditions, mental health, autism, and more.  Learn more at trustedcannanurse.com  Additional Resources chylorelief.com - USE CODE "CANNMED20" for 20% OFF! Email Deb - dkimless@gmail.com Review the Podcast CannMed Archive

David Aronson is a cannabis educator who since 2018 has directly educated more than 5,000 health professionals nationwide on the medical applications of cannabis. He is on the faculty for PESI, one of the nation's largest providers of professional continuing education, and he independently provides seminars for health professionals nationwide. I learned during our conversation that David also has post-treatment Lyme disease, which is a condition that causes fatigue, neuropathic pain, brain fog, forgetfulness, and other chronic symptoms that he treats with cannabis. His experience made him curious whether others have found success using cannabis to treat persistent Lyme. He shared his findings at CannMed 24 as a poster presentation and with me in the conversation you are about to hear.  We covered:  What is Lyme disease and how does one acquire it The different stages of Lyme disease  Treatments that are available to treat chronic Lyme disease  How David collected data for his study  Which types of products are effective for chronic Lyme symptoms  and more  Thank You to This Episode's Sponsor: McKinney RSA  McKinney is made up of regulatory science veterans who apply lessons learned in the nicotine space to help cannabis manufacturers better understand the toxicological and societal implications of their product.  They do that by Identifying base compounds, extracts, flavors and terpenes, understanding how they interact, and ensuring effectiveness for the intended use. They also provide dosing recommendations and establish guidelines for product consistency.  Learn more at mckinneyrsa.com  Additional Resources lymedisease.org ilads.org strainprint.ca Review the Podcast! CannMed Archive

Zac has been involved in the cannabis industry since 2005. He has had experience with all kinds of growing environments. From outdoor plots in Northern California to warehouses throughout the United States, his journey has taken him to almost every corner of the country. Zac worked at some of the most reputable supply companies and cultivations before landing his job at BioSafe Systems. He is the National Cannabis Specialist for the company, a position that did not exist before Zac was hired. He has comprehensive knowledge of all aspects of cultivation but specializes in integrated pest management (IPM). He has even written the book “Clean Growing: Integrated Pest Management for Cannabis Growers: The Ultimate Guide to Clean Crops & Safe Cultivation Practices That Protect Growers & Consumers” that is available to growers on Amazon. During our conversation we discuss: How Zac got involved with IPM What is IPM and why it’s important to cannabis growers How cannabis growers can implement IPM into their operations  Common pests and pathogens that cannabis growers are battling  Common mistakes cannabis growers make when it comes to IPM  and more  Thanks to This Episode's Sponsor: Advanced Nutrients Founded in 1999, Advanced Nutrients was the first to develop a complete nutrient system that unlocks the true genetic potential of the cannabis plant. Since its inception, the brand has introduced more than 50 innovations to the cultivation community, and continues to revolutionize the space through proprietary scientific discoveries.  Learn more at advancednutrients.com  Additional Resources Clean Growing: Integrated Pest Management for Cannabis Growers: The Ultimate Guide to Clean Crops & Safe Cultivation Practices That Protect Growers & Consumers Review the Podcast! CannMed Archive

We will be back with new episodes of the CannMed Coffee Talk Podcast next month! Please be patient as we recharge following the CannMed 24 Innovation and Investment Summit, and prepare for next year's event! Be sure to sign up for email alerts at CannMedEvents.com so you will receive notifications when we publish the CannMed 24 oral presentation videos and announce details for CannMed 25!

Dr. Shannon Smith received his PhD in molecular biosciences from Middle Tennessee State University. There his research focused on plant biotechnology, with work in Cannabis, Panax, and Vitis tissue culture and manipulation. This led to the development of new and unique technologies for the production of both plants and secondary metabolites. He later founded Greenway Lab, a plant biotech company that collaborates with agricultural partners to implement plant biotech solutions to botanical challenges facing the modern agricultural industry. During our conversation, we discuss: How recent advances in plant tissue culture can address major problems faced by the Cannabis industry How rapid, reliable propagation of identical daughter plants can be achieved in tissue culture How long-term storage of explant tissues can be used to regenerate whole plants How developments in meristematic tissue culture protocols can eliminate viral contamination of plant tissues And more! Additional Resources Greenwaylab.co dr.smith@gwlabtn.com Medical Cannabis and Industrial Hemp Tissue Culture: Present Status and Future Potential Cryopreservation of 13 Commercial Cannabis sativa Genotypes Using In Vitro Nodal Explants Initiation, growth and cryopreservation of plant cell suspension cultures ELIMINATION OF HOP LATENT VIROID FROM HOP PLANTS BY COLD TREATMENT AND MERISTEM TIP CULTURE Under siege: virus control in plant meristems and progeny

Tim Lefever is the Director of Discovery at Nalu Bio. He is an experienced Director with a demonstrated history of 20+ years of preclinical in vivo research and leading effective teams at organizations such as Canopy Growth and Research Triangle Institute. He has authored or co-authored numerous manuscripts and presented research findings at a variety of scientific conferences over the past 20 years. At CannMed 24, Tim will present "Characterization of Less Studied Cannabis Phytochemicals” which investigates the pharmacological, physicochemical, and basic toxicological characteristics of cannabis phytochemicals. During our conversation, we discuss: How Tim and his team choose which phytochemicals to study What makes the varin cannabinoids particularly interesting The difference between chemically derived compounds vs plant-derived compounds Which phytochemicals show the most promise Modifying phytochemicals to improve their effectiveness Thanks to This Episode's Sponsor: Brains Bioceutical Brains Bioceutical is a global leader in EU-GMP-certified production of naturally-sourced active pharmaceutical ingredients for the pharmaceutical and nutraceutical industries. With a unique suite of licences, Brains Bioceutical is one of the only natural plant-based phytochemical API manufacturers in commercial production today, and is involved in academic and clinical trials across the globe. Learn more at brainsbioceutical.com Additional Resources nalubio.com Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Dr. Kimberly Gwinn is a Professor of Entomology and Plant Pathology at the University of Tennessee. Her lab currently investigates natural products that are produced by plants and microbes and their uses as medicines and as bio-pesticides.  At CannMed 24 she will present Hemp Processing by-products as Biopesticides which describes her team’s work using terpene-rich industrial hemp by-products to control plant diseases and pests.  We discuss:  Why terpenes are effective biopesticides  Which pathogens and pests terepene-rich biopesticide can fight  What are nanaemulsions and why they are important in this application  How this technology can open up a new revenue stream for growers  The regulatory lift for getting biopesticides approved  and more  Thanks to this episode’s Sponsor: Rare Earth Genomics.  Rare Earth Genomics is a dynamic partnership formed with Texas A&M AgriLife, one of the world’s leading research institutions, to accelerate hemp research and create tools for farmers. Their mission is to increase the likelihood of a successful harvest for farmers through genetic analysis and rigorous environmental testing of vigorous cultivars.  learn more at rareearchgenomics.com  Additional Resources Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Megan Mbengue is the revolutionary force behind Trusted Canna Nurse. Recognizing a gap between elderly patients and cannabis, Megan sought to provide that demographic with the extra hand-holding and guidance they need to have the best possible experience. With over a decade of nursing experience in diverse fields like oncology, labor delivery, and hospice care, she brings a unique perspective to her practice. At CannMed 24 Megan will be participating in a Cannabis Nursing Panel and presenting a poster titled “Microdosing Psilocybin for Cannabis Dependency: A Nurse Led Intervention”  During our conversation, we discuss:  The important role nurses play in cannabis medicine How brands can tap into the expertise cannabis nurses have How psilocybin can be used to treat addictive behavior  The results from Trusted Canna Nurses 6-week beta for using psilocybin to treat cannabis dependency  and more  Thanks to This Episode's Sponsor: Trusted Canna Nurse Trusted Canna Nurse was founded by Megan Mbengue and Ariane Williams, two nurses who are dedicated to bridging the gap between traditional medicine and the world of cannabis and psychedelics. They specialize in creating evidence-based treatment plans for all ages that address chronic illnesses, treatment-resistant conditions, mental health, autism, and more.  Learn more at trustedcannanurse.com  Additional Resources Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

TJ Martin is the VP of R&D at Abstrax, a company that specializes in the research, development, and production of botanically derived and cannabis-inspired terpenes.  TJ and his team recently published a paper that identified several non-terpenoid compounds that are responsible for the unique aromas associated with exotic cannabis varieties, including the berry, tropical, candy, and fruity notes found in Zkittlez and Gelato as well as the rich, intense, chemical scents found in GMO. This research opens up a new world of aromatic compounds and challenges the idea of classifying cultivars based on terpenes alone.  We discuss: How cannabis aroma affects consumer and patient experience  The variety of aromas the cannabis plant can produce and how it compares to other plants  Define exotic cannabis varieties and compare them to more prototypical cultivars  Why terpenes alone do not tell the entire aroma story in exotic cannabis varieties  How to communicate information about non-terpeninoid compounds to consumers and patients in a meaningful way  Thanks to This Episode's Sponsor: Agilent Technologies Whether you manufacture or test cannabis, you face the challenge of delivering high-quality products, increasing sample volume, and meeting emerging regulations. Agilent offers best-in-class cannabis and hemp analysis solutions featuring robust instruments, software, services, and consumables. Their team of experts can develop, implement, and optimize methods to get you up and running quickly. Learn more at agilent.com Additional Resources Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis Abstraxtech.com  [Podcast] Discovering New Aromatic Compounds in Cannabis with TJ Martin Cannasulfur Compounds: A New Class of Secondary Metabolites Discovered in Cannabis Cannabis Aroma Predicts User Experience with Adie Rae, PhD The Nose Knows: Aroma, but Not THC Mediates the Subjective Effects of Smoked and Vaporized Cannabis Flower Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Dr. Dustin Sulak is a traditional osteopathic physician and expert in integrative medicine. His clinical practice in Maine focuses on treating refractory conditions in adults and children. Dr. Sulak is an internationally-renowned expert in medical cannabis, the author of Handbook of Cannabis for Clinicians: Principles and Practice, and co-founder of Healer, a medical cannabis education resource and products company. He serves on the board of directors of The Society of Cannabis Clinicians and is a passionate educator and leader in the medical cannabis field. Dustin is also a true CannMed veteran, having participated in every CannMed event dating back to our first conference at Harvard Medical School. He returns to CannMed 24 this year as one of the medical practicum instructors and an oral presenter, presenting “The Art and Science of Combining Cannabinoids for Treatment Success” * We discuss: What attendees can expect from CannMed Medical Practicum The expansion of avialble cannabinoids and how Dustin evaluates new options Which Cannabinoid Dustin would choose if he could only use one to treat patients The difference between acidic and neutral forms of cannabinoids The process for combining cannabinoids Challenging old assumptions about the benefits of combining CBD and THC Thanks to This Episode's Sponsor: Healer Healer is a trusted, physician-developed medical cannabis brand founded to address the challenges of helping patients and health providers get the best results with safe, reliably dosable products and education on how to best use them. Healer’s distinctive product formulations and educational material are based on the work of leading cannabis clinician, Dr. Dustin Sulak, D.O. Learn More at healer.com Additional Resources Healer.com Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Dr. Ethan Russo is a board-certified neurologist, psychopharmacologist, and Founder/CEO of CReDO Science. He is an internationally recognized authority on cannabis medicine. He has authored/edited seven books and has published more than 60 peer-reviewed articles. He also holds director/advisor positions with several cannabis therapeutics companies, and he was instrumental in developing Sativex® for pain and MS, and Epidiolex® for intractable epilepsy while at GW Pharmaceuticals. At CannMed 24, Ethan will present “Cannabinoid Hyperemesis Syndrome (CHS): Unraveling the Gordian Knot”. CHS is an enigmatic condition where some chronic, heavy users of THC develop a cyclic pattern of vomiting and nausea that is only relieved by hot bathing and topical capsaicin. Ethan and his coinvestigators surveyed more than 500 cannabis users, including 205 diagnosed CHS patients, and investigated genetic mutations in 28 CHS patients and 12 controls to identify behaviors and genetic markers that could indicate CHS risk. During our conversation, we discuss:  What is CHS and who does it affect  Why cases of CHS appear to be on the rise  Possible genetic markers that could indicate CHS susceptibility     Steps cannabis users can take to prevent developing CHS  Why some people in the cannabis community don’t believe CHS is a real thing and more  Thanks to This Episode's Sponsor: Cannabis Nurses Network Established in 2015, the Cannabis Nurses Network™ is a professional nursing and professional development organization for nurses around the globe. By educating nurses on the science behind the plant and providing a global nursing network, nurses are supported and empowered to implement their knowledge within their community. Learn more at cannabisnursesnetwork.com Additional Resources what-is-chs.com ethanrusso.org CReDO-science.com Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation Unraveling the Mystery of Cannabinoid Hyperemesis Syndrome - CannMed 2019 Panel Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Akeem Gardner is the Founder and CEO of Canurta. He is an innovative entrepreneur with over five years of experience in industrial hemp enterprises. He has a proven track record in leading high-performance teams that work across multi-channel platforms and strategically aligning profitability with sustainability and economic development in Ontario. At CannMed 24 Akeem will present Effect of Cannflavins on Mitigating a Motor Neuron Disease. During our conversation we discuss: The minor molecules found in cannabis that Canurta is investigating for therapeutics Canurta’s process for evaluating indications for cannflavins and polyphenols How the diverse molecules in cannabis make it a great therapeutic for multifactoral diseases like ALS The potential for cannflavins and polyphenols may be used as a anti-inflammatory nutraceutical and more Thanks to This Episode's Sponsor: American Cannabis Nurses Association ACNA is a national nursing organization whose mission is to advance excellence in cannabis nursing practice through advocacy, collaboration, education, research, and policy development. Founded in 2010, ACNA continues to work on providing its members with up-to-date cannabis information and resources to care for patients who use cannabis. Join them today at cannabisnurses.org and be a part of the change. Additional Resources Akeem on LinkedIn - Email Akeem at Akeem@Canurta.com Canurta Journal Page Register for CannMed 24 What Makes CannMed Unique and Why You Don’t Want to Miss It Review the Podcast! CannMed Archive

Kevin McKernan is the Chief Scientific Officer and Founder of Medicinal Genomics. Kevin has pioneered the genomics of cannabis and hemp to build a stronger scientific environment for the study of cannabis based therapeutics and blockchain technologies for tracking and verifying cannabis genetics. At CannMed 24 he will present “Understanding the Prevalence and Risks Associated with Endotoxins on Cannabis Flower”, which will include novel research he did to measure the level of endotoxins in store-bought cannabis flower. Our conversation covers: What inspired Kevin to look into endotoxin levels on cannabis Which microbes produce endotoxins How endotoxins affect humans Whether remediation techniques mask endotoxin risks and more Thanks to This Episode's Sponsor: Agilent Technologies. Whether you manufacture or test cannabis, you face the challenge of delivering high-quality products, increasing sample volume, and meeting emerging regulations. Agilent offers best-in-class cannabis and hemp analysis solutions featuring robust instruments, software, services, and consumables. Their team of experts can develop, implement, and optimize methods to get you up and running quickly. Learn more at agilent.com Additional Resources High levels of endotoxins in commercial cannabis flower [Pre-Print] Total Yeast and Mold - A Comparison Study - Jini Glaros [CannMed 23 Presentation] What Makes CannMed Unique and Why You Don’t Want to Miss It Register for CannMed 24 Review the Podcast! CannMed Archive