Cautionary Tales with Tim Harford

In 1960, FDA scientist Frances Oldham Kelsey is tasked with approving an application for a mild sedative to be sold in America. The drug is popular across Europe and is touted to be free of side effects, so this should be a routine job. But something doesn't sit right with Frances and she starts digging for evidence to support her suspicions. As the pharmaceutical company pushes for speedy approval, Frances discovers the drug's devastating impact. Katie Hafner, host of The Lost Women of Science podcast, joins Tim to explain why America should remember the woman who kept Thalidomide off the market. To join the brand new Cautionary Club and get access to exclusive episodes and ad-free listening, head to patreon.com/cautionaryclub See omnystudio.com/listener for privacy information.

Do you want more Cautionary Tales episodes in your life? Do you want access to behind the scenes stories and bonus conversations with Tim? Do you want to support us in making the show? We're excited to announce the brand new Cautionary Club on Patreon. Subscribers will gain access to exclusive content every month, including a newsletter uncovering new details behind a recent episode, a conversation between Tim and one of the team, and a full length Cautionary Tale.  The Cautionary Club is also going to be a space where you can discuss episodes with other members, vote for topics you want to hear about, ask questions, and be the first to hear any Cautionary Tales news. Join today at patreon.com/cautionaryclub  Our weekly free episodes of Cautionary Tales will continue to drop every Friday, and, if you are a Pushkin + subscriber, you will continue to gain access to exclusive shows from across the Pushkin network. If you are interested in switching your subscription, or have any questions, please email info@pushkin.fm  To join the club today, head to patreon.com/cautionaryclubSee omnystudio.com/listener for privacy information.

In 1923, legendary navigator Captain Dolly Hunter led a squadron of warships into America’s worst peacetime naval catastrophe. The mission was supposed to be a speed trial, a display of the squadron’s skill. But it ended in a maritime pile-up, with some destroyers stranded on rocks, others sinking fast, and deadly oil leaking into the Pacific Ocean. How?See omnystudio.com/listener for privacy information.

Dore Strauch and Friedrich Ritter make an unconventional couple, united by their contempt for shoes, root vegetables and, above all, society. In 1929 they leave Germany and begin anew on the deserted Galapagos island of Floreana. At first, it feels like a paradise, but soon cracks begin to show. Parasitic fleas, bombastic interlopers, and buried tensions turn their escape into a nightmare. Can they learn to thrive away from civilisation, or will Floreana claim more than their dreams?See omnystudio.com/listener for privacy information.

William McGonagall's poems are something else. The jarring meter, the banal imagery, the awkward rhymes: they made him a laughing stock in 19th Century Scotland and are still derided to this day. How does someone get that bad at poetry? Or have we been misunderstanding McGonagall all along?See omnystudio.com/listener for privacy information.

In the early 90s, cutting-edge advertising agency Chiat/Day announced a radical plan, aimed at giving the company a jolt of creative renewal. They would sweep away corner offices and cubicles and replace them with zany open spaces, as well as innovative portable computers and phones. A brand new era of “hot-desking” had arrived. Problems quickly began. Disgruntled employees found themselves hauling temperamental, clunky laptops and armfuls of paperwork all over the office; some even had to use the trunks of their cars as filing cabinets. Soon, the unhappy nomads had had enough. Bad execution was to blame for the failure of this “playful” workspace. But Chiat/Day had made another mistake here, too – one that was more serious, more fundamental and altogether more common. For a full list of sources for this episode, go to timharford.com.See omnystudio.com/listener for privacy information.

Pepsi twice ended up in court after promotions went disastrously wrong. Other big companies have fallen into the same trap - promising customers rewards so generous that to fulfil the promise might mean corporate bankruptcy.Businesses and customers alike are sometimes blinded by the big numbers in such PR stunts - but it's usually the customers, not the businesses, who end up losing out.For a full list of show notes see http://timharford.com/See omnystudio.com/listener for privacy information.

It's been five years since Cautionary Tales ran a mini-series about the Covid-19 pandemic, exploring the lessons we were learning in real time as the crisis unfolded. 'Fire at The Beverly Hills Supper Club' tells the story of a deadly blaze in a Cincinnati hotel and Tim's own experience reacting to new information about the virus. After the episode, Tim reflects on the anniversary, the cautionary tales the pandemic still had to teach us, and whether we've learned enough to deal with the next one.See omnystudio.com/listener for privacy information.

Lying on the cold metal table, Voyne Ray Cox knew the drill. This was his ninth round of cancer treatment - which is why he was certain that what happened next couldn't be right. He heard a sizzling sound and saw a blue flash. And then - agony. It was like someone had thrust a hot skewer through his shoulder. He cried out in pain, but the operator was down the corridor and she couldn't hear him. She blasted him again and again with the red-hot radiation beam. Ray wasn't the first patient to be burned by the Therac-25 therapy machine, and he wouldn't be the last. Its dual-purpose design, controlled by a software programme, was supposed to offer hospitals more bang for their buck. But as patient after patient suffered ulcerated skin and yawning lesions, it should have been clear that something was horribly wrong. Why did it take so long for anyone to put this awful puzzle together? For a full list of sources, see the show notes at timharford.com.See omnystudio.com/listener for privacy information.

Acclaimed author Michael Lewis discusses his time with Sam Bankman-Fried and why he thinks both high finance and Effective Altruism shaped the 'Crypto King's' worldview, ultimately landing him in jail. Plus, we hear about the people fighting terrorism, cave-ins and brain-eating amoeba from Michael's new book 'Who Is Government?'. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

A radical thought experiment transforms the lives of a new breed of philanthropists, as they follow the logic of altruism to extraordinary lengths. The most famous convert to the Effective Altruism movement, Sam Bankman-Fried, is either a humanitarian hero, a con artist at an astonishing scale, or most bafflingly, both. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

George Price is on a mission to prove that human kindness is real. He's seen the latest research suggesting any altruism is ultimately selfish and finds it deeply depressing. George decides to learn the mathematics he needs to prove that research wrong, and throws his career, and life, into the quest for complete kindness.See omnystudio.com/listener for privacy information.

Steven Spielberg thought his career was finished. He was behind schedule, his actors were fighting, the crew were mutinous and worst of all, his shark was broken. It looked like Jaws was destined for failure, but the movie that came out defined the Hollywood blockbuster. In this special episode celebrating 50 years of Jaws, we take lessons from the greatest monster movie that almost wasn't made. Thanks to Alastair Greig for additional music. For a full list of sources, see the show notes at timharford.com.  See omnystudio.com/listener for privacy information.

The annual Le Mans 24 Hour race brings in hundreds of thousands of spectators to watch the giants of motor racing put their endurance to the ultimate test. Every year, technology improves and the cars get a little faster. In 1955, that push for ultimate speed results in a catastrophe that changes the sport forever. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

Lise Meitner has fought for her entire life to be seen as a scientist, slowly building a career as a nuclear physicist in Berlin. When Adolf Hitler rises to power, the small gains she's made are snatched away. As a Jewish woman, Lise has a critical decision to make: is her passion for science worth her life? An earlier version of this podcast mistakenly gave the wrong date for the bombing of Hiroshima. We apologize for the error. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

Can game theory be used to win a world cup? Can you pay the way out of political corruption? And are there winning strategies in life we don't use because we're too embarrassed? Tim teams up with Nate Silver and Maria Konnikova, poker connoisseurs and the hosts of podcast Risky Business to answer your questions, tackling everything from sports, to tariffs, to the evils of smartphones. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

Sixteen years have passed since Ferdinand De Lesseps' catastrophic failure in Panama and the dramatic collapse of the French Panama Canal company. Now, President Theodore Roosevelt has picked up the task. “No single great material work,” Roosevelt tells Congress, “is of such consequence to the American people.”The Americans have their work cut out. Enter chief engineer John Stevens. How does he spot a problem no-one else has noticed? And what does he do to solve it? For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

Ferdinand De Lesseps, "the Great Frenchman", is convinced that he is the man to build the Panama Canal. No, he isn't an engineer and, no, he's never actually been to Panama before. But he managed to dig the Suez Canal, and everyone said that would be impossible too. How hard can it be? For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

In 1978 the world is on the brink of declaring victory over smallpox. No cases have been seen for months, and it looks like the end for a deadly, painful disease. When a photographer in Birmingham begins to feel ill, doctors are mystified: it looks like smallpox, but how could she have caught it? As they try to contain the outbreak, questions about blame and lab safety erupt in a media frenzy, questions that remain today. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.

In 1900, two friends in the flourishing Arts and Crafts Movement in London share a vision: to print the ultimate edition of the Bible. Together they create The Doves Press, and its unique font, Doves. But in their quest to make something beautiful, the friends spiral towards an act of incredible ugliness. For a full list of sources, see the show notes at timharford.com. Get ad-free episodes, plus an exclusive monthly bonus episode, to Cautionary Tales by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin: pushkin.fm/plusSee omnystudio.com/listener for privacy information.