Discovery

The COP30 climate summit is taking place in the Brazilian city of Belém, a gateway to the Amazon rainforest, which continues to face widespread deforestation. We all know that our climate is changing and that we are largely responsible for this, but we can’t tackle the problem unless we understand what’s going on.One scientist who’s done more than most to rectify this is Professor Pierre Friedlingstein. He’s a prominent climate scientist and Chair in Mathematical Modelling of the Climate System at Exeter University. His models have transformed our understanding of climate change, revealing a complex dynamical system with carbon at its centre, cycling between the atmosphere, oceans and land, to directly influence the level of carbon dioxide in the atmosphere.Pierre is actively involved in assessing the state of our climate through the Intergovernmental Panel on Climate Change and, as director of the Global Carbon Budget, estimates the remaining amount of carbon dioxide that can be emitted before we breach our global climate targets. It’s the ultimate test of effective climate action and the latest annual update will be released at COP.Pierre explains how we can all play our part to reduce carbon emissions, and he practises what he preaches - he won’t be flying to COP this year so as to minimise his own carbon footprint.

Imagine if you were listening to an opera or a Taylor Swift concert, and as the lights in the auditorium dimmed, the music was accompanied by a rainbow of colours only you could see. Perhaps while listening to your friends talking, you simultaneously experience a smorgasbord of tastes, with different words evoking different flavours, maybe a delicious ice cream, or something as disgusting as ear wax... This merging of the senses is known as synaesthesia, and it’s the rich research world of neuropsychologist Professor Julia Simner. Julia runs the Multisense lab at the University of Sussex and has pioneered research into understanding how special brains process our sensory world in special ways. In the studio she tests Jim to see if he might be a synaesthete or have aphantasia, which is the inability to view images in the mind’s eye. The results are surprising. Julia’s discovered links to autism, and to different personality types, as well as a number of previously unknown sensory differences. She describes her career and her life as a series of swerves, or sliding door moments, that have led her to study the subject and the people she’s passionate about. She says that the more she looks for these unusual traits in us the more she finds.

Caroline Smith is passionate about space rocks, whether they’re samples collected from the surface of asteroids and the Moon and hopefully Mars one day soon, or meteorites, those alien rock fragments that have survived their fiery descents through our atmosphere to land here on Earth. She is Head of Collections and Principal Curator of Meteorites at the Natural History Museum, home to one of the finest meteorite collections in the world. Her interest in rocks began while wandering the foothills of the Rocky Mountains, as a child, picking up the ones that caught her eye and bashing them with a hammer, hoping to find treasure inside, whether it’s gold, diamonds or dinosaur fossils. Her work today, studying rocks that have landed here on Earth or those still out there in space, is no less ambitious. She analyses their chemical composition looking for tantalising clues that might reveal how our Solar System formed, and potentially the presence of the chemical building blocks necessary for life itself.

From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen’s University Belfast, Prof. AP (Amilra Prasanna) De Silva’s research into molecular photosensors has led to a pioneering career in that’s evolved from chemistry to medical diagnostics on one hand, to information processing on the other. Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen’s University. Inspired by his grandmother’s struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world. AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They’ve been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons.

In July 1545, King Henry VIII watched from Southsea Castle on England's south coast as his fleet sailed out to face the French - only to witness his prized warship, the Mary Rose, sink before his eyes. Raised from the Solent in 1982, the ship is now the centrepiece of the Mary Rose Museum, along with thousands more artefacts that were recovered from the seabed. But keeping the 500-year-old ship and its associated Tudor relics in good condition is no small task, which is where Dr Eleanor Schofield comes in. As Director of Collections at the Mary Rose Trust and a materials engineer by training, Eleanor has spent years tackling the unique scientific challenges of conserving centuries-old wood and metal. From the United States to Portsmouth, Eleanor's research is helping ensure this iconic vessel remains 'ship-shape' for generations to come. In a special edition of The Life Scientific, recorded in front of an audience at the museum in Portsmouth's Historic Dockyards, Professor Jim Al-Khalili discovers how cutting-edge science is keeping history afloat.

There are problems and tasks so hard and complicated that it would take today’s most powerful supercomputers millions of years to crack them. But in the next decade, we may well have quantum computers which could solve such problems in seconds.Professor Sir Peter Knight is a British pioneer in the realms of quantum optics and quantum information science. During his three decades as a researcher at Imperial College London, he has advanced our understanding of the physics which underpins how quantum computers work.Quantum optics was a new field of physics at the start of Peter Knight’s career in the early 1970s and he tells Jim Al-Khalili about the excitement and opportunities for a young scientist at the birth of a new scientific discipline. He also talks about the UK National Quantum Technologies Programme. Since his retirement in 2010, Peter Knight has been the driving force behind this £1 billion government-funded endeavour which has positioned the UK as a world leader in the development and commercialisation of quantum computing and other revolutionary quantum inventions.

The very latest developments in the world of Earth science with Roland Pease, recorded at the American Geophysical Union (AGU) meeting in New Orleans, where thousands of Earth, atmospheric, glacial, ocean and hydrologic scientists come together to promote discovery in Earth science for the benefit of humanity.Twenty years on, we discuss the enduring lessons from the Hurricane Katrina disaster of 2005, hearing from Lieutenant General Russel Honoré who led the military relief effort, and Roland speaks to Jill Trepanier, hurricane climatologist from Louisiana State University. We also hear about the mouth of the Mississippi River, known as the Bird's Foot Delta, south of New Orleans. Carol Wilson, assistant professor in the Department of Geology and Geophysics at Louisiana State University, tells us how important these wetlands are as storm protections, yet they’re under threat from sea level rise and lack of sediment.Roland takes a look at fifty-thousand-year-old Antarctic ice whilst speaking to Ed Brook, Professor at Oregon State University and director of COLDEX (Center for Oldest Ice Exploration), whose team is searching for ice which is potentially ten million years old. And he speaks to Allison Chartrand, assistant research scientist at the University of Maryland and NASA Goddard Space Flight Center, who has been working to reveal the hidden landscapes of Greenland under the ice. And Bob Hazen, scientist at the Carnegie Science Earth & Planets Laboratory, takes us back to the origins of life on Earth. He is investigating rocks which could be over four billion years old and may contain molecular fragments of ancient life.Presenter: Roland Pease Producer: Jonathan Blackwell

The very latest developments in the world of space science with Roland Pease, recorded at the American Geophysical Union (AGU) meeting in New Orleans, where thousands of space and planetary scientists come together to promote discovery in space science for the benefit of humanity.Roland talks to Andy Rivkin, planetary astronomer at the Johns Hopkins University Applied Physics Laboratory, about planetary defence from asteroids, including the small potential for asteroid 2024 YR4 to hit the moon in 2032.We hear from Craig DeForest, principle investigator for the PUNCH mission (Polarimeter to Unify the Corona and Heliosphere), which is a constellation of four small satellites that aim to learn how the Sun's corona becomes the solar wind. And Lara Waldrop, principle investigator of the Carruthers Geocorona Observatory, discusses the Earth's exosphere which plays an important role in Earth’s response to space weather caused by the Sun.We also talk lunar earthquakes, or moonquakes, and plans to put seismometers on the moon to measure them with Philippe Lognonné, professor at Université Paris Cité and planetary seismologist at Institut de Physique du Globe de Paris, and Ceri Nunn, lunar seismologist from NASA Jet Propulsion Laboratory.Presenter: Roland Pease Producer: Jonathan Blackwell

Quantum theory – our best understanding of the world at the smallest level – is famously weird and notoriously confusing. It’s a theory that seems to say particles can be in two places at once, or somehow “know” if you’re looking at them. Or at least, that’s what you might have heard. But is that really what quantum theory tells us about reality?To find out, presenter Marnie Chesterton travels to the birthplace of quantum theory: the remote, windswept island of Helgoland. Here, a century ago, a young scientist called Werner Heisenberg made a leap of understanding that laid the foundations of quantum mechanics, and changed the world.To mark a century of quantum, leading physicists from across the globe have gathered on Helgoland for a conference, and Marnie joins them with an unconventional plan. She’s allowed to ask them JUST ONE QUESTION, in the hope it can get to the heart of what this strange and difficult subject is really about: “What IS quantum?”Presenter: Marnie Chesterton Producer: Anand Jagatia Editor: Martin Smith Production Co-ordinator: Jazz George

"My ideas are often labelled as impossible, or useless, or both. Usually when people say that I'm on the right track." George Church is a geneticist, molecular engineer, and one of the pioneers of modern genomics. He's also someone who makes a habit of finding solutions to the seemingly impossible. Over the course of his career so far, George developed the first method for direct genomic sequencing, helped initiate the Human Genome Project, and founded the Personal Genome Project: making huge quantities of DNA data publicly available for research. Today, as a professor at Harvard Medical School and MIT, he’s working on some of the most headline-grabbing - and controversial - science on the planet: from the so-called "de-extinction" of woolly mammoths, to growing transplant-suitable organs in pigs, to virus-proofing humans. When inspiration strikes, there seems to be little that will slow him down - even the fact that he has narcolepsy, the neurological disorder that causes sudden sleep attacks. In fact, as George tells Professor Jim Al-Khalili, some of his best ideas come in those moments between waking and sleep...

Movies might have us believe that bomb disposal comes down to cutting the right wire. In fact, explosive devices are complex and varied - and learning how to dispose of them safely involves intense training, as well as the ability to stay calm under pressure. This was the world of Dr Gareth Collett, a retired British Army Brigadier General and engineer, specialising in bomb disposal; whose 32-year military career took him around the world, including heading up major ordnance clearance projects in Iraq and Afghanistan. After retiring from the army, Gareth became a university lecturer – but following his diagnosis with bladder cancer, started researching a possible link between bomb disposal veterans and higher rates of urological cancers. In conversation with Professor Jim Al-Khalili, Gareth discusses this ongoing research, dealing with PTSD - and why he just can't watch Oscar-winning movie The Hurt Locker...

Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the fastest-growing neurological condition in the world. Today it affects around 11.8 million people and that’s forecast to double by 2030. Dr Sonia Gandhi is one of the scientists working to change that trend. As Professor of Neurology at University College London and Assistant Research Director at the Francis Crick Institute, her work involves using stem cells to build models of the human brain, helping to drive the development of drugs and other therapies for Parkinson’s patients. Talking to Professor Jim Al-Khalili, Sonia explains why this destructive condition is on the rise - and the promising routes they're studying to find new ways to tackle it.

How do you feel about snakes? What about highly venomous ones?For Mark O’Shea, close encounters with the world’s most rare and deadly snakes are not only his profession, but his passion. Mark is a Professor of Herpetology - the area of zoology focusing on reptiles and amphibians - at the University of Wolverhampton.After dropping out of college in his teens, Mark's life could have taken a very different direction; but prompted by a fascination with reptiles that started with a childhood trip to the zoo, he's gone on to have a career spanning research, international expeditions and broadcasting. He's also worked with international medical teams, studying deadly species and helping to generate antidotes for some of the world’s deadliest venoms.In conversation with Professor Jim Al-Khalili, Mark reveals the challenges around generating antivenom for countries that need it, the pros and cons of keeping snakes as pets, and what you need to know if you ever get bitten...Presented by Jim Al-Khalili Produced by Lucy Taylor

What’s it like to wake up with a brand new voice? For those with foreign accent syndrome, this is their reality. Patients who develop this rare speech disorder start speaking in a brand new accent that they often have no connection to.So how does losing the voice you’ve known your entire life shape, or break, your identity?Presenter Ella Hubber speaks to Althia Bryden, who developed foreign accent syndrome last year, and Sarah Colwill, who has lived with the condition for the past 15 years. They share the deep impact it has had on their identity and connection to those around them.And to understand what is happening in the brain to cause this complete change in accent, and whether it’s really even an accent at all, Ella speaks to professor Nicholas Miller, who has been unpicking the mystery of foreign accent syndrome for decades. Also, professor Stefanie Keulen shares that there are actually multiple types of the condition.Even though foreign accent syndrome is rare, it is found around the world, can affect anyone, and highlights just how deeply our voices influence all aspects of our lives.Presenter: Ella Hubber Producers: Sophie Ormiston, Ella Hubber Assistant Producer: Minnie Harrop Editor: Martin Smith

We live in a time of automation and robotics; the machines run the factories, and AI will soon take all the jobs. Yet, even today, there are certain niche jobs where only an animal will do. Comedian and biologist Simon Watt meets some of them and the people who train them, study them, and love them. He starts with a business of ferrets (yes, that is their collective noun) at the National Ferret School in Derbyshire, who have swapped rabbit holes and trouser legs for drain-clearing, rewiring, and laying fibre optic cables. Ferret Trainer James McKay demonstrates why they are perfect for the job, as he casually folds one trainee into a tight pretzel.Simon visits the HQ of Medical Detection Dogs, a training facility in Milton Keynes where dogs are being trained to sniff the tell-tale signs of a host of diseases. You may have heard of their 'cancer dogs', but it goes much further - epilepsy, malaria, Parkinson's, even Covid-19. Dr Claire Guest explains.Although we have no real idea exactly how dogs do what they do, AI may be on the cusp of solving this puzzle for us. Simon speaks to Dr Andreas Mershin from start-up Realnose, which is developing “electronic noses".Finally, Simon meets some real heroes - HeroRats, to be precise. Not the same species that haunts our sewers, these are African Giant Pouched Rats, and their job as landmine detection specialists is saving lives across Thailand, Mozambique, Cambodia and Zimbabwe. Dr Cynthia Fast from UCLA trains them for the job.Presenter: Simon Watt Producer: Emily Knight

The London Anatomy Office accepts around 350 human bodies donated for medical research and education annually. You may imagine that these bodies are presevered in chemicals for medical students to study over weeks and months. And some are. But many are used - almost fresh - to train surgeons in the procedures which may one day save your life.Journalist Jenny Kleeman gains rare access to a surgical training course at Brighton and Sussex Medical School which uses these "fresh" donor bodies. She talks to the people who work with them every day and the surgeons who have come to be trained to find out how they feel about the people who have given the ultimate gift and if we still need real human cadavers in medical education.Presenter: Jenny Kleeman Producer: Ella Hubber

There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysics and trauma medicine, to working with NASA, to becoming an Air Ambulance doctor.Kevin is a consultant anaesthetist and professor of public engagement and innovation at University College London. He’s worked on the front line in hospitals, dealing with major incidents and helping shape policy; but he's also stayed true to his childhood passion for space, working on multiple projects with NASA and even going through the astronaut application process himself. As if that wasn’t enough, he’s also become a well-known figure in science broadcasting through his various radio and TV shows.Speaking to Professor Jim Al-Khalili, Kevin admits it hasn't always been an easy path – but his passion for both space and medicine have got him through. And today, he's channelling his energies into ensuring we protect the NHS's most precious commodity: its staff.Presented by Jim Al-Khalili Produced by Lucy Taylor Revised for World Service by Minnie Harrop

Chemical reactions are the backbone of modern society: the energy we use, the medicines we take, our housing materials, even the foods we eat, are created by reacting different substances together. If we zoom in, it’s the atoms within these substances that rearrange themselves to give rise to new substances with the properties we need.However, chemical reactions are far from perfect. They're often inefficient and their waste products can be harmful to the environment. Getting to grips with what goes on at the scale of individual atoms has long been a sticking point.Dame Pratibha Gai has spent much of her career pioneering novel microscopes to bring this seemingly inaccessible atomic world into sharp focus. Now Emeritus Professor of Chemistry at York University, her microscope, known as the environmental transmission electron microscope, is housed in labs around the world. It allows scientists, like herself, to observe chemical reactions in real-time, in exquisite atomic detail, and tinker with them to create products that are not only better for all of us, but also the environment.Presented by Jim Al-Khalili Produced by Beth Eastwood Revised for World Service by Minnie Harrop

Have you ever considered the lighter side of dark matter? Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand.Astrophysicist Catherine Heymans is a Professor at the University of Edinburgh and the current Astronomer Royal for Scotland. She’s spent her career studying dark matter and dark energy: the mysterious ingredients that make up an estimated 95% of our cosmos, but which we still know surprisingly little about. Using increasingly powerful telescopes, both on earth and in space, Catherine has spent years building detailed maps of dark matter - even to the extent of capturing rare images of this mysterious cosmic component.On top of her research achievements, she's committed to making science accessible to all; not least by taking an astronomy-themed comedy show to the Edinburgh Festival and beyond.In conversation with Professor Jim Al-Khalili, Catherine talks about her passion for sharing the joys of astrophysics - and reveals how health challenges over the last few years have forced her to readdress her career, her ambitions and even her sense of self...Presented by Jim Al-Khalili Produced by Lucy Taylor Revised for World Service by Minnie Harrop

As a young man, traveling in Africa, Tim Coulson - now Professor of Zoology at the University of Oxford - became seriously ill with malaria and was told a second bout would probably kill him. Aged only 20, this brush with his own mortality led him to promise himself he would write a complete guide to science: life, the universe and everything. His aim was to understand the existence of all living things - no mean feat!Over the course of a colourful career, Tim's work has taken him all over the world: including researching wolves in Yellowstone National Park, little fish called guppies in the rivers of Trinidad and silvereye birds on Heron Island on the Great Barrier Reef. Using complicated mathematical models he builds up a picture of ecosystems seeking to explain how predators impact both evolution and ecosystems. And finally, more than thirty years after he vowed to write the book that would explain everything we know about science, he's done just that.In conversation with Professor Jim Al-Khalili, Tim talks about his journey from youthful ambition to science demystifier.Presented by Jim Al-Khalili Produced by Geraldine Fitzgerald Revised for World Service by Minnie Harrop