Discovery

What does it take to earn the nickname, ‘The Leonardo da Vinci of heart surgery’?That's the moniker given to today's guest - a man who pioneered high-profile and often controversial procedures, but also helped drive huge medical progress; carrying out around 2,000 heart transplants and 400 dual heart-lung transplants during his 60-year career.Sir Magdi Yacoub is Emeritus Professor of Cardiothoracic Surgery at Imperial College London, and Director of Research at Harefield Hospital’s Magdi Yacoub Institute. Inspired by a surgeon father and impacted by the tragic early death of his aunt from a heart condition, his medical career includes various surgical firsts alongside numerous research projects, to further our understanding of and ability to treat heart disease. He headed up the teams that discovered it is possible to reverse heart failure, and that successfully grew part of a human heart valve from stem cells for the first time.But it hasn't always been plain sailing. At times, his work – such as early, unsuccessful transplant attempts, or using a baboon as a life-support system for a baby – attracted serious public criticism.Speaking to Professor Jim Al-Khalili, Sir Magdi reflects on the highs and lows of his cardio career, and offers his advice to the next generation of surgeons and researchers hoping to make their mark in heart medicine.Presented by Jim Al-Khalili Produced by Lucy Taylor Reversion for World Service by Minnie Harrop

Claudia de Rham has rather an unusual relationship with gravity.While she has spent her career exploring its fundamental nature, much of her free time has involved trying to defy it - from scuba diving in the Indian Ocean to piloting small aircraft over the Canadian waterfalls. Her ultimate ambition was to escape gravity’s clutches altogether and become an astronaut, a dream that was snatched away by an unlikely twist of fate.However, Claudia has no regrets - and says defying gravity for much of her life has helped her to truly understand it.As Professor of theoretical physics at Imperial College London, she now grapples with deep mathematics, where the fields of particle physics, gravity and cosmology intersect, on a quest to understand how the universe really works. She is a pioneer of the theory of massive gravity, a theory which could take us beyond even Einstein’s theory of relativity and shed light on why the universe is expanding at an ever-increasing rate.Presented by Jim Al-Khalili Produced for BBC Studios by Beth Eastwood Reversion for World Service by Minnie Harrop

When you think of Artificial Intelligence, does it inspire confidence, or concern?Although it's now generally accepted that this technology will play a major role in our future, a lot of conversations around AI and machine learning come back to the argument over us losing control and robots taking over.Happily, Neil Lawrence has a more optimistic view of the power of AI, and how we might navigate the potential pitfalls. Neil is the DeepMind Professor of Machine Learning at the University of Cambridge, and over the course of his career has been involved in deploying AI and machine learning in both academic and commercial scenarios, with a stint at Amazon as well as working across fields as varied as movie animation, Formula 1 strategy, and medical research.Speaking with Professor Jim Al-Khalili, Neil says ultimately his efforts are all about making a difference to our everyday lives - and that we need to learn how to embrace AI, albeit with a healthy dollop of scepticism; not least when it comes to how our data is used, and the power of 'the digital oligarchy'...Presented by Jim Al-Khalili Produced for BBC Studios by Lucy Taylor Reversion for World Service by Minnie Harrop

A frozen, white world at the far-reaches of the globe, where you're surrounded by snow and silence, might sound rather appealing. Factor in temperatures that drop to -57°C and a few of us might be put off - but for glaciologist Liz Morris, that's very much her happy place.Liz is an Emeritus Associate at the University of Cambridge’s Scott Polar Research Institute, and was among the first British women scientists to work on the planet’s coldest continent, Antarctica. Over the course of her career, Liz has gathered vital data on polar ice sheets and how they’re affected by climate change. She's also made numerous research trips across the Greenland Ice Shelf, and has a glacier named after her in Antarctica.In conversation with Professor Jim Al-Khalili, Liz discusses her fascination with glaciers and ice - and explains her unwavering determination to break into what was once a heavily male-dominated field.Presented by Jim Al-Khalili Produced for BBC Studios by Lucy Taylor Reversion for World Service by Minnie Harrop

Welcome to a world where medicine meets politics: a space that brings together scientific research, government wrangling, public push-back and healthcare conspiracies…Dr Anthony Fauci was the Director of America’s National Institute of Allergy and Infectious Diseases for nearly four decades, during which time he not only helped study, treat and prevent viruses such as HIV/AIDS and Covid-19; he also advised seven US Presidents, from Ronald Regan through to Joe Biden.Along the way, Tony Fauci's picked up a public profile and taken a fair amount of flack; not least because of his complicated relationship with President Donald Trump. But he's also made great strides in medical research and policy, from working with activists who initially challenged him on the government response to HIV/AIDS - to spearheading the USA's PEPFAR project to share vital medication with developing nations.In a candid conversation with Professor Jim Al-Khalili, Tony discusses his childhood in Brooklyn, the dark early days of the HIV/AIDS epidemic and lessons from the Covid-19.Presented by Jim Al-Khalili Produced for BBC Studios by Lucy Taylor Reversion for World Service by Minnie Harrop

Investigating an insect known for eating its prey alive – including, at times, its own species - the praying mantis! With bulging eyes and a triangular head, this predator uses it specially adapted front legs to trap its prey. Able to predate animals of a size much larger than themselves, including birds, lizards and even fish, presenter Adam Hart hears about their cultural significance to human populations all around the world, as well as addressing their reputation for sexual cannibalism. We also hear about their biomaterial qualities and potential importance in agriculture, and also look into a parasitic relationship the praying mantis has with a worm in South America which has given them the name ‘the mother of snakes’.Contributors:Dr. Julio Rivera, entomologist and researcher at the Université de Montréal in Canada and research associate at the Montréal Insectarium.Dr. Bianca Greyvenstein, postdoctoral fellow at North-West University in Potchefstroom and an expert in the praying mantises of South Africa.Presenter: Professor Adam Hart Producer: Jonathan Blackwell(Photo: Praying Mantis, Credit: Paul Starosta via Getty Images)

Investigating an elusive big cat known for its excellent tree climbing abilities - the leopard! This master of camouflage is found from the south of Africa to the far east of Asia – a spotted predator that stalks and ambushes its prey!Presenter Adam Hart will investigate their relationships with tigers and lions, as well as learning about a recent discovery that leopards each have their own unique roar. He’ll also discuss the future of the Arabian leopard and the potential for a reintroduction to Saudi Arabia, and find out about the role of synthetic fur capes known as ‘Heritage Furs’ in leopard conservation. Contributors:Dr. Gareth Mann, who is based in South Africa, is Leopard Program Director for Panthera, the global wild cat conservation organisation.Dr. Charlotte Searle, postdoctoral researcher and conservationist based in Tanzania, who is associated with the Wildlife Conservation Research Unit at the University of Oxford.Presenter: Professor Adam Hart Producer: Jonathan BlackwellPhoto: Leopard in tree Credit: Valentin Wolf via Getty Images

On this episode of The Evidence, Claudia Hammond discusses all things hydration with a panel of experts. Where do our hydration guidelines come from? How do we determine the perfect amount of water we should drink? What are the issues with water access that people and populations face aroud the globe? And how will climate change affect the amount of water we need, and our access to it. In front of a live audience at the Wellcome Collection in London, Claudia discusses these questions and more with Neil Turner, nephrologist and professor emeritus at Edinburhg University, Yael Velleman, Director of Policy and Innovation at Unlimit Health, working at the intersection of water access, sanitation, and disease; and Anthony Acciavatti, an associate professor at Yale Architecture School and creator of the exhibtion Groundwater Earth: The World Before and After The Tubewell.

Named after a beast from Greek mythology, the harpy eagle is widely considered to be the most powerful bird of prey due to its strong legs and huge talons. With a crown of feathers atop its head, and known for eating monkeys and sloths, this regal-looking raptor dominates the rainforest canopies across much of South and Central America. Presenter Adam Hart looks into the folklore and cultural importance of these imposing birds, as well as finding out why these apex predators of the treetops are having to increasingly search for ground-dwelling prey such as armadillos. He also hears how harpy eagle researchers were the pioneers for biological applications of GPS in order to study and track these animals in the dense rainforest.Contributors:Dr. Helena Aguiar-Silva, biologist and associate research scientist at the National Institute for Amazonian Research and a member of Projeto Harpia Brasil.Dr. Eduardo Alvarez founder of a non-profit organisation called EarthMatters.org, to concentrate on the study and conservation of harpy eagles and to preserve their rainforest habitat.Presenter: Professor Adam Hart Producer: Jonathan BlackwellImage: Harpy eagle and nest with chick Credit: João Marcos Rosa

Investigating the black-and-white apex predator of the sea – the killer whale! Able to predate even great white sharks, this marine mammal is the largest member of the dolphin family. From tropical seas, to the Arctic and Antarctic, killer whales (or orcas) are found across the world. Living in family groups and often led by a post-menopausal matriarch, killer whales have passed on their hunting methods, which vary depending on which prey they specialise in hunting, through the generations.Presenter Adam Hart finds out about the killer whales incredible social behaviours (such as wearing salmon as hats) and hears how a dog is helping killer whale researchers access a gold mine of information about this predator. He also hears what challenges killer whale populations are facing and why killer whales may be attacking boats off the coast of the Iberian peninsula.Contributors:Dr. Leigh Hickmott, whale biologist and conservationist, who is an expert on Pack Ice killer whales, and whose research uses them as indicators to assess human disturbance of marine habitats.Dr. Deborah Giles, who is an expert on Southern Resident killer whales, based with the SeaDoc Society, a program of the Karen C. Drayer Wildlife Health Center at the UC Davis School of Veterinary Medicine.Presenter: Professor Adam Hart Producer: Jonathan Blackwell(Photo: Killer Whales, Credit: Serge MELESAN via Getty Images)

What's it like living underwater for two weeks? What's the trickiest part of training to be an astronaut? What are the most memorable sights you see from space? Several extreme questions, all of which can be answered by one man: Major Tim Peake. After a childhood packed with outdoor adventures, via the Cub Scouts and school Cadet Force, Tim joined the British Army Air Corps and became a military flying instructor then a test pilot; before eventually being selected as a European Space Agency (ESA) astronaut. In 2015, Tim became the first British ESA astronaut to visit the International Space Station. Over the course of a six-month mission, he took part in more than 250 scientific experiments and worked with more than two million schoolchildren across Europe. In a special New Year’s episode recorded in front of an audience at London’s Royal Society, Professor Jim Al-Khalili talks to Tim about his lifelong passion for adventure, the thrill of flight and why scientific experiments in space are so important. Presented by Jim Al-Khalili Produced by Lucy Taylor

What effect will warming temperatures have on health? One place to look for answers is Bulgaria. In the summer of 2023, Bulgaria experienced numerous heatwaves, leading to the country experiencing one of the highest rates of heat mortality in Europe. But how are these numbers calculated? How exactly does heat affect us? Who is most likely to suffer from ill health due to heat? And how can we protect ourselves in an increasingly warming world? Along with a panel of experts, Claudia Hammond will explore these questions and more with a live audience at the Sofia Science Festival in Bulgaria. Are we prepared for how rising temperatures will affect our health? This programme aims to find out.

From growing up in a progressive Denmark to studying mathematics at a gender-segregated Cambridge University, Inge Lehmann had to power through the shock of cultural change to pursue her love of mathematics. Whilst managing several seismological stations, Inge notices the peculiar readings in the data she was collecting. Was the Earth’s composition actually different to what the experts had thought?Dr Julia Ravey and Dr Ella Hubber tell the story of Danish seismologist Inge Lehmann who used earthquakes to uncover the truth about the composition of the Earth’s inner core.Presenters: Ella Hubber and Julia Ravey Guest Speakers: Dr Lif Lund Jacobsen and Dr Trine Dahl-Jensen Producers: Ella Hubber and Julia Ravey Assistant producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound designer: Ella Roberts Production co-ordinator: Ishmael Soriano Editor: Holly Squire (Photo: Inge Lehmann Credit: Neuhaus, Even (6.2.1863-20.4.1946) /Royal Danish Library)

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there’s a lot they don’t know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they’d known about when they were starting out in science. This week, the story of a woman who gained her education by herding sheep during her childhood to becoming one of Africa’s most prominent scientists.Born under Apartheid in South Africa, Tebello Nyokong and her family uprooted their lives to escape the unequal education system enforced upon Black South Africans. After herding sheep proved she could do anything a boy could do, Tebello ended up studying science and found a love for chemistry. In the face of limited opportunities, she once again uprooted her life and took her studies oversees, but this was when she was introduced to something huge: a new, ground-breaking cancer treatment. Now Tebello is using nanotechnology to get this therapy off the ground, all while she fights to make Africa a science superpower.Presenters: Ella Hubber and Julia Ravey Guest Speaker: Professor Tebello Nyokong Producers: Ella Hubber and Julia Ravey Assistant producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire (Image: Professor Tebello Nyokong. Credit: Professor Tebello Nyokong)

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there’s a lot they don’t know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they’d known about when they were starting out in science. This week, a Māori marine scientist is combining indigenous knowledge with marine science to save the oceans that are so integral to her heritage.Growing up in 1970s New Zealand, Kura-Paul Burke faced stigma due to her Māori roots. But, after finding herself studying marine science as an adult, Kura leaned on her heritage to take on a problem where many had already failed: restoring a lost population of precious, green-lipped mussels. Discover how Māori ancestresses, tribal elders and centuries-old knowledge inspired the ingenious methods of Aotearoa's first female Māori professor of marine science.Presenters: Ella Hubber and Julia Ravey Guest Speaker: Dr Kura Paul-Burke Producers: Ella Hubber and Julia Ravey Assistant Producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire(Image: Dr Kura Paul-Burke. Credit: Dr Kura Paul-Burke)

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there’s a lot they don’t know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they’d known about when they were starting out in science. This week, the story of a young PhD student whose discovery of a previously unknown object in the universe won a Nobel Prize...but not for her.On a cold night in 1967, Jocelyn Bell Burnell sits alone in an observatory, reading the data from a radio telescope. As the pattern in the data suddenly changes, she realises she has discovered an entirely new kind of cosmic phenomenon. Uncover her life story, from getting snubbed for the Nobel Prize to paving our knowledge of distant and invisible aspects of the universe.Presenters: Ella Hubber and Julia Ravey Guest Speaker: Professor Dame Jocelyn Bell Burnell Producers: Ella Hubber and Julia Ravey Assistant Producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire (Image: Jocelyn Bell Burnell attends the 2019 Breakthrough Prize at NASA Ames Research Center on November 4, 2018 in Mountain View, California. Credit: Kimberly White/Getty Images for Breakthrough Prize)

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there’s a lot they don’t know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they’d known about when they were starting out in science. This week, a Chinese malariologist who hunted for clues in ancient medical texts to find a cure for one of the world’s deadliest diseases. During a time of global political tension, the Chinese government set up a top-secret project to help communist troops in North Vietnam struggling with malaria. And tasked with this mission was young scientist, Tu Youyou. With a drive to help people after falling ill as a teenager and seeing the horrors of malaria firsthand, Tu turned to traditional Chinese medicine to look for potential treatments. And, after finding a hit, decided she should be the one to trial it... Named as arguably the most important pharmaceutical discovery in the last half-century, winning the 2015 Nobel Prize, discover how one woman used an overlooked herb combined with modern science to ultimately save millions of lives. Presenters: Ella Hubber and Julia Ravey Guest Speaker: Dr Xun Zhou Producers: Ella Hubber and Julia Ravey Assistant Producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire (Image: Chief Professor Tu Youyou, laureate of the Nobel Prize in Physiology or Medicine acknowledges applause after she received her Nobel Prize from King Carl XVI Gustaf of Sweden during the Nobel Prize Awards Ceremony at Concert Hall on December 10, 2015 in Stockholm, Sweden. Credit: Pascal Le Segretain/WireImage via GettyImages)

Dr Julia Ravey and Dr Ella Hubber are both scientists, but it turns out there’s a lot they don’t know about the women that came before them. In Unstoppable, Julia and Ella tell each other the hidden, world-shaping stories of the scientists, engineers and innovators that they wish they’d known about when they were starting out in science. This week, the story of an Indian conservationist who combines stork preservation with female empowerment. On the banks of the Brahmaputra River in the Indian state of Assam, a young Purnima Barman discovers a love of storks whilst singing songs with her farmer grandmother. Fast forward decades later, she has created a community like no other by recruiting an army of over 20,000 village women to bring the Hargila storks from her childhood back from the brink of extinction. With their shared goal of restoring the relationship between the people and the wildlife, discover how Purnima is empowering women in the face of gender inequality. Presenters: Ella Hubber and Julia Ravey Guest Speaker: Dr Purnima Devi Barman Producers: Ella Hubber and Julia Ravey Assistant Producers: Sophie Ormiston, Anna Charalambou and Josie Hardy Sound Designer: Ella Roberts Production Coordinator: Ishmael Soriano Editor: Holly Squire(Image: Purnima Devi Barman. Credit: Purnima Devi Barman)

As the famous frog once said, it's not easy being green. And when it comes to decarbonising industry, indeed, reducing emissions of all sorts, the task is a complex one.Fossil fuels are used to manufacture some of mankind’s most ubiquitous products, from plastics to cement to steel; and even in areas where we’re trying to improve our footprint, there are repercussions. Mining lithium for electric car batteries isn’t exactly without impact. Add to the mix stories of corporations prioritising profits, and governments focusing on short-term popular policies – and it would be easy to feel disheartened.Professor Anna Korre says her role is to be the champion of science in this debate: providing clear evidence to help reduce environmental impacts, while allowing vital production processes to continue.Anna is an environmental engineer at Imperial College London and Co-Director of the university’s Energy Futures Lab. Her work has led to a risk model that's now used in mining operations around the world – and her current research into underground CO2 storage could hold the key to decarbonising British industry. But as she tells Jim Al-Khalili, social and family expectations when she was growing up in her native Greece meant her successful career in engineering very nearly didn't happen...

Rosalie David is a pioneer in the study of ancient Egypt. In the early 1970s, she launched a unique project to study Egyptian mummified bodies using the techniques of modern medicine. Back then, the vast majority of Egyptologists regarded mummies as unimportant sources of information about life in ancient Egypt. Instead they focussed on interpreting hieroglyphic inscriptions, the written record in papyrus documents and archaeological remains and artefacts. Rosalie David proved that the traditionalists were quite wrong.Professor David’s mummy research started at the Manchester Museum when she began to collaborate with radiologists at in Manchester, taking the museum’s mummies for x-rays at the hospital. Her multi-disciplinary team later moved to a dedicated institute at the University of Manchester, the KNH Centre for Biomedical Egyptology. Over the decades, the team there has made remarkable discoveries about disease and medicine in ancient Egyptian society, providing a new perspective on the history of medicine and giving extraordinary insights into the lives of individuals all those years ago.Rosalie tells Jim Al-Khalili about her journey from classics and ancient history to biomedicine, including some of her adventures in Egypt in the 1960s. She talks about some of her most significant research projects, and the 21st Century forensic detective work on the mummy of a young woman which revealed a gruesome murder 3,000 years ago...