In this special EP Edge Journal Watch episode, Dr. Niraj Sharma delivers a critical analysis of the landmark AQUATIC Trial, published in the New England Journal of Medicine (October 2025). This pivotal study explores optimal antithrombotic strategies in patients with atrial fibrillation (AF) and coronary artery disease (CAD) — balancing ischemic protection with bleeding risk.Dr. Sharma dissects trial design, outcomes, and clinical implications, comparing AQUATIC with AUGUSTUS, AFIRE, and AST-Efficient trials, and provides practical insights for real-world decision-making.Stay tuned for concise, evidence-driven interpretation — where every data point translates into better patient care.EP Edge Journal Watch Podcast — From Data to Decision in Cardiac Electrophysiology.
In this episode, Dr. Niraj Sharma breaks down six pivotal studies shaping today’s electrophysiology and cardiology practice—from lifestyle-driven AF control (ARREST-AF) and post-CABG atrial fibrillation management to the DOAC + aspirin conundrum in stable CAD, the return of digitoxin in HFrEF, insights from CABANA-Substudy, and the latest ICD registry data on shock rates.
In this inaugural episode, Dr. Niraj Sharma breaks down three pivotal studies that could shift daily EP practice:How high-normal potassium targeting can reduce VT burden (POT-CAST trial).When GDMT withdrawal may be safe after recovery from tachycardia-induced cardiomyopathy.Why adverse pregnancy outcomes may predict long-term AF risk.Get the signal — not the noise — with expert analysis, clinical context, and practical takeaways for the EP lab.