Evidence-Based GI: An ACG Publication and Podcast

A new monthly publication from the American College of Gastroenterology, Evidence-Based GI (EBGI) uses evidence-based methods to create abstracts and explain study results of new and important articles in the field of gastroenterology and hepatology. Listen as editors of EBGI discuss the articles they review and how the recommendations can be applied to your practice.

Subcutaneous Infliximab for Maintenance of IBD Remission: Added Convenience with Potential for Improved Efficacy?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie S. Al Kazzi, MD, MPH discuss “Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY),” Gastroenterology. 2024;167:919–933.

11-19
19:04

On-Demand Vonoprazan for Non-Erosive Reflux Disease Symptoms: A New Option

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease,” by Fass R, Vaezi M, Sharma P, et al. Aliment Pharmacol Ther. 2023 Nov;58(10):1016-1027.

11-19
14:50

Suboptimal Adherence to Guidelines When Recommending Timing of Repeat Colonoscopy

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret Zhou, MD, MS discuss “Colonoscopy quality measures and adherence to follow-up guidelines among endoscopists participating in a U.S. endoscopy registry,” by Shapiro JA, Holub JL, Dominitz JA R, et al. Gastrointest Endosc. 2024 Aug 5:S0016-5107(24)03404-7.

11-19
15:40

Reintroducing Foods After Completing Restrictive Low FODMAP Diet

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome,” by Van den Houte K, Colomier E, Routhiaux K, et al. Gastroenterology. 2024; 167: 333-42.

11-19
14:56

Quality Indicators for Colonoscopy: New Targets… But Will They Be Measured?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Douglas K. Rex, MD discuss “Quality Indicators for Colonoscopy,” by Rex DK, Anderson JC, Butterly LF, et al. Am J Gastroenterol. 2024;119:1754-80.

10-22
25:00

Decreasing Cirrhosis Risk in MASLD: Don’t Drink Alcohol!

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “Impact of longitudinal alcohol use patterns on long-term risk of cirrhosis among US veterans with steatotic liver disease,” by Wong RJ, Yang Z, Cheung R, et al. Gastroenterology. 2024; 166(6):1156-1165.

10-22
10:33

A PPI a Day Keeps the GI Bleed Away in the ICU

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Stress ulcer prophylaxis during invasive mechanical ventilation,” by Cook D, Deane A, Lauzier F, et al. NEJM. 2024 July 4; 391(1):9-20.

10-22
12:33

A Laser Ruler to Hit the Mark on Polyp Size

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Timothy Yen, MD discuss “Measuring size of colorectal polyps using a virtual scale endoscope or visual assessment: A randomized controlled trial,” by Taghiakbari M, Djinbachian R, Haumesser C, et al. Am J Gastroenterol. 2024 Jul 1;119(7):1309-1317.

10-22
14:22

ACG Guideline on Treatment of Helicobacter pylori: New Recommendations… Will Practice Change?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Colin Howden, MD discuss “ACG Clinical Guideline: Treatment of Helicobacter pylori Infection,” by Chey W, Howden C, Moss S, et al. Am J Gastroenterol. 2024;119:1730-53.

09-17
20:08

Risankizumab is Superior to Placebo for Induction and Maintenance of Moderate-Severe Ulcerative Colitis (UC): Assessing the UC Treatment Paradigm

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Risankizumab for Ulcerative Colitis: Two Randomized Clinical Trials,” by Louis E, Schreiber S, Panaccione R, Bossuyt P, et al for the INSPIRE and COMMAND Study Group. JAMA. 2024 Jul 22:e2412414

09-17
16:38

Standardized Training for Endoscopic Mucosal Resection of Large Polyps: Does it Reduce Recurrence?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial,” by Meulen LWT, Bogie RMM, Siersema PD, et al. Gut. 2024 Apr 5;73(5):741-750

09-17
17:00

Diagnostic Yield of Prolonged Wireless pH vs 24-hour pH-Impedance Monitoring for Evaluation of Chronic Laryngeal Symptoms

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Diagnostic Yield of Ambulatory Reflux Monitoring Systems for Evaluation of Chronic Laryngeal Symptoms,” by Krause AJ, Greytak M, Kaizer MA, et al. Am J Gastroenterol. 2024 Apr 1;119(4):627-634.

09-17
20:12

Risankizumab is Superior to Ustekinumab for Induction and Maintenance of Crohn’s disease: The SEQUENCE Trial

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn's Disease,” by Peyrin-Biroulet L, Chapman JC, Colombel JF, et al. N Engl J Med 2024;391:213-223.

08-20
21:59

Vonoprazan is Efficacious for Non-Erosive Reflux Disease (NERD): An Alternative for PPI-Resistant NERD Patients?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial,” by Laine L, Spechler S, and Yadlapati R et al. Clinical Gastroenterology and Hepatology 2024; In Press.

08-20
12:28

ERCP with Extracorporeal Shock-Wave Lithotripsy for Chronic Pancreatitis: Is It A “Sham” for Improving Pain?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret J. Zhou, MD, MS discuss “Extracorporeal Shock-Wave Lithotripsy and Endoscopy for the Treatment of Pain in Chronic Pancreatitis : A Sham-Controlled, Randomized Trial,” by Talukdar R, Olesen SS, Unnisa M et al. Ann Intern Med 2024 Jun;177(6):749-758.

08-20
11:25

ICYMI: ACG Clinical Guideline on Gastroparesis-Limited Evidence-Based Options

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie Al Kazzi, MD, MPH discuss “ACG Clinical Guideline: Gastroparesis,” by Camilleri M, Kuo B, Nguyen L, et al. Am J Gastroenterol 2022;117(8):1197-1220.

08-20
20:21

Tirzepatide Produces NASH Resolution and Decreases Fibrosis: Results from the SYNERGY-NASH Trial

Philip Schoenfeld, MD, MSEd, MSc (Epi) discusses “Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis,” by Loomba R, Hartman ML, Lawitz EJ, et al. N Engl J Med June 8, 2024.

07-16
10:07

Oral Vonoprazan for Prevention of High-Risk Peptic Ulcer Rebleeding: A Better Alternative than IV PPIs?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Comparison of vonoprazan vs intravenous proton pump inhibitor for prevention of high-risk peptic ulcers rebleeding after successful endoscopic hemostasis: a multicenter randomized noninferiority trial,” by Geeratragool T, Kaosombatwattana U, Boonchote A, et al. Gastroenterology 2024; In Press.

07-16
14:52

Long-Term Efficacy and Safety of Ustekinumab for Ulcerative Colitis: 4-Year Data from the UNIFI Maintenance Study

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Efficacy and safety of ustekinumab for ulcerative colitis through 4 years: final results of the UNIFI long-term maintenance study,” by Afif W, Arasaradnam RP, Abreu MT, Danese S, et al. Am J Gastroenterol 2024 May 1;119(5):910-921.

07-16
13:59

Do Not Extend Interval Between CRC Screening Colonoscopies from 10 to 15 Years: Perils of Administrative Databases

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Longer interval between first colonoscopy with negative findings for colorectal cancer and repeat colonoscopy,” by Liang Q, Mukama T, Sundquist K, et al. JAMA Oncology 2024; In Press.

07-16
13:09

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