Evidence-Based GI: An ACG Publication and Podcast

A new monthly publication from the American College of Gastroenterology, Evidence-Based GI (EBGI) uses evidence-based methods to create abstracts and explain study results of new and important articles in the field of gastroenterology and hepatology. Listen as editors of EBGI discuss the articles they review and how the recommendations can be applied to your practice.

What to expect when expecting with IBD

Associate Editor Elie Al Kazzi, MD, MPH and Vasantham Chaudhary, MD discuss "Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease," by Mahadevan U, Seow CH, Barnes EL, et al. Published in Am J Gastroenterol, August 27, 2025.

11-20
12:40

Surgery in cirrhosis: Strategies for risk stratification and optimization

Leandro Sierra, MD interviews author Zachary Fricker, MD on "ACG Clinical Guideline: Perioperative risk assessment and management in patients with cirrhosis," by Mahmud N, Fricker ZP, McElroy LM, Qayed E, Wong RJ, Ioannou GN. Published in Am J Gastroenterol, 2025;120:1968-1984.

10-02
11:10

Can tacrolimus tame esophageal lichen planus?

Christopher Vélez, MD and Noor Syed, MD discuss "The Efficacy and Safety of Tacrolimus in Reducing Inflammation and Need for Dilation," by Kukreja K, Kumar A, Camisa C, Jacobs J, Richter JE. Published in Clin Transl Gastroenterol, 2024 Dec 1;15(12):e00752.

06-19
08:11

IBD surveillance colonoscopy: to spray or not to spray!

Vasantham Chaudhary, MD and Elie Al Kazzi, MD, MPH discuss "Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy – a multi-arm randomised controlled trial (HELIOS)," by Te Groen M, Wijnands AM, den Broeder N, et al. Published in Gut 2025;75:547-556.

05-21
11:25

Increased ATTENTION to Early Initiation of Antiviral Therapies in Chronic Hepatitis B Based on Viral Load

Leandro Sierra, MD and Joseph Lim, MD discuss "Early antiviral treatment with tenofovir alafenamide to prevent serious clinical adverse events in adults with chronic hepatitis B and moderate or high viraemia (ATTENTION): interim results from a randomised controlled trial,” by Lim Y. S., Yu M. L., Choi J., et al. Published in Lancet Gastroenterol Hepatol 2025; 10(4):295-305.

05-15
12:30

Optimizing Bowel Preparation for Colonoscopy: Insights from the USMSTF Recommendations

Rachael Hagen, MD and Joseph C. Anderson, MD, FACG discuss "Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi-Society Task Force on Colorectal Cancer,” by Jacobson BC, Anderson JC, Burke CA, Dominitz JA, Gross SA, May FP, Patel SG, Shaukat A, Robertson DJ. Published in Am J Gastroenterol. 2025: 120(4):738-764.

04-16
05:56

Tulisokibart, a New Drug for Moderate-to-Severe UC That May Come With Personalized Medicine

Ellen Axenfeld, MD and Elie Al Zazzi, MD, MPH discuss "Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis,” by Sands BE, Feagan BG, Peyrin-Biroulet L, et al and the ARTEMIS-UC Study Group. Published in N Engl J Med. 2024 Sep 26;391(12):1119-1129.

04-16
09:55

Tofacitinib in Acute Severe Ulcerative Colitis (TACOS): A Randomized Controlled Trial

Editor-in-Chief Paul Y. Kwo, MD, FACG and Associate Editor Elie S. Al Kazzi, MD, MPH discuss "Tofacitinib in acute severe ulcerative colitis (TACOS): A randomized controlled trial," by Singh A, Goyal MK, Midha V, et al. Am J Gastroenterol 2024; 119 (7), 1365-1372.

02-26
12:36

Hot Take: Can We Lengthen Surveillance Intervals After EMR With Margin Thermal Ablation?

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence," by O'Sullivan T, Mandarino FV, Gauci JL, et al. Gut. 2024 Dec 10;74(1):67-74.

01-14
10:35

Redefining Risks in CDH1 Hereditary Diffuse Gastric Cancer

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Germline CDH1 variants and lifetime cancer risk,” by Ryan CE, Fasaye G, Gallanis AF, et al. JAMA. 2024;332(9):722–729.

01-14
09:15

The Edge of a New Frontier: Anti-TL1A Monoclonal Antibodies for Ulcerative Colitis

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis,” by Sands BE, Feagan BG, Biroulet LP, et al. N Engl J Med. 2024; 391: 1119-29.

12-11
17:45

Cold vs Hot Snare Resection of Large Polyps: A Cooler, Safer Approach for Large Colorectal Polyps

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Cold Versus Hot Snare Endoscopic Resection of Large Nonpedunculated Colorectal Polyps: Randomized Controlled German CHRONICLE Trial,” by Steinbrück I, Ebigbo A, Kuellmer A, et al. Gastroenterology. 2024 Sep;167(4):764-777

12-11
13:06

Combination Therapy as Primary Prophylaxis for High-Risk Esophageal Varices

Philip Schoenfeld, MD, MSEd, MSc (Epi) discusses “Combination of Carvedilol with Variceal Band Ligation in Prevention of First Variceal Bleed in Child-Turcotte-Pugh B and C Cirrhosis with High-Risk Oesophageal Varices: the ‘CAVARLY’ Trial,” by Tevethia HV, Pande A, Vijayaraghavan R, et al. Gut. 2024; 73: 1844-53.

12-11
13:26

Long Term Efficacy and Safety of Dupilumab for Eosinophilic Esophagitis

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MS discuss “Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial,” by Summarizing Rothenber M, Dellon E, Collins M, et al. Lancet Gastroenterol Hep. 2023; 9: 990-1004

12-11
12:27

Subcutaneous Infliximab for Maintenance of IBD Remission: Added Convenience with Potential for Improved Efficacy?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie S. Al Kazzi, MD, MPH discuss “Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY),” Gastroenterology. 2024;167:919–933.

11-20
19:04

On-Demand Vonoprazan for Non-Erosive Reflux Disease Symptoms: A New Option

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease,” by Fass R, Vaezi M, Sharma P, et al. Aliment Pharmacol Ther. 2023 Nov;58(10):1016-1027.

11-20
14:50

Suboptimal Adherence to Guidelines When Recommending Timing of Repeat Colonoscopy

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret Zhou, MD, MS discuss “Colonoscopy quality measures and adherence to follow-up guidelines among endoscopists participating in a U.S. endoscopy registry,” by Shapiro JA, Holub JL, Dominitz JA R, et al. Gastrointest Endosc. 2024 Aug 5:S0016-5107(24)03404-7.

11-20
15:40

Reintroducing Foods After Completing Restrictive Low FODMAP Diet

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome,” by Van den Houte K, Colomier E, Routhiaux K, et al. Gastroenterology. 2024; 167: 333-42.

11-20
14:56

Quality Indicators for Colonoscopy: New Targets… But Will They Be Measured?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Douglas K. Rex, MD discuss “Quality Indicators for Colonoscopy,” by Rex DK, Anderson JC, Butterly LF, et al. Am J Gastroenterol. 2024;119:1754-80.

10-23
25:00

Decreasing Cirrhosis Risk in MASLD: Don’t Drink Alcohol!

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “Impact of longitudinal alcohol use patterns on long-term risk of cirrhosis among US veterans with steatotic liver disease,” by Wong RJ, Yang Z, Cheung R, et al. Gastroenterology. 2024; 166(6):1156-1165.

10-23
10:33

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