Evidence-Based GI: An ACG Publication and Podcast

A new monthly publication from the American College of Gastroenterology, Evidence-Based GI (EBGI) uses evidence-based methods to create abstracts and explain study results of new and important articles in the field of gastroenterology and hepatology. Listen as editors of EBGI discuss the articles they review and how the recommendations can be applied to your practice.

Budesonide Oral Suspension Improves Outcomes in Eosinophilic Esophagitis

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial,” by Hirano I, Collins MH, Katzka DA, et al. Clin Gastroenterol Hepatol. 2022 Mar;20(3):525-534.e10

05-15
19:10

Multi-Target Stool DNA Test for CRC Screening: How Accurate is the New Version?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Next-generation multitarget stool DNA test for colorectal cancer screening,” by T, Porter K, Zella J, et al. N Engl J Med. 2024; 390: 984-93.

05-15
13:52

Linaclotide Effective for Functional Constipation in 6-17 Year Olds: First FDA-Approved Constipation Treatment for Children

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial,” by Di Lorenzo C, Khlevner J, Rodriguez-Araujo G, et al. Lancet Gastroenterol Hepatol. 2024 Mar;9(3):238-250.

05-15
16:05

PROFILE: Can Molecular Biomarkers Predict Outcomes to Crohn’s Disease Treatment?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial,” by Noor NM et al. Lancet Gastroenterol Hepatol. 2024; 9: 415-27.

05-15
22:09

Cell-free DNA Blood Test for CRC Screening: A Promising Development but Won’t “Eclipse” Current Tools

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening,” by Chung DC, Gray DM, Singh H, et al. N Engl J Med 2024; 390: 973-83.

04-24
16:08

Resmetirom Produces NASH Resolution and Decreases Fibrosis: Results from the MAESTRO-NASH Trial

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “A phase 3, randomized controlled trial of resmetirom in NASH with liver fibrosis,” by Harrison SA, Bedossa P, Guy CD et al. NEJM 2024; 390(6): 497-509.

04-24
16:28

How Effective Are Obesity Medications for Reducing Hepatic Decompensation in NASH?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD discuss “Association of Glucagon-Like Peptide-1 Receptor Agonists with Serious Liver Events among Patients with Type 2 Diabetes Mellitus: A Scandinavian Cohort Study,” Engstom A, Wintzell V, Melbye M, et al. Hepatology 2024; In Press.

04-24
13:44

Ustekinumab and Vedolizumab Demonstrate Safety During Pregnancy: Updates from the PIANO Registry

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Maternal and Neonatal Outcomes in Vedolizumab and Ustekinumab Exposed Pregnancies: Results from the PIANO registry,” by Chugh R, Long MD, Jiang Y, Weaver KN, Beaulieu DB, Scherl EJ, Mahadevan U. Am J Gastroenterol. 2023 Oct 5. Epub ahead of print.

04-24
11:02

ESD vs EMR for Large Non-Pedunculated Colon Polyps: Fewer Recurrences but More Complications

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Endoscopic En Bloc Versus Piecemeal Resection of Large Nonpedunculated Colonic Adenomas: A Randomized Comparative Trial,” by Jacques J, Schaefer M, Wallenhorst T, et al. Ann Intern Med 2024; 177: 29-38.

03-19
14:52

ICYMI: Eating “Healthy” to Minimize Colon Cancer

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Association of Ultra-Processed Food Consumption with Colorectal Cancer Risk Among Men and Women,” by Wang L, Du M, Wang K, et al. BMJ 2022; 378:e068921.

03-19
14:18

When to Discontinue Colorectal Cancer Screening in Older Adults: Chronological Age or Life Expectancy?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Colorectal Cancer Screening Receipt Does Not Differ by 10-Year Mortality Risk among Older Adults,” by Liu PH, Singal AG, Murphy CC. Am J Gastroenterol 2024; 119: 353-63.

03-19
13:21

ICYMI: How Frequently Should We Perform Colonoscopy in Patients with Serrated Polyposis Syndrome?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Timothy Yen, MD discuss “Personalised Surveillance for Serrated Polyposis Syndrome: Results from a Prospective 5-Year International Cohort Study,” by Bleijenberg AG, IJspeert JE, van Herwaarden YJ, et al. Gut 2020; 69: 112-21.

03-19
16:44

Add Prophylactic Pancreatic Duct Stents to Rectal Indomethacin to Minimize Post-ERCP Pancreatitis in High-Risk Patients

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Joseph Elmunzer, MD, MSc discuss “Indomethacin with or without prophylactic pancreatic stent placement to prevent pancreatitis after ERCP: a randomised trial,” by Elmunzer BJ, Foster LD, Serrano J et al. Lancet 2024; 403: 450-58.

02-21
25:38

Non-Erosive GERD Does Not Lead to an Increased Risk of Esophageal Adenocarcinoma

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study,” by Holmberg D, Giola S, von Euler-Chelpin M, et al. BMJ 2023; 382: e076017

02-21
14:39

Making Bowel Preparation Palatable: Efficacy of a Novel Sports Drink Flavor-Optimized PEG and Sulfate Bowel Preparation

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Comparison of a novel, flavor-optimized, polyethylene glycol and sulfate bowel preparation with oral sulfate solution in adults undergoing colonoscopy,” by Summarizing Bhandari R, Goldstein M, Mishkin DS, et al. J Clin Gastroenterol; 2023;57(9):920-927.

02-21
15:32

Continued Treatment With Tirzepatide Is Necessary to Maintain Weight Loss

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD discuss “Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: The SURMOUNT-4 randomized clinical trial,” by Aronne LJ, Horn DB, Bays HE, et al. JAMA 2024; 3310: 38-48.

02-21
13:37

Mirikizumab Is Effective for Induction and Maintenance of Ulcerative Colitis

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis,” by D'Haens G, Dubinsky M, Kobayashi T, et al. N Engl J Med. 2023 Jun 29;388(26):2444-2455.

01-17
11:06

Is Early Ileocecal Resection for Crohn’s Disease An Appropriate Primary Treatment?

Philip Schoenfeld, MD, MSEd, MSc and Bharati Kochar, MD, MS discuss “Early Ileocecal Resection for Crohn’s Disease is Associated with Improved Long-Term Outcomes Compared with Anti-Tumor Necrosis Factor Therapy: A Population-Based Cohort Study,” by Agrawal M, Ebert AC, Poulsen G, et al. Gastroenterology 2023; 165:976-985.

01-17
12:03

Which Endoscopists Benefit from Using Computer-Aided Detection of Polyps During Colonoscopy?

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Endoscopist-Level and Procedure-Level Factors Associated with Increased Adenoma Detection With the Use of a Computer-Aided Detection Device,” by Shaukat A, Lichtenstein DR, Chung DC, et al. Am J Gastroenterol 2023; 118: 1891-94.

01-17
12:56

Post-Colonoscopy Colorectal Cancer Due to Missed Polyps in Proximal Colon or Rectum with Sub-Optimal Bowel Cleansing

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Root-cause Analysis of 762 Danish Post-colonoscopy Colorectal Cancer Patients,” by Troelsen FS, Sørensen HT, Pedersen L, Brix LD, Grode LB, Dekker E, Erichsen R. Clin Gastroenterol Hepatol. 2023 Nov;21(12):3160-3169.e5. Epub 2023 Apr 7.

01-17
14:25

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