Explain Podcast

The open-source DIY Sequencer was here.Update: 454.bio is now dead, but the archives still have it: https://web.archive.org/web/20250723191639/https://454.bio/Their GitHub:https://github.com/454bioElements new VITARI: https://www.elementbiosciences.com/products/preorder-vitari

We have the same thing at home!- yes, but in worse, cheaper or bothQitan:https://pmc.ncbi.nlm.nih.gov/articles/PMC8985760/https://www.qitantech.com/The QPinnacle2: https://www.vcbeathealth.com/article/1821CycloneSEQ, the MGI-internal clone:https://en.cyclone-seq.com/nanopTechhttps://www.prnewswire.com/news-releases/mgi-launches-new-nanopore-sequencing-products-with-advanced-cycloneseq-technology-302241816.htmlhttps://www.biorxiv.org/content/10.1101/2024.08.19.608720v1https://rrwick.github.io/2024/12/17/cycloneseq.htmlhttps://gigabytejournal.com/articles/154https://gigasciencejournal.com/blog/open-cycloneseq-benchmarking-for-complete-bacterial-genomes/Polyseq:https://polyseq.com/Axbio:https://www.axbio.cn/products/45.htmlGeneus-tech:http://www.geneus-tech.com/proddetail.aspx?id=1Nice not up-to-date table of specs:https://github.com/zhangtianyuan666/NanoporeReview2024ONT to double promethion throughput: https://www.genomeweb.com/sequencing/jpm-oxford-nanopore-shares-plans-double-flow-cell-output-expand-menu-biopharma-market

Artificial Intelligence everywhere, and sometimes its useful.Correction: apparently the Biostar Handbook is not free anymore :(AlphaGenome:https://omicsomics.blogspot.com/2026/02/non-coding-dnas-alpha-moment.htmlhttps://www.alphagenomedocs.com/installation.htmlhttps://www.genomeweb.com/informatics/google-alphagenome-users-scrutinize-ai-models-ability-predict-variant-effectshttps://deepmind.google.com/science/alphagenome/Bioinformatics Forums:Bioinformatics mistakes on Biostars: https://www.biostars.org/p/7126/Bioinformatics stackexchange:https://bioinformatics.stackexchange.com/Seqanswers:https://www.seqanswers.com/forum/sequencing-technologies-companiesVibecoding (current setup, top to bottom):https://claude.ai/newhttps://gemini.google.com/apphttps://duck.ai/If danger is something you enjoy, use this: https://openclaw.ai/YOU HAVE BEEN WARNEDPaper about old LLMs that can solve simple, old and solved bioinformatics problems:https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011511Youtube has useful bioinformatics courses:1: https://www.youtube.com/watch?v=3XFpxQF0J74&list=PLWVKUEZ25V95IKyBrxHtRTK_6Ig8Xi9-f2: https://www.youtube.com/watch?v=LvtPXZHNoCc&list=PLeB-Dlq-v6taAXK6ZCGfqImrNWJzFt3p3

When do you get your Illumina sticker for your ONSO? This is the first part of a two-parts news roundup.PacBio News:https://aseq.substack.com/p/pacbio-sells-short-read-tech-to-illuminahttps://www.pacb.com/press_releases/pacbio-completes-sale-of-short-read-sequencing-assets/https://albertvilella.substack.com/p/pacbio-sells-short-read-ip-to-illuminaThe 6-base sequencing run:https://www.pacb.com/wp-content/uploads/PAG-5hmC-Portik.pdfhttps://www.nature.com/articles/s42003-025-07681-0ONT's P2 solo drama:https://omicsomics.blogspot.com/2026/01/p2-solo-ont-extends-support-but-not.html

For when matching and sticking is enough to getLinks:Nice Youtube explainer: https://www.youtube.com/watch?v=NgRfc6atXQ8Another nice one: https://www.youtube.com/watch?v=4bOY2Oh5tEQExplaining this and more: https://berkeleygenomics.org/articles/How_many_human_genomes_have_been_sequenced_.htmlSince 2018, the West German Genome Center (⁠https://wggc.de/⁠) supports research in genomics & transcriptomics by providing expertise and sequencing services. WGGC is a part of the Next Generation Sequencing Competence Network (NGS-CN: ⁠https://ngs-kn.de/⁠) – network of NGS core facilities in Germany. Listen to our podcast and we're happy to receive your feedback&questions via Email (podcast[dot]explain[at]gmail[dot]com ).License NoticeThis podcast including all episodes, unless otherwise noted, is licensed under a ⁠⁠⁠⁠⁠Creative Commons Attribution 4.0 International License⁠⁠⁠⁠⁠.You are free to share, remix, and use this content as long as you give appropriate credit, provide a link to the license, and indicate if changes were made.Attribution:Podcast Title: Explain PodcastCreators: Iuliia Novoselova, Daniel RickertWebsite: ⁠⁠⁠⁠⁠https://ngs-cn.de/explain-podcast/⁠