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Extend Podcast with Darshan Shah, MD
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Extend Podcast with Darshan Shah, MD

Author: Darshan Shah, MD

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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.

Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.

That's why this podcast is all about cutting through the noise on how to turn back the aging clock.
I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.

Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.
44 Episodes
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What if the symptoms you’ve been chalking up to aging, low energy, brain fog, stubborn belly fat, and lack of motivation, were actually signs of a deeper hormonal imbalance?  The truth is, testosterone levels in men have been plummeting for decades, and it’s not just about aging. Environmental toxins, chronic stress, poor sleep, and nutrient deficiencies are creating a perfect storm for hormonal disruption, affecting not only performance but long-term health and longevity. In today’s episode, I sat down with Dr. Tracy Gapin, a board-certified urologist and expert in men’s health optimization, to break down the science of testosterone, hormone balance, and high-performance living. We dive into why traditional medicine is failing men, how environmental toxins are silently crushing testosterone levels across generations, and the critical role of biomarker testing in personalizing health strategies. Dr. Tracy Gapin is a board-certified urologist with 23 years of clinical experience in men's health, functional medicine, and longevity. As the founder of the Gapin Institute and author of Male 2.0, he specializes in precision health, leveraging genetics, epigenetics, and advanced diagnostics to optimize performance and extend healthspan. We Also Discuss:   00:00 - Introduction to Men's Health and Hormones 02:15 - Significance of Testosterone in Men's Health 05:30 - Limitations of Traditional Healthcare in Addressing Men's Health Issues 08:45 - Understanding Underlying Reasons for Health Concerns 12:00 - Comprehensive Biomarker Testing for Health Optimization 15:20 - Impact of Lifestyle Factors (Nutrition, Stress) on Hormone Levels 18:35 - Effects of Environmental Toxins on Testosterone Levels and Overall Health 22:10 - Distinction Between Total Testosterone and Free Testosterone 25:45 - Relevance of Testosterone for Both Men and Women 29:00 - Various Methods of Testosterone Therapy (Injectable, Topical, Pellets) 32:30 - Management and Necessity of Regular Testing in Hormone Therapy 35:50 - Personalized Approaches to Hormone Therapy Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Dr. Tracy Gapin:  Website: https://drtracygapin.com/ https://gapininstitute.com/start-here-gapin/ Instagram: https://www.instagram.com/drtracygapin/   Thank You To Our Sponsors:    Deliverance: Give your liver the care it deserves! Deliverance is a powerful plant-based formula designed to support and restore liver health. Get 10% off your first order with code DRSHAH at loveyourliver.com Timeline: Upgrade your energy from within! Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah
Have you ever wondered why gut health is at the root of everything, from metabolism and cravings to immunity and even mental clarity? Why do some people struggle with weight gain, energy crashes, and digestive issues despite eating well? And could the rise of GLP-1 medications like Ozempic be a sign that we’ve been ignoring a natural solution all along? In today’s episode of Extend, I’m joined by Colleen Cutcliffe, a microbiome scientist and co-founder of Pendulum, a company leading the way in gut health research. She’s here to break down why your microbiome isn’t just about digestion, it plays a critical role in weight regulation, blood sugar balance, and even hormone production. We’ll explore how your gut bacteria influence GLP-1, the hormone behind popular weight loss drugs, and why restoring your microbiome may be the key to naturally optimizing metabolism, reducing cravings, and improving long-term health. If you’ve ever dealt with stubborn weight, gut issues, or unexplained fatigue, this episode will give you science-backed strategies to rebuild your gut health, support natural GLP-1 production, and take control of your metabolism, without relying on injections. Colleen Cutcliffe, PhD, is a biochemist and microbiome researcher with over 20 years of experience in biotechnology and life sciences. She is the CEO and co-founder of Pendulum, a company pioneering next-generation probiotics to optimize metabolic and gut health. We Also Discuss: (00:00) What Is the Microbiome & Why It Matters (14:40) How Your Skin & Oral Microbiome Affect Overall Health (33:48) The Gut-GLP-1 Connection: How Your Microbiome Regulates Metabolism (44:24) How Menopause Transforms Your Gut Microbiome (51:05) The Gut-Brain Connection: How Your Microbiome Produces Neurotransmitters (58:02) How an Unhealthy Microbiome Leads to Disease (01:03:51) How to Improve Your Gut Health With Diet & Testing (01:14:32) The Future of Microbiome Science: Supplements & Targeted Probiotics   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Colleen Cutcliffe:   Website: https://pendulumlife.com/ Instagram: https://www.instagram.com/pendulumlifeco/  Instagram: https://www.instagram.com/drcolleencutcliffe/   Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/
What if everything you’ve been told about nutrition is only half the story? It’s not just about avoiding carbs, counting macros, or following the latest health trend—it’s about how food impacts your metabolism, gut, and long-term health on a deeper level. The problem? Most people are stuck in a cycle of restrictive diets, misinformation, and ultra-processed foods that silently sabotage their well-being. In this episode, I sit down with registered dietitian and longevity expert Ella Davar to break down the science of personalized nutrition. We’ll explore why gut health is the foundation of everything from digestion to mental clarity, how glucose monitoring can help you optimize your diet, and why ultra-processed foods are doing more damage than you realize. Ella shares her journey from Wall Street to wellness and reveals how a bio-individual, data-driven approach to food can help you feel better, think clearer, and age stronger. Ella Davar is a registered dietitian, gut health expert, and longevity advocate specializing in personalized nutrition. She is also the author of The Guide to a Euterian Diet and the founder of The Gut-Brain Method, a program designed to help people harness the power of food to improve cognitive function, energy levels, and longevity. If you’re ready to improve your energy, digestion, and overall health, this episode is for you. Let’s get started. We Also Discuss: (00:38) The Problem with Modern Dieting & Why Most People Struggle (04:18) Why Food Is Medicine & How It Transforms Your Health (09:48) Gut Health 101: The Key to Energy, Mood & Metabolism (16:27) How to Use CGM & Stool Testing for Personalized Nutrition (22:13) The Truth About Ultra-Processed Foods & Their Impact on Health (29:02) Bio-Individuality: Why There’s No One-Size-Fits-All Diet   Thank You To Our Sponsors:  Deliverance: Give your liver the care it deserves! Deliverance is a powerful plant-based formula designed to support and restore liver health. Get 10% off your first order with code DRSHAH at loveyourliver.com Timeline: Upgrade your energy from within! Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn More about Ella Davar: Website: https://www.gutbrainmethod.com/ Instagram: https://www.instagram.com/ella.davar/   
Sleep isn't just about rest, it's a critical pillar of metabolic health, cognitive function, and longevity. In this solo episode of Extend, I dive deep into the science of sleep routines and circadian rhythms. I share how proper sleep habits are foundational to the new healthcare paradigm focused on vitality rather than disease management. I explain that your sleep routine actually begins the moment you wake up and continues throughout your day, not just before bedtime. I also cover relaxation techniques like four-by-four box breathing and supplements that may help sleep quality, though I typically avoid recommending melatonin except for jet lag. Additionally, I address the common issue of nighttime urination disruptions and offer strategies for returning to sleep if you wake up in the middle of the night, including breathwork and non-sleep deep rest protocols. By implementing these evidence-based techniques consistently, you can transform your sleep quality and overall health. If you're struggling with falling asleep, waking up groggy, or insufficient deep sleep, this episode provides a concrete, step-by-step strategy to build a powerful sleep routine that optimizes your health, longevity, and daily performance. I Discuss: 03:40 The genetic factors that determine your natural sleep-wake tendencies 05:54 Morning routine strategies to optimize your circadian rhythm 07:37 Evening wind-down practices 09:09 Lifestyle factors affecting sleep quality 11:34 Supplements for sleep and managing common sleep disruptions 13:14 Breathwork and journaling   Studies Cited: https://academic.oup.com/sleep/article/40/2/zsw048/2662182 https://pubmed.ncbi.nlm.nih.gov/33054339/ Links: https://sleepdoctor.com/sleep-quizzes/chronotype-quiz   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
Have you ever felt like mental health care is stuck in the past? Why are rates of depression, anxiety, and even conditions like autism skyrocketing in today’s world? And why does traditional treatment often fall short? Spoiler: the answer lies deeper than just brain chemistry… it’s all about your metabolic health. In this week’s episode of Extend, I’m joined by Dr. Chris Palmer, a psychiatrist and author of Brain Energy. Together, we’re unraveling the powerful connection between your metabolic health and your brain, exploring how poor nutrition, environmental toxins, and lifestyle choices are driving the modern mental health epidemic. But this isn’t just a conversation about problems, it’s about solutions. Dr. Palmer shares groundbreaking insights into how addressing metabolic dysfunction can lead to dramatic recoveries for people with conditions once thought untreatable, like schizophrenia, bipolar disorder, and severe depression. Dr. Chris Palmer is a Harvard-trained psychiatrist, researcher, and the author of Brain Energy, a groundbreaking book that challenges conventional views on mental health.His work integrates cutting-edge neuroscience with practical, science-backed strategies to heal the brain through nutrition, lifestyle, and metabolic therapies.  If you’re ready to transform the way you think about mental health and learn actionable steps to heal from the inside out, this episode will give you the hope and tools you need. Let’s dive in! We Also Discuss: (00:08) Mental Health Epidemic and Root Causes (16:00) Metabolic Health in Mental Wellness (33:38) Metabolic Health and Neurodevelopmental Disorders (44:46) Holistic Approach to Mental Health (59:26) Lifestyle and Metabolic Health Strategies (01:13:16) Personal Stories of Dietary Transformation (01:24:03) The Power of Metabolic Health   Thank You to Our Sponsors:   TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Dr. Chris Palmer: Website:  https://www.chrispalmermd.com/ Instagram: https://www.instagram.com/chrispalmermd
What if the key to peak performance and longevity isn’t just in your workouts, diet, or sleep, but in how well your body handles stress? Optimizing your health isn’t just about the latest supplements or fitness trends, it’s about understanding your nervous system, heart rate variability (HRV), and how small daily habits shape your resilience over time. Most people try to eliminate stress, but the real goal is building the ability to recover faster and adapt better. In this episode, I sit down with Salim Najjar, an HRV expert and biohacker who took his health to the next level by learning how to regulate his nervous system. We break down why stress is a signal, not a problem, how HRV can predict when your body needs rest before you even feel it, and the most effective ways to improve recovery, sleep, and overall well-being. Salim is a biohacker, entrepreneur, and founder of Sound Beverages, a company focused on functional health drinks. After years of pushing his body with extreme training and biohacking, he discovered the missing piece: HRV as a measure of how well the body adapts to stress. Now, he teaches others how to improve their HRV, manage stress more effectively, and use data to optimize performance and longevity. If you’re looking for real, actionable strategies to train your nervous system, boost recovery, and perform at your best, this episode is for you! Let’s dive in. We Also Discuss: 00:00 - 07:45 — Why HRV Is the Most Important Health Metric 07:46 - 14:30 — The Connection Between Stress, Emotions, and HRV 14:31 - 19:00 — Science-Backed Hacks to Improve HRV 19:01 - 24:30 — The Biggest Mistakes People Make When Trying to Boost HRV 24:31 - 27:30 — Tracking HRV: The Best Wearables and Tools for Accurate Data 27:31 - 30:00 — How to Use HRV Data for Better Performance & Longevity   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn More about Salim Najjar: If you are ready to unlock your body's innate wisdom and tap into the transformative power of HRV, join Salim's mailing list for exclusive early access to his HRV Mastery program below: https://mailchi.mp/thathrvguy/br64h15j2n  Instagram: @thathrvguy Website: www.thathrvguy.com  
If you’re struggling to fall asleep, waking up in the middle of the night, or feeling groggy in the morning, the problem might not be you—it might be your sleep environment. Most people don’t realize just how much their bedroom setup impacts sleep quality. In this episode of Xtend, I’m breaking down exactly how you can optimize your space to promote deep, restorative sleep. Your bedroom should mimic the ideal sleep conditions humans evolved with—a cool, dark, and quiet environment. That's why in today's episode of Extend, I’ll be sharing 10 key changes you can make to transform your sleep environment. Your bedroom should be your sanctuary for sleep, and small changes can lead to huge benefits in energy, focus, and long-term health. Tune in as I share practical, science-backed strategies to optimize your sleep setup so you can wake up truly restored. What's Discussed:  Eliminating light exposure (hint: blackout curtains and sleep masks are game-changers) Removing clocks and charging your phone outside the bedroom Cooling your room to the ideal sleep temperature Decluttering for a stress-free sleep space Using white noise or earplugs to block out disruptions Investing in a supportive mattress and pillow Choosing the right sleepwear and sleep position for optimal rest Addressing snoring and potential sleep apnea risks Creating separate sleep spaces for pets—and maybe even your partner Using sleep tracking tools to measure improvements Learn more about Dr. Shah: Instagram: https://www.instagram.com/darshanshahmd/ Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Products Mentioned: Eight Sleep Cooling Matress Pad: https://www.eightsleep.com/ The Snore Lab App: https://www.snorelab.com/ The Smart Nova Pillow: https://www.smartnora.com/ 
Do you ever feel like your wellness journey is missing something? We often focus on physical health—what we eat, how we exercise—but overlook the powerful role our mind plays in driving true transformation. From reducing stress to optimizing focus, your thoughts and beliefs shape every aspect of your well-being.  The key to lasting change may be closer than you think: it starts in your mind… What if you could reverse your biological age just by changing your mindset? In this episode, Vishen Lakhiani joins me for a powerful conversation about the mind-body connection. We break down how practices like meditation, breathwork, and visualization can unlock your full potential. You’ll learn how these tools improve everything from sleep to energy levels and even cellular health, helping you stay vibrant and strong for years to come. We also discuss the groundbreaking work in personal transformation, including the science behind intuition, the six-phase meditation, and how hyper-personalized wellness is changing the game.  Vishen Lakhiani is a bestselling author, founder of Mindvalley, and a pioneer in personal transformation and wellness. With a mission to elevate human potential, he’s revolutionized how millions approach meditation, intuition, and longevity practices. His latest innovations combine science and spirituality to create accessible, life-changing tools for everyone. This episode will inspire you to rethink your approach to health—and show you how to use your mind to future-proof your body. Don’t miss this! We Also Discuss: (00:02) Personal Development and Wellness Discussion (12:10) Exploring the Power of Intuition (22:06) The Power of Mind-Body Healing (26:27) The Power of Meditation and Mindfulness (39:45) The Code of the Extraordinary Mind (48:09) Personalized Health and Wellness Practices (53:31) Mindfulness, Meditation, Fitness, and Supplementation (58:48) Mastering the Mind for Brain Health   Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Vishen Lakhiani Website: https://www.mindvalley.com/ Instagram: https://www.instagram.com/vishen/
Most people think longevity is about expensive treatments, cutting-edge technology, or the latest supplements. But what if the real key to aging well comes down to something much simpler, understanding your body, making informed choices, and building habits that last?  Healthspan matters more than lifespan, and the small, consistent actions you take today will determine how you feel decades from now. In this episode, I sit down with Julie Gibson Clark, a longevity researcher and biohacker who took her health into her own hands.  We explore how the modern medical system is primarily structured to manage symptoms rather than address root causes, focusing on reactive treatments like pharmaceuticals instead of proactive strategies that could prevent disease in the first place.  We also break down the biochemical impact of food on metabolic health, including how nutrients influence mitochondrial function, inflammation, and insulin sensitivity at a cellular level. Finally, we dive into the science of biological age tracking, how DNA methylation and epigenetic markers reveal the true state of aging, and what you can do to slow (or even reverse) the aging process. Julie is proof that anyone can take control of their health with the right strategies. Her journey led her to become one of the top-ranked individuals on the global longevity leaderboard, showing that aging well isn’t about luck or genetics, it’s about knowledge, consistency, and the willingness to experiment.  We Also Discuss: (00:29 - 01:52) — Why real-life longevity journeys matter (08:00 - 10:00) — The limitations of Western medicine in long-term health (16:16 - 19:31) — How genetics influence aging and why lifestyle changes are key (24:14 - 27:43) — The importance of self-education in health and longevity (30:15 - 34:28) — The "wellness wheel" approach to optimizing health (39:53 - 44:28) — Biomarkers and tracking real progress in aging Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn More about Julie Gibson Clark Website: https://www.juliegibsonclark.com/ Instagram: juliegibsonclark
Sleep isn’t just about rest, it’s a critical pillar of metabolic health, cognitive function, and longevity. Poor sleep quality is linked to increased risks of cardiovascular disease, diabetes, neurodegeneration, and even cancer. In this episode of Extend, I break down how tracking your sleep can uncover hidden disorders, optimize recovery, and improve long-term health. I’ll share my personal struggle with undiagnosed sleep apnea and how data-driven sleep optimization completely transformed my energy, metabolism, and resilience. We’ll discuss the key warning signs of sleep disorders, including excessive daytime fatigue, morning headaches, and snoring, and why conditions like sleep apnea go undetected for years. Understanding sleep quality requires more than just tracking hours slept. I’ll explain the most critical sleep metrics, sleep efficiency, deep and REM sleep cycles, HRV (Heart Rate Variability), and nighttime oxygen levels, and how they reflect nervous system balance and recovery. We’ll also explore cutting-edge sleep tracking tools like Oura, Whoop, and advanced mattress sensors, plus at-home sleep studies for diagnosing apnea risk. If you’re serious about health and longevity, sleep tracking is non-negotiable… Tune in to learn how to upgrade your sleep and unlock peak performance! I Also Discuss: (00:19) Unlocking Better Health Through Sleep Monitoring (05:23) Snoring vs. Sleep Apnea: How to Identify the Warning Signs (07:27) The Best Sleep Trackers and What Your Data Actually Means (09:09) Key Sleep Metrics: Sleep Stages, HRV, and Sleep Efficiency Explained (11:39) Unlocking Your Highest Sleep Potential   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
Most of us think hitting the gym a few times a week is enough—but what about the other 23 hours of your day? Your daily habits could be silently limiting your mobility and longevity without you even realizing it. In this episode of Extend, I sit down with Kelly and Juliet Starrett, bestselling authors of Built to Move and pioneers in the world of mobility and movement. We break down why small, everyday actions—like how you stand, sit, and breathe—are more important for your health than chasing big fitness milestones. You’ll learn why mobility is a critical biomarker of longevity, how walking is your ultimate low-tech health hack, and why simple assessments (like the sit-and-rise test) can reveal more about your future health than you might think. The Starretts also share actionable tips to counteract “tech neck,” build joint resilience, and integrate mobility work into your daily life without it feeling like a chore. Kelly and Juliet Starrett are the co-founders of The Ready State and are globally recognized for their work in improving human performance and movement. Their latest book, Built to Move, is a guide to sustainable fitness and pain-free living—no matter your age or fitness level. If you’re ready to rethink what it means to stay active and build a body that thrives for decades, this episode is for you. We Also Discuss: (00:02) The Importance of Mobility and Movement (12:19) Reviving Movement Through Playful Context (27:27) Transforming Movement Culture in Education (38:15) The Importance of Walking for Health (01:00:22) Understanding Movement Deficits and Solutions (01:21:51) The Importance of Breathing Mechanics (01:34:00) Creating a Daily Mobility Routine (01:48:18) Incorporating Balance and Rest for Health Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Kelly and Juliet Starrett :    Website: https://thereadystate.com/  Instagram: https://www.instagram.com/julietstarrett/?hl=en  Instagram: https://www.instagram.com/thereadystate/?hl=en    Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/
How often do you find yourself struggling with cravings, feeling like your hunger is out of control, or wondering why weight loss feels impossible? The truth is, your gut is running the show, specifically, a powerful hormone called GLP-1 that regulates appetite, metabolism, and even inflammation. And the secret to boosting it naturally? Bitterness. In this episode of Extend, I sit down with Dr. Ed Walker, a leading researcher in translational medicine, to break down how bitter compounds, used for centuries in traditional medicine, can help regulate hunger, control glucose levels, and support long-term weight management.  Together we’ll explore the groundbreaking science behind gut hormone therapies, the connection between GLP-1 and cognitive performance, and why modern diets are disrupting our natural appetite signals. If you’re looking for sustainable, science-backed ways to improve your metabolism, curb cravings, and optimize your health, without relying on extreme diets or pharmaceuticals, this episode is for you! Dr. Ed Walker is a PhD researcher at the New Zealand Institute of Plant and Food Research, where he specializes in using plant-based compounds for chronic disease prevention. His work led to the discovery of Amarasate, a natural dietary supplement designed to enhance appetite regulation and metabolic health.   We Also Discuss: (00:00 - 09:44) Bitterness & Appetite Regulation (24:57 - 38:18) Boosting GLP-1 Naturally (44:05 - 50:19) Discovering & Testing GLP-1 Triggers (50:19 - 59:40) Amarasate: A Natural GLP-1 Booster Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn More about Dr. Ed Walker Website: https://www.calocurb.com/ Instagram: @calocurb   
You hit the gym, push your limits, and stay consistent, but if you’re skipping recovery, you’re actually holding yourself back. Overtraining doesn’t just slow muscle growth; it ramps up inflammation, messes with your metabolism, and puts unnecessary stress on your heart.  In today’s episode of Extend, I’m breaking down why recovery is the missing piece in your fitness routine. We’ll cover how overtraining wrecks your hormones, metabolism, and nervous system (and how to fix it), the science-backed “sweet spot” for exercise frequency that maximizes gains without burnout, seven next-level recovery strategies, like breathwork, sauna therapy, and sleep tracking, to speed up muscle repair and prevent injury, and why tracking HRV (Heart Rate Variability) and HRR (Heart Rate Recovery) can help you gauge whether you’re actually recovering or just digging yourself into a hole.  If you’re constantly sore, exhausted, or stuck in a plateau, this episode is for you! More workouts aren’t the answer, better recovery is. Tune in now to level up your training, recover faster, and stay strong for life. I also discuss: (00:03) Optimizing Fitness Recovery Protocols (04:56) The Science of Overtraining & Performance Plateaus (07:19) Cold Plunges, Sauna & Advanced Recovery Hacks (10:15) Maximizing Fitness Recovery Strategies (00:03) Optimizing Fitness Recovery Protocols (10:15) Maximizing Fitness Recovery Strategies Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
How many nights have you told yourself you’ll catch up on sleep later? You push through exhaustion, thinking it’s just part of life. But here’s the truth: chronic sleep deprivation isn’t just making you tired—it’s rewiring your brain, disrupting your hormones, and holding you back from living your best life. In this episode of Extend, I sit down with sleep expert Dr. Matt Walker to dive into why sleep is the ultimate game changer for your health. We unpack how poor sleep impacts everything from your memory to your metabolism and share science-backed tips to improve your sleep quality without overhauling your entire routine. If you’re ready to stop running on empty and start waking up energized and focused, this conversation is for you. It’s not about perfection—it’s about making small changes that lead to big transformations.  Dr. Matt Walker is a renowned neuroscientist and sleep expert dedicated to unraveling the mysteries of sleep and its profound impact on mental and physical health. As a bestselling author and host of The Matt Walker Podcast, he’s known for making complex science accessible and inspiring people to prioritize rest.    We Also Discuss: (00:00) The Importance of Good Sleep (12:33) Optimizing Sleep With Technology (25:08) The Incredible Impact of Sleep (40:49) Understanding the Impact of Caffeine (45:32) The Truth About Coffee and Alcohol (57:21) CBD and THC for Sleep (01:09:04) Detecting and Treating Sleep Apnea (01:22:16) Improving Sleep Through Environment and Routine (01:36:15) Fostering Innovation in Sleep Science Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn More about Matt Walker:   Website: https://www.sleepdiplomat.com/  Instagram: https://www.instagram.com/drmattwalker
What’s the point of living longer if you’re stiff, in pain, or struggling to stay independent? Mobility isn’t just about stretching, it’s about keeping your joints fluid, your muscles strong, and your balance sharp so you can move with ease at any age. In today’s episode of Extend, I’m breaking down why mobility is the most overlooked pillar of longevity and how you can start improving yours right now. We’ll cover why mobility declines with age (and how to stop it), the five simple at-home tests that reveal how well your body moves, and how sitting too much is silently wrecking your joints and metabolism. I’ll also explain why exercise snacks, quick bursts of movement, can make a huge difference, and why traditional workouts aren’t enough if you want to stay agile for life. Plus, I’ll share my personal mobility routine, including the one-minute test I do every morning and the simple habit—yes, even brushing your teeth—that can help prevent falls, injuries, and stiffness as you age. Your mobility is 100% trainable, and it’s never too late to start. Tune in now and learn how to future-proof your movement for decades to come! I also discuss: (00:21) - Why Mobility Is the Missing Piece in Longevity (05:44) - 5 Simple Tests to Measure Your Mobility (10:36) - How Sitting Too Much Wrecks Your Joints & Balance (16:16) - The Key to Maintaining Mobility for Life Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
How often do you reach for a sugary snack, telling yourself it’s just a small indulgence? Or justify skipping your morning walk because you’re "too busy"? Here’s the truth: your daily habits are either fueling your longevity or quietly sabotaging it. In this episode of Extend, I sit down with Dr. David Perlmutter, a neurologist and five-time New York Times bestselling author known for his groundbreaking work on brain health, inflammation, and metabolic resilience. We dig deep into the connection between blood sugar, brain aging, and chronic disease—and how small, intentional lifestyle changes can make a massive difference in your long-term vitality. You’ll learn how excess glucose can erode your cognitive function and why uric acid—a molecule most of us ignore—may be the key to unlocking better metabolic health. We also share practical tips to curb cravings, improve your sleep, and enhance your focus by rebalancing your diet and mindset. Dr. David Perlmutter is a board-certified neurologist, researcher, and advocate for lifestyle interventions that promote cognitive health and resilience. He is the author of bestselling books like Grain Brain and Drop Acid, and he continues to inspire millions with his work on the gut-brain connection.   We Also Discuss: (00:00) Connecting Through Conversation and Brain Health Foundations (04:40) Evolutionary Biology’s Role in Brain Health (14:21) Neurology Meets Functional Medicine (25:52) Metabolic Health and Its Impact on Brain Wellness (41:28) The Gut-Brain Connection Explained (56:09) Understanding Brain Disease Through Metabolic Health (01:03:34) Exercise as a Pillar for Brain Health (01:23:23) Nutrition, Lifestyle, and the Future of Brain Care Thank You to Our Sponsors:  TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Dr. David Perlmutter:   Website: https://drperlmutter.com/  Instagram: https://www.instagram.com/davidperlmutter
Title: Dr. Mindy Pelz: The Metabolic Reset Every Woman Needs Your hormones deserve better care—and you do too. So many women feel stuck when it comes to their health—frustrated by unexplained weight gain, unpredictable mood swings, and low energy that no diet or workout seems to fix. The truth is, our healthcare system was built around research that overlooked the female body’s complexity. But the great news? There’s a way to support your body that works with your biology, not against it. In today’s episode of Extend, I’m diving into how you can break free from metabolic imbalances and reclaim your energy with the right strategies for fasting, nutrition, and movement. You’ll learn why women experience hormonal chaos during perimenopause and menopause—and how understanding your body’s natural rhythm can make all the difference. I’ll also uncover the truth about hidden disruptors in your food and environment, like obesogens and toxins, and how they affect your ability to lose weight and stay healthy. Plus, I’ll share game-changing insights on building strength, improving bone health, and balancing your hormones through strategic lifestyle changes. Joining me is Dr. Mindy Pelz, a pioneer in women’s health and the bestselling author of Eat Like a Girl. Dr. Mindy’s groundbreaking work has empowered thousands of women to embrace fasting, rethink their nutrition, and overcome hormonal imbalances. As the host of The Resetter Podcast, she’s built a global community dedicated to helping women live vibrant, resilient lives. This conversation will open your eyes to what’s possible when you tune into your body’s innate intelligence—you won’t want to miss it! We Also Discuss: (00:00) Women's Health Disparities in Medicine (14:06) Medical Paradigm Shift Towards Individualized Care (21:28) Exploring Fasting and Metabolic Health (33:00) The Truth About Obesogens and Toxins (45:00) The Power of Strength Training and Movement (01:12:00) Reclaiming Balance: Key Lifestyle Shifts for Hormonal Health   Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Dr. Mindy Pelz   Website: https://drmindypelz.com/ Instagram: https://www.instagram.com/dr.mindypelz
In today’s episode of Extend, I’m diving into one of the most powerful and underutilized tools for your health and longevity: strength training. Whether you’re a gym regular or just getting started, this episode will break down the science and practical strategies you need to transform your fitness routine. Together, we’ll explore the four essential pillars of strength training: building and preserving muscle as you age, how your muscles directly impact your metabolism, the surprising role of muscles as an endocrine organ, and how to create an effective, sustainable routine that fits your lifestyle. From understanding the difference between slow and fast-twitch muscle fibers to how myokines impact everything from brain health to inflammation, this episode is packed with game-changing insights. I’m also sharing actionable tips for optimizing your workouts, from training to failure for muscle growth to recovery techniques like proper sleep, protein intake, and using saunas post-workout. Whether you’re 20 or 70, it’s never too late to reap the life-extending benefits of strength training. Ready to take your fitness to the next level? Tune in ! I also discuss: (00:12) Why Strength Training is the Ultimate Longevity Tool (03:14) The Truth About Muscle Loss and Aging (06:35) How Strength Training Transforms Metabolic Health (17:38) Strength Training: The Key to Consistency and Longevity   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
Feeling stuck with your health? Maybe you're doing all the right things—or at least you think you are—but you're still not seeing the results you want. It’s frustrating, right? But here’s the thing: modern life is working against you. Chronic stress, hidden toxins in your environment, and mixed messages about what actually works—it’s no wonder so many of us feel lost when it comes to wellness. In today’s episode of Extend with Dr. Shah, I’m sitting down with Mona Sharma—nutritionist, wellness expert, and someone who truly gets what it takes to turn things around. We’re diving into the real reasons you might not be feeling your best, from the role of your gut health to how stress affects your body more than you realize. We also share simple, actionable ways to detox your life—without feeling overwhelmed—and how to build daily habits that stick, so you can finally feel like the best version of yourself. Mona Sharma is a leading voice in the wellness space, blending her background in integrative nutrition with her expertise in mindfulness and Ayurveda. Mona’s worked with top athletes, A-list celebrities, and people just like you to rebuild their health from the inside out. If you’re ready to break free from the cycle of exhaustion, stress, and frustration, you’re going to love this conversation. Let's jump in!    We Also Discuss: (00:00) Podcast Launch Strategy and Personal Journey (08:43) Exploring Health, Vibrational Shifts (17:19) Navigating Wellness (28:02) Optimizing Digestion and Reducing Toxins (39:52) Detoxifying Your Environment for Health (52:35) Embracing Emotional Health and Wellness (55:53) Creating Daily Rituals for Optimal Health (01:29:24) Foundations of Everyday Health Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/ IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Mona Sharma: Website: www.monasharma.com Instagram: @monasharma  
In this solo episode of Extend, I’m breaking down the science behind sustainable fitness progress and goal-setting so you can finally make those health resolutions stick. From understanding your baseline fitness level with key assessments to the power of setting small, realistic goals, I’m guiding you step-by-step through the tools that build long-term consistency. We’ll talk about everything from DEXA scans for precise body composition analysis to why grip strength and lower body power are vital indicators of longevity. I also share actionable strategies to keep you motivated, avoid plateaus, and make progress checks work for you—not against you. Whether you're starting fresh or trying to push past a plateau, you’ll walk away with a personalized blueprint for success. Ready to upgrade your fitness journey? Tune in for proven insights you can start applying today!   I Also Discuss:   (00:06) Testing Fitness Progress and Goals   (03:50) Measuring and Improving Physical Fitness   (10:17) Comprehensive Strength and Fitness Testing   (22:00) Motivating Fitness Testing and Goal Setting   Resources mentioned: PDF - Strength, Mobility, and Cardiorespiratory Fitness Assessment   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/
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